| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Li, Huiting Zhao, Hui Liao, Jingxuan Chen, Jin Liu, Jianjun Che. Discovery of novel quinazoline-based covalent inhibitors of KRAS G12C with various cysteine-targeting warheads as potential anticancer agents. Bioorganic chemistry. vol 110. 2021-10-12. PMID:33774492. |
llk10 maintained the mechanism of action by forming a covalent bond with kras g12c protein, thus decreasing the level of phosphorylated mek and erk, and leading to tumor cell apoptosis. |
2021-10-12 |
2023-08-13 |
Not clear |
| Jiuna Zhang, Xiaoyu Jiang, Jie Yin, Shiying Dou, Xiaoli Xie, Ting Liu, Yijun Wang, Shuling Wang, Xue Zhou, Dongxuan Zhang, Huiqing Jian. RNF141 interacts with KRAS to promote colorectal cancer progression. Oncogene. vol 40. issue 39. 2021-10-09. PMID:34345014. |
moreover, kras silencing partially abolished the effect of rnf141 on cell proliferation and apoptosis. |
2021-10-09 |
2023-08-13 |
Not clear |
| Makoto Koyama, Masato Kitazawa, Satoshi Nakamura, Tomio Matsumura, Satoru Miyazaki, Yusuke Miyagawa, Futoshi Muranaka, Shigeo Tokumaru, Masahiro Okumura, Yuta Yamamoto, Takehito Ehara, Nao Hondo, Shugo Takahata, Michiko Takeoka, Shin-Ichi Miyagawa, Yuji Soejim. Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells. International journal of oncology. vol 57. issue 5. 2021-09-13. PMID:32901840. |
compared with the effects of low‑dose trametinib monotherapy, combination treatment with abt263 had a synergistic effect on apoptosis in mutant kras transductants in vitro. |
2021-09-13 |
2023-08-13 |
Not clear |
| David G Covel. Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PloS one. vol 16. issue 4. 2021-09-13. PMID:33909629. |
the results of this analysis find a relatively small set of defective genes, inclusive of abl1, axl, braf, cdc25a, cdkn2a, igf1r, kras, mecom, mmp1, myc, notch1, nras, pik3cg, ptk2, rptor, sptbn1, stat2, tnks and zhx2, as possible candidates for roles in chemosensitivity for compound moas that target primarily, but not exclusively, kinases, nucleic acid synthesis, protein synthesis, apoptosis and tubulin. |
2021-09-13 |
2023-08-13 |
Not clear |
| Afsane Bahrami, Maryam Moradi Binabaj, Gordon A Fern. Exosomes: Emerging modulators of signal transduction in colorectal cancer from molecular understanding to clinical application. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34218003. |
exosomes may induce colorectal cancer by altering signaling cascades such as the wnt/β-catenin and kras pathways that are involved in cell proliferation, apoptosis, dissemination, angiogenesis, and drug resistance. |
2021-09-08 |
2023-08-13 |
Not clear |
| Vijayashree Murthy, Masanori Oshi, Yoshihisa Tokumaru, Itaru Endo, Kazuaki Takab. Increased apoptosis is associated with robust immune cell infiltration and cytolytic activity in breast cancer. American journal of cancer research. vol 11. issue 7. 2021-08-07. PMID:34354867. |
high apoptosis tumors enriched cancer promoting signaling pathways; hypoxia, kras, tgf-β, pi3k signaling, and was associated with low mki67 expression and less cell proliferation gene sets, less homologous recombination defects, and less altered fraction. |
2021-08-07 |
2023-08-13 |
Not clear |
| Ruli Gao, Shanshan Bai, Ying C Henderson, Yiyun Lin, Aislyn Schalck, Yun Yan, Tapsi Kumar, Min Hu, Emi Sei, Alexander Davis, Fang Wang, Simona F Shaitelman, Jennifer Rui Wang, Ken Chen, Stacy Moulder, Stephen Y Lai, Nicholas E Navi. Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes. Nature biotechnology. vol 39. issue 5. 2021-06-25. PMID:33462507. |
in three breast tumors, copykat resolved clonal subpopulations that differed in the expression of cancer genes, such as kras, and signatures, including epithelial-to-mesenchymal transition, dna repair, apoptosis and hypoxia. |
2021-06-25 |
2023-08-13 |
human |
| Y Zhang, J-L Liu, J Wan. KRAS gene silencing inhibits the activation of PI3K-Akt-mTOR signaling pathway to regulate breast cancer cell epithelial-mesenchymal transition, proliferation and apoptosis. European review for medical and pharmacological sciences. vol 24. issue 6. 2021-03-15. PMID:32271426. |
kras gene silencing inhibits the activation of pi3k-akt-mtor signaling pathway to regulate breast cancer cell epithelial-mesenchymal transition, proliferation and apoptosis. |
2021-03-15 |
2023-08-13 |
Not clear |
| Y Zhang, J-L Liu, J Wan. KRAS gene silencing inhibits the activation of PI3K-Akt-mTOR signaling pathway to regulate breast cancer cell epithelial-mesenchymal transition, proliferation and apoptosis. European review for medical and pharmacological sciences. vol 24. issue 6. 2021-03-15. PMID:32271426. |
our study was performed to investigate the effect of kras gene silencing on epithelial-mesenchymal transition (emt), proliferation, and apoptosis of breast cancer cells by mediating pi3k-akt-mtor signaling pathway. |
2021-03-15 |
2023-08-13 |
Not clear |
| Xiangyi He, Yunwei Sun, Rong Fan, Jing Sun, Douwu Zou, Yaozong Yua. Knockdown of the DJ-1 ( Molecular therapy oncolytics. vol 20. 2021-02-23. PMID:33614917. |
knockdown of dj-1 expression accelerated erlotinib-induced cell apoptosis and improved the inhibitory effect of erlotinib on pancreatic cancer cell proliferation (for the bxpc-3, panc-1, and miapaca-2 cell lines, regardless of kras mutation status) |
2021-02-23 |
2023-08-13 |
Not clear |
| Takanobu Shimizu, Takeshi Nakamura, Hironori Inaba, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Takao Nakata, Hiroshi Nishina, Yutaka Hat. The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. The Journal of biological chemistry. vol 295. issue 32. 2021-02-19. PMID:32554467. |
we observed that unc119a promotes the binding of kras to rassf6, enhances the interaction between rassf6 and mdm2, and induces apoptosis. |
2021-02-19 |
2023-08-13 |
human |
| Zongsheng He, Lieven Thorrez, Geraldine Siegfried, Sandra Meulemans, Serge Evrard, Sabine Tejpar, Abdel-Majid Khatib, John W M Creemer. The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer. Oncogene. vol 39. issue 17. 2020-11-23. PMID:32139876. |
in a mouse xenograft model, these kras or braf mutant cells lacking furin displayed reduced growth and angiogenesis, and increased apoptosis. |
2020-11-23 |
2023-08-13 |
mouse |
| Xinzhou Bao, Yangbo Han, Yifeng Son. Effects of MiR-27a on proliferation and apoptosis of breast cancer cells by targeting KRAS. Minerva medica. 2020-11-17. PMID:33198441. |
effects of mir-27a on proliferation and apoptosis of breast cancer cells by targeting kras. |
2020-11-17 |
2023-08-13 |
Not clear |
| Samaneh Hashemi, Amirhossein Sharifi, Sara Zareei, Ghazale Mohamedi, Mahmood Biglar, Massoud Amanlo. Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies. Research in pharmaceutical sciences. vol 15. issue 3. 2020-10-23. PMID:33088323. |
one of the promising strategies to overcome such cancers is the inhibition of kras protein, a subtype of ras family involved in cell growth, differentiation, and apoptosis, through preventing its effector, sos1, from being attached to the protein. |
2020-10-23 |
2023-08-13 |
human |
| Lian-Xiang Luo, Ying Li, Zhong-Qiu Liu, Xing-Xing Fan, Fu-Gang Duan, Run-Ze Li, Xiao-Jun Yao, Elaine Lai-Han Leung, Liang Li. Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28443025. |
honokiol induces apoptosis, g1 arrest, and autophagy in kras mutant lung cancer cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Min Kang, Yan Li, Shengtao Zhu, Shutian Zhang, Shuilong Guo, Peng L. MicroRNA-193b acts as a tumor suppressor gene in human esophageal squamous cell carcinoma via target regulation of KRAS. Oncology letters. vol 17. issue 4. 2020-10-01. PMID:30881513. |
kras was indicated as the direct target of mir-193b, and upregulation of mir-193b increased the percentage of cell apoptosis, and suppressed cell proliferation as well as cell migration/invasion via direct regulation of kras. |
2020-10-01 |
2023-08-13 |
human |
| Ze-An Qiu, Guo-Ping H. MicroRNA-134 functions as a tumor suppressor gene in gastric cancer. American journal of translational research. vol 8. issue 10. 2020-09-30. PMID:27830015. |
over-expression of mir-134 significantly inhibited the proliferation and growth in vivo, as well as promoted the apoptosis of gastric cancer cells by targeting kras. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hamada A Mokhlis, Recep Bayraktar, Nashwa N Kabil, Ayse Caner, Nermin Kahraman, Cristian Rodriguez-Aguayo, Erika P Zambalde, Jianting Sheng, Kübra Karagoz, Pinar Kanlikilicer, Abdel Aziz H Abdel Aziz, Tamer M Abdelghany, Ahmed A Ashour, Stephen Wong, Michael L Gatza, George A Calin, Gabriel Lopez-Berestein, Bulent Ozpola. The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers. Molecular therapy. Nucleic acids. vol 14. 2020-09-28. PMID:30654191. |
notably, restoring mir-873 expression induced apoptosis; recapitulated the effects of kras inhibition on cell proliferation, colony formation, and invasion; and suppressed the activity of erk and pi3k/akt, while overexpression of kras rescued the effects mediated by mir-873. |
2020-09-28 |
2023-08-13 |
human |
| Qifeng Luo, Hongming Song, Xiaochong Deng, Jiayi Li, Wei Jian, Junyong Zhao, Xueyu Zheng, Shiva Basnet, Haiyan Ge, Twingle Daniel, Bin Xu, Lin Fan. A Triple-Regulated Oncolytic Adenovirus Carrying MicroRNA-143 Exhibits Potent Antitumor Efficacy in Colorectal Cancer. Molecular therapy oncolytics. vol 16. 2020-09-28. PMID:32123722. |
the upregulation of mir-143 could inhibit cell proliferation and induce cell apoptosis by targeting kras in colorectal cancer cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jieun Park, Yong-Hee Cho, Wook-Jin Shin, Sang-Kyu Lee, JaeHeon Lee, Taehyung Kim, Pu-Hyeon Cha, Jee Sun Yang, Jaebeom Cho, Do Sik Min, Gyoonhee Han, Ho-Young Lee, Kang-Yell Cho. A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Scientific reports. vol 9. issue 1. 2020-08-07. PMID:30679620. |
as a result, kya1797k treatment suppressed the growth and transformation of kras mutant nsclc cells and also induced apoptosis. |
2020-08-07 |
2023-08-13 |
Not clear |