| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M P Flavin, G Zhao, L T H. Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro. Glia. vol 29. issue 4. 2000-04-11. PMID:10652444. |
we previously showed that conditioned medium (cm) harvested from peritoneal macrophages or from activated microglia triggered apoptosis in rat hippocampal neurons in culture. |
2000-04-11 |
2023-08-12 |
human |
| P J Kingham, J M Pococ. Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737601. |
treatment of primary cultures of rat brain microglia or the murine n9 microglial cell line with chromogranin a resulted in nitric oxide production, which triggered microglial apoptosis. |
2000-04-11 |
2023-08-12 |
rat |
| K Bulloch, M Sadamatsu, A Patel, B S McEwe. Calcitonin gene-related peptide immunoreactivity in the hippocampus and its relationship to cellular changes following exposure to trimethyltin. Journal of neuroscience research. vol 55. issue 4. 2000-03-29. PMID:10723055. |
we have specifically focused on comparing the changes in cgrp-ir with the pattern of apoptosis (via tunel staining), cell-cycle activation (ki67-ir), and in alteration in microglia (ox-42-ir) and astrocyte (ggfap-ir) immunocytochemistry in tmt-treated hippocampus. |
2000-03-29 |
2023-08-12 |
Not clear |
| K Bulloch, M Sadamatsu, A Patel, B S McEwe. Calcitonin gene-related peptide immunoreactivity in the hippocampus and its relationship to cellular changes following exposure to trimethyltin. Journal of neuroscience research. vol 55. issue 4. 2000-03-29. PMID:10723055. |
our results show a marked change in cgrp-ir in regions of the hippocampus that are temporally and anatomically correlated with the induction of apoptosis and activation of microglia, astrocyte, and the cell-cycle marker. |
2000-03-29 |
2023-08-12 |
Not clear |
| M Sawad. [Brain cytokine network and novel characteristics of microglia]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 4. 2000-02-16. PMID:10681160. |
although little is known about microglia in the normal cns, it is obvious that they are quickly activated in all acute pathological events including apoptosis, neurodegeneration and inflammation. |
2000-02-16 |
2023-08-12 |
Not clear |
| M Sawad. [Brain cytokine network and novel characteristics of microglia]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 4. 2000-02-16. PMID:10681160. |
activation of microglia in apoptosis is a double-edged response; under severe apoptotic conditions, microglia act as scavengers removing tissue debris and inducing apoptosis in damaged cells, whereas in more subtle injury they exert a surveillance function and might play a protective role. |
2000-02-16 |
2023-08-12 |
Not clear |
| M Sawad. [Brain cytokine network and novel characteristics of microglia]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 4. 2000-02-16. PMID:10681160. |
to understand the molecular basis of controlling mechanisms of microglia in apoptosis, the study requires in vivo models. |
2000-02-16 |
2023-08-12 |
Not clear |
| M Sawad. [Brain cytokine network and novel characteristics of microglia]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 4. 2000-02-16. PMID:10681160. |
for such purpose, we developed the brain-targeting gene delivery system using immortalized microglia, which can facilitate investigation into the roles of particular microglial genes in apoptosis and the gene therapy of several brain disorders. |
2000-02-16 |
2023-08-12 |
Not clear |
| H J James, L R Sharer, Q Zhang, H G Wang, L G Epstein, J C Reed, H A Gelbar. Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis. Neuropathology and applied neurobiology. vol 25. issue 5. 1999-11-30. PMID:10564527. |
apoptosis of neurones, macrophages, and microglia occurs in the brains of paediatric patients with human immunodeficiency virus (hiv) type 1 encephalitis, which is often associated with pre-mortem neurological disease (progressive encephalopathy). |
1999-11-30 |
2023-08-12 |
human |
| P J Kingham, M L Cuzner, J M Pococ. Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428049. |
conditioned medium from activated microglia kills cerebellar granule cells by inducing caspase-3-dependent neuronal apoptosis. |
1999-08-13 |
2023-08-12 |
rat |
| K Tanabe, H Nakanishi, H Maeda, T Nishioku, K Hashimoto, S Y Liou, A Akamine, K Yamamot. A predominant apoptotic death pathway of neuronal PC12 cells induced by activated microglia is displaced by a non-apoptotic death pathway following blockage of caspase-3-dependent cascade. The Journal of biological chemistry. vol 274. issue 22. 1999-06-29. PMID:10336472. |
when treated with activated microglia, neuronal pc12 cells undergo apoptosis accompanied by caspase-3-like protease activation and dna fragmentation. |
1999-06-29 |
2023-08-12 |
Not clear |
| M Sawad. [Apoptosis and microglia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190125. |
[apoptosis and microglia]. |
1999-05-10 |
2023-08-12 |
Not clear |
| M Sawad. [Apoptosis and microglia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190125. |
although little is known about microglia in the normal cns, it is obvious that they are quickly activated in all acute pathological events including apoptosis, neurodegeneration and inflammation. |
1999-05-10 |
2023-08-12 |
Not clear |
| M Sawad. [Apoptosis and microglia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190125. |
activation of microglia in apoptosis is a double-edged response; under severe apoptotic conditions microglia act as scavengers removing tissue debris and inducing apoptosis in damaged cells, whereas in more subtle injury they exert a surveillance function and might play a protective role. |
1999-05-10 |
2023-08-12 |
Not clear |
| M Sawad. [Apoptosis and microglia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190125. |
to understand molecular basis of controlling mechanisms of microglia in apoptosis, the study will need in vivo models. |
1999-05-10 |
2023-08-12 |
Not clear |
| M Sawad. [Apoptosis and microglia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190125. |
for such purpose, we developed the brain-targeting gene delivery system using immortalized microglia, which can facilitate investigation into the roles of particular microglial genes in apoptosis and gene therapy of several brain disorders. |
1999-05-10 |
2023-08-12 |
Not clear |
| S P Ledoux, C C Shen, V I Grishko, P A Fields, A L Gard, G L Wilso. Glial cell-specific differences in response to alkylation damage. Glia. vol 24. issue 3. 1999-01-12. PMID:9775981. |
in the present study, apoptosis, as determined by dna laddering and ultrastructural analysis, was clearly induced by mnu treatment of cultured oligodendrocyte progenitors and microglia, but not in astroglia. |
1999-01-12 |
2023-08-12 |
rat |
| N Takai, H Nakanishi, K Tanabe, T Nishioku, T Sugiyama, M Fujiwara, K Yamamot. Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine. Journal of neuroscience research. vol 54. issue 2. 1999-01-07. PMID:9788280. |
involvement of caspase-like proteinases in apoptosis of neuronal pc12 cells and primary cultured microglia induced by 6-hydroxydopamine. |
1999-01-07 |
2023-08-12 |
rat |
| N Takai, H Nakanishi, K Tanabe, T Nishioku, T Sugiyama, M Fujiwara, K Yamamot. Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine. Journal of neuroscience research. vol 54. issue 2. 1999-01-07. PMID:9788280. |
pepstatin a and leupeptin, potent inhibitors of aspartic and cysteine proteinases, respectively, partly inhibited the apoptosis of microglia but not neuronal pc12 cells. |
1999-01-07 |
2023-08-12 |
rat |
| N Takai, H Nakanishi, K Tanabe, T Nishioku, T Sugiyama, M Fujiwara, K Yamamot. Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine. Journal of neuroscience research. vol 54. issue 2. 1999-01-07. PMID:9788280. |
these results suggest that mechanisms by which 6-ohda induces apoptosis in these two cell types are distinct; 6-ohda incorporated into neuronal pc12 cells and its metabolites may activate the caspase-like enzymes, whereas oxidative metabolites of the agent produced extracellularly may activate the caspase and the endosomal/lysosomal proteolytic systems in microglia. |
1999-01-07 |
2023-08-12 |
rat |