| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek A Singh, Rachana Garg, Amit Mandoli, Dinesh Kuma. Discovery of fluorinated 2‑Styryl 4(3H)-quinazolinone as potential therapeutic hit for oral cancer. Bioorganic & medicinal chemistry. vol 81. 2023-02-16. PMID:36796126. |
subsequent rna-seq analysis revealed that the compound induces the activation of molecular pathways involved in apoptosis (such as tnf signalling through nf-κb, p53 pathways) and cell differentiation and suppresses the pathways of cellular growth and development (such as kras signaling) in cal-27 cancer cells. |
2023-02-16 |
2023-08-14 |
Not clear |
| Wen-Hsuan Chang, Yinzhe Liu, Emma A Hammes, Kirsten L Bryant, Richard A Cerione, Marc A Antonya. Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein (IAP) family member Survivin. The Journal of biological chemistry. 2022-12-29. PMID:36581205. |
here, we identify how this essential signaling connection between oncogenic kras and myc expression is mediated by the inhibitor of apoptosis protein (iap) family member survivin. |
2022-12-29 |
2023-08-14 |
Not clear |
| Cristina Mesas, Francisco Quiñonero, Kevin Doello, José L Revueltas, Gloria Perazzoli, Laura Cabeza, Jose Prados, Consolación Melguiz. Active Biomolecules from Vegetable Extracts with Antitumoral Activity against Pancreas Cancer: A Systematic Review (2011-2021). Life (Basel, Switzerland). vol 12. issue 11. 2022-11-11. PMID:36362920. |
our results reflect the most important biomolecules from natural compounds that induce cell death in pc and their essential mechanism of cell death, including apoptosis, pathways activated by the kras mutation and cycle cell arrest, among others. |
2022-11-11 |
2023-08-14 |
Not clear |
| Yan Song, Juan Zhang, Lei Zhang, Suxia Zhang, Chengcheng She. PDP1 Promotes Cell Malignant Behavior and Is Associated with Worse Clinical Features in Ovarian Cancer Patients: Evidence from Bioinformatics and In Vitro Level. Computational and mathematical methods in medicine. vol 2022. 2022-10-24. PMID:36276992. |
gsea analysis showed that in the oc patients with high pdp1 expression, the pathway of il6/jak/stat3 signaling, interferon-alpha response, apoptosis, adipogenesis, kras signaling, and il2/stat5 signaling was activated, which might be responsible for its oncogenic effect in oc. |
2022-10-24 |
2023-08-14 |
Not clear |
| Zhao-Shou Yang, Qin Yang, Xiao-Xiao Sun, Kui Xiong, Xiao-Ting Zhu, Yi-Chen Wang, Qian-Yao Ren, Guo-Hui Wu, Shi-Min Wang, Xu-Qin Cao, Xiao-Rong Yang, Wen-Gong Jian. GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma. Journal of immunology research. vol 2022. 2022-09-02. PMID:36052280. |
interestingly, high gpx8 expression is correlated positively with the hedgehog and kras signaling pathways and negatively with g2 checkpoint, apoptosis, reactive oxygen species (ros) pathway, and interferon gamma pathway, which could be beneficial for the proliferation of glioma cells. |
2022-09-02 |
2023-08-14 |
Not clear |
| Zi-Yang Liu, Yi Shu, Guo Fu, Hong-Yu Su, Dan Zhu, La-Mei Zeng, De-Yu Ma, Lin Zo. [The Effect of KRAS on Proliferation and Apoptosis of T-ALL Cell Lines]. Zhongguo shi yan xue ye xue za zhi. vol 30. issue 4. 2022-08-18. PMID:35981360. |
[the effect of kras on proliferation and apoptosis of t-all cell lines]. |
2022-08-18 |
2023-08-14 |
Not clear |
| Anabela Ferreira, Flávia Pereira, Celso Reis, Maria José Oliveira, Maria João Sousa, Ana Pret. Crucial Role of Oncogenic Cells. vol 11. issue 14. 2022-07-27. PMID:35883626. |
crucial role of oncogenic kras, one of the ras protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. |
2022-07-27 |
2023-08-14 |
Not clear |
| Sunanda Singh, Genoveva Murillo, Justin Richner, Samara P Singh, Erica Berleth, Vijay Kumar, Rajendra Mehta, Vijay Ramiya, Ashutosh S Pariha. A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35886918. |
stat3 and kras regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. |
2022-07-27 |
2023-08-14 |
human |
| Russell Moser, James Annis, Olga Nikolova, Clifford J Whatcott, Kay E Gurley, Eduardo Mendez, Kim Moran-Jones, Craig Dorrell, Rosalie C Sears, Calvin J Kuo, Haiyong Han, Andrew V Biankin, Carla Grandori, Daniel D Von Hoff, Christopher J Kem. Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL. Cancer research. 2022-07-12. PMID:35819261. |
loss of rpb1 following tfiih inhibition led to downregulation of key transcriptional effectors of kras mutant signaling and negative regulators of apoptosis, including mcl1, xiap, and cflar, initiating caspase-8 dependent apoptosis. |
2022-07-12 |
2023-08-14 |
Not clear |
| Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko Sugiur. ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells. Cells. vol 11. issue 4. 2022-02-25. PMID:35203351. |
acagt-007a, an erk mapk signaling modulator, in combination with akt signaling inhibition induces apoptosis in kras mutant pancreatic cancer t3m4 and mia-pa-ca-2 cells. |
2022-02-25 |
2023-08-13 |
human |
| Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko Sugiur. ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells. Cells. vol 11. issue 4. 2022-02-25. PMID:35203351. |
gt-7 induced apoptosis in pdac cells with different kras mutations (mia-pa-ca-2 (kras g12c), t3m4 (kras q61h), and panc-1 (kras g12d)), being t3m4 most susceptible, followed by mia-pa-ca-2, and panc-1 was most resistant to apoptosis induction by gt-7. |
2022-02-25 |
2023-08-13 |
human |
| Young Seok Cho, Gui Chul Kim, Hye Min Lee, Byoungmo Kim, Ha Rin Kim, Seung Woo Chung, Hyo Won Chang, Yoon Gun Ko, Yoon Se Lee, Seong Who Kim, Youngro Byun, Sang Yoon Ki. Albumin metabolism targeted peptide-drug conjugate strategy for targeting pan-KRAS mutant cancer. Journal of controlled release : official journal of the Controlled Release Society. 2022-02-24. PMID:35202743. |
increased albumin metabolism in kras mutant cancer cells induced apoptosis via the intracellular uptake of albumin-bound mpd1. |
2022-02-24 |
2023-08-13 |
mouse |
| Young Seok Cho, Gui Chul Kim, Hye Min Lee, Byoungmo Kim, Ha Rin Kim, Seung Woo Chung, Hyo Won Chang, Yoon Gun Ko, Yoon Se Lee, Seong Who Kim, Youngro Byun, Sang Yoon Ki. Albumin metabolism targeted peptide-drug conjugate strategy for targeting pan-KRAS mutant cancer. Journal of controlled release : official journal of the Controlled Release Society. 2022-02-24. PMID:35202743. |
in summary, albumin metabolism-induced apoptosis, together with the bystander killing effect of mpd1 boosted by caspase-3 mediated activation, intensified the efficacy of mpd1 in kras mutant cancers. |
2022-02-24 |
2023-08-13 |
mouse |
| Chunliu Mi, Xiangxiang Cao, Kai Ma, Mian Wei, Wenjing Xu, Yan Lin, Jihong Zhang, Tian-Yun Wan. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717917. |
digitoxin promotes apoptosis and inhibits proliferation and migration by reducing hif-1α and stat3 in kras mutant human colon cancer cells. |
2021-12-10 |
2023-08-13 |
mouse |
| Christy W S Tong, Mia M X Wu, Vivi W Yan, William C S Cho, Kenneth K W T. Repurposing loperamide to overcome gefitinib resistance by triggering apoptosis independent of autophagy induction in KRAS mutant NSCLC cells. Cancer treatment and research communications. vol 25. 2021-11-17. PMID:33152554. |
repurposing loperamide to overcome gefitinib resistance by triggering apoptosis independent of autophagy induction in kras mutant nsclc cells. |
2021-11-17 |
2023-08-13 |
Not clear |
| Dong Hoon Shin, Sun Ha Kim, Minyoung Choi, Young-Ki Bae, Chungyong Han, Beom K Choi, Sang Soo Kim, Ji-Youn Ha. Oncogenic KRAS promotes growth of lung cancer cells expressing SLC3A2-NRG1 fusion via ADAM17-mediated shedding of NRG1. Oncogene. 2021-11-07. PMID:34743207. |
targeted inhibition of mek1/2, and adam17 significantly induced apoptosis singly and when combined with each mutation singly or with chemotherapy in both the concurrent kras mutant and s-n fusion xenograft and lung orthotopic models. |
2021-11-07 |
2023-08-13 |
Not clear |
| Xiaobo Zheng, Li Feng, Yunfan Yin, Chune Yu, Xiujing He, Jiao Zhu, Ming Zhang, Jing Yu, Mingqing X. Comprehensive analysis of aberrant alternative splicing related to carcinogenesis and prognosis of papillary thyroid cancer. Aging. vol 13. issue 19. 2021-11-03. PMID:34628367. |
parent genes with cases remarkably enriched in the pathways were linked with carcinogenesis, such as p53, kras, il6-jak-stat3, apoptosis, and myc signaling. |
2021-11-03 |
2023-08-13 |
Not clear |
| Yuta Adachi, Ryo Kimura, Kentaro Hirade, Hiromichi Eb. Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers. Cancers. vol 13. issue 20. 2021-10-26. PMID:34680229. |
when mutated, the kras protein becomes constitutively active, stimulating various effector pathways and leading to the deregulation of key cellular processes, including the suppression of apoptosis and enhancement of proliferation. |
2021-10-26 |
2023-08-13 |
human |
| Sreevidya Santha, Xiang Ling, Ieman A M Aljahdali, Sailee S Rasam, Xue Wang, Jianqun Liao, Jue Wang, Christos Fountzilas, Qingyong Li, Jun Qu, Fengzhi L. Mutant Kras as a Biomarker Plays a Favorable Role in FL118-Induced Apoptosis, Reactive Oxygen Species (ROS) Production and Modulation of Survivin, Mcl-1 and XIAP in Human Bladder Cancer. Cancers. vol 12. issue 11. 2021-10-22. PMID:33217967. |
mutant kras as a biomarker plays a favorable role in fl118-induced apoptosis, reactive oxygen species (ros) production and modulation of survivin, mcl-1 and xiap in human bladder cancer. |
2021-10-22 |
2023-08-13 |
human |
| Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavall. miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer. Cancer gene therapy. vol 28. issue 5. 2021-10-18. PMID:32948832. |
in vitro assays on immortalized and patient-derived primary nsclc cells revealed that mir-34c-3p overexpression increased apoptosis and lowered proliferation rate in kras |
2021-10-18 |
2023-08-13 |
Not clear |