| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feifei Zhao, Sara Whiting, Sarah Lambourne, R John Aitken, Ying-Pu Su. Melatonin alleviates heat stress-induced oxidative stress and apoptosis in human spermatozoa. Free radical biology & medicine. vol 164. 2021-06-24. PMID:33482333. |
furthermore, the pretreatment of human spermatozoa by melatonin was able to alleviate such damage by suppressing sperm mitochondrial ros generation, increasing mitochondrial membrane potential, reducing the formation of the lipid peroxidation product, 4-hne, and reducing sperm dna damage and apoptosis. |
2021-06-24 |
2023-08-13 |
human |
| Jiatong Hao, Yue Ding, Wen Shi, Chaofeng Zhang, Renshi L. Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1/Nrf-2 Signaling Pathway. Chemistry & biodiversity. vol 17. issue 12. 2021-06-23. PMID:33084229. |
the results showed that xjt treatment significantly alleviated ali, ameliorated lipid peroxidation, improved the liver function impaired by alcohol and inhibited the hepatocytes apoptosis in vitro and in vivo. |
2021-06-23 |
2023-08-13 |
mouse |
| Samira Naderi Noreini, Mahdi Malmir, Aliasghar Ghafarizadeh, Tayebeh Faraji, Razieh Baya. Protective effect of L-carnitine on apoptosis, DNA fragmentation, membrane integrity and Lipid peroxidation of spermatozoa in the asthenoteratospermic men. Andrologia. vol 53. issue 2. 2021-06-21. PMID:33368462. |
protective effect of l-carnitine on apoptosis, dna fragmentation, membrane integrity and lipid peroxidation of spermatozoa in the asthenoteratospermic men. |
2021-06-21 |
2023-08-13 |
Not clear |
| Samira Naderi Noreini, Mahdi Malmir, Aliasghar Ghafarizadeh, Tayebeh Faraji, Razieh Baya. Protective effect of L-carnitine on apoptosis, DNA fragmentation, membrane integrity and Lipid peroxidation of spermatozoa in the asthenoteratospermic men. Andrologia. vol 53. issue 2. 2021-06-21. PMID:33368462. |
this in vitro study aimed to measure the ameliorative effect of l-carnitine against apoptosis, dna fragmentation, membrane integrity and lipid peroxidation of spermatozoa from men with asthenoteratozoospermia (ats). |
2021-06-21 |
2023-08-13 |
Not clear |
| Samira Naderi Noreini, Mahdi Malmir, Aliasghar Ghafarizadeh, Tayebeh Faraji, Razieh Baya. Protective effect of L-carnitine on apoptosis, DNA fragmentation, membrane integrity and Lipid peroxidation of spermatozoa in the asthenoteratospermic men. Andrologia. vol 53. issue 2. 2021-06-21. PMID:33368462. |
concentrating on the reasons for apoptosis is an arduous process, but in the present research for this evaluation, mitochondrial membrane potential (mmp), dna fragmentation by tunel and scd methods, and lipid peroxidation were carried out. |
2021-06-21 |
2023-08-13 |
Not clear |
| Mahdi Malmir, Samira Naderi Noreini, Aliasghar Ghafarizadeh, Tayebeh Faraji, Zahra Asal. Ameliorative effect of melatonin on apoptosis, DNA fragmentation, membrane integrity and lipid peroxidation of spermatozoa in the idiopathic asthenoteratospermic men: In vitro. Andrologia. vol 53. issue 2. 2021-06-21. PMID:33368491. |
ameliorative effect of melatonin on apoptosis, dna fragmentation, membrane integrity and lipid peroxidation of spermatozoa in the idiopathic asthenoteratospermic men: in vitro. |
2021-06-21 |
2023-08-13 |
Not clear |
| Mahdi Malmir, Samira Naderi Noreini, Aliasghar Ghafarizadeh, Tayebeh Faraji, Zahra Asal. Ameliorative effect of melatonin on apoptosis, DNA fragmentation, membrane integrity and lipid peroxidation of spermatozoa in the idiopathic asthenoteratospermic men: In vitro. Andrologia. vol 53. issue 2. 2021-06-21. PMID:33368491. |
this work was achieved to evaluate the protective role of melatonin versus apoptosis, dna fragmentation, membrane integrity and lipid peroxidation of spermatozoa from men with asthenoteratozoospermia (ats). |
2021-06-21 |
2023-08-13 |
Not clear |
| Mahdi Malmir, Samira Naderi Noreini, Aliasghar Ghafarizadeh, Tayebeh Faraji, Zahra Asal. Ameliorative effect of melatonin on apoptosis, DNA fragmentation, membrane integrity and lipid peroxidation of spermatozoa in the idiopathic asthenoteratospermic men: In vitro. Andrologia. vol 53. issue 2. 2021-06-21. PMID:33368491. |
concentrating on the reasons for apoptosis is an arduous process, but in the present study for this evaluation mitochondrial membrane potential (mmp), dna fragmentation by tunel and sperm chromatin dispersion (scd) methods and lipid peroxidation were carried out. |
2021-06-21 |
2023-08-13 |
Not clear |
| Fatih Mehmet Gur, Sema Timurkaan, Eylem Taskin, Celal Guven, Hatice Emel Gur, Meryem Senturk, Sevgi Dastan, Nursultan Nurdinov, Adnan Unalan, Senay Cankut, Ilhan Tatyu. Thymoquinone improves testicular damage and sperm quality in experimentally varicocele-induced adolescent rats. Andrologia. vol 53. issue 5. 2021-06-21. PMID:33660882. |
although the exact mechanism of action of thymoquinone has not been fully elucidated, the findings obtained in this study support the view that thymoquinone showed a cytoprotective effect by reducing apoptosis, oxidative stress and lipid peroxidation. |
2021-06-21 |
2023-08-13 |
rat |
| Fernando Lopes, Patrícia Pinto-Pinho, Isabel Gaivão, Ana Martins-Bessa, Zélia Gomes, Osvaldo Moutinho, Maria Manuel Oliveira, Francisco Peixoto, Rosário Pinto-Leit. Sperm DNA damage and seminal antioxidant activity in subfertile men. Andrologia. vol 53. issue 5. 2021-06-21. PMID:33686676. |
supraphysiological ros levels can lead to apoptosis, lipid peroxidation, and dna and protein damage. |
2021-06-21 |
2023-08-13 |
human |
| Kemal Ertilav, Mustafa Nazıroğlu, Zeki Serdar Ataizi, Kenan Yıldızha. Melatonin and Selenium Suppress Docetaxel-Induced TRPV1 Activation, Neuropathic Pain and Oxidative Neurotoxicity in Mice. Biological trace element research. vol 199. issue 4. 2021-06-18. PMID:32578137. |
the results of plate reader assay and laser confocal microscopy image analyses indicated a protective role of mt and se on the dt-induced increase of mitochondrial ros, cytosolic ros, apoptosis, lipid peroxidation, intracellular free zn |
2021-06-18 |
2023-08-13 |
mouse |
| Qingzheng Kang, Chunxue Yan. Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications. Redox biology. vol 37. 2021-06-18. PMID:33248932. |
excessive accumulation of ros induces mitochondrial damage, cellular apoptosis, inflammation, lipid peroxidation, and structural and functional alterations in retina. |
2021-06-18 |
2023-08-13 |
Not clear |
| Haiquan Zhu, Shaobo Zhu, Xiuchao Shang, Xiangsheng Meng, Sheng Jing, Li Yu, Yu Den. Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A. Frontiers in genetics. vol 12. 2021-06-08. PMID:34093648. |
functionally, both blocking circ_0136474 and upregulating mir-766-3p could rescue cell viability and levels of pcna, bcl-2, reduced glutathione (gsh), and total superoxide dismutase (sod), and attenuate apoptosis rate and levels of bax, reactive oxygen species (ros), and lipid peroxidation malondialdehyde (mda). |
2021-06-08 |
2023-08-13 |
human |
| Kenan Yıldızhan, Mustafa Nazıroğl. Glutathione Depletion and Parkinsonian Neurotoxin MPP Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32535761. |
mpp-induced increases in apoptosis, death, os, lipid peroxidation, parp1, caspase-3 and caspase-9, inflammatory cytokines (il-1β, tnf-α, il-6), and intracellular free zn |
2021-06-07 |
2023-08-13 |
mouse |
| Rosita A Condorelli, Sandro La Vignera, Federica Barbagallo, Angela Alamo, Laura M Mongioì, Rossella Cannarella, Antonio Aversa, Aldo E Caloger. Bio-Functional Sperm Parameters: Does Age Matter? Frontiers in endocrinology. vol 11. 2021-05-26. PMID:33362711. |
mitochondrial membrane potential (mmp) correlates positively with sperm motility, the evaluation of sperm apoptosis by flow cytometry allows us to identify a population of spermatozoa not recognizable at the optical microscopy and finally, lipid peroxidation (lp) and mitochondrial superoxide levels measurements are rational oxidative stress indices. |
2021-05-26 |
2023-08-13 |
Not clear |
| M J Kuhn, L M Sordill. Vitamin E analogs limit in vitro oxidant damage to bovine mammary endothelial cells. Journal of dairy science. vol 104. issue 6. 2021-05-24. PMID:33773776. |
further, γ-tocotrienol (10 μm) decreased cell cytotoxicity to a greater amount than other analogs at like concentrations, whereas γ-tocopherol (10 μm) reduced lipid peroxidation and apoptosis more effectively than other analogs. |
2021-05-24 |
2023-08-13 |
cattle |
| Zi-Hao Wang, Li-Hui Deng, Chang-Wei Chi, Hong Wang, Yue-Yue Huang, Qun Zhen. A Preclinical Systematic Review of Curcumin for Protecting the Kidney with Ischemia Reperfusion Injury. Oxidative medicine and cellular longevity. vol 2020. 2021-05-20. PMID:33274000. |
curcumin (cur), a polyphenol extracted from turmeric, possesses a variety of biological activities involving antioxidation, inhibition of apoptosis, inhibition of inflammation, and reduction of lipid peroxidation. |
2021-05-20 |
2023-08-13 |
mouse |
| Jie Yang, Wen-Wen Mu, Guo-Yun Li. Synthesis and evaluation of the anticancer activity of bischalcone analogs in human lung carcinoma (A549) cell line. European journal of pharmacology. vol 888. 2021-05-17. PMID:32798508. |
in this study, we synthesized a series of bischalcone analogs via aldol condensation reaction; mtt method was used to evaluate the antiproliferation effects; the 2',7'-dichlorofluorescein fluorescence assay was used to determine the intracellular reactive oxygen species levels; the glutathione reductase-dtnb recycling assay was used to detect the redox imbalance; determination of thiobarbituric acid-reactive substance was used to evaluate the lipid peroxidation; rhodamine 123 was used to test the mitochondrial membrane potential (mmp); the fitc/pi kit was used to detect the apoptosis; western blotting was used to detect the expression of bax and caspase 3. |
2021-05-17 |
2023-08-13 |
human |
| Jie Yang, Wen-Wen Mu, Guo-Yun Li. Synthesis and evaluation of the anticancer activity of bischalcone analogs in human lung carcinoma (A549) cell line. European journal of pharmacology. vol 888. 2021-05-17. PMID:32798508. |
further mechanism of action studies revealed that 1d and 1g exhibited more stronger reactive oxygen species production abilities than curcumin and accompanied by the redox imbalance, lipid peroxidation, the loss of mmp, the activition of bax and caspase 3, and ultimately resulted in apoptosis of a549 cell. |
2021-05-17 |
2023-08-13 |
human |
| Paul B Tchounwou, Shaloam Dasari, Felicite K Noubissi, Paresh Ray, Sanjay Kuma. Advances in Our Understanding of the Molecular Mechanisms of Action of Cisplatin in Cancer Therapy. Journal of experimental pharmacology. vol 13. 2021-05-11. PMID:33776489. |
its primary molecular mechanism of action has been associated with the induction of both intrinsic and extrinsic pathways of apoptosis resulting from the production of reactive oxygen species through lipid peroxidation, activation of various signal transduction pathways, induction of p53 signaling and cell cycle arrest, upregulation of pro-apoptotic genes/proteins, and down-regulation of proto-oncogenes and anti-apoptotic genes/proteins. |
2021-05-11 |
2023-08-13 |
human |