| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Salma Aboelela, Abeer Ashmawy, Sabry Shaarawy, Mohammed El-Hefny, Amina Medha. Telomerase as a Possible Candidate Targeting Therapy in Different Breast Cancer Cell Lines. Asian Pacific journal of cancer prevention : APJCP. vol 21. issue 8. 2021-06-03. PMID:32856851. |
the present work investigated the effects of telomerase inhibition by sirna on breast cancer cell lines and studied the feasibility of whether the combined effect of doxorubicin with sirna treatment on breast cancer cells potentiates a rapid cellular response to the cytotoxic effect of chemotherapy. methods: this study was performed on luminal a (mcf-7), triple negative (mda-mb-468), and her-2/neu (skbr-3) human breast cancer cell lines, wherein telomerase activity inhibition by htert sirna and doxorubicin was detected by measuring telomerase activity using telomeric repeat amplification protocol (trap assay), assessing cell viability through mtt assay, and evaluating apoptosis through scanning electron microscopy (sem) and through estimating caspase-3 and -8 activities using enzyme-linked immunosorbent assay (elisa). |
2021-06-03 |
2023-08-13 |
human |
| Wei He, Songyuan Chi, Xing Jin, Jieyu Lu, Wei Zheng, Jie Yan, Duo Zhan. Long Non-Coding RNA BACE1-AS Modulates Isoflurane-Induced Neurotoxicity to Alzheimer's Disease Through Sponging miR-214-3p. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32681443. |
the proliferation and apoptosis of aβ-treated sk-n-sh and sk-n-as cells were determined via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-h-tetrazolium bromide (mtt) or flow cytometry assays, respectively. |
2021-06-01 |
2023-08-13 |
Not clear |
| Furong Song, Jun Liu, Yawei Feng, Yi Ji. Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458. International journal of molecular medicine. vol 46. issue 3. 2021-06-01. PMID:32705160. |
mtt assay, flow cytometry analysis and transwell assays were conducted to examine cell proliferation, apoptosis, migration and invasion, respectively. |
2021-06-01 |
2023-08-13 |
human |
| Fangdong Guo, Xiaoyu Zhu, Qingquan Zhao, Qirong Huan. miR‑589‑3p sponged by the lncRNA TINCR inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the Akt pathway via IGF1R. International journal of molecular medicine. vol 46. issue 3. 2021-06-01. PMID:32705168. |
the effects of tincr and mir‑589‑3p on the proliferation, apoptosis, migratory and invasive abilities of some breast cancer cell lines were detected by mtt assay, flow cytometry, wound healing assay and transwell assay. |
2021-06-01 |
2023-08-13 |
Not clear |
| Zhongjin Liu, Haiyan Zhang, Lihui Sun, Kunjie Zhu, Weiya Lan. miR-29c-3p Increases Cell Viability and Suppresses Apoptosis by Regulating the TNFAIP1/NF-κB Signaling Pathway via TNFAIP1 in Aβ-Treated Neuroblastoma Cells. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32712875. |
besides, cell proliferation and apoptosis rate were determined by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-h-tetrazolium bromide (mtt) assay and flow cytometry analysis, respectively. |
2021-06-01 |
2023-08-13 |
Not clear |
| Tulin Ozkan, Yalda Hekmatshoar, Hanife Pamuk, Merve Ozcan, Guler Yaman, Gulsah Ceylan Yagiz, Cigdem Akdemir, Asuman Sungurogl. Cytotoxic effect of 6-Shogaol in Imatinib sensitive and resistant K562 cells. Molecular biology reports. vol 48. issue 2. 2021-06-01. PMID:33515349. |
cell viability and apoptosis were investigated with spectrophotometric mtt assay and flow cytometric annexin v staining, respectively. |
2021-06-01 |
2023-08-13 |
Not clear |
| Yanfa Dai, Jingyuan Nie, Zhongqin Luo, Dongsong Ni. Expression profile analysis of a new testis-specifically expressed gene C17ORF64 and its association with cell apoptosis in MCF-7 cells. Molecular biology reports. vol 48. issue 2. 2021-06-01. PMID:33566224. |
c17orf64 overexpression not only promoted cell apoptosis in mcf-7 cells, but also significantly decreased cell viability via mtt assay. |
2021-06-01 |
2023-08-13 |
mouse |
| Xifeng Tao, Yafei Fang, Chen Hu. Long non-coding RNA Rian protects against experimental bronchopulmonary dysplasia by sponging miR-421. Experimental and therapeutic medicine. vol 22. issue 1. 2021-06-01. PMID:34055080. |
cell growth and apoptosis were evaluated using an mtt assay and flow cytometry, respectively. |
2021-06-01 |
2023-08-13 |
mouse |
| Guoxuan Luo, Shengqiang Jiang, Xu Zhang, Yunzhi Ling, Hengshan Luo, Yong Zhan. Gambogic Acid Affects Ribosomal Occurrence in Glioma Cells by Downregulating the Phosphoinositide Kinase-3/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway. Journal of nanoscience and nanotechnology. vol 20. issue 6. 2021-05-31. PMID:31748028. |
cell viability and apoptosis were evaluated by mtt and annexin v/pi double staining. |
2021-05-31 |
2023-08-13 |
human |
| Yaqian Han, Feng Liu, Yujuan Zhou, Qian He, Lin Zhang, Le Luo, Yun Li, Lin Liu, Hongzhi Ma, Hui Wan. Radiosensitivity Effect of Epidermal Growth Factor Receptor Nanoparticles on Head and Neck Squamous Cell Carcinoma. Journal of nanoscience and nanotechnology. vol 20. issue 10. 2021-05-31. PMID:32384946. |
after radiotherapy intervention, a cell cloning test and mtt test were used to detect the radiosensitivity of the cells, and flow cytometry was used to detect the cell cycle distribution and apoptosis to establish a model of head and neck cancer in mice. |
2021-05-31 |
2023-08-13 |
mouse |
| Zai-Biao Zhu, Jin-Feng Yang, Qiao-Sheng Guo, Wen-Xia Zhan. [Protective effects of aqueous extracts from Sedum sarmentosum growing under different light intensity on CCl_4-induced damage in HepG2 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 10. 2021-05-31. PMID:34047093. |
cell viability, cell cycle, and cell apoptosis were individually detected by mtt, pi single staining, and annexin-v fitc/pi double staining assays. |
2021-05-31 |
2023-08-13 |
Not clear |
| Yue Wang, Enqing Guan, Dehua Li, Lirong Su. miRNA-34a-5p regulates progression of neuroblastoma via modulating the Wnt/β-catenin signaling pathway by targeting SOX4. Medicine. vol 100. issue 20. 2021-05-27. PMID:34011046. |
the proliferation, apoptosis, migration and invasion of neuroblastoma cells were determined using mtt, flow cytometry and transwell assays.in this study, we sought to investigate the role of mirna-34a-5p on neuroblastoma and the possible molecular mechanism. |
2021-05-27 |
2023-08-13 |
Not clear |
| Fengqin Wang, Hanzhong Zhang, Zhigang Chen. EPHA2 Promotes the Invasion and Migration of Human Tongue Squamous Cell Carcinoma Cal-27 Cells by Enhancing AKT/mTOR Signaling Pathway. BioMed research international. vol 2021. 2021-05-25. PMID:33834064. |
the expression of epha2 was detected by qrt-pcr, cell proliferation was evaluated by mtt assay, cell migration and invasion were examined by scratch and transwell assay, and cell morphology and apoptosis were assessed by hoechst 33258 staining. |
2021-05-25 |
2023-08-13 |
human |
| Dejiang Yang, Yu Tan, Huanhuan Li, Xiaowei Zhang, Xinming Li, Feng Zho. Upregulation of miR-20b Protects Against Cerebral Ischemic Stroke by Targeting Thioredoxin Interacting Protein (TXNIP). Experimental neurobiology. vol 30. issue 2. 2021-05-25. PMID:33972468. |
cell viability was detected by mtt assay, and cell apoptosis was evaluated by flow cytometry. |
2021-05-25 |
2023-08-13 |
human |
| Zheng Chen, Tao Qi, Xiao-Ping Qin, Jue Wang, Zhang-Sen Huang, Xiao-Yong Hu, Guo Chen, Li-Jun Qu, Yu-Min Zhu. Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation. BioMed research international. vol 2020. 2021-05-24. PMID:33426070. |
then, colony formation assays, mtt experiments, and flow cytometry were used to examine the effect of snhg12 on proliferation, cell cycle distribution, and apoptosis of du145 cells. |
2021-05-24 |
2023-08-13 |
Not clear |
| Chunmei Zhang, Xi Chen, Chao Wang, Yu Ran, Kai Shen. Inhibition of XBP1 Alleviates LPS-Induced Cardiomyocytes Injury by Upregulating XIAP through Suppressing the NF-κB Signaling Pathway. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33453047. |
the viability and apoptosis of h9c2 cells was detected by mtt assay and tunel assay. |
2021-05-24 |
2023-08-13 |
Not clear |
| Yongsheng Qu, Jing Zhang, Jingjing Zhang, Wentao Xia. MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33492555. |
cell apoptosis and viability were monitored by flow cytometry analysis and mtt assay. |
2021-05-24 |
2023-08-13 |
rat |
| Yuan Gao, Shengfang Wang, Shikun Dang, Shulan Han, Cholil Yun, Wenjie Wang, Huimei Wan. Optimized ultrasound-assisted extraction of total polyphenols from Empetrum nigrum and its bioactivities. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1173. 2021-05-24. PMID:33915384. |
the evaluation of antitumor activity by the mtt assay and flow cytometric analysis indicated that the tpp extracts significantly inhibited b 16f 10 melanoma cell proliferation and effectively induced apoptosis of melanoma cells. |
2021-05-24 |
2023-08-13 |
Not clear |
| Xi Wang, Guojun Zhang, Zhe Cheng, Lingling Dai, Liuqun Jia, Xiaogang Jing, Huan Wang, Rui Zhang, Meng Liu, Tianci Jiang, Yuanjian Yang, Meng Yan. Knockdown of lncRNA ANRIL inhibits the development of cisplatin resistance by upregulating miR‑98 in lung cancer cells. Oncology reports. vol 44. issue 3. 2021-05-21. PMID:32705261. |
cell proliferation and apoptosis were detected by mtt assay and flow cytometry analysis, respectively. |
2021-05-21 |
2023-08-13 |
Not clear |
| Aihua Liu, Zhongfu Zuo, Linlin Liu, Lihua Li. Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 5. 2021-05-20. PMID:32125883. |
western blot analysis, real-time pcr, immunofluorescence staining, mtt, cell cycle assay, cell apoptosis assay, hoechst staining, caspase-3 and caspase-9 activity assays, cell adhesion assay, wound healing assay, and a transwell assay were used in this study. |
2021-05-20 |
2023-08-13 |
Not clear |