| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baolu Zha. Natural antioxidants for neurodegenerative diseases. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953828. |
the author reviews the studies on the preventing effects of natural antioxidants, such as vitamins e and c, flavonoids, and polyphenols on neurodegenerative diseases, especially summarizing the results on the protective effect of ginkgo biloba extract on neuron cells, preventing effects of green tea polyphenols on apoptosis of pc12 cells (parkison's disease model), preventing effects of genestien on amyloid-beta-induced apoptosis of hippocampal neuronal cells (alzhemer's disease model), and preventing effect of crataegus flavonoids on ischemic-reperfusion damage to the brain of the mongolian gerbil (stroke model) in the laboratory. |
2006-01-24 |
2023-08-12 |
Not clear |
| G Baydas, R J Reiter, M Akbulut, M Tuzcu, S Tame. Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16213988. |
melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. |
2005-12-22 |
2023-08-12 |
rat |
| G Baydas, R J Reiter, M Akbulut, M Tuzcu, S Tame. Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16213988. |
we propose that, in addition to its antioxidant properties, melatonin has the ability to protect neuronal cells against apoptosis mediated homocysteine neurotoxicity by modulating apoptosis-regulatory proteins in the hippocampus of rats. |
2005-12-22 |
2023-08-12 |
rat |
| Li-ying Wu, Ai-shi Ding, Tong Zhao, Zi-min Ma, Fu-zhuang Wang, Ming Fa. Underlying mechanism of hypoxic preconditioning decreasing apoptosis induced by anoxia in cultured hippocampal neurons. Neuro-Signals. vol 14. issue 3. 2005-12-15. PMID:16088225. |
underlying mechanism of hypoxic preconditioning decreasing apoptosis induced by anoxia in cultured hippocampal neurons. |
2005-12-15 |
2023-08-12 |
Not clear |
| Li-ying Wu, Ai-shi Ding, Tong Zhao, Zi-min Ma, Fu-zhuang Wang, Ming Fa. Underlying mechanism of hypoxic preconditioning decreasing apoptosis induced by anoxia in cultured hippocampal neurons. Neuro-Signals. vol 14. issue 3. 2005-12-15. PMID:16088225. |
these results indicate that the increased anoxic tolerance, which is induced by hp in cultured hippocampal cells, may be correlated with bcl-2 overexpression and enhanced stability of mmp, which ultimately reduces apoptosis 24 h after reoxygenation. |
2005-12-15 |
2023-08-12 |
Not clear |
| Stephan Schubert, Gisela Stoltenburg-Didinger, Anke Wehsack, Dirk Troitzsch, Wolfgang Boettcher, Michael Huebler, Matthias Redlin, Majid Kanaan, Michael Meissler, Peter E Lange, Hashim Abdul-Khali. Large-dose pretreatment with methylprednisolone fails to attenuate neuronal injury after deep hypothermic circulatory arrest in a neonatal piglet model. Anesthesia and analgesia. vol 101. issue 5. 2005-11-22. PMID:16243986. |
in comparison to the control group, large-dose pretreatment with systemic mp lead to an increase of necrotic neuronal cell death and induced significant neuronal apoptosis in the dentate gyrus of the hippocampus (p = 0.001). |
2005-11-22 |
2023-08-12 |
Not clear |
| Sheila A Doggrel. A neuroprotective derivative of erythropoietin that is not erythropoietic. Expert opinion on investigational drugs. vol 13. issue 11. 2005-11-02. PMID:15500399. |
however, in common with epo, cepo does inhibit the apoptosis associated with glutamate toxicity in hippocampal cells. |
2005-11-02 |
2023-08-12 |
mouse |
| Zhihua Li, Bingwei Wang, Xuefei Wu, Shi-Yuan Cheng, Luminita Paraoan, Jiawei Zho. Identification, expression and functional characterization of the GRAL gene. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16086688. |
overexpression of gral-a protected pc12 cells and cultured hippocampal neurons from serum starvation-induced cell apoptosis. |
2005-11-02 |
2023-08-12 |
mouse |
| C Crochemore, J Lu, Y Wu, Z Liposits, N Sousa, F Holsboer, O F X Almeid. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Molecular psychiatry. vol 10. issue 8. 2005-10-27. PMID:15940303. |
direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. |
2005-10-27 |
2023-08-12 |
Not clear |
| A Y Chang, C H Wang, T H Chiu, J W Chi, C F Chen, L T Ho, A M Y Li. Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus. Experimental neurology. vol 195. issue 1. 2005-10-27. PMID:15950222. |
the neuroprotective effect of hypoxic preconditioning on kainate (ka)-induced neurotoxicity, including apoptosis and necrosis, was investigated in rat hippocampus. |
2005-10-27 |
2023-08-12 |
rat |
| A Y Chang, C H Wang, T H Chiu, J W Chi, C F Chen, L T Ho, A M Y Li. Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus. Experimental neurology. vol 195. issue 1. 2005-10-27. PMID:15950222. |
furthermore, tunel-positive cells, indicative of apoptosis, in the infused hippocampus were detected 72 h after ka infusion. |
2005-10-27 |
2023-08-12 |
rat |
| A Y Chang, C H Wang, T H Chiu, J W Chi, C F Chen, L T Ho, A M Y Li. Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus. Experimental neurology. vol 195. issue 1. 2005-10-27. PMID:15950222. |
our data suggest that hypoxic preconditioning may exert its neuroprotection of ka-induced oxidative injuries via attenuating both apoptosis and necrosis in rat hippocampus. |
2005-10-27 |
2023-08-12 |
rat |
| Natalie N Rizk, Jose Rafols, Joseph C Dunba. Cerebral ischemia induced apoptosis and necrosis in normal and diabetic rats. Brain research. vol 1053. issue 1-2. 2005-10-27. PMID:16038884. |
reperfusion after a 2 h mcao compared to 24 h mcao was associated with a decrease in tunel staining and caspase-3 activity in the control animal but exacerbated apoptosis, especially in the hippocampus of insulin-resistant diabetic rats. |
2005-10-27 |
2023-08-12 |
rat |
| Masaki Kamakura, Keisuke Tamaki, Toshiyuki Sakaki, Yukio Yoned. Increase of AMPA receptor glutamate receptor 1 subunit and B-cell receptor-associated protein 31 gene expression in hippocampus of fatigued mice. Neuroscience letters. vol 387. issue 1. 2005-10-13. PMID:16051435. |
we found that the genes of glur1 and b-cell receptor-associated protein 31 (bap31), which acts as a transport molecule in the secretory pathway or as a mediator of apoptosis, were upregulated in the hippocampus of fatigued mice, and increases of glur1 and bap31 were confirmed by northern blotting and real-time pcr. |
2005-10-13 |
2023-08-12 |
mouse |
| Evelyne Gozal, Zahoor A Shah, Jean-Marc Pequignot, Jacqueline Pequignot, Leroy R Sachleben, Maria F Czyzyk-Krzeska, Richard C Li, Shang-Z Guo, David Goza. Tyrosine hydroxylase expression and activity in the rat brain: differential regulation after long-term intermittent or sustained hypoxia. Journal of applied physiology (Bethesda, Md. : 1985). vol 99. issue 2. 2005-09-30. PMID:15817718. |
intermittent hypoxia, a characteristic feature of sleep apnea, leads to significant memory deficits, as well as to cortex and hippocampal apoptosis that are absent after sustained hypoxia. |
2005-09-30 |
2023-08-12 |
rat |
| Mohammed Akbar, Frances Calderon, Zhiming Wen, Hee-Yong Ki. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 31. 2005-09-20. PMID:16040805. |
consistently, in vivo reduction of dha by dietary depletion of n-3 fatty acids decreased hippocampal ps and increased neuronal susceptibility to apoptosis in cultures. |
2005-09-20 |
2023-08-12 |
Not clear |
| Alan R Brown, Selma Rebus, Clive S McKimmie, Kevin Robertson, Alun Williams, John K Fazakerle. Gene expression profiling of the preclinical scrapie-infected hippocampus. Biochemical and biophysical research communications. vol 334. issue 1. 2005-09-15. PMID:15992767. |
the results indicate oxidative and endoplasmic reticulum (er) stress, activated er and mitochondrial apoptosis pathways, and activated cholesterol biosynthesis within the scrapie-infected hippocampus, and offer insight into the molecular events which underlie the neuropathology. |
2005-09-15 |
2023-08-12 |
mouse |
| V Chaparro-Huerta, M C Rivera-Cervantes, M E Flores-Soto, U Gómez-Pinedo, C Beas-Zárat. Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats. Journal of neuroimmunology. vol 165. issue 1-2. 2005-09-08. PMID:15972237. |
proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 mapk in the hippocampus of neonatal rats. |
2005-09-08 |
2023-08-12 |
rat |
| Egemen Savaskan, Rivka Ravid, Fides Meier, Franz Müller-Spahn, Ralf Jocker. Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus. Applied immunohistochemistry & molecular morphology : AIMM. vol 13. issue 2. 2005-08-18. PMID:15894934. |
because apoptosis is a common mechanism leading to neuronal death in neurodegenerative disorders, the authors investigated the immunohistochemical distribution of fap-1 in the hippocampus of elderly control subjects and alzheimer disease (ad) patients. |
2005-08-18 |
2023-08-12 |
human |
| Nazan Uysal, Kazim Tugyan, Berkant Muammer Kayatekin, Osman Acikgoz, Husnu Alper Bagriyanik, Sevil Gonenc, Durgul Ozdemir, Ilkay Aksu, Ayca Topcu, Ilgi Semi. The effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis and spatial memory. Neuroscience letters. vol 383. issue 3. 2005-08-09. PMID:15878799. |
the effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis and spatial memory. |
2005-08-09 |
2023-08-12 |
rat |