| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Izumi Nakashima, Wei Liu, Anwarul A Akhand, Kozue Takeda, Yoshiyuki Kawamoto, Masashi Kato, Haruhiko Suzuk. 4-hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Molecular aspects of medicine. vol 24. issue 4-5. 2004-05-19. PMID:12893001. |
4-hydroxynonenal (hne), an aldehyde product of membrane lipid peroxidation, has been suggested to mediate a number of oxidative stress-linked pathological events in humans, including cellular growth inhibition and apoptosis induction. |
2004-05-19 |
2023-08-12 |
Not clear |
| Ho Jin Heo, Dae-Ok Kim, Soo Cheol Shin, Mi Jeong Kim, Byung Gee Kim, Dong-Hoon Shi. Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection. Journal of agricultural and food chemistry. vol 52. issue 6. 2004-05-07. PMID:15030205. |
abeta increased free radical production and lipid peroxidation in pc12 nerve cells, resulting in apoptosis and cell death. |
2004-05-07 |
2023-08-12 |
mouse |
| Alicja Krasowska, Tadeusz Włostowski, Elzbieta Bond. Zinc protection from fluoride-induced testicular injury in the bank vole (Clethrionomys glareolus). Toxicology letters. vol 147. issue 3. 2004-05-04. PMID:15104114. |
the 4-month exposure period to fluoride (200 microg/ml of drinking water) induced histopathological changes (hemorrhage in interstitium, necrosis and apoptosis in seminiferous tubule epithelium) which were accompanied by decreased testicular zinc concentration and increased lipid peroxidation. |
2004-05-04 |
2023-08-12 |
Not clear |
| Teresa Iuvone, Giuseppe Esposito, Ramona Esposito, Rita Santamaria, Massimo Di Rosa, Angelo A Izz. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. Journal of neurochemistry. vol 89. issue 1. 2004-04-26. PMID:15030397. |
this effect was associated with increased reactive oxygen species (ros) production and lipid peroxidation, as well as caspase 3 (a key enzyme in the apoptosis cell-signalling cascade) appearance, dna fragmentation and increased intracellular calcium. |
2004-04-26 |
2023-08-12 |
rat |
| Bin Wu, Akifumi Ootani, Ryuichi Iwakiri, Takehiro Fujise, Seiji Tsunada, Shuji Toda, Kazuma Fujimot. Ischemic preconditioning attenuates ischemia-reperfusion-induced mucosal apoptosis by inhibiting the mitochondria-dependent pathway in rat small intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 286. issue 4. 2004-04-19. PMID:15010362. |
ischemia-reperfusion alone induced mucosal apoptosis and mitochondrial respiratory dysfunction via promoted reactive oxygen species generation, reduced mitochondrial glutathione oxidation, increased mitochondrial lipid peroxidation, reduced mitochondrial membrane potential, and enhanced release of cytochrome c from mitochondria to activate caspase-9 and caspase-6 in the small intestine. |
2004-04-19 |
2023-08-12 |
rat |
| Hiroyoshi Yuki, Takashi Kondo, Qing-Li Zhao, Yoshisada Fujiwara, Kiyoshi Tanabe, Ryohei Ogawa, Akitoshi Nakashima, Hiroshi Fushiki, Masaki Fujimura, Shigeru Sait. A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines. Free radical research. vol 37. issue 6. 2003-12-16. PMID:12868490. |
when combined with nontoxic aaph (50mm), significant enhancement of apoptosis was observed, where the initial rate of free radical formation was about twice as high than that at 37 degrees c. augmentation of the growth delay, lipid peroxidation (lpo), activation of caspase-3 and increase in [ca2+]i were also observed after the combined treatment. |
2003-12-16 |
2023-08-12 |
human |
| Hiroyoshi Yuki, Takashi Kondo, Qing-Li Zhao, Yoshisada Fujiwara, Kiyoshi Tanabe, Ryohei Ogawa, Akitoshi Nakashima, Hiroshi Fushiki, Masaki Fujimura, Shigeru Sait. A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines. Free radical research. vol 37. issue 6. 2003-12-16. PMID:12868490. |
these results indicate that hyperthermia and aaph induce enhanced apoptosis and subsequent cell killing via two pathways; a pathway dependenton increase in lpo and [ca2+]i, and a pathway associated with cytochrome c release and subsequent caspase activation without changes of mitochondrial membrane potential and bax/bcl-2 expression in these cell lines. |
2003-12-16 |
2023-08-12 |
human |
| Abdel-Raheim A M Meki, Hosney A Hasan, Zeinab M Mohey El-Deen, Saly Bakka. Dysregulation of apoptosis in scorpion envenomed children: its reflection on their outcome. Toxicon : official journal of the International Society on Toxinology. vol 42. issue 3. 2003-12-15. PMID:14559073. |
in conclusion, our study revealed that scorpion envenomation can increase apoptosis as shown by up-regulation of sfas/sfasl system and down-regulation of bcl-2 that was associated by elevation of lpo and no. |
2003-12-15 |
2023-08-12 |
Not clear |
| Azza B El-Remessy, Ibrahim E Khalil, Suraporn Matragoon, Gamal Abou-Mohamed, Nai-Jer Tsai, Penny Roon, Ruth B Caldwell, Robert W Caldwell, Keith Green, Gregory I Lio. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. The American journal of pathology. vol 163. issue 5. 2003-12-05. PMID:14578199. |
nmda induced a dose- and time-dependent accumulation of nitrite/nitrate, lipid peroxidation, and nitrotyrosine (foot print of peroxynitrite), and a dose-dependent apoptosis and loss of inner retinal neurons. |
2003-12-05 |
2023-08-12 |
rat |
| Yusong Yang, Abha Sharma, Rajendra Sharma, Brad Patrick, Sharad S Singhal, Piotr Zimniak, Sanjay Awasthi, Yogesh C Awasth. Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. The Journal of biological chemistry. vol 278. issue 42. 2003-12-03. PMID:12888579. |
276, 41213-41223) and uva irradiation also causes lipid peroxidation, we have examined the role of 4-hne in uva-mediated apoptosis. |
2003-12-03 |
2023-08-12 |
Not clear |
| Olena Shakhman, Matthias Herkert, Christine Rose, Andreas Humeny, Cord-Michael Becke. Induction by beta-bungarotoxin of apoptosis in cultured hippocampal neurons is mediated by Ca(2+)-dependent formation of reactive oxygen species. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535943. |
these observations indicate that beta-butx-induced cell death resulted from an intracellular signalling cascade involving subsequent stages of a dramatic rise in free ca2+, the accumulation of ros, membrane lipid peroxidation and, finally, apoptosis. |
2003-11-24 |
2023-08-12 |
rat |
| Tzeon-Jye Chiou, Sin-Tak Chu, Woan-Fang Tzen. Protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation. Toxicology. vol 191. issue 2-3. 2003-10-28. PMID:12965111. |
protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation. |
2003-10-28 |
2023-08-12 |
mouse |
| Tzeon-Jye Chiou, Sin-Tak Chu, Woan-Fang Tzen. Protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation. Toxicology. vol 191. issue 2-3. 2003-10-28. PMID:12965111. |
pre-treatment of cells with cysteine suppressed the menadione-induced apoptosis and prevented changes in reactive oxygen species levels, glutathione levels and lipid peroxidation. |
2003-10-28 |
2023-08-12 |
mouse |
| Tzeon-Jye Chiou, Sin-Tak Chu, Woan-Fang Tzen. Protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation. Toxicology. vol 191. issue 2-3. 2003-10-28. PMID:12965111. |
pre-treatment of cells with deferoxamine mesylate, an iron chelator, also reduced both menadione-induced apoptosis and lipid peroxidation. |
2003-10-28 |
2023-08-12 |
mouse |
| Tzeon-Jye Chiou, Sin-Tak Chu, Woan-Fang Tzen. Protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation. Toxicology. vol 191. issue 2-3. 2003-10-28. PMID:12965111. |
thus, the inhibition of lipid peroxidation by deferoxamine mesylate prevented apoptosis even though cellular glutathione remained depleted. |
2003-10-28 |
2023-08-12 |
mouse |
| Tzeon-Jye Chiou, Sin-Tak Chu, Woan-Fang Tzen. Protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation. Toxicology. vol 191. issue 2-3. 2003-10-28. PMID:12965111. |
our data suggest that menadione-induced apoptosis is directly linked to iron-dependent lipid peroxidation. |
2003-10-28 |
2023-08-12 |
mouse |
| Laurens Kruidenier, Ineke Kuiper, Cornelis B H W Lamers, Hein W Verspage. Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants. The Journal of pathology. vol 201. issue 1. 2003-10-24. PMID:12950014. |
the extent of apoptosis, peroxynitrite-mediated protein nitration (3-nt), and lipid peroxidation were assessed in relation to the expression of nitric oxide synthase (nos) and the superoxide-producing enzyme xanthine oxidase (xo). |
2003-10-24 |
2023-08-12 |
Not clear |
| Hsiu-Chuan Yen, Chung-Yi Nien, Hideyuki J Majima, Chia-Pei Lee, Sz-Yun Chen, Jeng-Shu Wei, Lai-Chu Se. Increase of lipid peroxidation by cisplatin in WI38 cells but not in SV40-transformed WI38 cells. Journal of biochemical and molecular toxicology. vol 17. issue 1. 2003-10-23. PMID:12616645. |
in this study, by using normal human lung fibroblast (w138) cells and sv40-transformed wi38 (va13) cells as a model, we compared the effect of cpt on cytotoxicity, apoptosis, lipid peroxidation, and mitochondrial gene expression, which could be regulated by oxidative stress, between normal and tumor cells. |
2003-10-23 |
2023-08-12 |
human |
| Jingyuan Chen, Yaoming Chen, Wenjing Luo, Xiuhong Li. [Toxicity effects of manganese on PC12 cells]. Wei sheng yan jiu = Journal of hygiene research. vol 31. issue 4. 2003-08-21. PMID:12600022. |
mtt test, trypan blue exclusion test, malondiadehyde(mda) colorimetry and dna gel electrophoresis were performed to exam proliferation, lipid peroxidation, and apoptosis of pc12 cells. |
2003-08-21 |
2023-08-12 |
Not clear |
| Jingyuan Chen, Yaoming Chen, Wenjing Luo, Xiuhong Li. [Toxicity effects of manganese on PC12 cells]. Wei sheng yan jiu = Journal of hygiene research. vol 31. issue 4. 2003-08-21. PMID:12600022. |
it is concluded that manganese can inhibit proliferation of pc12 cells, the mechanism includes the interference of dna metabolism, inhibitory of lipid peroxidation, and cell apoptosis. |
2003-08-21 |
2023-08-12 |
Not clear |