| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Dhein, H Walczak, M O Westendorp, C Bäumler, K Stricker, R Frank, K M Debatin, P H Kramme. Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS. Behring Institute Mitteilungen. issue 96. 1995-11-22. PMID:7575348. |
the cell surface molecule apo-1/fas(cd95), a member of the tumor necrosis factor (tnf) receptor/nerve growth factor (ngf) receptor superfamily mediates apoptosis upon cross-linking by agonistic antibodies or its ligand. |
1995-11-22 |
2023-08-12 |
Not clear |
| R Beyaert, B Vanhaesebroeck, W Declercq, J Van Lint, P Vandenabele, P Agostinis, J R Vandenheede, W Fier. Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis. The Journal of biological chemistry. vol 270. issue 40. 1995-11-14. PMID:7559483. |
in contrast, tnf signaling via p75 seems so far largely restricted to cells of lymphoid origin, where it can induce proliferation, cytokine production, and/or apoptosis. |
1995-11-14 |
2023-08-12 |
Not clear |
| L Genestier, N Bonnefoy-Berard, J P Rouault, M Flacher, J P Revillar. Tumor necrosis factor-alpha up-regulates Bcl-2 expression and decreases calcium-dependent apoptosis in human B cell lines. International immunology. vol 7. issue 4. 1995-11-06. PMID:7547679. |
we show here that tumor necrosis factor (tnf)-alpha protects these b cell lines against ca(2+)-dependent apoptosis. |
1995-11-06 |
2023-08-12 |
human |
| L Zheng, G Fisher, R E Miller, J Peschon, D H Lynch, M J Lenard. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature. vol 377. issue 6547. 1995-11-06. PMID:7566090. |
here we show that tumour necrosis factor (tnf) can mediate mature t-cell receptor-induced apoptosis through the p75 tnf receptor. |
1995-11-06 |
2023-08-12 |
mouse |
| K Hofmann, J Tschop. The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance. FEBS letters. vol 371. issue 3. 1995-10-26. PMID:7556620. |
the death domain motif found in fas (apo-1) and tnf receptor is present in proteins involved in apoptosis and axonal guidance. |
1995-10-26 |
2023-08-12 |
Not clear |
| C B Powell, T J Herzog, J H Scott, J L Collin. Evidence for a protein synthesis-dependent and -independent TNF alpha cytolytic mechanism. Gynecologic oncology. vol 58. issue 3. 1995-10-17. PMID:7545633. |
both tnf alpha cytolytic mechanisms cause apoptosis (fragmentation of dna) as shown by the tnf alpha-mediated release of tritiated thymidine, apoptag, and dapi staining, in the presence or absence of em or act-d. |
1995-10-17 |
2023-08-12 |
Not clear |
| M Higuchi, S Singh, H Chan, B B Aggarwa. Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation. Blood. vol 86. issue 6. 1995-10-12. PMID:7662972. |
therefore, we conclude that tnf activates two distinct tpck-sensitive pathways, one leading to apoptosis and the other to nf-kappa b activation. |
1995-10-12 |
2023-08-12 |
human |
| M Miura, R M Friedlander, J Yua. Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 18. 1995-10-12. PMID:7667287. |
these results suggest that one or more members of the ice family sensitive to crma inhibition are activated and play a critical role in apoptosis induced by tnf. |
1995-10-12 |
2023-08-12 |
Not clear |
| A Cossarizza, C Franceschi, D Monti, S Salvioli, E Bellesia, R Rivabene, L Biondo, G Rainaldi, A Tinari, W Malorn. Protective effect of N-acetylcysteine in tumor necrosis factor-alpha-induced apoptosis in U937 cells: the role of mitochondria. Experimental cell research. vol 220. issue 1. 1995-10-06. PMID:7664840. |
our results show that tnf exposure is capable of altering the mitochondria and that nac protection from chx + tnf-induced apoptosis could be due to a direct effect of the drug on mitochondrial integrity and function. |
1995-10-06 |
2023-08-12 |
Not clear |
| P H Tan, Y Liu, E B Santos, B M Sandmaie. Mechanisms of enhancement of natural killer activity by an antibody to CD44: increase in conjugate formation and release of tumor necrosis factor alpha. Cellular immunology. vol 164. issue 2. 1995-10-02. PMID:7544692. |
this factor was found to lyse only tnf alpha-sensitive targets (ctac and l929 cell lines) and caused apoptosis in the target cells. |
1995-10-02 |
2023-08-12 |
Not clear |
| C Fady, A Gardner, F Jacoby, K Briskin, Y Tu, I Schmid, A Lichtenstei. Atypical apoptotic cell death induced in L929 targets by exposure to tumor necrosis factor. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 15. issue 1. 1995-09-28. PMID:7648436. |
this atypical pattern of apoptosis was a characteristic of l929 target cells rather than a generalized cytotoxic response to tnf because tnf-treated squamous cancer cells showed typical features of apoptosis (dna fragmentation before cytotoxicity) and etoposide-treated l929 cells demonstrated the same atypical kinetics as tnf-treated cells. |
1995-09-28 |
2023-08-12 |
Not clear |
| V B O'Donnell, S Spycher, A Azz. Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. The Biochemical journal. vol 310 ( Pt 1). 1995-09-20. PMID:7646435. |
using specific inhibitors, we ruled out involvement of several oxidant-generating enzymes [cyclo-oxygenase (indomethacin), cytochrome p-450 (metyrapone), nitric oxide synthase (ng-methyl-l-arginine), nadph oxidase (iodonium diphenyl), xanthine oxidase (allopurinol), ribonucleotide reductase (hydroxyurea)] in tnf alpha-mediated apoptosis of the murine fibrosarcoma line, l929. |
1995-09-20 |
2023-08-12 |
Not clear |
| P Vandenabeele, V Goossens, R Beyaert, W Declercq, J Grooten, B Vanhaesebroeck, M Van de Craen, D Vercammen, B Depuydt, G Denecke. Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity. Circulatory shock. vol 44. issue 4. 1995-09-07. PMID:7628061. |
functional requirement of the two tnf receptors for induction of apoptosis in pc60 cells and the role of mitochondria in tnf-induced cytotoxicity. |
1995-09-07 |
2023-08-12 |
human |
| P Vandenabeele, V Goossens, R Beyaert, W Declercq, J Grooten, B Vanhaesebroeck, M Van de Craen, D Vercammen, B Depuydt, G Denecke. Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity. Circulatory shock. vol 44. issue 4. 1995-09-07. PMID:7628061. |
but only in cells carrying both htnf-r55 and htnf-r75, was tnf able to induce apoptosis. |
1995-09-07 |
2023-08-12 |
human |
| E Decoster, B Vanhaesebroeck, P Vandenabeele, J Grooten, W Fier. Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor. The Journal of biological chemistry. vol 270. issue 31. 1995-09-07. PMID:7629174. |
induction of apoptosis, proliferation, or cytokine production by triggering of either 55-kda or 75-kda tnf receptors in appropriate cell lines occurred efficiently both with soluble and with membrane-bound tnf. |
1995-09-07 |
2023-08-12 |
Not clear |
| L Ji, G Zhang, Y Hirabayash. Inhibition of tumor necrosis factor alpha- and ceramide-induced internucleosomal DNA fragmentation by herbimycin A in U937 cells. Biochemical and biophysical research communications. vol 212. issue 2. 1995-08-31. PMID:7542883. |
in many tumor cell lines, tumor necrosis factor alpha (tnf alpha) causes apoptosis with characteristic internucleosomal dna fragmentation. |
1995-08-31 |
2023-08-12 |
Not clear |
| D R Beidler, M Tewari, P D Friesen, G Poirier, V M Dixi. The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. The Journal of biological chemistry. vol 270. issue 28. 1995-08-25. PMID:7542648. |
we now show for the first time that p35 also inhibits fas- and tumor necrosis factor (tnf)-induced apoptosis. |
1995-08-25 |
2023-08-12 |
caenorhabditis_elegans |
| A Ayala, C D Herdon, D L Lehman, C M DeMaso, C A Ayala, I H Chaudr. The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor. Shock (Augusta, Ga.). vol 3. issue 4. 1995-08-08. PMID:7600193. |
thymic programmed cell death (pcd) or apoptosis (ao) is elevated during inflammation by a variety of stressors in vitro (i.e., glucocorticoids, tumor necrosis factor (tnf), prostanoids, etc. |
1995-08-08 |
2023-08-12 |
mouse |
| H Matsue, H Kobayashi, T Hosokawa, T Akitaya, A Ohkawar. Keratinocytes constitutively express the Fas antigen that mediates apoptosis in IFN gamma-treated cultured keratinocytes. Archives of dermatological research. vol 287. issue 3-4. 1995-08-03. PMID:7541192. |
we then tested the ability of several cytokines (tgf beta, tnf alpha and ifn gamma) to induce fas-mediated keratinocyte apoptosis. |
1995-08-03 |
2023-08-12 |
human |
| M Jäättelä, M Benedict, M Tewari, J A Shayman, V M Dixi. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7540278. |
bcl-x and bcl-2 inhibit tnf and fas-induced apoptosis and activation of phospholipase a2 in breast carcinoma cells. |
1995-07-18 |
2023-08-12 |
Not clear |