| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong H. p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation. World journal of gastroenterology. vol 24. issue 33. 2018-11-14. PMID:30197477. |
as important down-stream effectors of kras, p21-activated kinases (paks) are involved in regulating cell proliferation, apoptosis, invasion/migration and chemo-resistance. |
2018-11-14 |
2023-08-13 |
Not clear |
| Yan-Yih Goh, Yaw-Kai Yan, Nguan Soon Tan, Su-Ann Goh, Shang Li, You-Chuan Teoh, Peter P F Le. Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex. Scientific reports. vol 6. 2018-05-21. PMID:27841290. |
overall, we demonstrated that complex 1 induces apoptosis, at least in part, by suppressing kras, c-kit and c-myc oncogene expression and the pro-survival mek-erk and pi3k-akt signalling pathways. |
2018-05-21 |
2023-08-13 |
human |
| Chaoying You, Hongwei Liang, Wu Sun, Jialu Li, Yanqing Liu, Qian Fan, Haiyang Zhang, Xin Yue, Jing Li, Xi Chen, Yi B. Deregulation of the miR-16-KRAS axis promotes colorectal cancer. Scientific reports. vol 6. 2018-05-17. PMID:27857191. |
furthermore, the in vitro results showed that the repression of kras by mir-16 suppressed the proliferation and invasion and induced the apoptosis of crc cells, and the in vivo results revealed that mir-16 exerted a tumor-suppressive effect by negatively regulating kras in xenograft mice. |
2018-05-17 |
2023-08-13 |
mouse |
| Haiwei Mou, Jill Moore, Sunil K Malonia, Yingxiang Li, Deniz M Ozata, Soren Hough, Chun-Qing Song, Jordan L Smith, Andrew Fischer, Zhiping Weng, Michael R Green, Wen Xu. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 14. 2018-05-09. PMID:28320962. |
genetic disruption of oncogenic kras sensitizes lung cancer cells to fas receptor-mediated apoptosis. |
2018-05-09 |
2023-08-13 |
Not clear |
| Xian-Tao Zeng, Xiao-Ping Liu, Tong-Zu Liu, Xing-Huan Wan. The clinical significance of COL5A2 in patients with bladder cancer: A retrospective analysis of bladder cancer gene expression data. Medicine. vol 97. issue 10. 2018-03-19. PMID:29517678. |
gene set enrichment analysis was conducted to study the relevant mechanisms.bladder cancer patients in col5a2 low expression group were associated with better invasiveness (p < .0001), tumor grade (p = .001), t staging (p < .0001), n staging (p = .002), cancer specific survival (p < .0001), overall survival (p < .0001), and a trend of better m staging (p = .053) than those in col5a2 high expression group.col5a2 might affect the progression of bladder cancer through "coagulation," "hypoxia," "apical junction," "ultraviolet response," "epithelial mesenchymal transition," "angiogenesis," "kras (kras proto-oncogene, gtpase) signaling,""complement,""il2-stat5-signaling," "inflammatory response," "il6-jak-stat3-signaling," "myogenesis," "tnf α signaling," "apoptosis," and "hedgehog-signaling. |
2018-03-19 |
2023-08-13 |
Not clear |
| Maria Sofia Fernandes, Soraia Melo, Sérgia Velho, Patrícia Carneiro, Fátima Carneiro, Raquel Seruc. Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers. Oncotarget. vol 7. issue 42. 2018-02-12. PMID:27602501. |
in agreement with these cellular effects, pi3k p110α silencing led to alterations in the expression levels of proteins implicated in apoptosis and cell cycle, namely xiap and pbad in kras/pik3ca mutant cells and cyclin d1 in kras mutant cells. |
2018-02-12 |
2023-08-13 |
Not clear |
| Li Gao, Xiao-Dong Wang, Yang-Yang Niu, Dan-Dan Duan, Xue Yang, Jian Hao, Cui-Hong Zhu, Dan Chen, Ke-Xin Wang, Xue-Mei Qin, Xiong-Zhi W. Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology. Scientific reports. vol 6. 2018-01-16. PMID:27143508. |
network pharmacology analysis revealed that the 8 herbs regulated multiple hcc relative genes, among which the genes affected proliferation (kras, akt2, mapk), metastasis (src, mmp), angiogenesis (ptgs2) and apoptosis (casp3) etc. |
2018-01-16 |
2023-08-13 |
Not clear |
| Giulia Miglietta, Susanna Cogoi, Jessica Marinello, Giovanni Capranico, Alexander S Tikhomirov, Andrey Shchekotikhin, Luigi E Xod. RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation. Journal of medicinal chemistry. vol 60. issue 23. 2017-12-29. PMID:29140695. |
the kras down-regulation induces apoptosis together with a dramatic reduction of cell growth and colony formation. |
2017-12-29 |
2023-08-13 |
human |
| Esma Yagdi Efe, Aloran Mazumder, Jin-Young Lee, Anthoula Gaigneaux, Flavia Radogna, Muhammad Jawad Nasim, Christo Christov, Claus Jacob, Kyu-Won Kim, Mario Dicato, Patrick Chaimbault, Claudia Cerella, Marc Diederic. Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer. Cancer letters. vol 410. 2017-11-21. PMID:28943451. |
braf(v600e)-mutated ht-29 cells were resistant to dbtts, as evidenced by mitotic arrest for 48 h prior to apoptosis induction compared to kras(g12v)-mutated sw480/620 cells, which committed to death earlier. |
2017-11-21 |
2023-08-13 |
zebrafish |
| Karianne Risberg, Kathrine Røe Redalen, Linda Sønstevold, Tonje Bjørnetrø, Janne Sølvernes, Anne Hansen Re. Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells. BMC cancer. vol 16. 2017-10-02. PMID:27461218. |
the use of targeted agents to impel dual inhibition of anti-apoptotic mechanisms and mtor-mediated pro-survival signaling in colorectal carcinoma (crc) cell lines with kras or braf mutation has been shown to induce apoptosis, a timely result given crc entities harboring such mutations are in need of new therapies. |
2017-10-02 |
2023-08-13 |
Not clear |
| S Murakami, D Shahbazian, R Surana, W Zhang, H Chen, G T Graham, S M White, L M Weiner, C Y. Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene. vol 36. issue 9. 2017-09-26. PMID:27546622. |
pancreas-specific knockout of yap or antibody-mediated depletion of mdscs promoted macrophage reprogramming, reactivation of t cells, apoptosis of kras mutant neoplastic ductal cells and pancreatic regeneration after acute pancreatitis. |
2017-09-26 |
2023-08-13 |
mouse |
| Omar Youssef, Aija Knuuttila, Päivi Piirilä, Tom Böhling, Virinder Sarhadi, Sakari Knuutil. Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28199989. |
one healthy non-smoker subject had a kras g12d mutation in ebc dna.our results demonstrate that dna from ebc of healthy subjects can reveal mutations that could represent very early neoplastic changes or alternatively a normal process of apoptosis eliminating damaged cells with mutations or altered genetic material. |
2017-09-20 |
2023-08-13 |
human |
| Sebastian Griesing, Taisuke Kajino, Mei Chee Tai, Zhuoran Liu, Masahiro Nakatochi, Yukako Shimada, Motoshi Suzuki, Takashi Takahash. Thyroid transcription factor-1-regulated microRNA-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells. Cancer science. vol 108. issue 7. 2017-09-15. PMID:28474808. |
thyroid transcription factor-1-regulated microrna-532-5p targets kras and mkl2 oncogenes and induces apoptosis in lung adenocarcinoma cells. |
2017-09-15 |
2023-08-13 |
Not clear |
| Sebastian Griesing, Taisuke Kajino, Mei Chee Tai, Zhuoran Liu, Masahiro Nakatochi, Yukako Shimada, Motoshi Suzuki, Takashi Takahash. Thyroid transcription factor-1-regulated microRNA-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells. Cancer science. vol 108. issue 7. 2017-09-15. PMID:28474808. |
introduction of mir-532-5p mimics markedly induced apoptosis in kras-mutant as well as kras wild-type lung adenocarcinoma cell lines. |
2017-09-15 |
2023-08-13 |
Not clear |
| E Salas, S Roy, T Marsh, B Rubin, J Debnat. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. vol 35. issue 22. 2017-08-28. PMID:26434592. |
by comparing the treatment effects of the antimalarials chloroquine (cq) and quinacrine (q) on kras mutant lung cancer cells, we demonstrate that inhibition of the oxidative arm of the pentose phosphate pathway (oxppp) is required for antimalarial induced apoptosis. |
2017-08-28 |
2023-08-13 |
Not clear |
| Kensuke Nishi, Hao Luo, Shuhei Ishikura, Keiko Doi, Yuri Iwaihara, Lauren Wills, George S Baillie, Toshifumi Sakata, Senji Shirasawa, Toshiyuki Tsunod. Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant Anticancer research. vol 37. issue 7. 2017-08-25. PMID:28668883. |
apremilast induces apoptosis of human colorectal cancer cells with mutant we previously reported the crucial roles of oncogenic kirsten rat sarcoma viral oncogene homologue (kras) in inhibiting apoptosis and disrupting cell polarity via the regulation of phosphodiesterase type 4b2 (pde4b2) expression in human colorectal cancer (crc) hct116 cells in a three-dimensional culture (3dc). |
2017-08-25 |
2023-08-13 |
mouse |
| Kensuke Nishi, Hao Luo, Kazuhiko Nakabayashi, Keiko Doi, Shuhei Ishikura, Yuri Iwaihara, Yasuhiro Yoshida, Kumpei Tanisawa, Tomio Arai, Seijiro Mori, Motoji Sawabe, Masaaki Muramatsu, Masashi Tanaka, Toshifumi Sakata, Senji Shirasawa, Toshiyuki Tsunod. An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids. Anticancer research. vol 37. issue 7. 2017-08-25. PMID:28668886. |
alpha-kinase 2 (alpk2), suggested to be a novel tumour-suppressor gene down-regulated by oncogenic kras, plays a pivotal role in luminal apoptosis in normal colonic crypts. |
2017-08-25 |
2023-08-13 |
Not clear |
| Susanne Holck, Jesper Bonde, Helle Pedersen, Anja Alex Petersen, Amita Chaube, Hans Jørgen Nielsen, Lars-Inge Larsso. Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations. Human pathology. vol 54. 2017-08-14. PMID:27036313. |
colorectal cancers (crc) often show activating mutations of the kras or braf genes, which stimulate the extracellular signal-regulated kinase (erk) pathway, thus increasing cell proliferation and inhibiting apoptosis. |
2017-08-14 |
2023-08-13 |
Not clear |
| Jipei Du, Yufang Wang, Degao Chen, Guangyu Ji, Qizhao Ma, Shiping Liao, Yanjiang Zheng, Ji Zhang, Yiping Ho. BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB. Cancer letters. vol 383. issue 2. 2017-08-08. PMID:27721019. |
here we show that the orally available tyrosine kinase inhibitor, bay61-3606, enhances the sensitivity of human colon cancer cells, especially those harboring active mutations in kirsten rat sarcoma viral oncogene homolog (kras) gene, to trail-induced apoptosis in vitro and in vivo. |
2017-08-08 |
2023-08-13 |
human |
| María Hernández-Sánchez, Ana E Rodríguez-Vicente, José-Ángel Hernández, Eva Lumbreras, María-Eugenia Sarasquete, Ana-África Martín, Rocío Benito, Carlos Vicente-Gutiérrez, Cristina Robledo, Natalia de Las Heras, Juan-Nicolás Rodríguez, Miguel Alcoceba, Alfonso García de Coca, Carlos Aguilar, Marcos González, Jesús-María Hernández-Riva. MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion. Leukemia research. vol 46. 2017-07-17. PMID:27111859. |
this deregulation affected important validated target genes involved in apoptosis (bcl2, mdm2, tp53inp1) and proliferation (kras, pi3k-akt signaling), that could lead to decreased apoptosis and increased proliferation in 13q-h patients. |
2017-07-17 |
2023-08-13 |
Not clear |