| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qifeng Luo, Hongming Song, Xiaochong Deng, Jiayi Li, Wei Jian, Junyong Zhao, Xueyu Zheng, Shiva Basnet, Haiyan Ge, Twingle Daniel, Bin Xu, Lin Fan. A Triple-Regulated Oncolytic Adenovirus Carrying MicroRNA-143 Exhibits Potent Antitumor Efficacy in Colorectal Cancer. Molecular therapy oncolytics. vol 16. 2020-09-28. PMID:32123722. |
the upregulation of mir-143 could inhibit cell proliferation and induce cell apoptosis by targeting kras in colorectal cancer cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jieun Park, Yong-Hee Cho, Wook-Jin Shin, Sang-Kyu Lee, JaeHeon Lee, Taehyung Kim, Pu-Hyeon Cha, Jee Sun Yang, Jaebeom Cho, Do Sik Min, Gyoonhee Han, Ho-Young Lee, Kang-Yell Cho. A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Scientific reports. vol 9. issue 1. 2020-08-07. PMID:30679620. |
as a result, kya1797k treatment suppressed the growth and transformation of kras mutant nsclc cells and also induced apoptosis. |
2020-08-07 |
2023-08-13 |
Not clear |
| Gulsah Albayrak, Funda Demirtas Korkmaz, Duygu Tozcu, Irem Dogan Turacl. The outcomes of an impaired powerhouse in KRAS mutant lung adenocarcinoma cells by Elesclomol. Journal of cellular biochemistry. vol 120. issue 6. 2020-08-05. PMID:30628735. |
in this study, we evaluated its effect on cellular apoptosis, survival, and metastasis mechanisms on kras mutant a549 and calu-1 cell lines. |
2020-08-05 |
2023-08-13 |
Not clear |
| Krizelle Mae M Alcantara, Joshua Reginald P Malapit, Ryan Timothy D Yu, Jose Antonio Ma G Garrido, John Paul T Rigor, Arlou Kristina J Angeles, Eva Maria Cutiongco-de la Paz, Reynaldo L Garci. Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants. Cells. vol 8. issue 12. 2020-08-03. PMID:31816869. |
hct116 cells transfected with the novel nras a11v and the canonical nras g12d, but not the kras mutants, display enhanced resistance to apoptosis. |
2020-08-03 |
2023-08-13 |
mouse |
| Irem Dogan Turacli, Funda Demirtas Korkmaz, Tuba Candar, Abdullah Ekmekc. Flavopiridol's effects on metastasis in KRAS mutant lung adenocarcinoma cells. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-08. PMID:30317654. |
in this study, we evaluated its effect on cellular apoptosis, survival, and metastasis mechanisms on kras mutant a549, calu-1, and h2009 cell lines. |
2020-07-08 |
2023-08-13 |
Not clear |
| Ailin Liu, Wanli Zhang, Tao Zhao, Ming Xiao, Qijian Mei, Hui Zh. A single nuclear polymorphism in let-7g binding site affects the doubling time of thyroid nodule by regulating KRAS-induced cell proliferation. Journal of cellular physiology. vol 234. issue 12. 2020-06-08. PMID:31152438. |
kras messenger rna (mrna)/protein levels in the gg group were upregulated with a decreased apoptosis index. |
2020-06-08 |
2023-08-13 |
Not clear |
| Ailin Liu, Wanli Zhang, Tao Zhao, Ming Xiao, Qijian Mei, Hui Zh. A single nuclear polymorphism in let-7g binding site affects the doubling time of thyroid nodule by regulating KRAS-induced cell proliferation. Journal of cellular physiology. vol 234. issue 12. 2020-06-08. PMID:31152438. |
the cell apoptosis index was evidently elevated in the kras sirna/let-7g precursors group compared with that in the scramble controls. |
2020-06-08 |
2023-08-13 |
Not clear |
| Zhanhui Du, Xiuxiang Song, Fangfang Yan, Jingjing Wang, Yuxia Zhao, Shangming Li. Genome-wide transcriptional analysis of BRD4-regulated genes and pathways in human glioma U251 cells. International journal of oncology. vol 52. issue 5. 2020-03-06. PMID:29568956. |
downregulated kras expression in u251 cells restrained cell proliferation and promoted cell apoptosis, suggesting that the effect of brd4 on glioma cells might occur through the ras pathway. |
2020-03-06 |
2023-08-13 |
human |
| Rajpal S Burmi, Elaina N Maginn, Hani Gabra, Euan A Stronach, Harpreet S Wasa. Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells. Cancer biology & therapy. vol 20. issue 1. 2020-02-26. PMID:30261145. |
here, we demonstrate that combining the dual pi3k/mtor inhibitor pf5212384 (pf384) and mek inhibitor pd325901 (pd901) more effectively induces apoptosis compared with either agent alone, independent of kras mutational status in pdac cell lines. |
2020-02-26 |
2023-08-13 |
Not clear |
| Elaine Lai-Han Leung, Lian Xiang Luo, Ying Li, Zhong-Qiu Liu, Lan Lan Li, Dan Feng Shi, Ying Xie, Min Huang, Lin Lin Lu, Fu Gang Duan, Ju Min Huang, Xing Xing Fan, Zhong Wen Yuan, Jian Ding, Xiao Jun Yao, David C Ward, Liang Li. Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer. International journal of cancer. vol 145. issue 5. 2020-01-13. PMID:30786019. |
in vitro and in vivo studies demonstrated that nhtd suppressed proliferation, induced apoptosis and inhibited oncogenic k-ras signaling pathways by disrupting kras-pdeδ interaction in nonsmall cell lung cancer (nsclc) harboring kras mutations. |
2020-01-13 |
2023-08-13 |
mouse |
| Habib Zarredar, Shadi Pashapour, Khalil Ansarin, Majid Khalili, Roghayyeh Baghban, Safar Farajni. Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30132854. |
this article is dedicated to evaluating the synergistic effect of a novel egfr inhibitor azd8931 and kras small interfering rna (sirna) on the proliferation and apoptosis of lung adenocarcinoma cancer cells. |
2019-12-10 |
2023-08-13 |
human |
| Habib Zarredar, Shadi Pashapour, Khalil Ansarin, Majid Khalili, Roghayyeh Baghban, Safar Farajni. Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30132854. |
the cytotoxic effects of kras sirna and te egfr inhibitor were determined usingmtt assay, and induction of apoptosis was determined by facs analysis. |
2019-12-10 |
2023-08-13 |
human |
| Habib Zarredar, Shadi Pashapour, Khalil Ansarin, Majid Khalili, Roghayyeh Baghban, Safar Farajni. Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30132854. |
the results also indicated that the silencing of kras and egfr has synergistic effects on the induction of apoptosis on the a549 cells. these results indicated that kras and egfr might play important roles in the progression of lung cancer and could be potential therapeutic targets for treatment of lung cancer. |
2019-12-10 |
2023-08-13 |
human |
| Su Jin Kim, Tae Hwan Noh, Sujin Son, Do Hyun Kim, Wooseong Kim, Yunna Lee, Jieun Choo, Gwangbeom Heo, Min Jae Kim, Hae Young Chung, Yunjin Jung, Jee Hyung Jung, Hyung Ryong Moon, Eunok I. Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer. Cell death & disease. vol 9. issue 9. 2019-11-20. PMID:30158525. |
novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing src-mediated apoptosis in wild-type kras colon cancer. |
2019-11-20 |
2023-08-13 |
Not clear |
| Su Jin Kim, Tae Hwan Noh, Sujin Son, Do Hyun Kim, Wooseong Kim, Yunna Lee, Jieun Choo, Gwangbeom Heo, Min Jae Kim, Hae Young Chung, Yunjin Jung, Jee Hyung Jung, Hyung Ryong Moon, Eunok I. Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer. Cell death & disease. vol 9. issue 9. 2019-11-20. PMID:30158525. |
collectively, src can play a key role in apoptosis induced by the novel egfr inhibitor mhys, suggesting that activation of src might prove effective in treating egfr/wild-type kras colon cancer. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chun-Hua Dai, Yang Shu, Ping Chen, Jian-Nong Wu, Li-Haun Zhu, Rong-Xia Yuan, Wei-Guo Long, Yu-Min Zhu, Jian L. YM155 sensitizes non-small cell lung cancer cells to EGFR-tyrosine kinase inhibitors through the mechanism of autophagy induction. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 12. 2019-06-24. PMID:30315932. |
in this study, we showed that ym155 markedly enhanced the sensitivity of erlotinib to egfr-tki resistant nsclc cell lines h1650 (egfr exon 19 deletion and pten loss) and a549 (egfr wild type and kras mutation) through inducing autophagy-dependent apoptosis and autophagic cell death. |
2019-06-24 |
2023-08-13 |
Not clear |
| Kuo-Hao Ho, Chih-Ju Chang, Tzu-Wen Huang, Chwen-Ming Shih, Ann-Jeng Liu, Peng-Hsu Chen, Kur-Ta Cheng, Ku-Chung Che. Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. PloS one. vol 13. issue 12. 2019-05-17. PMID:30521597. |
we obtained five upregulated signaling pathways from the gene landscape: apoptosis, tumor necrosis factor (tnf)-α signaling via nuclear factor (nf)-κb, apical surface, interferon-α response, and kras signaling. |
2019-05-17 |
2023-08-13 |
Not clear |
| Michail Sideris, Elif Iliria Emin, Ziena Abdullah, John Hanrahan, Konstantina Maria Stefatou, Vasileios Sevas, Ece Emin, Tony Hollingworth, Funlayo Odejinmi, Savvas Papagrigoriadis, Sotiris Vimplis, Fredric Willmot. The Role of KRAS in Endometrial Cancer: A Mini-Review. Anticancer research. vol 39. issue 2. 2019-02-20. PMID:30711927. |
current evidence correlates kras mutations with increased cell proliferation and apoptosis, as well as up-regulation of endometrial cell oestrogen receptors. |
2019-02-20 |
2023-08-13 |
rat |
| Dana M Gwinn, Alex G Lee, Marcela Briones-Martin-Del-Campo, Crystal S Conn, David R Simpson, Anna I Scott, Anthony Le, Tina M Cowan, Davide Ruggero, E Alejandro Sweet-Corder. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer cell. vol 33. issue 1. 2018-12-11. PMID:29316436. |
the tumor suppressor keap1 strongly influences the outcome of activation of this pathway during nutrient stress; loss of keap1 in kras mutant cells leads to apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Chun Yan Wang, Su Tang Guo, Amanda Croft, Xu Guang Yan, Lei Jin, Xu Dong Zhang, Chen Chen Jian. BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922. Molecular carcinogenesis. vol 57. issue 2. 2018-11-20. PMID:29068469. |
past studies have shown that mutant kras colon cancer cells are susceptible to apoptosis induced by the hsp90 inhibitor auy922. |
2018-11-20 |
2023-08-13 |
Not clear |