| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K S Spanaus, R Schlapbach, A Fontan. TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL. European journal of immunology. vol 28. issue 12. 1999-01-05. PMID:9862377. |
tnf-alpha and ifn-gamma render microglia sensitive to fas ligand-induced apoptosis by induction of fas expression and down-regulation of bcl-2 and bcl-xl. |
1999-01-05 |
2023-08-12 |
Not clear |
| K S Spanaus, R Schlapbach, A Fontan. TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL. European journal of immunology. vol 28. issue 12. 1999-01-05. PMID:9862377. |
in the present study we investigated the susceptibility of primary murine microglia and of the murine microglial cell line bv-2 to undergo fas-mediated apoptosis. |
1999-01-05 |
2023-08-12 |
Not clear |
| K S Spanaus, R Schlapbach, A Fontan. TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL. European journal of immunology. vol 28. issue 12. 1999-01-05. PMID:9862377. |
whereas resting microglia are resistant to fas ligand (fasl) treatment, induction of fasl-mediated apoptosis was achieved by treatment with tnf-alpha or ifn-gamma. |
1999-01-05 |
2023-08-12 |
Not clear |
| K S Spanaus, R Schlapbach, A Fontan. TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL. European journal of immunology. vol 28. issue 12. 1999-01-05. PMID:9862377. |
activation of microglia by tnf-alpha and ifn-gamma was also accompanied by increased amounts of mrna for the apoptosis inhibitor flip, an effect which did not protect the cells from fasl-induced apoptosis. |
1999-01-05 |
2023-08-12 |
Not clear |
| K S Spanaus, R Schlapbach, A Fontan. TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL. European journal of immunology. vol 28. issue 12. 1999-01-05. PMID:9862377. |
the fasl-induced cell death pathway in microglia involves reactive oxygen intermediates because the antioxidants n-acetylcysteine and glutathione interfere with induction of apoptosis. |
1999-01-05 |
2023-08-12 |
Not clear |
| T Adayev, R Estephan, S Meserole, B Mazza, E J Yurkow, P Banerje. Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the phosphatidylserine-displaying apoptotic cells are phagocytosed by microglia. Journal of neurochemistry. vol 71. issue 5. 1998-11-30. PMID:9798909. |
externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the phosphatidylserine-displaying apoptotic cells are phagocytosed by microglia. |
1998-11-30 |
2023-08-12 |
mouse |
| V H Perr. A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation. Journal of neuroimmunology. vol 90. issue 2. 1998-11-24. PMID:9817438. |
although in vitro studies show that microglia do not support a primary immune response leading to t-cell proliferation, they do show that microglia may protect the cns from the unwanted attentions of autoreactive t-cells by inducing their apoptosis. |
1998-11-24 |
2023-08-12 |
Not clear |
| K Rupalla, P R Allegrini, D Sauer, C Wiessne. Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice. Acta neuropathologica. vol 96. issue 2. 1998-11-06. PMID:9705133. |
time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice. |
1998-11-06 |
2023-08-12 |
mouse |
| C Yong, P M Arnold, M N Zoubine, B A Citron, I Watanabe, N E Berman, B W Festof. Apoptosis in cellular compartments of rat spinal cord after severe contusion injury. Journal of neurotrauma. vol 15. issue 7. 1998-10-27. PMID:9674550. |
about one-third were microglia, whereas neurons, both large and small, also underwent apoptosis, again peaking at day 3. |
1998-10-27 |
2023-08-12 |
rat |
| C A White, P A McCombe, M P Pende. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). International immunology. vol 10. issue 7. 1998-10-16. PMID:9701031. |
microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving fas (cd95). |
1998-10-16 |
2023-08-12 |
rat |
| C A White, P A McCombe, M P Pende. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). International immunology. vol 10. issue 7. 1998-10-16. PMID:9701031. |
morphological studies have shown that macrophages and microglia undergo apoptosis in the central nervous system (cns) in acute experimental autoimmune encephalomyelitis (eae) in the lewis rat. |
1998-10-16 |
2023-08-12 |
rat |
| C A White, P A McCombe, M P Pende. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). International immunology. vol 10. issue 7. 1998-10-16. PMID:9701031. |
microglia were highly vulnerable to apoptosis and were over-represented in the apoptotic population. |
1998-10-16 |
2023-08-12 |
rat |
| C A White, P A McCombe, M P Pende. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). International immunology. vol 10. issue 7. 1998-10-16. PMID:9701031. |
macrophages were less susceptible to apoptosis than microglia and underwent mitosis more frequently than microglia. |
1998-10-16 |
2023-08-12 |
rat |
| C A White, P A McCombe, M P Pende. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). International immunology. vol 10. issue 7. 1998-10-16. PMID:9701031. |
the different susceptibilities of microglia and macrophages to apoptosis did not appear to be due to variations in fas, fasl or bcl-2 expression, as the proportions of microglia and macrophages expressing these proteins were similar, and were relatively high. |
1998-10-16 |
2023-08-12 |
rat |
| C A White, P A McCombe, M P Pende. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). International immunology. vol 10. issue 7. 1998-10-16. PMID:9701031. |
these results indicate that the apoptosis of microglia and cns macrophages in eae is not mediated through the fas pathway, and that bcl-2 expression does not protect them from apoptosis. |
1998-10-16 |
2023-08-12 |
rat |
| C A White, P A McCombe, M P Pende. Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95). International immunology. vol 10. issue 7. 1998-10-16. PMID:9701031. |
the high level of microglial apoptosis in eae indicates that microglial apoptosis may be an important homeostatic mechanism for controlling the number of microglia in the cns following microglial activation and proliferation. |
1998-10-16 |
2023-08-12 |
rat |
| B Bonetti, J Pohl, Y L Gao, C S Rain. Cell death during autoimmune demyelination: effector but not target cells are eliminated by apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 11. 1998-04-20. PMID:9548518. |
infiltrating cd4+ t cells and parenchymal microglia expressed fas, fasl, and bax, and about half of these cells showed dna fragmentation, a combination indicative of ongoing apoptosis. |
1998-04-20 |
2023-08-12 |
Not clear |
| F Yang, X Sun, W Beech, B Teter, S Wu, J Sigel, H V Vinters, S A Frautschy, G M Col. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. The American journal of pathology. vol 152. issue 2. 1998-03-06. PMID:9466564. |
antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in alzheimer's disease. |
1998-03-06 |
2023-08-12 |
human |
| S L Shuman, J C Bresnahan, M S Beatti. Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. Journal of neuroscience research. vol 50. issue 5. 1998-02-18. PMID:9418967. |
apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. |
1998-02-18 |
2023-08-12 |
rat |
| S L Shuman, J C Bresnahan, M S Beatti. Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. Journal of neuroscience research. vol 50. issue 5. 1998-02-18. PMID:9418967. |
the hypothesis that oligodendrocyte apoptosis is secondary to microglial activation is supported by our observations of microglia with an activated morphology in the same regions as apoptosis and apparent contact between some of the apoptotic oligodendrocytes and microglial processes. |
1998-02-18 |
2023-08-12 |
rat |