| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Dent, D B Reardon, J S Park, G Bowers, C Logsdon, K Valerie, R Schmidt-Ullric. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Molecular biology of the cell. vol 10. issue 8. 1999-10-12. PMID:10436007. |
neutralization of tgfalpha function by an anti-tgfalpha antibody or inhibition of mapk function by mek1/2 inhibitors (pd98059 and u0126) radiosensitized a431 and mda-mb-231 cells after irradiation in apoptosis, 3-[4, 5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt), and clonogenic assays. |
1999-10-12 |
2023-08-12 |
Not clear |
| R Migheli, C Godani, L Sciola, M R Delogu, P A Serra, D Zangani, G De Natale, E Miele, M S Desol. Enhancing effect of manganese on L-DOPA-induced apoptosis in PC12 cells: role of oxidative stress. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461907. |
in this study, exposure of pc12 cells to 0.2 mm mncl2 or 10-20 microm l-dopa neither affected cell viability, determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, nor induced apoptosis, tested by flow cytometry, fluorescence microscopy, and the tunel technique. |
1999-09-14 |
2023-08-12 |
Not clear |
| J Zheng, Y P Deng, C Lin, M Fu, P G Xiao, M W. Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression. International journal of cancer. vol 82. issue 2. 1999-07-19. PMID:10389765. |
this effect was evidenced by a reduction of cell viability in the mtt assay, g1 arrest and significant apoptosis upon flow-cytometric analysis, presence of apoptotic bodies, formation of dna ladders upon gel electrophoresis and inhibition of viral early gene expression by rt-pcr and western blot. |
1999-07-19 |
2023-08-12 |
human |
| D J Roovers, M van Vliet, A C Bloem, H M Lokhors. Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines. Leukemia research. vol 23. issue 6. 1999-07-07. PMID:10374847. |
cytotoxicity assays using mtt (viability) or annexin v (apoptosis) showed a 10-50-fold higher potency of ida compared with dnr or dox in the mdr variant cell lines. |
1999-07-07 |
2023-08-12 |
human |
| S E Kim, Y H Lee, J H Park, S K Le. Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells. Anticancer research. vol 19. issue 1A. 1999-05-20. PMID:10226587. |
the cell growth suppressive and apoptosis inducing effects were confirmed by mtt assays together with flow cytometric analyses, morphological changes and dna fragmentation. |
1999-05-20 |
2023-08-12 |
Not clear |
| M Hagenaars, N G Ensink, L E Jonges, W H Chambers, A M Eggermont, C J van de Velde, G J Fleuren, P J Kuppe. The development of a bi-specific anti-CD161A x anti-tumor antibody for rat NK cell targeting. Immunobiology. vol 200. issue 1. 1999-05-03. PMID:10084694. |
we also tested the 3.2.3xcc52 bimab for its capacity to enhance nk cell-mediated lysis of cc531 tumor cells in 4 h and 19 h 51cr release assays; in a prolonged (2 day) tumor neutralization assay using a tetrazolium salt (mtt)-based assay; and in tests for apoptosis using annexin v-fitc. |
1999-05-03 |
2023-08-12 |
rat |
| Y Zhao, J Cao, H Zh. [Induction of apoptosis by tea polyphenols in MGC cells]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 22. issue 5. 1999-04-16. PMID:10073014. |
the apoptosis effects of tea polyphenols were observed on the human gastric carcinoma cells (mgc) by mtt reduction test, dna agarose gel electrophoresis and transmission electron microscopy (tem) technique. |
1999-04-16 |
2023-08-12 |
human |
| F Centeno, A Mora, J M Fuentes, G Soler, E Clar. Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons. Neuroreport. vol 9. issue 18. 1999-04-13. PMID:9926873. |
primary cultures of cerebellar granule neurons, maintained in a serum-containing medium, underwent apoptosis when exposed to c2-ceramide, as assessed by mitochondrial reduction of mtt and intranucleosomal dna fragmentation. |
1999-04-13 |
2023-08-12 |
Not clear |
| G H Zhu, B C Wong, M C Eggo, C K Ching, S T Yuen, E Y Chan, K C Lai, S K La. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. British journal of cancer. vol 79. issue 3-4. 1999-03-05. PMID:10027304. |
after treatment with aspirin or indomethacin, cell growth was quantified by mtt assay, and apoptosis was determined by acridine orange staining, dna fragmentation and flow cytometry. |
1999-03-05 |
2023-08-12 |
human |
| B Zoll, P Lefterova, M Csipai, S Finke, B Trojaneck, O Ebert, B Micka, K Roigk, M Fehlinger, G D Schmidt-Wolf, D Huhn, I G Schmidt-Wol. Generation of cytokine-induced killer cells using exogenous interleukin-2, -7 or -12. Cancer immunology, immunotherapy : CII. vol 47. issue 4. 1999-01-21. PMID:9875675. |
cellular proliferation was analyzed using an mtt proliferation assay, surface antigen expression via flow cytometry, cytotoxic activity using an ldh release assay, and apoptosis via flow cytometric analysis. |
1999-01-21 |
2023-08-12 |
Not clear |
| W Lee-Kwon, D Park, M Bernie. Nucleotide excision repair is not required for the antiapoptotic function of insulin-like growth factor 1. Experimental cell research. vol 241. issue 2. 1998-07-14. PMID:9637787. |
igf-1 effectively blocked apoptosis, concomitant with increased mtt activity, in a pair of cho cell lines expressing inactive ercc1 (43-3b cells) and the transfected line of the mutant carrying the expressed human ercc1 gene (83-g5 cells). |
1998-07-14 |
2023-08-12 |
human |
| H Burger, K Nooter, A W Boersma, C J Kortland, G Stote. Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. British journal of cancer. vol 77. issue 10. 1998-06-29. PMID:9635829. |
for all four cell lines, the induction of apoptosis by cisplatin correlated with drug sensitivity in the mtt assay. |
1998-06-29 |
2023-08-12 |
Not clear |
| Y Zhao, J Cao, H Ma, J Li. Apoptosis induced by tea polyphenols in HL-60 cells. Cancer letters. vol 121. issue 2. 1998-05-13. PMID:9570354. |
the apoptosis effects of tea polyphenols were observed on the human promyelocytic leukemic cells (hl-60) by an mtt reduction test, dna agarose gel electrophoresis and a transmission electronic microscopy technique. |
1998-05-13 |
2023-08-12 |
human |
| K Nonaka, A Ishisaki, M Muro, S Kato, M Oido, K Nakashima, Y Kowashi, T Nishihar. Possible involvement of protein kinase C in apoptotic cell death of macrophages infected with Actinobacillus actinomycetemcomitans. FEMS microbiology letters. vol 159. issue 2. 1998-03-26. PMID:9503618. |
in this study, we examined the role of protein kinases in the induction of apoptosis in a. actinomycetemcomitans-infected j774.1 cells by the mtt assay, fluorescence microscopy and flow cytometric analysis. |
1998-03-26 |
2023-08-12 |
mouse |
| M Matsuoka, B Wispriyono, H Igis. Induction of c-fos gene by mercury chloride in LLC-PK1 cells. Chemico-biological interactions. vol 108. issue 1-2. 1998-02-24. PMID:9463523. |
the cytotoxicity of hgcl2 as assayed by mitochondrial dehydrogenase activity (mtt conversion) was observed after 18 h exposure but not at 0.5-8 h. also, the decrease in cell viability was accompanied with dna fragmentation, which is characteristic of apoptosis. |
1998-02-24 |
2023-08-12 |
Not clear |
| T Efferth, U Fabry, R Osiek. Apoptosis and resistance to daunorubicin in human leukemic cells. Leukemia. vol 11. issue 7. 1997-07-17. PMID:9205009. |
on the other hand, we used the mtt assay and measured apoptosis and proliferative activity (s- and g2m-phases of the cell cycle) by flow cytometry. |
1997-07-17 |
2023-08-12 |
human |
| T Efferth, U Fabry, R Osiek. Apoptosis and resistance to daunorubicin in human leukemic cells. Leukemia. vol 11. issue 7. 1997-07-17. PMID:9205009. |
low proficiency of mnc to undergo apoptosis and low proliferative activity rather than p-gp-mediated mdr correlated with dnr resistance as measured by the mtt assay. |
1997-07-17 |
2023-08-12 |
human |
| T Efferth, U Fabry, R Osiek. Apoptosis and resistance to daunorubicin in human leukemic cells. Leukemia. vol 11. issue 7. 1997-07-17. PMID:9205009. |
thus, measurement of apoptosis by flow cytometry may be less convenient than the mtt assay for determination of chemosensitivity, if clinical samples with unknown patterns of responsiveness are to be tested. |
1997-07-17 |
2023-08-12 |
human |
| T Efferth, U Fabry, R Osiek. Apoptosis and resistance to daunorubicin in human leukemic cells. Leukemia. vol 11. issue 7. 1997-07-17. PMID:9205009. |
spontaneous apoptosis in untreated mnc following 24 h incubation in vitro correlated significantly with dnr sensitivity in the mtt assay. |
1997-07-17 |
2023-08-12 |
human |
| Y Huang, A M Ibrado, J C Reed, G Bullock, S Ray, C Tang, K Bhall. Co-expression of several molecular mechanisms of multidrug resistance and their significance for paclitaxel cytotoxicity in human AML HL-60 cells. Leukemia. vol 11. issue 2. 1997-02-24. PMID:9009089. |
pgp, but not mrp, overexpression significantly impaired paclitaxel accumulation and paclitaxel-induced apoptosis, as well as reduced its cytotoxic effects as determined by the mtt assay. |
1997-02-24 |
2023-08-12 |
human |