| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Gianinazzi, Denis Grandgirard, Hans Imboden, Lotti Egger, Damian N Meli, Yoeng-Delphine Bifrare, Philipp C Joss, Martin G Täuber, Christoph Borner, Stephen L Lei. Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta neuropathologica. vol 105. issue 5. 2003-06-06. PMID:12677451. |
bacterial meningitis causes neuronal apoptosis in the hippocampal dentate gyrus, which is associated with learning and memory impairments after cured disease. |
2003-06-06 |
2023-08-12 |
rat |
| Christian Gianinazzi, Denis Grandgirard, Hans Imboden, Lotti Egger, Damian N Meli, Yoeng-Delphine Bifrare, Philipp C Joss, Martin G Täuber, Christoph Borner, Stephen L Lei. Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta neuropathologica. vol 105. issue 5. 2003-06-06. PMID:12677451. |
intracisternal administration of the caspase-3-specific inhibitor ac-devd-cho significantly reduced apoptosis in the hippocampal dentate gyrus. |
2003-06-06 |
2023-08-12 |
rat |
| Christian Gianinazzi, Denis Grandgirard, Hans Imboden, Lotti Egger, Damian N Meli, Yoeng-Delphine Bifrare, Philipp C Joss, Martin G Täuber, Christoph Borner, Stephen L Lei. Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta neuropathologica. vol 105. issue 5. 2003-06-06. PMID:12677451. |
in contrast to a study where the decrease of hippocampal apoptosis after administration of a pan-caspase inhibitor was due to downmodulation of the inflammatory response, our data demonstrate that specific inhibition of caspase-3 did not affect inflammation assessed by tnf-alpha and il-1beta concentrations in the cerebrospinal fluid space. |
2003-06-06 |
2023-08-12 |
rat |
| C K Tan, J Yan, C Ananth, C Kau. Dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095657. |
dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats. |
2003-06-05 |
2023-08-12 |
rat |
| C K Tan, J Yan, C Ananth, C Kau. Dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095657. |
neuronal death by apoptosis in the hippocampus was investigated by immunohistochemistry using bcl2, bax and caspase3 antibodies. |
2003-06-05 |
2023-08-12 |
rat |
| C K Tan, J Yan, C Ananth, C Kau. Dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095657. |
the results of this study indicate that dexamethasone induces degeneration of the dendrites but does not induce neuronal apoptosis in the hippocampus of postnatal rats. |
2003-06-05 |
2023-08-12 |
rat |
| Umit Sayin, Susan Osting, Joshua Hagen, Paul Rutecki, Thomas Sutul. Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684462. |
previous studies have demonstrated that the initial seizures evoked by kindling increase paired-pulse inhibition at 15-25 msec interpulse intervals in the dentate gyrus and also induce apoptosis, progressive neuronal loss, mossy fiber sprouting, and neurogenesis, which could potentially alter the balance of excitation and/or inhibition and modify functional properties of hippocampal circuits. |
2003-05-30 |
2023-08-12 |
rat |
| Yoshiki Koriyama, Kenzo Chiba, Tetsuro Mohr. Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. European journal of pharmacology. vol 458. issue 3. 2003-05-20. PMID:12504778. |
propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. |
2003-05-20 |
2023-08-12 |
rat |
| Yoshiki Koriyama, Kenzo Chiba, Tetsuro Mohr. Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. European journal of pharmacology. vol 458. issue 3. 2003-05-20. PMID:12504778. |
beta-amyloid protein 1-42 (beta42) can induce apoptosis in the cultured hippocampal neurons, suggesting that it plays an important role in causing neurodegeneration in alzheimer's disease. |
2003-05-20 |
2023-08-12 |
rat |
| Yoshiki Koriyama, Kenzo Chiba, Tetsuro Mohr. Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. European journal of pharmacology. vol 458. issue 3. 2003-05-20. PMID:12504778. |
the present study investigated whether or not propentofylline affected the beta42-induced apoptosis of hippocampal neurons, and if so, which type of signaling machinery works in the neuroprotective action of propentofylline. |
2003-05-20 |
2023-08-12 |
rat |
| Yoshiki Koriyama, Kenzo Chiba, Tetsuro Mohr. Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. European journal of pharmacology. vol 458. issue 3. 2003-05-20. PMID:12504778. |
the amyloid protein certainly induced apoptosis in the cultured hippocampal cells revealed by nuclear condensation, caspase-3 activation and an increase of bax. |
2003-05-20 |
2023-08-12 |
rat |
| Dana Perkins, Kymberly A Gyure, Edna F R Pereira, Laure Aurelia. Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase. Journal of neurovirology. vol 9. issue 1. 2003-05-09. PMID:12587073. |
herpes simplex virus type 1 (hsv-1) triggered apoptosis in hippocampal cultures, as determined by terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling (tunel) and immunohistochemistry with antibody specific for the large fragment of activated caspase 3. |
2003-05-09 |
2023-08-12 |
Not clear |
| Dana Perkins, Kymberly A Gyure, Edna F R Pereira, Laure Aurelia. Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase. Journal of neurovirology. vol 9. issue 1. 2003-05-09. PMID:12587073. |
hsv-2 activated the mitogen-activated protein kinase/extracellular regulated protein kinase (mek/erk) survival pathway and did not trigger apoptosis in hippocampal cultures. |
2003-05-09 |
2023-08-12 |
Not clear |
| Devin S Gary, Mark P Mattso. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622404. |
pten regulates akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. |
2003-05-09 |
2023-08-12 |
mouse |
| Devin S Gary, Mark P Mattso. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622404. |
these findings demonstrate a cell death function of pten in hippocampal neurons and identify pten as a potential therapeutic target for neurodegenerative disorders that involve excitotoxicity and apoptosis. |
2003-05-09 |
2023-08-12 |
mouse |
| Jeong-Jin Je, Hyun-Taeg Shin, Seok-Hee Chung, Jong-Soo Lee, Sung-Soo Kim, Hyun-Dae Shin, Mi-Hyeon Jang, Youn-Jung Kim, Joo-Ho Chung, Ee-Hwa Kim, Chang-Ju Ki. Protective effects of Wuyaoshunqisan against H2O2-induced apoptosis on hippocampal cell line HiB5. The American journal of Chinese medicine. vol 30. issue 4. 2003-05-07. PMID:12568283. |
protective effects of wuyaoshunqisan against h2o2-induced apoptosis on hippocampal cell line hib5. |
2003-05-07 |
2023-08-12 |
Not clear |
| Jeong-Jin Je, Hyun-Taeg Shin, Seok-Hee Chung, Jong-Soo Lee, Sung-Soo Kim, Hyun-Dae Shin, Mi-Hyeon Jang, Youn-Jung Kim, Joo-Ho Chung, Ee-Hwa Kim, Chang-Ju Ki. Protective effects of Wuyaoshunqisan against H2O2-induced apoptosis on hippocampal cell line HiB5. The American journal of Chinese medicine. vol 30. issue 4. 2003-05-07. PMID:12568283. |
to investigate the protective effects of wuyaoshunqisan against h2o2-induced apoptosis in the central nervous system, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, the terminal deoxynucleotidyl transferase (tdt)-mediated dutp nick end-labeling (tunel) method, flow cytometric analysis, and the dna fragmentation assay were performed on cells of the hippocampal cell line hib5. |
2003-05-07 |
2023-08-12 |
Not clear |
| Yoshitaka Tatebayashi, Moon H Lee, Liang Li, Khalid Iqbal, Inge Grundke-Iqba. The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease. Acta neuropathologica. vol 105. issue 3. 2003-04-23. PMID:12557008. |
cerebrolysin, a neurotrophic drug which has been shown to improve cognition and mood of ad patients, was found to increase neuron-like differentiated adult rat hippocampal progenitors in culture both by reducing apoptosis and by counteracting the fgf-2-induced polarity shift. |
2003-04-23 |
2023-08-12 |
human |
| Madhuri Roy, Robert M Sapolsk. The exacerbation of hippocampal excitotoxicity by glucocorticoids is not mediated by apoptosis. Neuroendocrinology. vol 77. issue 1. 2003-04-23. PMID:12624538. |
the exacerbation of hippocampal excitotoxicity by glucocorticoids is not mediated by apoptosis. |
2003-04-23 |
2023-08-12 |
Not clear |
| Madhuri Roy, Robert M Sapolsk. The exacerbation of hippocampal excitotoxicity by glucocorticoids is not mediated by apoptosis. Neuroendocrinology. vol 77. issue 1. 2003-04-23. PMID:12624538. |
in this study we investigate whether the gc-mediated exacerbation of hippocampal excitotoxicity in culture involves apoptosis. |
2003-04-23 |
2023-08-12 |
Not clear |