| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karl C Bruckman, Frank Schönleben, Wanglong Qiu, Victoria L Woo, Gloria H S. Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. vol 110. issue 5. 2011-03-24. PMID:20813562. |
of particular interest in this regard are genes involved in cell cycling and apoptosis, such braf, kras, and pik3ca genes. |
2011-03-24 |
2023-08-12 |
Not clear |
| Chen Quyun, Zhiyun Ye, Sheng-Cai Lin, Biaoyang Li. Recent patents and advances in genomic biomarker discovery for colorectal cancers. Recent patents on DNA & gene sequences. vol 4. issue 2. 2011-03-01. PMID:20426761. |
the interesting patents include: 1) a patent for a method to differentiate normal exfoliated cells from cancer cells based on whether they were subjected to apoptosis and dna degradation; 2) a model (pm-33 multiple molecular marker model) based on expression changes of up-regulation of the mdm2, dusp6, and nfl genes down-regulation of the rnf4, mmd and eif2s3 genes, which achieved an 88% sensitivity, and an 82% specificity for crc diagnosis; 3) gene mutations in pten, kras, pik3ca for predicting the response to anti-egfr therapies, a common drug used for crc treatment; 4) patents on epigenetic changes of itga4, sept9, alx4, tfap2e foxl2, sarm1, id4 etc. |
2011-03-01 |
2023-08-12 |
Not clear |
| Xiuli Liu, Maureen Jakubowski, Jennifer L Hun. KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis. American journal of clinical pathology. vol 135. issue 2. 2011-02-17. PMID:21228365. |
kras gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis. |
2011-02-17 |
2023-08-12 |
Not clear |
| Xiuli Liu, Maureen Jakubowski, Jennifer L Hun. KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis. American journal of clinical pathology. vol 135. issue 2. 2011-02-17. PMID:21228365. |
kras mutation occurs in 30% to 50% of colorectal cancers (crcs) and has been suggested to be associated with proliferation and decreased apoptosis. |
2011-02-17 |
2023-08-12 |
Not clear |
| Xiuli Liu, Maureen Jakubowski, Jennifer L Hun. KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis. American journal of clinical pathology. vol 135. issue 2. 2011-02-17. PMID:21228365. |
compared with wild-type kras crcs, kras-mutated crcs had a lower frequency of msi-h (15% vs 42%; p = .015), a higher chance of having brisk mitosis (77% vs 43%, p = .022) and apoptosis (77% vs 28%; p = .00012), and a greater mean of mitotic figures (p = .0002) and apoptotic cells (p = .0008). |
2011-02-17 |
2023-08-12 |
Not clear |
| Luca Mologni, Hafedh Dekhil, Monica Ceccon, Stefania Purgante, Cathy Lan, Loredana Cleris, Vera Magistroni, Franca Formelli, Carlo B Gambacorti-Passerin. Colorectal tumors are effectively eradicated by combined inhibition of {beta}-catenin, KRAS, and the oncogenic transcription factor ITF2. Cancer research. vol 70. issue 18. 2010-10-19. PMID:20823162. |
inducible short hairpin rna (shrna)-mediated silencing of β-cat, itf2, or kras decreased proliferation by 88%, 72%, and 45%, respectively, with no significant apoptosis in any case. |
2010-10-19 |
2023-08-12 |
Not clear |
| Hiroshi Tsujioka, Toru Hachisuga, Shoko Hikita, Taeko Ueda, Fusanori Yotsumoto, Kyoko Shirota, Toshiyuki Yoshizato, Tatsuhiko Kawarabayashi, Masahide Kuroki, Shingo Miyamot. Apoptosis as a possible candidate mechanism for removal of tamoxifen-related endometrial cells with KRAS mutations. Anticancer research. vol 30. issue 8. 2010-10-05. PMID:20871029. |
apoptosis as a possible candidate mechanism for removal of tamoxifen-related endometrial cells with kras mutations. |
2010-10-05 |
2023-08-12 |
Not clear |
| Shuangni Yu, Zhaohui Lu, Changzheng Liu, Yunxiao Meng, Yihui Ma, Wugan Zhao, Jianping Liu, Jia Yu, Jie Che. miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer research. vol 70. issue 14. 2010-08-24. PMID:20610624. |
ectopic expression of mir-96 through a synthetic mirna precursor inhibited kras, dampened akt signaling, and triggered apoptosis in cells. |
2010-08-24 |
2023-08-12 |
human |
| Toshiyuki Tsunoda, Yasuo Takashima, Takahiro Fujimoto, Midori Koyanagi, Yasuhiro Yoshida, Keiko Doi, Yoko Tanaka, Masahide Kuroki, Takehiko Sasazuki, Senji Shirasaw. Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model. Neoplasia (New York, N.Y.). vol 12. issue 5. 2010-08-13. PMID:20454511. |
on the basis of the features of hct116 cells, activated kras inhibited normal cell polarity and apoptosis in 3d culture. |
2010-08-13 |
2023-08-12 |
human |
| Toshiyuki Tsunoda, Yasuo Takashima, Takahiro Fujimoto, Midori Koyanagi, Yasuhiro Yoshida, Keiko Doi, Yoko Tanaka, Masahide Kuroki, Takehiko Sasazuki, Senji Shirasaw. Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model. Neoplasia (New York, N.Y.). vol 12. issue 5. 2010-08-13. PMID:20454511. |
these results together suggest that activated kras plays critical roles in the accumulation of genetic alterations through inhibition of dna repair genes and apoptosis and that this 3d culture model will provide a useful tool for investigating the molecular mechanisms of crc development. |
2010-08-13 |
2023-08-12 |
human |
| Heng-Yu Fan, Joanne S Richard. Minireview: physiological and pathological actions of RAS in the ovary. Molecular endocrinology (Baltimore, Md.). vol 24. issue 2. 2010-04-26. PMID:19880654. |
by contrast, conditional expression of a constitutively active kras(g12d) mutant in granulosa cells results in ovulation defects due to the complete disruption of normal follicular growth, cessation of granulosa cell proliferation, and blockage of granulosa cell apoptosis and differentiation. |
2010-04-26 |
2023-08-12 |
mouse |
| Seung-Hyeok Seok, Yi-Rang Na, Ju-Hee Han, Tae-Hyoun Kim, Hyun Jung, Byoung-Hee Lee, Alexander Emelyanov, Serguei Parinov, Jae-Hak Par. Cre/loxP-regulated transgenic zebrafish model for neural progenitor-specific oncogenic Kras expression. Cancer science. vol 101. issue 1. 2010-03-30. PMID:19961491. |
brain histology showed that neuronal cell differentiation could occur in spite of oncogenic kras(v12) overexpression, but massive apoptosis and brain edema caused early embryonal death. |
2010-03-30 |
2023-08-12 |
human |
| Seung-Hyeok Seok, Yi-Rang Na, Ju-Hee Han, Tae-Hyoun Kim, Hyun Jung, Byoung-Hee Lee, Alexander Emelyanov, Serguei Parinov, Jae-Hak Par. Cre/loxP-regulated transgenic zebrafish model for neural progenitor-specific oncogenic Kras expression. Cancer science. vol 101. issue 1. 2010-03-30. PMID:19961491. |
in summary, the overexpression of kras(v12) induces extensive apoptosis of neural progenitor cells followed by severe edema of the brain. |
2010-03-30 |
2023-08-12 |
human |
| David A Barbie, Pablo Tamayo, Jesse S Boehm, So Young Kim, Susan E Moody, Ian F Dunn, Anna C Schinzel, Peter Sandy, Etienne Meylan, Claudia Scholl, Stefan Fröhling, Edmond M Chan, Martin L Sos, Kathrin Michel, Craig Mermel, Serena J Silver, Barbara A Weir, Jan H Reiling, Qing Sheng, Piyush B Gupta, Raymond C Wadlow, Hanh Le, Sebastian Hoersch, Ben S Wittner, Sridhar Ramaswamy, David M Livingston, David M Sabatini, Matthew Meyerson, Roman K Thomas, Eric S Lander, Jill P Mesirov, David E Root, D Gary Gilliland, Tyler Jacks, William C Hah. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. vol 462. issue 7269. 2009-12-23. PMID:19847166. |
suppression of tbk1 induced apoptosis specifically in human cancer cell lines that depend on oncogenic kras expression. |
2009-12-23 |
2023-08-12 |
human |
| Kathryn Balmanno, Simon D Chell, Annette S Gillings, Shaista Hayat, Simon J Coo. Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. International journal of cancer. vol 125. issue 10. 2009-11-05. PMID:19637312. |
cells that were sensitive arrested in g(1) and/or underwent apoptosis and the presence of braf or kras mutation was not sufficient to predict either fate. |
2009-11-05 |
2023-08-12 |
Not clear |
| Daekee Lee, Ming Yu, Eunjung Lee, Hyunok Kim, Yanan Yang, Kyoungmi Kim, Christina Pannicia, Jonathan M Kurie, David W Threadgil. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. The Journal of clinical investigation. vol 119. issue 9. 2009-10-02. PMID:19690388. |
consistent with the mouse data, which suggest that erbb3-erbb4 heterodimers contribute to colon cancer survival, experimentally induced loss of erbb3 in a kras mutant human colon cancer cell line was associated with loss of erbb4 expression, and sirna knockdown of either erbb3 or erbb4 resulted in elevated levels of apoptosis. |
2009-10-02 |
2023-08-12 |
mouse |
| Cristina P R Xavier, Cristovao F Lima, Ana Preto, Raquel Seruca, Manuel Fernandes-Ferreira, Cristina Pereira-Wilso. Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer letters. vol 281. issue 2. 2009-07-15. PMID:19344998. |
luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both kras and braf mutated human colorectal cancer cells. |
2009-07-15 |
2023-08-12 |
human |
| Cristina P R Xavier, Cristovao F Lima, Ana Preto, Raquel Seruca, Manuel Fernandes-Ferreira, Cristina Pereira-Wilso. Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer letters. vol 281. issue 2. 2009-07-15. PMID:19344998. |
because diet is one of the most important determinants of crc incidence and progression, we studied the effects of the dietary phytochemicals quercetin (q), luteolin (l) and ursolic acid (ua) on cell proliferation and apoptosis in two human crc derived cell lines, hct15 and co115, harboring kras and braf activating mutations, respectively. |
2009-07-15 |
2023-08-12 |
human |
| N Nakayama, K Nakayama, S Yeasmin, M Ishibashi, A Katagiri, K Iida, M Fukumoto, K Miyazak. KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. British journal of cancer. vol 99. issue 12. 2009-01-02. PMID:19018267. |
profound growth inhibition and apoptosis were observed in ci-1040-treated cancer cells with mutations in either kras or braf in comparison with the ovarian cancer cells containing wild-type sequences. |
2009-01-02 |
2023-08-12 |
Not clear |
| José M Escandell, Pawan Kaler, M Carmen Recio, Takehiko Sasazuki, Senji Shirasawa, Leonard Augenlicht, José-Luis Ríos, Lidija Klampfe. Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. Biochemical pharmacology. vol 76. issue 2. 2008-07-31. PMID:18561895. |
activated kras protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. |
2008-07-31 |
2023-08-12 |
human |