| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Koyama, Y Kimura, Y Yoshioka, D Wakamatsu, R Kozaki, H Hashimoto, T Matsuda, A Bab. Serum-deprivation induces cell death of rat cultured microglia accompanied with expression of Bax protein. Japanese journal of pharmacology. vol 83. issue 4. 2001-02-02. PMID:11001183. |
these observations suggest that bax expression underlies the apoptosis of cultured microglia after serum deprivation. |
2001-02-02 |
2023-08-12 |
rat |
| R Schlapbach, K S Spanaus, U Malipiero, S Lens, A Tasinato, J Tschopp, A Fontan. TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia. European journal of immunology. vol 30. issue 12. 2001-01-26. PMID:11169411. |
tgf-beta induces the expression of the flice-inhibitory protein and inhibits fas-mediated apoptosis of microglia. |
2001-01-26 |
2023-08-12 |
Not clear |
| R Schlapbach, K S Spanaus, U Malipiero, S Lens, A Tasinato, J Tschopp, A Fontan. TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia. European journal of immunology. vol 30. issue 12. 2001-01-26. PMID:11169411. |
despite the presence of tnf-alpha and ifn-gamma, both being capable of sensitizing microglia to fasl, apoptosis of microglia is not a hallmark of inflammatory diseases of the cns. |
2001-01-26 |
2023-08-12 |
Not clear |
| R Schlapbach, K S Spanaus, U Malipiero, S Lens, A Tasinato, J Tschopp, A Fontan. TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia. European journal of immunology. vol 30. issue 12. 2001-01-26. PMID:11169411. |
in the present study, tgf-beta is found to counteract the effect of tnf-alpha and ifn-gamma to sensitize microglia to fasl-mediated apoptosis. |
2001-01-26 |
2023-08-12 |
Not clear |
| R Schlapbach, K S Spanaus, U Malipiero, S Lens, A Tasinato, J Tschopp, A Fontan. TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia. European journal of immunology. vol 30. issue 12. 2001-01-26. PMID:11169411. |
as a key inhibitor of fas-mediated apoptosis, we found expression of the cellular flice-inhibitory protein (c-flip) to be induced by tgf-beta in resting as well as in activated microglia. |
2001-01-26 |
2023-08-12 |
Not clear |
| D H Shin, H Y Lee, H W Lee, K H Lee, H S Lim, G S Jeon, S S Cho, D H Hwan. Activation of microglia in kainic acid induced rat retinal apoptosis. Neuroscience letters. vol 292. issue 3. 2000-11-09. PMID:11018301. |
activation of microglia in kainic acid induced rat retinal apoptosis. |
2000-11-09 |
2023-08-12 |
rat |
| D H Shin, H Y Lee, H W Lee, K H Lee, H S Lim, G S Jeon, S S Cho, D H Hwan. Activation of microglia in kainic acid induced rat retinal apoptosis. Neuroscience letters. vol 292. issue 3. 2000-11-09. PMID:11018301. |
when histochemical studies were performed to determine the cellular identity of the phagocytes, the microglia were thought to be the one and only type of phagocytes involved in the ka-induced retinal apoptosis. |
2000-11-09 |
2023-08-12 |
rat |
| S B Hollensworth, C Shen, J E Sim, D R Spitz, G L Wilson, S P LeDou. Glial cell type-specific responses to menadione-induced oxidative stress. Free radical biology & medicine. vol 28. issue 8. 2000-11-07. PMID:10889445. |
apoptosis was detected and quantitated in menadione-treated oligodendrocytes and microglia (but not astrocytes) using either positive annexin-v staining or positive staining for 3'-oh groups in dna. |
2000-11-07 |
2023-08-12 |
rat |
| S B Hollensworth, C Shen, J E Sim, D R Spitz, G L Wilson, S P LeDou. Glial cell type-specific responses to menadione-induced oxidative stress. Free radical biology & medicine. vol 28. issue 8. 2000-11-07. PMID:10889445. |
the differential susceptibility of glial cell types to oxidative damage and apoptosis did not appear related to cellular antioxidant capacity, because under the current culture conditions astrocytes had lower total glutathione content and superoxide dismutase activity than oligodendrocytes and microglia. |
2000-11-07 |
2023-08-12 |
rat |
| O Ohya, H Ikeda, U Tomaru, I Yamashita, T Kasai, K Morita, A Wakisaka, T Yoshik. Human T-lymphocyte virus type I (HTLV-I)-induced myeloneuropathy in rats: oligodendrocytes undergo apoptosis in the presence of HTLV-I. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 108. issue 6. 2000-10-25. PMID:11028810. |
in the thoracic spinal cord of rats with htlv-i infection, the first event was the appearance of apoptosis of oligodendrocytes beginning at 7 months after induced infection, thereafter followed by the appearance of white matter degeneration, increase of macrophages/activated microglia and of gemistocytic astrocytes at 12, 15 and 20 months, respectively. |
2000-10-25 |
2023-08-12 |
human |
| K Morigiwa, Y Fukuda, M Yamashit. [Neurotransmitter ATP and cytokine release]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 115. issue 4. 2000-10-02. PMID:10876802. |
p2z activation was simultaneously anti-mitotic and induced apoptosis of microglia. |
2000-10-02 |
2023-08-12 |
rat |
| T Nishioku, N Takai, K Miyamoto, K Murao, C Hara, K Yamamoto, H Nakanish. Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia. Brain research. vol 871. issue 1. 2000-09-29. PMID:10882796. |
involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia. |
2000-09-29 |
2023-08-12 |
rat |
| T Nishioku, N Takai, K Miyamoto, K Murao, C Hara, K Yamamoto, H Nakanish. Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia. Brain research. vol 871. issue 1. 2000-09-29. PMID:10882796. |
these results indicate that a relatively low concentration of mehg predominantly induces caspase-3-like protease-executed apoptosis of microglia, while the endosomal/lysosomal system is also partially involved in the cell death pathway. |
2000-09-29 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
identities of cell types undergoing apoptosis were assessed using immunohistochemistry or in situ hybridization using markers for neurons, glial progenitor cells, microglia, oligodendrocytes and astrocytes. |
2000-09-28 |
2023-08-12 |
rat |
| D Gabuzda, J Wan. Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis. Journal of neurovirology. vol 6 Suppl 1. 2000-08-11. PMID:10871762. |
the neurodegenerative mechanisms may involve infection of microglia by certain cxcr4 tropic viruses in addition to cellular dysfunction and apoptosis induced by hiv-1 gp120 binding to cxcr4. |
2000-08-11 |
2023-08-12 |
Not clear |
| A M Sandmair, M Turunen, K Tyynelä, S Loimas, P Vainio, R Vanninen, M Vapalahti, R Bjerkvig, J Jänne, S Ylä-Herttual. Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions. Cancer gene therapy. vol 7. issue 3. 2000-08-04. PMID:10766347. |
tissue reactions after 14 days of gcv treatment are characterized by astrogliosis and apoptosis, whereas microglia response and immunoactivation of the brain cells appear to play a minor role. |
2000-08-04 |
2023-08-12 |
human |
| B Badie, J Schartner, J Vorpahl, K Presto. Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739635. |
interferon-gamma induces apoptosis and augments the expression of fas and fas ligand by microglia in vitro. |
2000-05-23 |
2023-08-12 |
Not clear |
| B Badie, J Schartner, J Vorpahl, K Presto. Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739635. |
nuclear fragmentation, suggestive of apoptosis, was noted within 24 h of incubation of microglia with ifn-gamma (10 u/ml). |
2000-05-23 |
2023-08-12 |
Not clear |
| B Badie, J Schartner, J Vorpahl, K Presto. Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739635. |
these findings suggest that in addition to its role as a microglia activator, ifn-gamma may also induce apoptosis of microglia, possibly through simultaneous upregulation of fas and fasl. |
2000-05-23 |
2023-08-12 |
Not clear |
| B Badie, J Schartner, J Vorpahl, K Presto. Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739635. |
interferon-gamma modulation of the fas pathway and apoptosis in microglia may be important in the pathogenesis of inflammatory cns disease processes. |
2000-05-23 |
2023-08-12 |
Not clear |