| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongjiang Zhao, Yuan Xu, Hongkai Shan. Ferroptosis: A New Promising Target for Ovarian Cancer Therapy. International journal of medical sciences. vol 19. issue 13. 2022-11-28. PMID:36438923. |
ferroptosis is a novel kind of regulated cell death distinct from autophagy, apoptosis, and necrosis; it is predominantly caused by the iron-dependent lipid peroxidation. |
2022-11-28 |
2023-08-14 |
Not clear |
| Huma Rizwan, Sonu Kumar, Golden Kumari, Arttatrana Pa. High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes. Life sciences. 2022-11-25. PMID:36427546. |
further, hg-induced rna production caused an increase in the production of inflammatory mediators accompanied by activation of erk1/2mapk/akt/tuberin-mtor/irf3 signaling cascade, lipid peroxidation (lpo), and protein carbonylation (pc) reactions followed by breakdown the cell-cell communication and apoptosis. |
2022-11-25 |
2023-08-14 |
Not clear |
| Qiao Zhou, Ting Li, Qin Qin, Xiaobo Huang, Yi Wan. Ferroptosis in lymphoma: Emerging mechanisms and a novel therapeutic approach. Frontiers in genetics. vol 13. 2022-11-21. PMID:36406116. |
unlike apoptosis, necroptosis, autophagy, and pyroptosis, ferroptosis represents a new type of cell death, which is characterized by iron-dependent lipid peroxidation. |
2022-11-21 |
2023-08-14 |
Not clear |
| Shang-Ming Dai, Feng-Jiao Li, Hui-Zhi Long, Zi-Wei Zhou, Hong-Yu Luo, Shuo-Guo Xu, Li-Chen Ga. Relationship between miRNA and ferroptosis in tumors. Frontiers in pharmacology. vol 13. 2022-11-21. PMID:36408273. |
ferroptosis is a kind of programmed death caused by iron dependent lipid peroxidation, which is different from apoptosis, necrosis and other cell death modes. |
2022-11-21 |
2023-08-14 |
human |
| Paul R J Ames, Tommaso Bucci, Mira Merashli, Alessia Arcaro, Fabrizio Gentil. Thrombocytopenia in antiphospholipid syndrome: a free radical perspective. Rheumatology (Oxford, England). 2022-11-17. PMID:36394142. |
although antiphospholipid antibodies may induce platelet activation in vitro, additional stimuli may contribute to their activation in vivo, amongst which reactive oxygen and nitrogen species and lipid peroxidation products, elevated in patients with the antiphospholipid syndrome: an excess of the same stimuli may induce megakaryocyte and platelet apoptosis that leads to decreased platelet production and increased destruction, exposure resulting ultimately in thrombocytopaenia. |
2022-11-17 |
2023-08-14 |
Not clear |
| Yajing Li, Zhendong Zhu, Haixiang Cui, Kexin Ding, Yong Zhao, Xiangping Ma, Adedeji Olufemi Adetunji, Lingjiang Mi. Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis. Animals : an open access journal from MDPI. vol 12. issue 21. 2022-11-11. PMID:36359150. |
ferroptosis is a newly identified type of programmed cell death that is different from apoptosis and it depends on iron accumulation and lipid peroxidation. |
2022-11-11 |
2023-08-14 |
mouse |
| Xixiang Tang, Jinli Wang, Hanna E Abboud, Yanming Chen, Joshua J Wang, Sarah X Zhan. Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes. Diabetes. 2022-11-02. PMID:36321974. |
in vitro study revealed enhanced apoptosis in brain microvascular ecs (bmecs) derived from hnox4ec-tg mice, concomitant with increased mitochondrial ros, elevated lipid peroxidation, decreased mitochondrial membrane potential (ΔΨm), and reduced mitochondrial respiratory function. |
2022-11-02 |
2023-08-14 |
mouse |
| Xiaoqin Zeng, Jingda Li, Fuyuan Yang, Rui Xi. The effect of narcotics on ferroptosis-related molecular mechanisms and signalling pathways. Frontiers in pharmacology. vol 13. 2022-10-31. PMID:36313359. |
ferroptosis is a novel programmed cell death form characterized by iron-mediated reactive oxygen species-induced lipid peroxidation and subsequent cell damage that is distinct from apoptosis, necroptosis, pyroptosis, and autophagy. |
2022-10-31 |
2023-08-14 |
Not clear |
| Roland E Akhigbe, Sulagna Dutta, Moses A Hamed, Ayodeji F Ajayi, Pallav Sengupta, Gulfam Ahma. Viral Infections and Male Infertility: A Comprehensive Review of the Role of Oxidative Stress. Frontiers in reproductive health. vol 4. 2022-10-28. PMID:36303638. |
this is accompanied by reduced circulatory testosterone, impaired spermatogenesis, reduced sperm motility, lipid peroxidation, dna fragmentation and apoptosis of the sperm cells. |
2022-10-28 |
2023-08-14 |
human |
| Farah Ballout, Heng Lu, Zheng Chen, Tianling Hu, Lei Chen, Mary Kay Washington, Wael El-Rifai, Dunfa Pen. Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290582. |
we discovered that in addition to inducing apoptosis, brusatol alone or in combination with cisplatin (cddp) induced significant lipid peroxidation and ferroptosis, as evidenced by reduced xct and gpx4 expression, two known ferroptosis markers. |
2022-10-27 |
2023-08-14 |
Not clear |
| Chongshan Dai, Erjie Tian, Zhihui Hao, Shusheng Tang, Zhanhui Wang, Gaurav Sharma, Haiyang Jiang, Jianzhong She. Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290754. |
the mechanisms of afb1-induced toxicity are connected to the generation of excess reactive oxygen species (ros), upregulation of cyp450 activities, oxidative stress, lipid peroxidation, apoptosis, mitochondrial dysfunction, autophagy, necrosis, and inflammatory response. |
2022-10-27 |
2023-08-14 |
Not clear |
| Syed Shams Ul Hassan, Saptadip Samanta, Raju Dash, Tomasz M Karpiński, Emran Habibi, Abdul Sadiq, Amirhossin Ahmadi, Simona Bunag. The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress. Frontiers in pharmacology. vol 13. 2022-10-27. PMID:36299900. |
high level of ros in the brain tissue decreases atp levels, and mitochondrial membrane potential and induces lipid peroxidation, chronic inflammation, dna damage, and apoptosis. |
2022-10-27 |
2023-08-14 |
Not clear |
| Ivan Cokic, Shing Fai Chan, Xingmin Guan, Anand R Nair, Hsin-Jung Yang, Ting Liu, Yinyin Chen, Diego Hernando, Jane Sykes, Richard Tang, John Butler, Alice Dohnalkova, Libor Kovarik, Robert Finney, Avinash Kali, Behzad Sharif, Louis S Bouchard, Rajesh Gupta, Mayil Singaram Krishnam, Keyur Vora, Balaji Tamarappoo, Andrew G Howarth, Andreas Kumar, Joseph Francis, Scott B Reeder, John C Wood, Frank S Prato, Rohan Dharmakuma. Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium. Nature communications. vol 13. issue 1. 2022-10-27. PMID:36302906. |
specifically, we show that the fatty degeneration of the hemorrhagic mi zone stems from iron-induced macrophage activation, lipid peroxidation, foam cell formation, ceroid production, foam cell apoptosis and iron recycling. |
2022-10-27 |
2023-08-14 |
Not clear |
| Xianbo Liu, He Yang, Zhenning Li. Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs. International immunopharmacology. vol 113. issue Pt A. 2022-10-24. PMID:36279672. |
free radicals can further cause cellular damage via lipid peroxidation, mitochondrial damage, inflammatory response, and apoptosis in many organs including lung, liver, and kidney. |
2022-10-24 |
2023-08-14 |
Not clear |
| Pengxiao Li, Yazhong Ma, Ke Wang, Xiaohan Shi, Jie Yang, Guoyun Li. Design, synthesis and antitumor activity of potent and safe para-quinone methides derivatives in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-24. PMID:36279719. |
further biological studies demonstrated that the cytotoxicity of p-qms derivatives originated from their ros-generation abilities, which could further disrupt the redox balance, lipid peroxidation, the loss of mmp, cell cycle arrest at g0/g1 phase and apoptosis. |
2022-10-24 |
2023-08-14 |
Not clear |
| Mohammad Reza Divar, Asghar Mogheiseh, Fatemeh Mohammadi, Leili Mavalizade. Effects of extender filtration and egg yolk concentration on canine semen cryopreservation. Reproduction in domestic animals = Zuchthygiene. 2022-10-20. PMID:36264284. |
the frozen-thawed spermatozoa evaluations included motility parameters (casa), membrane and acrosome integrity (hypo-osmotic swelling test, chlortetracycline binding assay), dna fragmentation (sperm chromatin dispersion assay), membrane lipid peroxidation (mda levels), apoptosis (annexin v/propidium iodide assay), and fertility-associated sperm mrna transcript abundance (protamine 2 and 3). |
2022-10-20 |
2023-08-14 |
chicken |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
this review delineates how in in vivo models mhdis suppress aβ deposition by downregulating β- and γ-secretase activities; inhibit oxidative stress by enhancing the antioxidant activities and reducing lipid peroxidation; prevent tau hyperphosphorylation by upregulating protein phosphatase 2a expression and downregulating glycogen synthase kinase-3β expression; reduce inflammatory mediators partly by upregulating brain-derived neurotrophic factor/extracellular signal-regulated protein kinase 1/2-mediated signaling and downregulating p38 mitogen-activated protein kinase (p38 mapk)/c-jun n-terminal kinase (jnk)-mediated signaling; attenuate synaptic dysfunction by increasing presynaptic protein, postsynaptic protein, and acetylcholine levels and preventing acetylcholinesterase activity; and protect against neuronal apoptosis mainly by upregulating akt/cyclic amp response element-binding protein/b-cell lymphoma 2 (bcl-2)-mediated anti-apoptotic signaling and downregulating p38 mapk/jnk/bcl-2-associated x protein (bax)/caspase-3-, bax/apoptosis-inducing factor-, c/ebp homologous protein/glucose-regulated protein 78-, and autophagy-mediated apoptotic signaling. |
2022-10-14 |
2023-08-14 |
Not clear |
| Seenipandi Arunachalam, M F Nagoor Meeran, Sheikh Azimullah, Niraj Kumar Jha, Dhanya Saraswathiamma, Sandeep Subramanya, Alia Albawardi, Shreesh Ojh. α-Bisabolol Attenuates Doxorubicin Induced Renal Toxicity by Modulating NF-κB/MAPK Signaling and Caspase-Dependent Apoptosis in Rats. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142441. |
however, treatment with α-bisabolol prevented body weight loss, restored antioxidants, mitigated lipid peroxidation, and inhibited the rise in proinflammatory cytokines, as well as favorably modulated the expressions of nf-κb/mapk signaling and apoptosis markers in dox-induced nephrotoxicity. |
2022-09-23 |
2023-08-14 |
rat |
| Shuo Ni, Yin Yuan, Shangdao Song, Xiaolin L. A double-edged sword with a therapeutic target: iron and ferroptosis in immune regulation. Nutrition reviews. 2022-09-21. PMID:36130411. |
unlike apoptosis, ferroptosis, a feature of iron-dependent lipid peroxidation, is thought to be associated with immune regulation because of its immunogenic nature. |
2022-09-21 |
2023-08-14 |
Not clear |
| Raghul Murugan, Ravi Rajesh, Boopathi Seenivasan, B Haridevamuthu, Gokul Sudhakaran, Ajay Guru, R Rajakrishnan, Palaniselvam Kuppusamy, Annie Juliet, Pushparathinam Gopinath, Jesu Arockiara. Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach. Microbial pathogenesis. 2022-09-18. PMID:36116607. |
the results indicate that the level of ros, and its related lipid peroxidation and apoptosis were significantly reduced after treated with withaferin a. consequently, an increment in antioxidant enzymes level such as superoxide dismutase (sod) and catalase (cat) was observed. |
2022-09-18 |
2023-08-14 |
cat |