| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E D Clarkson, J Edwards-Prasad, C R Freed, K N Prasa. Immortalized dopamine neurons: A model to study neurotoxicity and neuroprotection. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 222. issue 2. 1999-11-30. PMID:10564540. |
our results showed that 6-ohda treatment for 24 hr decreased the viability of undifferentiated and differentiated immortalized da neurons in vitro, as determined by the mtt assay, and increased the rate of apoptosis in differentiated da neurons. |
1999-11-30 |
2023-08-12 |
rat |
| J Liu, J Kolath, J Anderson, C Kolar, T A Lawson, J Talmadge, W H Gmeine. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. Antisense & nucleic acid drug development. vol 9. issue 5. 1999-11-23. PMID:10555156. |
effects on cell viability were measured using an assay for 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), while cytotoxicity and apoptosis were investigated using clonogenic and tunel assays, respectively. |
1999-11-23 |
2023-08-12 |
human |
| E G Haarman, G J Kaspers, R Pieters, C H van Zantwijk, G J Broekema, K Hählen, A J Veerma. BCL-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance. Advances in experimental medicine and biology. vol 457. 1999-11-04. PMID:10500808. |
in this study we evaluated the relation between bcl-2 expression, spontaneous and dexamethasone (dxm) induced apoptosis, and in vitro resistance to dxm, prednisolone (prd) and cytarabine (ara) determined using the total cell kill colorimetric methyl-thiazol-tetrazolium salt (mtt) assay, in childhood acute lymphoblastic leukemia (all). |
1999-11-04 |
2023-08-12 |
Not clear |
| P Dent, D B Reardon, J S Park, G Bowers, C Logsdon, K Valerie, R Schmidt-Ullric. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Molecular biology of the cell. vol 10. issue 8. 1999-10-12. PMID:10436007. |
neutralization of tgfalpha function by an anti-tgfalpha antibody or inhibition of mapk function by mek1/2 inhibitors (pd98059 and u0126) radiosensitized a431 and mda-mb-231 cells after irradiation in apoptosis, 3-[4, 5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt), and clonogenic assays. |
1999-10-12 |
2023-08-12 |
Not clear |
| R Migheli, C Godani, L Sciola, M R Delogu, P A Serra, D Zangani, G De Natale, E Miele, M S Desol. Enhancing effect of manganese on L-DOPA-induced apoptosis in PC12 cells: role of oxidative stress. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461907. |
in this study, exposure of pc12 cells to 0.2 mm mncl2 or 10-20 microm l-dopa neither affected cell viability, determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, nor induced apoptosis, tested by flow cytometry, fluorescence microscopy, and the tunel technique. |
1999-09-14 |
2023-08-12 |
Not clear |
| J Zheng, Y P Deng, C Lin, M Fu, P G Xiao, M W. Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression. International journal of cancer. vol 82. issue 2. 1999-07-19. PMID:10389765. |
this effect was evidenced by a reduction of cell viability in the mtt assay, g1 arrest and significant apoptosis upon flow-cytometric analysis, presence of apoptotic bodies, formation of dna ladders upon gel electrophoresis and inhibition of viral early gene expression by rt-pcr and western blot. |
1999-07-19 |
2023-08-12 |
human |
| D J Roovers, M van Vliet, A C Bloem, H M Lokhors. Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines. Leukemia research. vol 23. issue 6. 1999-07-07. PMID:10374847. |
cytotoxicity assays using mtt (viability) or annexin v (apoptosis) showed a 10-50-fold higher potency of ida compared with dnr or dox in the mdr variant cell lines. |
1999-07-07 |
2023-08-12 |
human |
| S E Kim, Y H Lee, J H Park, S K Le. Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells. Anticancer research. vol 19. issue 1A. 1999-05-20. PMID:10226587. |
the cell growth suppressive and apoptosis inducing effects were confirmed by mtt assays together with flow cytometric analyses, morphological changes and dna fragmentation. |
1999-05-20 |
2023-08-12 |
Not clear |
| M Hagenaars, N G Ensink, L E Jonges, W H Chambers, A M Eggermont, C J van de Velde, G J Fleuren, P J Kuppe. The development of a bi-specific anti-CD161A x anti-tumor antibody for rat NK cell targeting. Immunobiology. vol 200. issue 1. 1999-05-03. PMID:10084694. |
we also tested the 3.2.3xcc52 bimab for its capacity to enhance nk cell-mediated lysis of cc531 tumor cells in 4 h and 19 h 51cr release assays; in a prolonged (2 day) tumor neutralization assay using a tetrazolium salt (mtt)-based assay; and in tests for apoptosis using annexin v-fitc. |
1999-05-03 |
2023-08-12 |
rat |
| Y Zhao, J Cao, H Zh. [Induction of apoptosis by tea polyphenols in MGC cells]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 22. issue 5. 1999-04-16. PMID:10073014. |
the apoptosis effects of tea polyphenols were observed on the human gastric carcinoma cells (mgc) by mtt reduction test, dna agarose gel electrophoresis and transmission electron microscopy (tem) technique. |
1999-04-16 |
2023-08-12 |
human |
| F Centeno, A Mora, J M Fuentes, G Soler, E Clar. Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons. Neuroreport. vol 9. issue 18. 1999-04-13. PMID:9926873. |
primary cultures of cerebellar granule neurons, maintained in a serum-containing medium, underwent apoptosis when exposed to c2-ceramide, as assessed by mitochondrial reduction of mtt and intranucleosomal dna fragmentation. |
1999-04-13 |
2023-08-12 |
Not clear |
| G H Zhu, B C Wong, M C Eggo, C K Ching, S T Yuen, E Y Chan, K C Lai, S K La. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. British journal of cancer. vol 79. issue 3-4. 1999-03-05. PMID:10027304. |
after treatment with aspirin or indomethacin, cell growth was quantified by mtt assay, and apoptosis was determined by acridine orange staining, dna fragmentation and flow cytometry. |
1999-03-05 |
2023-08-12 |
human |
| B Zoll, P Lefterova, M Csipai, S Finke, B Trojaneck, O Ebert, B Micka, K Roigk, M Fehlinger, G D Schmidt-Wolf, D Huhn, I G Schmidt-Wol. Generation of cytokine-induced killer cells using exogenous interleukin-2, -7 or -12. Cancer immunology, immunotherapy : CII. vol 47. issue 4. 1999-01-21. PMID:9875675. |
cellular proliferation was analyzed using an mtt proliferation assay, surface antigen expression via flow cytometry, cytotoxic activity using an ldh release assay, and apoptosis via flow cytometric analysis. |
1999-01-21 |
2023-08-12 |
Not clear |
| W Lee-Kwon, D Park, M Bernie. Nucleotide excision repair is not required for the antiapoptotic function of insulin-like growth factor 1. Experimental cell research. vol 241. issue 2. 1998-07-14. PMID:9637787. |
igf-1 effectively blocked apoptosis, concomitant with increased mtt activity, in a pair of cho cell lines expressing inactive ercc1 (43-3b cells) and the transfected line of the mutant carrying the expressed human ercc1 gene (83-g5 cells). |
1998-07-14 |
2023-08-12 |
human |
| H Burger, K Nooter, A W Boersma, C J Kortland, G Stote. Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. British journal of cancer. vol 77. issue 10. 1998-06-29. PMID:9635829. |
for all four cell lines, the induction of apoptosis by cisplatin correlated with drug sensitivity in the mtt assay. |
1998-06-29 |
2023-08-12 |
Not clear |
| Y Zhao, J Cao, H Ma, J Li. Apoptosis induced by tea polyphenols in HL-60 cells. Cancer letters. vol 121. issue 2. 1998-05-13. PMID:9570354. |
the apoptosis effects of tea polyphenols were observed on the human promyelocytic leukemic cells (hl-60) by an mtt reduction test, dna agarose gel electrophoresis and a transmission electronic microscopy technique. |
1998-05-13 |
2023-08-12 |
human |
| K Nonaka, A Ishisaki, M Muro, S Kato, M Oido, K Nakashima, Y Kowashi, T Nishihar. Possible involvement of protein kinase C in apoptotic cell death of macrophages infected with Actinobacillus actinomycetemcomitans. FEMS microbiology letters. vol 159. issue 2. 1998-03-26. PMID:9503618. |
in this study, we examined the role of protein kinases in the induction of apoptosis in a. actinomycetemcomitans-infected j774.1 cells by the mtt assay, fluorescence microscopy and flow cytometric analysis. |
1998-03-26 |
2023-08-12 |
mouse |
| M Matsuoka, B Wispriyono, H Igis. Induction of c-fos gene by mercury chloride in LLC-PK1 cells. Chemico-biological interactions. vol 108. issue 1-2. 1998-02-24. PMID:9463523. |
the cytotoxicity of hgcl2 as assayed by mitochondrial dehydrogenase activity (mtt conversion) was observed after 18 h exposure but not at 0.5-8 h. also, the decrease in cell viability was accompanied with dna fragmentation, which is characteristic of apoptosis. |
1998-02-24 |
2023-08-12 |
Not clear |
| T Efferth, U Fabry, R Osiek. Apoptosis and resistance to daunorubicin in human leukemic cells. Leukemia. vol 11. issue 7. 1997-07-17. PMID:9205009. |
on the other hand, we used the mtt assay and measured apoptosis and proliferative activity (s- and g2m-phases of the cell cycle) by flow cytometry. |
1997-07-17 |
2023-08-12 |
human |
| T Efferth, U Fabry, R Osiek. Apoptosis and resistance to daunorubicin in human leukemic cells. Leukemia. vol 11. issue 7. 1997-07-17. PMID:9205009. |
low proficiency of mnc to undergo apoptosis and low proliferative activity rather than p-gp-mediated mdr correlated with dnr resistance as measured by the mtt assay. |
1997-07-17 |
2023-08-12 |
human |