| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie Langsch, Ulrich Baumgartner, Stefan Haemmig, Cornelia Schlup, Stephan C Schäfer, Sabina Berezowska, Gregor Rieger, Patrick Dorn, Mario P Tschan, Erik Vassell. miR-29b Mediates NF-κB Signaling in KRAS-Induced Non-Small Cell Lung Cancers. Cancer research. vol 76. issue 14. 2017-07-17. PMID:27199349. |
in kras(g12v)-transduced beas-2b cells, introduction of anti-mir-29b constructs increased the sensitivity to apoptosis, arguing that mir-29b mediated apoptotic resistance conferred by mutant kras. |
2017-07-17 |
2023-08-13 |
Not clear |
| Yiqiang Wang, Andreas Hedblom, Steffi K Koerner, Mailin Li, Finith E Jernigan, Barbara Wegiel, Lijun Su. Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation. Bioorganic & medicinal chemistry letters. vol 26. issue 23. 2017-06-27. PMID:27810244. |
novel synthetic chalcones induce apoptosis in the a549 non-small cell lung cancer cells harboring a kras mutation. |
2017-06-27 |
2023-08-13 |
human |
| Yiqiang Wang, Andreas Hedblom, Steffi K Koerner, Mailin Li, Finith E Jernigan, Barbara Wegiel, Lijun Su. Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation. Bioorganic & medicinal chemistry letters. vol 26. issue 23. 2017-06-27. PMID:27810244. |
treatment of human lung cancer cell line harboring kras mutation (a549) with the chalcones induced dose-dependent apoptosis. |
2017-06-27 |
2023-08-13 |
human |
| Xiaomin Zhong, Lan Zheng, Jianfeng Shen, Dongmei Zhang, Minmin Xiong, Youyou Zhang, Xinhong He, Janos L Tanyi, Feng Yang, Kathleen T Montone, Xiaojun Chen, Congjian Xu, Andy P Xiang, Qihong Huang, Xiaowei Xu, Lin Zhan. Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer. Molecular and cellular biology. vol 36. issue 21. 2017-06-12. PMID:27550813. |
restoration of mir-200 expression compromised kras-induced cellular transformation in vitro and tumor formation in vivo in addition, we found that enforced expression of mir-200 abrogated kras-induced resistance to apoptosis by directly targeting the antiapoptotic gene bcl2 finally, mir-200 was able to antagonize the epithelial-mesenchymal transition (emt) driven by mutant kras. |
2017-06-12 |
2023-08-13 |
human |
| Kathrin Klein, Kristin Werner, Christian Teske, Miriam Schenk, Thomas Giese, Jürgen Weitz, Thilo Welsc. Role of TFEB-driven autophagy regulation in pancreatic cancer treatment. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27175909. |
kras silencing caused pdac cell apoptosis and a reciprocal increase in tfeb expression. |
2017-03-30 |
2023-08-13 |
mouse |
| Bing-Yuan Fei, Xiu-Ying Wang, Xue-Dong Fan. MicroRNA-143 replenishment re-sensitizes colorectal cancer cells harboring mutant, but not wild-type, KRAS to paclitaxel treatment. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-03. PMID:26581910. |
combination of mir-143 mimic and paclitaxel induced the onset of apoptosis, and reverted in vitro metastatic properties (migration and invasion) in kras mutant tumor cells. |
2017-02-03 |
2023-08-13 |
Not clear |
| Xin Dai, Wei Fan, Yingzhe Wang, Lijie Huang, Ying Jiang, Lei Shi, DeAngelo Mckinley, Wen Tan, Chalet Ta. Combined Delivery of Let-7b MicroRNA and Paclitaxel via Biodegradable Nanoassemblies for the Treatment of KRAS Mutant Cancer. Molecular pharmaceutics. vol 13. issue 2. 2016-12-20. PMID:26636714. |
in non-small cell lung cancer a549 cells that harbor mutant kras, paclitaxel and let-7b mimic-loaded nanoassemblies (n-ptx/let-7b) markedly potentiated the cytotoxicity of paclitaxel, induced apoptosis, and diminished the invasiveness of tumor cells. |
2016-12-20 |
2023-08-13 |
mouse |
| Chun Yan Wang, Su Tang Guo, Jia Yu Wang, Fen Liu, Yuan Yuan Zhang, Hamed Yari, Xu Guang Yan, Lei Jin, Xu Dong Zhang, Chen Chen Jian. Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress. Molecular cancer therapeutics. vol 15. issue 3. 2016-12-13. PMID:26832792. |
here we report that mutant kras colon cancer cells are nevertheless more susceptible to apoptosis induced by the hsp90 inhibitor auy922 than those carrying wild-type kras. |
2016-12-13 |
2023-08-13 |
Not clear |
| Chun Yan Wang, Su Tang Guo, Jia Yu Wang, Fen Liu, Yuan Yuan Zhang, Hamed Yari, Xu Guang Yan, Lei Jin, Xu Dong Zhang, Chen Chen Jian. Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress. Molecular cancer therapeutics. vol 15. issue 3. 2016-12-13. PMID:26832792. |
although auy922 inhibited hsp90 activity with comparable potency in colon cancer cells irrespective of their kras mutational statuses, those with mutant kras were markedly more sensitive to auy922-induced apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jingying Han, Lina Wang, Xiaofeng Wang, Kun L. Downregulation of Microrna-126 Contributes to Tumorigenesis of Squamous Tongue Cell Carcinoma via Targeting KRAS. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2016-11-07. PMID:26883054. |
we further performed luciferase assay to validate kras as a target of mir-126, and conducted transfection to study the effect of mir-126 on proliferation and apoptosis of the cells. |
2016-11-07 |
2023-08-13 |
Not clear |
| Kristin Werner, Franziska Lademann, May-Linn Thepkaysone, Beatrix Jahnke, Daniela E Aust, Christoph Kahlert, Georg Weber, Jürgen Weitz, Robert Grützmann, Christian Pilarsk. Simultaneous gene silencing of KRAS and anti-apoptotic genes as a multitarget therapy. Oncotarget. vol 7. issue 4. 2016-11-01. PMID:26716649. |
therefore multimodal therapy strategies, targeting signaling pathways simultaneously should improve treatment.sirnas against kras and the apoptosis associated genes bclxl, flip, mcl1l, survivin and xiap were transfected into human and murine pancreatic cancer cell lines. |
2016-11-01 |
2023-08-13 |
human |
| Haizhen Wang, Tao Yang, Xiangwei W. 5-Fluorouracil preferentially sensitizes mutant KRAS non-small cell lung carcinoma cells to TRAIL-induced apoptosis. Molecular oncology. vol 9. issue 9. 2016-08-11. PMID:26130327. |
5-fluorouracil preferentially sensitizes mutant kras non-small cell lung carcinoma cells to trail-induced apoptosis. |
2016-08-11 |
2023-08-13 |
mouse |
| Haizhen Wang, Tao Yang, Xiangwei W. 5-Fluorouracil preferentially sensitizes mutant KRAS non-small cell lung carcinoma cells to TRAIL-induced apoptosis. Molecular oncology. vol 9. issue 9. 2016-08-11. PMID:26130327. |
compared with other chemotherapeutic agents, 5fu displayed the highest synergy with trail in inducing apoptosis in mutant kras nsclc cells. |
2016-08-11 |
2023-08-13 |
mouse |
| Lois Resnick-Silverman, James J Manfred. Two Faces of SIVA. Cancer discovery. vol 5. issue 6. 2016-06-02. PMID:26037915. |
in non-small cell lung cancer cells that contain a mutated kras gene, siva, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mtor signaling. |
2016-06-02 |
2023-08-13 |
mouse |
| Xin Dai, Ying Jiang, Chalet Ta. Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy. PloS one. vol 10. issue 5. 2016-04-25. PMID:25946136. |
combination of let-7b mimic with paclitaxel or gemcitabine diminished mek/erk and pi3k/akt signaling concurrently, triggered the onset of apoptosis, and reverted the epithelial-mesenchymal transition in kras mutant tumor cells. |
2016-04-25 |
2023-08-13 |
human |
| Elena Gabriela Chiorean, Andrew L Covele. Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies. Drug design, development and therapy. vol 9. 2016-04-18. PMID:26185420. |
among the core pathways reproducibly shown to lead the development and progression of this disease, dna repair, apoptosis, g1/s cell cycle transition, kras, wnt, notch, hedgehog, tgf-beta, and other cell invasion pathways, have been the target of "precision therapeutics". |
2016-04-18 |
2023-08-13 |
Not clear |
| Annalisa Conti, Maria Teresa Majorini, Richard Elliott, Alan Ashworth, Christopher J Lord, Carlotta Cancelliere, Alberto Bardelli, Pierfausto Seneci, Henning Walczak, Domenico Delia, Daniele Leci. Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway. Oncotarget. vol 6. issue 13. 2016-03-15. PMID:26028667. |
oncogenic kras sensitizes premalignant, but not malignant cells, to noxa-dependent apoptosis through the activation of the mek/erk pathway. |
2016-03-15 |
2023-08-13 |
human |
| Koichi Okamoto, Aziz Zaanan, Hisato Kawakami, Shengbing Huang, Frank A Sinicrop. Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. Molecular cancer research : MCR. vol 13. issue 4. 2016-02-04. PMID:25548100. |
kras mutations are frequently detected in human colorectal cancer and contribute to de novo apoptosis resistance and ultimately therapeutic failure. |
2016-02-04 |
2023-08-13 |
human |
| Anna Lena Ress, Verena Stiegelbauer, Elke Winter, Daniela Schwarzenbacher, Tobias Kiesslich, Sigurd Lax, Stefan Jahn, Alexander Deutsch, Thomas Bauernhofer, Hui Ling, Hellmut Samonigg, Armin Gerger, Gerald Hoefler, Martin Pichle. MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients. Molecular carcinogenesis. vol 54. issue 11. 2016-02-01. PMID:25256312. |
forced expression of mir-96-5p in crc cells entailed no effects on apoptosis or emt-related genes but decreased the expression levels of the kras oncogene (p < 0.05). |
2016-02-01 |
2023-08-13 |
Not clear |
| João Lavrado, Hugo Brito, Pedro M Borralho, Stephan A Ohnmacht, Nam-Soon Kim, Clara Leitão, Sílvia Pisco, Mekala Gunaratnam, Cecília M P Rodrigues, Rui Moreira, Stephen Neidle, Alexandra Paul. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. Scientific reports. vol 5. 2016-01-06. PMID:25853628. |
additionally, iqcs induce cancer cell death by apoptosis, explained in part by their capacity to repress kras expression. |
2016-01-06 |
2023-08-13 |
human |