| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yajuan Ni, Jie Deng, Xin Liu, Qing Li, Juanli Zhang, Hongyuan Bai, Jingwen Zhan. Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33314649. |
here, we firstly induce cellular model of oxidative stress by iso with ac-16 cells and pre-treat with ech, the level of mitochondrial ros, mtdna oxidative injury, mmp, carbonylated protein, lipid peroxidation, intracellular ros and apoptosis are detected, confirm the effect of ech in mitochondrial oxidative stress and function in vitro. |
2021-09-15 |
2023-08-13 |
rat |
| Narjes Shahsavani, Arsalan Alizadeh, Hardeep Kataria, Soheila Karimi-Abdolrezae. Availability of neuregulin-1beta1 protects neurons in spinal cord injury and against glutamate toxicity through caspase dependent and independent mechanisms. Experimental neurology. vol 345. 2021-09-07. PMID:34314724. |
in the present study, using a clinically-relevant model of compressive/contusive sci in rats and an in vitro model of glutamate toxicity in primary neurons, we demonstrate nrg-1β1 provides early neuroprotection through attenuation of reactive oxygen species, lipid peroxidation, necrosis and apoptosis in acute and subacute stages of sci. |
2021-09-07 |
2023-08-13 |
rat |
| Elçin Bakır, Serpil Sarıözkan, Burcu Ünlü Endirlik, Ayşe Baldemir Kılıç, Arzu Hanım Yay, Fazile Cantürk Tan, Ayşe Eken, Gaffari Tür. Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410775. |
dimethoate significantly decreased body and reproductive organ weights, sperm motility and concentration, testicular superoxide dismutase, and glutathione-peroxidase activities and significantly increased lipid peroxidation, abnormal sperm rate, sperm dna damage, testicular apoptosis, and caused histopathological lesions. |
2021-08-30 |
2023-08-13 |
rat |
| Huifang Cao, Lichao Zhang, Zhenzhen Qu, Shuang Tian, Zhiyong Wang, Yuhang Jiang, Qian Hou, Lijing Jia, Weiping Wan. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus. Brain research. vol 1764. 2021-08-25. PMID:33831409. |
we found that expressions of nuclear nf-e2-related factor 2 (nnrf2), heme oxygenase-1 (ho-1) and nadph: quinone oxidoreductase-1 (nqo1) were upregulated 24 h after the onset of se, but the increase was not enough to combat oxidative stress damage, nor to attenuate lipid peroxidation and apoptosis. |
2021-08-25 |
2023-08-13 |
rat |
| Huifang Cao, Lichao Zhang, Zhenzhen Qu, Shuang Tian, Zhiyong Wang, Yuhang Jiang, Qian Hou, Lijing Jia, Weiping Wan. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus. Brain research. vol 1764. 2021-08-25. PMID:33831409. |
the expressions of these proteins in hfs pretreatment groups increased more significantly than those in the epilepsy (ep) group, which effectively reduced lipid peroxidation and apoptosis in the hippocampus. |
2021-08-25 |
2023-08-13 |
rat |
| Maria S Ferrer, Roberto Palomares, David Hurley, Anna-Claire Bullington, Alejandro Hoyos-Jaramillo, João H Bitta. Antisperm antibodies and sperm function in bulls undergoing scrotal insulation. Reproduction (Cambridge, England). vol 160. issue 5. 2021-08-24. PMID:33065546. |
on each collection day, scrotal circumference, sperm motility, morphology, membrane integrity, acrosome integrity, apoptosis, lipid peroxidation, mitochondrial membrane potential, asa binding and dna integrity were evaluated. |
2021-08-24 |
2023-08-13 |
cattle |
| Saif A Alharthy, Diane Harde. The role of transcription factor Nrf2 in the toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in C57BL/6 mouse astrocytes. Environmental toxicology and pharmacology. vol 86. 2021-08-20. PMID:33812015. |
exposure to 600 μm pfos and 800 μm pfoa showed significant increases in reactive oxygen species, lipid peroxidation, and apoptosis in nrf2-/- astrocytes as compared to wild-type astrocytes. |
2021-08-20 |
2023-08-13 |
mouse |
| Ying Wang, Zihao Wei, Keran Pan, Jing Li, Qianming Che. The function and mechanism of ferroptosis in cancer. Apoptosis : an international journal on programmed cell death. vol 25. issue 11-12. 2021-08-19. PMID:32944829. |
ferroptosis is a newly defined form of regulated cell death (rcd) characterized by iron overload, lipid reactive oxygen species (ros) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of rcd in morphology, biochemistry, function and gene expression. |
2021-08-19 |
2023-08-13 |
Not clear |
| Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Ariadna Jazmin Ortega-Lozano, José Pedraza-Chaverri, Francisco Mendoza-Hoffman. Lipid metabolism and oxidative stress in HPV-related cancers. Free radical biology & medicine. vol 172. 2021-08-19. PMID:34129929. |
hpv proteins induce oxidative stress (os), which in turn promotes lipid peroxidation and cell damage, resulting in cell death such as apoptosis, autophagy, and ferroptosis. |
2021-08-19 |
2023-08-13 |
human |
| Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Ariadna Jazmin Ortega-Lozano, José Pedraza-Chaverri, Francisco Mendoza-Hoffman. Lipid metabolism and oxidative stress in HPV-related cancers. Free radical biology & medicine. vol 172. 2021-08-19. PMID:34129929. |
furthermore, we emphasize the significant role of os in lipid peroxidation to induce cell death through apoptosis, autophagy, and ferroptosis to eliminate hpv-related cancers. |
2021-08-19 |
2023-08-13 |
human |
| Joan C Wijaya, Ramin Khanabdali, Harry M Georgiou, Maria I Kokkinos, Patrick F James, Shaun P Brennecke, Bill Kalioni. Functional changes in decidual mesenchymal stem/stromal cells are associated with spontaneous onset of labour. Molecular human reproduction. vol 26. issue 8. 2021-08-09. PMID:32609359. |
sol-dmscs showed reduced proliferation and increased lipid peroxidation, migration, necrosis, mitochondrial apoptosis, il-6 production and p38 mapk levels compared with nil-dmscs (p < 0.05). |
2021-08-09 |
2023-08-13 |
Not clear |
| Zhenjuan Chen, Ancheng Wu, Hongmei Jin, Fuhui Li. β-Sitosterol attenuates liver injury in a rat model of chronic alcohol intake. Archives of pharmacal research. vol 43. issue 11. 2021-08-02. PMID:33155166. |
the underlying mechanism was investigated by measuring lipid peroxidation, the antioxidant, the expression of cytochrome p450 2e1 and the expression of apoptosis related genes. |
2021-08-02 |
2023-08-13 |
rat |
| Eleazar Uchenna Ikonne, Victor Okezie Ikpeazu, Eziuche Amadike Ugbog. The potential health benefits of dietary natural plant products in age related eye diseases. Heliyon. vol 6. issue 7. 2021-07-29. PMID:32685729. |
oxidative stress plays a crucial role in the pathogenesis of age-related eye diseases through the activation of nuclear factor kappa b (nf-κb), vascular endothelial growth factor (vegf), and lipid peroxidation, which leads to the production of inflammatory cytokines, angiogenesis, protein and dna damages, apoptosis that causes macular degeneration (amd), cataract, diabetic retinopathy and glaucoma. |
2021-07-29 |
2023-08-13 |
Not clear |
| Ning Li, Wenyang Jiang, Wei Wang, Rui Xiong, Xiaojing Wu, Qing Gen. Ferroptosis and its emerging roles in cardiovascular diseases. Pharmacological research. vol 166. 2021-07-29. PMID:33548489. |
ferroptosis is a new form of regulated cell death (rcd) driven by iron-dependent lipid peroxidation, which is morphologically and mechanistically distinct from other forms of rcd including apoptosis, autophagic cell death, pyroptosis and necroptosis. |
2021-07-29 |
2023-08-13 |
Not clear |
| Feyza Sönmez Aydın, Berna Hukkamlı, Harun Buda. Coaction of hepatic thioredoxin and glutathione systems in iron overload-induced oxidative stress. Journal of biochemical and molecular toxicology. vol 35. issue 4. 2021-07-27. PMID:33393188. |
in conclusion, excess iron accumulation in mouse liver tissue causes os, which affects the redox state of the thioredoxin and gsh systems, inducing cell apoptosis and also ferroptosis due to increased lipid peroxidation and the depletion of gsh level. |
2021-07-27 |
2023-08-13 |
mouse |
| Zhang Ping, Hu Fan, Chai Wen, Zhang Ji, Shao Lian. GAPDH siRNA Regulates SH-SY5Y Cell Apoptosis Induced by Exogenous α-Synuclein Protein. Neuroscience. vol 469. 2021-07-27. PMID:34216695. |
the silencing of the expression of gapdh pre-knockdown was found to reduce the intracellular levels of ros and lipid peroxidation, enhance autophagy activity, thereby reducing the cell injury, apoptosis and necrosis induced by exogenous α-synuclein protein in sh-sy5y cells. |
2021-07-27 |
2023-08-13 |
human |
| Maryam Mazhar, Ahmad Ud Din, Hamid Ali, Guoqiang Yang, Wei Ren, Li Wang, Xiaohui Fan, Sijin Yan. Implication of ferroptosis in aging. Cell death discovery. vol 7. issue 1. 2021-07-24. PMID:34226536. |
in ferroptosis, the cell death occur neither by conventional apoptosis, necrosis nor by autophagy, rather dysregulated iron in the cell mediates excessive lipid peroxidation of accumulated lethal lipids. |
2021-07-24 |
2023-08-13 |
human |
| Marta Orlicka-Płocka, Agnieszka Fedoruk-Wyszomirska, Dorota Gurda-Woźna, Paweł Pawelczak, Patrycja Krawczyk, Małgorzata Giel-Pietraszuk, Grzegorz Framski, Tomasz Ostrowski, Eliza Wyszk. Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives. Antioxidants (Basel, Switzerland). vol 10. issue 6. 2021-07-10. PMID:34204594. |
both compounds induced ros generation and genotoxic os, resulting in lipid peroxidation and leading to apoptosis. |
2021-07-10 |
2023-08-13 |
Not clear |
| Hartmut Jaeschke, Anup Ramachandra. Does acetaminophen hepatotoxicity involve apoptosis, inflammatory liver injury, and lipid peroxidation? Journal of biochemical and molecular toxicology. vol 35. issue 2. 2021-07-09. PMID:33484021. |
does acetaminophen hepatotoxicity involve apoptosis, inflammatory liver injury, and lipid peroxidation? |
2021-07-09 |
2023-08-13 |
Not clear |
| Zhiyong Zhang, Yan Pan, Yan Zhao, Mudan Ren, Yarui Li, Guifang Lu, Kaichun Wu, Shuixiang H. Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells. Environmental toxicology. vol 36. issue 8. 2021-07-05. PMID:33955636. |
we noticed that delphinidin effectively induced oxidative stress-mediated apoptosis by generating intracellular ros, decreasing antioxidant levels, inducing lipid peroxidation, and single-strand break on colon cancer cells. |
2021-07-05 |
2023-08-13 |
human |