| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José M Escandell, Pawan Kaler, M Carmen Recio, Takehiko Sasazuki, Senji Shirasawa, Leonard Augenlicht, José-Luis Ríos, Lidija Klampfe. Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. Biochemical pharmacology. vol 76. issue 2. 2008-07-31. PMID:18561895. |
we confirmed that mutational activation of kras protects cells from cucurbitacin-induced apoptosis using nontransformed intestinal epithelial cells with inducible expression of krasv12. |
2008-07-31 |
2023-08-12 |
human |
| Yanan Yang, Marie Wislez, Nobukazu Fujimoto, Ludmila Prudkin, Julie G Izzo, Futoshi Uno, Lin Ji, Amy E Hanna, Robert R Langley, Diane Liu, Faye M Johnson, Ignacio Wistuba, Jonathan M Kuri. A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras. Molecular cancer therapeutics. vol 7. issue 4. 2008-07-18. PMID:18413809. |
in cell culture, pha-665752 induced apoptosis of a lung adenocarcinoma cell line derived from kras(la1) mice (lkr-13) and a murine lung endothelial cell line (mec). |
2008-07-18 |
2023-08-12 |
mouse |
| A Preto, J Figueiredo, S Velho, A S Ribeiro, P Soares, C Oliveira, R Seruc. BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. The Journal of pathology. vol 214. issue 3. 2008-03-25. PMID:18098337. |
no significant differences were seen in proliferation and apoptosis, in cell lines harbouring kras g13d, after braf inhibition. |
2008-03-25 |
2023-08-12 |
Not clear |
| A Roberts, J Allanson, S K Jadico, M I Kavamura, J Noonan, J M Opitz, T Young, G Ner. The cardiofaciocutaneous syndrome. Journal of medical genetics. vol 43. issue 11. 2006-12-15. PMID:16825433. |
the syndrome is caused by gain-of-function mutations in four different genes braf, kras, mitogen-activated protein/extracellular signal-regulated kinase mek1 and mek2, all belonging to the same ras-extracellular signal-regulated kinase (erk) pathway that regulates cell differentiation, proliferation and apoptosis. |
2006-12-15 |
2023-08-12 |
Not clear |
| Niels Smakman, Diana J M van den Wollenberg, Sjoerd G Elias, Takehiko Sasazuki, Senji Shirasawa, Rob C Hoeben, Inne H M Borel Rinkes, Onno Kranenbur. KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707468. |
kras(d13) promotes apoptosis of human colorectal tumor cells by reovirust3d and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand. |
2006-07-18 |
2023-08-12 |
human |
| Niels Smakman, Diana J M van den Wollenberg, Sjoerd G Elias, Takehiko Sasazuki, Senji Shirasawa, Rob C Hoeben, Inne H M Borel Rinkes, Onno Kranenbur. KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707468. |
however, deletion of kras(d13) or p53 did reduce apoptosis induction by reovirust3d whereas deletion of beta-catenin(deltas45) had no effect. |
2006-07-18 |
2023-08-12 |
human |
| Niels Smakman, Diana J M van den Wollenberg, Sjoerd G Elias, Takehiko Sasazuki, Senji Shirasawa, Rob C Hoeben, Inne H M Borel Rinkes, Onno Kranenbur. KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707468. |
oncogenic kras(d13) increases tumor cell sensitivity to activation of the cell-intrinsic apoptosis pathway without affecting reovirust3d replication. |
2006-07-18 |
2023-08-12 |
human |
| Marie Wislez, Nobukazu Fujimoto, Julie G Izzo, Amy E Hanna, Dianna D Cody, Robert R Langley, Hongli Tang, Marie D Burdick, Mitsuo Sato, John D Minna, Li Mao, Ignacio Wistuba, Robert M Strieter, Jonathan M Kuri. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer research. vol 66. issue 8. 2006-06-07. PMID:16618742. |
treatment of kras(la1) mice with a cxcr2-neutralizing antibody inhibited the progression of premalignant alveolar lesions and induced apoptosis of vascular endothelial cells within alveolar lesions. |
2006-06-07 |
2023-08-12 |
mouse |
| Niels Smakman, Diana J M van den Wollenberg, Inne H M Borel Rinkes, Rob C Hoeben, Onno Kranenbur. Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D. Journal of virology. vol 79. issue 23. 2006-01-23. PMID:16282499. |
rather, reovirus-induced tumor cell apoptosis was completely abrogated as a result of kras knockdown. |
2006-01-23 |
2023-08-12 |
Not clear |
| Gudrun Pohl, Chung-Liang Ho, Robert J Kurman, Robert Bristow, Tian-Li Wang, Ie-Ming Shi. Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations. Cancer research. vol 65. issue 5. 2005-04-19. PMID:15753399. |
profound growth inhibition and apoptosis were observed in ci-1040-treated tumor cells with mutations in either kras or braf in comparison with the ovarian cancer cells containing wild-type sequences. |
2005-04-19 |
2023-08-12 |
human |