| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao Sun, Ping Sun, Dong Zhen, Xiangli Xu, Li Yang, Danni Fu, Chengxi Wei, Xiaofeng Niu, Jiawei Tian, Hairu L. Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression. Toxicology and applied pharmacology. 2022-01-30. PMID:35093381. |
the results showed that yap downregulation abolished the protective effects of mel including apoptosis, mitochondrial lipid peroxidation, and ferroptosis. |
2022-01-30 |
2023-08-13 |
rat |
| Sepideh Khaksar, Mohammadreza Bigdeli, Arash Samiee, Zahra Shirazi-Zan. Antioxidant and Anti-apoptotic Effects of Cannabidiol in Model of Ischemic Stroke in Rats. Brain research bulletin. 2022-01-15. PMID:35031355. |
cbd played the anti-apoptosis and anti-oxidant roles in cerebral ischemia by affecting the pathways of intrinsic apoptosis, endogenous antioxidant enzymes, and lipid peroxidation. |
2022-01-15 |
2023-08-13 |
rat |
| Giulia Greco, Michael Schnekenburger, Elena Catanzaro, Eleonora Turrini, Fabio Ferrini, Piero Sestili, Marc Diederich, Carmela Fimognar. Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential. Cancers. vol 14. issue 1. 2022-01-11. PMID:35008240. |
at 25 μm, sfn induced caspase-dependent apoptosis and at 50 μm ferroptosis was induced through depletion of glutathione (gsh), decreased gsh peroxidase 4 protein expression, and lipid peroxidation. |
2022-01-11 |
2023-08-13 |
Not clear |
| Meirong Shan, Xujie Yu, Yajie Li, Changning Fu, Cheng Zhan. Vitamin B6 Alleviates Lipopolysaccharide-induced Myocardial Injury by Ferroptosis and Apoptosis Regulation. Frontiers in pharmacology. vol 12. 2022-01-10. PMID:35002705. |
we demonstrated that vitb6 can suppress lps-induced oxidative stress and lipid peroxidation that lead to ferroptosis and apoptosis |
2022-01-10 |
2023-08-13 |
Not clear |
| Peiyi Liu, Jiahui Zhu, Guanxiang Yuan, Di Li, Ying Wen, Suli Huang, Ziquan Lv, Yinsheng Guo, Jinquan Chen. The effects of selenium on GPX4-mediated lipid peroxidation and apoptosis in germ cells. Journal of applied toxicology : JAT. 2021-12-31. PMID:34970773. |
the effects of selenium on gpx4-mediated lipid peroxidation and apoptosis in germ cells. |
2021-12-31 |
2023-08-13 |
Not clear |
| Peiyi Liu, Jiahui Zhu, Guanxiang Yuan, Di Li, Ying Wen, Suli Huang, Ziquan Lv, Yinsheng Guo, Jinquan Chen. The effects of selenium on GPX4-mediated lipid peroxidation and apoptosis in germ cells. Journal of applied toxicology : JAT. 2021-12-31. PMID:34970773. |
to evaluate the effect of selenium on gpx4-mediated lipid peroxidation and apoptosis in germ cells, selenium deficiency was modeled by culturing gc2-spd cells in serum-free medium. |
2021-12-31 |
2023-08-13 |
Not clear |
| Peiyi Liu, Jiahui Zhu, Guanxiang Yuan, Di Li, Ying Wen, Suli Huang, Ziquan Lv, Yinsheng Guo, Jinquan Chen. The effects of selenium on GPX4-mediated lipid peroxidation and apoptosis in germ cells. Journal of applied toxicology : JAT. 2021-12-31. PMID:34970773. |
conclusively, gpx4 was involved in the regulation of lipid peroxidation and apoptosis in gc2-spd cells. |
2021-12-31 |
2023-08-13 |
Not clear |
| Lei Zhang, Ruohan Jia, Huizhen Li, Huarun Yu, Keke Ren, Shuangshuang Jia, Yanzhang Li, Qun Wan. Insight into the Double-Edged Role of Ferroptosis in Disease. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944434. |
ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (lp), reactive oxygen species (ros) production, and mitochondrial dysfunction. |
2021-12-24 |
2023-08-13 |
Not clear |
| Chhanda Bose, Ashly Hindle, Jihyun Lee, Jonathan Kopel, Sahil Tonk, Philip T Palade, Sharad S Singhal, Sanjay Awasthi, Sharda P Sing. Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells. Cancers. vol 13. issue 24. 2021-12-24. PMID:34944997. |
aa increased lipid peroxidation, 4-hne generation, apoptosis, cellular dox concentration and dox cytotoxicity in both cell lines while sparing cultured immortalized cardiomyocyte cells. |
2021-12-24 |
2023-08-13 |
Not clear |
| Marc Dahlmanns, Eduard Yakubov, Jana Katharina Dahlmann. Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction. Frontiers in oncology. vol 11. 2021-12-20. PMID:34926298. |
experimental studies have shown that the efficiency of temozolomide can be improved by inducing ferroptosis - a recently discovered form of cell death, which is different from apoptosis, necrosis, or necroptosis and, which is characterized by lipid peroxidation and reactive oxygen species accumulation. |
2021-12-20 |
2023-08-13 |
human |
| Priya Josson Akkara, Evan Prince Sabin. A biochemical approach to the anti-inflammatory, antioxidant and antiapoptotic potential of beta-carotene as a protective agent against bromobenzene-induced hepatotoxicity in female Wistar albino rats. Journal of applied biomedicine. vol 18. issue 2-3. 2021-12-15. PMID:34907730. |
pre-treatment with beta-carotene not only significantly decreased the levels of liver markers, lipid peroxidation and cytokines but also improved histo-architecture and increased antioxidant levels minimising oxidative stress, and reduced factors contributing to apoptosis. |
2021-12-15 |
2023-08-13 |
rat |
| Wei Hu, Qing-Ling Zhu, Jia-Lang Zheng, Zheng-Yong We. Cadmium induced oxidative stress, endoplasmic reticulum (ER) stress and apoptosis with compensative responses towards the up-regulation of ribosome, protein processing in the ER, and protein export pathways in the liver of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). vol 242. 2021-12-10. PMID:34798301. |
the present study identified that exposure to 5, 10, and 20 µg/l cd for 48 days reduced growth, increased cd accumulation and levels of reactive oxygen species (ros) and lipid peroxidation, and induced er stress and cellular apoptosis in the liver in a dose-dependent manner. |
2021-12-10 |
2023-08-13 |
cat |
| Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Ga. p53: A Double-Edged Sword in Tumor Ferroptosis. Pharmacological research. 2021-12-02. PMID:34856333. |
in addition to its effects on apoptosis, autophagy, and cell cycle, p53, through the way of transcription dependent or independent two-way, also regulates the biological processes of tumor cell sensitivity to ferroptosis, including the metabolism of amino acids, nicotinamide adenine dinucleotide phosphate, and lipid peroxidation, as well as the biosynthesis of glutathione, phospholipids, nadph and coenzyme q10.as reviewed here, we summarized the metabolic network of p53 and its signaling pathway in regulating ferroptosis and elucidated possible factors and potential clinical application of p53 regulating ferroptosis. |
2021-12-02 |
2023-08-13 |
Not clear |
| Lamia M El-Samad, Saeed El-Ashram, Hussein K Hussein, Karolin K Abdul-Aziz, Eman H Radwan, Nahed R Bakr, Abeer El Wakil, Maria Augustynia. Time-delayed effects of a single application of AgNPs on structure of testes and functions in Blaps polychresta Forskal, 1775 (Coleoptera: Tenebrionidae). The Science of the total environment. vol 806. issue Pt 2. 2021-11-30. PMID:34597572. |
revealed numerous adverse effects of nanoparticles in structure and ultrastructure, accompanied by increased apoptosis (but not necrosis), increased dna damage, increased lipid peroxidation, and decreased levels of antioxidant enzymes. |
2021-11-30 |
2023-08-13 |
Not clear |
| Alicja Kowalczy. The Role of the Natural Antioxidant Mechanism in Sperm Cells. Reproductive sciences (Thousand Oaks, Calif.). 2021-11-30. PMID:34845666. |
high levels of ros can have an adverse effect on sperm function through the initiation of dna damage, lipid peroxidation, loss of membrane integrity and increased permeability, inactivation of cellular enzymes, and cell apoptosis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Shunchen Song, Yaxuan Gao, Yi Sheng, Tongyu Rui, Chengliang Lu. Targeting NRF2 to suppress ferroptosis in brain injury. Histology and histopathology. vol 36. issue 4. 2021-11-29. PMID:33242213. |
as a novel form of regulated cell death (rcd) depending on lipid peroxidation caused by iron overload, ferroptosis (fpt) further aggravates brain injury, which is different from apoptosis, autophagy and other traditional cell death in terms of biochemistry, morphology and genetics. |
2021-11-29 |
2023-08-13 |
Not clear |
| Lu Jiang, Jingjing Fang, Kexian Li, Xinhong Xu, Jiangbo Qia. Lung tissue inflammatory response and pneumonocyte apoptosis of Sprague-Dawley rats after a 30-day exposure in methyl mercaptan vapor. Journal of the Air & Waste Management Association (1995). vol 71. issue 5. 2021-11-24. PMID:33295838. |
oxidative stress with lipid peroxidation, which affect blood antioxidant enzyme levels and induce apoptosis of alveolar epithelial cells, are recognized as a potential mechanism leading to terminal bronchiole constriction, alveoli congestion, and exudates of erythrocyte. |
2021-11-24 |
2023-08-13 |
rat |
| Tuba Parlak Ak, Pinar Tatli Seven, Seyfettin Gur, Burcu Gul, Mine Yaman, Ismail Seve. Chrysin and flunixin meglumine mitigate overloaded copper-induced testicular and spermatological damages via modulation of oxidative stress and apoptosis in rats. Andrologia. 2021-11-24. PMID:34817900. |
copper administration caused significant morphological, physiological and biochemical alterations compared to the control group, which are as follows: production of oxidative stress, thanks to rise in testis lipid peroxidation and fall in antioxidant enzyme concentrations, decrease in sperm quality and increase in morphologic sperm abnormalities, suppression of spermatogenesis and prominent alterations in the testis histomorphology and induction of apoptosis in the testis tissues. |
2021-11-24 |
2023-08-13 |
rat |
| Bao-Li Fei, Chun-Nuan Hui, Zuzhuang Wei, Ling-Yan Kong, Jian-Ying Long, Chunhua Qiao, Zhen-Feng Che. Copper(II) and iron(III) complexes of chiral dehydroabietic acid derived from natural rosin: metal effect on structure and cytotoxicity. Metallomics : integrated biometal science. vol 13. issue 4. 2021-11-23. PMID:33765148. |
all the results suggest that 1 could kill mcf-7 cells by generating oxidative stress, impairing dna, promoting lipid peroxidation and protein carbonylation, and inducing apoptosis and autophagy. |
2021-11-23 |
2023-08-13 |
Not clear |
| Claudia Matlakala Ntsapi, Ben Loo. Neurons die with heightened but functional macro- and chaperone mediated autophagy upon increased amyloid-ß induced toxicity with region-specific protection in prolonged intermittent fasting. Experimental cell research. vol 408. issue 2. 2021-11-23. PMID:34624324. |
these findings were confirmed when implementing a prolonged intermittent fasting (if) intervention in a model of paraquat-induced neuronal toxicity, where markers of autophagic activity were increased, while apoptosis onset and lipid peroxidation were robustly decreased in brain regions associated with neurodegeneration. |
2021-11-23 |
2023-08-13 |
Not clear |