| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Liu, Hong Zhang, Luwei Zhang, Qingming Zhou, Xiaohu Wang, Jing Long, Tao Dong, Weiping Zha. Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice. European journal of pharmacology. vol 575. issue 1-3. 2008-03-06. PMID:17825281. |
in addition, significant positive correlations were observed between mda level and dna damage or cell apoptosis, implying that lipid peroxidation plays a major role in x-ray-induced liver injury. |
2008-03-06 |
2023-08-12 |
mouse |
| Ke-Xuan Liu, Wei He, Timo Rinne, Ying Liu, Ming-Qi Zhao, Wei-Kang W. The effect of ginkgo biloba extract (EGb 761) pretreatment on intestinal epithelial apoptosis induced by intestinal ischemia/reperfusion in rats: role of ceramide. The American journal of Chinese medicine. vol 35. issue 5. 2008-02-05. PMID:17963320. |
ii/r caused intestinal mucosal epithelial apoptosis and over-production of the ceramide accompanied by up-regulation of smase mrna expression and increases of lipid peroxidation. |
2008-02-05 |
2023-08-12 |
rat |
| Ke-Xuan Liu, Wei He, Timo Rinne, Ying Liu, Ming-Qi Zhao, Wei-Kang W. The effect of ginkgo biloba extract (EGb 761) pretreatment on intestinal epithelial apoptosis induced by intestinal ischemia/reperfusion in rats: role of ceramide. The American journal of Chinese medicine. vol 35. issue 5. 2008-02-05. PMID:17963320. |
egb 761 pretreatment significantly decreased apoptosis index, and concurrently reduced the ceramide generation accompanied by down-regulation of smase expression and inhibition of lipid peroxidation. |
2008-02-05 |
2023-08-12 |
rat |
| Yuh-Chiang Shen, Yea-Hwey Wang, Yueh-Ching Chou, Kuo-Tong Liou, Jiin-Cherng Yen, Wen-Yen Wang, Jyh-Fei Lia. Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation. Journal of neurochemistry. vol 104. issue 2. 2008-02-05. PMID:18173806. |
dimemorfan treatment (10 microg/kg, i.v., at the time of reperfusion) inhibited the expressions of monocyte chemoattractant protein-1 and interleukin-1beta, which occurred in parallel with decreases in neutrophil infiltration, activation of inflammation-related signals (p38 mitogen-activated protein kinase, nuclear factor-kappab, and signal transducer and activator of transcription-1), expression of neuronal and inducible nitric oxide synthase, oxidative/nitrosative tissue damage (lipid peroxidation, protein nitrosylation, and 8-hydroxy-guanine formation), and apoptosis in the ipsilateral cortex after ci/r injury. |
2008-02-05 |
2023-08-12 |
rat |
| Neife Aparecida Guinaim dos Santos, Nádia Maria Martins, Carlos Curti, Maria de Lourdes Pires Bianchi, Antonio Cardozo dos Santo. Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats. Chemico-biological interactions. vol 170. issue 3. 2008-02-01. PMID:17850778. |
dmtu protected against (a) decreased hepatic atp levels; (b) lipid peroxidation; (c) cardiolipin oxidation; (d) sulfhydryl protein oxidation; (e) mitochondrial membrane rigidification; (f) gsh oxidation; (g) nadph oxidation; (h) apoptosis. |
2008-02-01 |
2023-08-12 |
rat |
| J A Solís Herruzo, I García Ruiz, M Pérez Carreras, M T Muñoz Yagü. Non-alcoholic fatty liver disease. From insulin resistance to mitochondrial dysfunction. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. vol 98. issue 11. 2007-12-13. PMID:17198477. |
consequences of oxidative stress include: lipid peroxidation in cell membranes, stellate cell activation in the liver, liver fibrosis, chronic inflammation, and apoptosis. |
2007-12-13 |
2023-08-12 |
Not clear |
| Hiroyuki Wakabayashi, Hirofumi Miyauchi, Kouichirou Shin, Koji Yamauchi, Ichiro Matsumoto, Keiko Abe, Mitsunori Takas. Orally administered lactoperoxidase increases expression of the FK506 binding protein 5 gene in epithelial cells of the small intestine of mice: a DNA microarray study. Bioscience, biotechnology, and biochemistry. vol 71. issue 9. 2007-12-12. PMID:17827675. |
lpo administration upregulated 78 genes, including genes involved in metabolism, immunity, apoptosis, and the cell cycle, and downregulated nine genes, including immunity-related genes. |
2007-12-12 |
2023-08-12 |
mouse |
| Andreja Leskovac, Gordana Joksic, Teodora Jankovic, Katarina Savikin, Nebojsa Menkovi. Radioprotective properties of the phytochemically characterized extracts of Crataegus monogyna, Cornus mas and Gentianella austriaca on human lymphocytes in vitro. Planta medica. vol 73. issue 11. 2007-12-06. PMID:17764067. |
significant radiorecovery potentials of c. mas and c. monogyna were observed, seen as a reduced incidence of radiation-induced micronuclei (19.23% and 13.24%, respectively), reduced levels of lipid peroxidation products (50.04% and 13.18%, respectively) and two-fold enhanced apoptosis. |
2007-12-06 |
2023-08-12 |
human |
| Andreja Leskovac, Gordana Joksic, Teodora Jankovic, Katarina Savikin, Nebojsa Menkovi. Radioprotective properties of the phytochemically characterized extracts of Crataegus monogyna, Cornus mas and Gentianella austriaca on human lymphocytes in vitro. Planta medica. vol 73. issue 11. 2007-12-06. PMID:17764067. |
g. austriaca possesses strong antioxidant properties, significantly reducing lipid peroxidation and the incidence of micronuclei (for 30.88% and 35.56%, respectively) while enhancing apoptosis with no perturbation of the cell cycle. |
2007-12-06 |
2023-08-12 |
human |
| Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Carmelo Muià, Rosanna Di Paola, Paolo Di Bella, Placido Bramanti, Salvatore Cuzzocre. Role of endogenous glutathione in the secondary damage in experimental spinal cord injury in mice. Neuroscience letters. vol 423. issue 1. 2007-12-03. PMID:17669594. |
the spinal cord of damaged animals showed a significant elevation of biochemical, immunohistochemical and functional parameters, increasing, respectively, neutrophils infiltration, lipid peroxidation, nitrotyrosine formation, par expression, apoptosis (measured by tunel staining) and loss of hind legs movement in sci-operated mice. |
2007-12-03 |
2023-08-12 |
mouse |
| Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Carmelo Muià, Rosanna Di Paola, Paolo Di Bella, Placido Bramanti, Salvatore Cuzzocre. Role of endogenous glutathione in the secondary damage in experimental spinal cord injury in mice. Neuroscience letters. vol 423. issue 1. 2007-12-03. PMID:17669594. |
in contrast, the administration of bso led to worsening of this already compromised setting, increasing the degree of (1) neutrophil infiltration, (2) lipid peroxidation, (3) histological damage, (4) apoptosis, (5) nitrotyrosine formation, (6) par expression, (7) apoptosis (measured by tunel staining) and (7) loss of hind legs movement. |
2007-12-03 |
2023-08-12 |
mouse |
| Ubaldo Bonuccelli, Nicola Paves. Role of dopamine agonists in Parkinson's disease: an update. Expert review of neurotherapeutics. vol 7. issue 10. 2007-11-29. PMID:17939774. |
this neuroprotection may be the result of different mechanisms including antioxidation, scavenging of free radicals, suppression of lipid peroxidation and inhibition of apoptosis. |
2007-11-29 |
2023-08-12 |
Not clear |
| Yoshiji Ohta, Sayaka Chiba, Masayo Tada, Yoichiro Imai, Akira Kitagaw. Development of oxidative stress and cell damage in the liver of rats with water-immersion restraint stress. Redox report : communications in free radical research. vol 12. issue 3. 2007-11-13. PMID:17623521. |
in the liver tissue, vacuolization and apoptosis occurred at 1.5 h of wirs and vacuolization further developed without further appearance of apoptosis at 3 h or 6 h. serum lipid peroxide (lpo) and nox (nitrite/nitrate) concentrations increased at 3 h of wirs and these increases were enhanced at 6 h. in liver tissue, increases in lpo and nox concentrations and myeloperoxidase activity and decreases in ascorbic acid and reduced glutathione concentrations and superoxide dismutase activity occurred at 3 h of wirs and these changes were enhanced at 6 h, although vitamin e concentration and xanthine oxidase activity were unchanged. |
2007-11-13 |
2023-08-12 |
rat |
| Xiang-lin Chi, Zhen-guang Li, Zhao-rong Guo, Li Zhou, Hong-hao Man, Chun-yu Dong, Ke-ping B. [Progress of studies on the mechanism of acupuncture treatment of acute ischemic cerebral stroke]. Zhen ci yan jiu = Acupuncture research. vol 32. issue 4. 2007-10-17. PMID:17907396. |
in the present paper, the authors review the current development of studies on mechanisms of acupuncture treatment of acute ischemic cerebral apoplexy from (1) blood rheology, (2) cerebral microcirculation, 3) metabolism of cerebral tissue, (4) cerebral electrical activity, (5) free radicals and lipid peroxidation reaction, (6) excitatory aminoacid, (7) calcium overload, (8) nitrogen monoxidum, and (9) cerebral apoptosis. |
2007-10-17 |
2023-08-12 |
Not clear |
| Lisa C Hutton, Margie Castillo-Melendez, David W Walke. Uteroplacental inflammation results in blood brain barrier breakdown, increased activated caspase 3 and lipid peroxidation in the late gestation ovine fetal cerebellum. Developmental neuroscience. vol 29. issue 4-5. 2007-10-05. PMID:17762202. |
placental lipopolysaccharide treatment had substantial effects on the fetal cerebellum, including increasing the number of cells undergoing apoptosis, widespread lipid peroxidation, and extravasation of plasma albumin, suggesting compromise of the cerebellar blood-brain barrier. |
2007-10-05 |
2023-08-12 |
Not clear |
| Eitan Okun, Thiruma V Arumugam, Sung-Chun Tang, Marc Gleichmann, Michael Albeck, Benjamin Sredni, Mark P Mattso. The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice. Journal of neurochemistry. vol 102. issue 4. 2007-10-04. PMID:17542809. |
studies of cultured neurons showed that as101 confers protection against apoptosis induced by either glucose deprivation or the lipid peroxidation product 4-hydroxynonenal. |
2007-10-04 |
2023-08-12 |
mouse |
| Maurizio Moretti, Carlo Felice Marchion. An overview of erdosteine antioxidant activity in experimental research. Pharmacological research. vol 55. issue 4. 2007-08-29. PMID:17267240. |
the final result is a protective effect on tissues which reduces lipid peroxidation, neutrophil infiltration or cell apoptosis mediated by noxious agents. |
2007-08-29 |
2023-08-12 |
Not clear |
| Jun Re. Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. vol 34. issue 5-6. 2007-08-15. PMID:17439412. |
influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats. |
2007-08-15 |
2023-08-12 |
rat |
| Jun Re. Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. vol 34. issue 5-6. 2007-08-15. PMID:17439412. |
oxidative stress, lipid peroxidation, protein damage and apoptosis were assessed by glutathione (gsh) : reduced glutathione (gssg) ratio, malondialdehyde (mda) levels, protein carbonyl levels and caspase-3 activity, respectively. |
2007-08-15 |
2023-08-12 |
rat |
| F Filipak Neto, S M Zanata, H C Silva de Assis, D Bussolaro, M V M Ferraro, M A F Randi, J R M Alves Costa, M M Cestari, H Roche, C A Oliveira Ribeir. Use of hepatocytes from Hoplias malabaricus to characterize the toxicity of a complex mixture of lipophilic halogenated compounds. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 4. 2007-08-06. PMID:17293077. |
the dmso at 0.1% increased the lipid peroxidation, gsh concentration, apoptosis and dna damage. |
2007-08-06 |
2023-08-12 |
Not clear |