| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Zhang, Ying Shan, Yong Li, Xinping Luo, Haiming Sh. Palmitate impairs angiogenesis via suppression of cathepsin activity. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440480. |
by using cell counting kit‑8, the transwell method and an annexin v‑fluorescein isothiocyanate/propidium iodide apoptosis detection kit, the present study reported that high levels of palmitate result in a significant decrease in endothelial cell proliferation and invasion, and induced cell apoptosis; cathepsin l and s inhibitors may suppress palmitate‑induced apoptosis. |
2018-03-05 |
2023-08-13 |
human |
| Nan Wang, Fan Zhao, Pengfei Lin, Guangle Zhang, Keqiong Tang, Aihua Wang, Yaping Ji. Knockdown of XBP1 by RNAi in Mouse Granulosa Cells Promotes Apoptosis, Inhibits Cell Cycle, and Decreases Estradiol Synthesis. International journal of molecular sciences. vol 18. issue 6. 2018-03-05. PMID:28555054. |
in this study, rna interference, flow cytometry, western blot, real-time pcr, cell counting kit (cck8), and elisa were used to investigate the effect of xbp1 on steroidogenesis, apoptosis, cell cycle, and proliferation of mouse granulosa cells. |
2018-03-05 |
2023-08-13 |
mouse |
| Denise Damasceno Guerreiro, Laritza Ferreira de Lima, Giovanna Quintino Rodrigues, Adeline de Andrade Carvalho, Simone Vieira Castro, Cláudio Cabral Campello, Cláudia do Ó Pessoa, Carla Renata Figueiredo Gadelha, José Ricardo de Figueiredo, Vilceu Bordignon, Ana Paula Ribeiro Rodrigue. In situ cultured preantral follicles is a useful model to evaluate the effect of anticancer drugs on caprine folliculogenesis. Microscopy research and technique. vol 79. issue 8. 2018-02-26. PMID:27311936. |
analyses were performed before and after culture to evaluate tissue integrity by classical histology, apoptosis by tunel assay, dna laddering kit and the detection of activated caspase 3, and dna damage by the immune detection of phosphorylated histone h2a.x (h2axph139). |
2018-02-26 |
2023-08-13 |
Not clear |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
apoptotic cells were determined using an annexin v/propidium iodide apoptosis detection kit. |
2018-02-23 |
2023-08-13 |
Not clear |
| Trajen Head, Peter Dau, Stephanie Duffort, Pirouz Daftarian, Pratibha M Joshi, Roberto Vazquez-Padron, Sapna K Deo, Sylvia Dauner. An enhanced bioluminescence-based Annexin V probe for apoptosis detection in vitro and in vivo. Cell death & disease. vol 8. issue 5. 2018-02-23. PMID:28542141. |
arfp represents an important new tool in the continuously growing kit of technologies for apoptosis detection, and our results from both in vitro and in vivo experiments suggest a diverse range of potential clinically relevant applications including cancer therapeutic screening and efficacy analysis, atherosclerosis and cardiovascular disease detection, and the monitoring of any number of other conditions in which apoptosis has a central role. |
2018-02-23 |
2023-08-13 |
Not clear |
| Jessica L Rausch, Sergei Boichuk, Areej A Ali, Sneha S Patil, Lijun Liu, Donna M Lee, Matthew F Brown, Kathleen R Makielski, Ying Liu, Takahiro Taguchi, Shih-Fan Kuan, Anette Duensin. Opposing roles of KIT and ABL1 in the therapeutic response of gastrointestinal stromal tumor (GIST) cells to imatinib mesylate. Oncotarget. vol 8. issue 3. 2018-02-22. PMID:27965460. |
using sirna-mediated knockdown, we demonstrate that depletion of kit in conjunction with abl1 - hence mimicking imatinib treatment - leads to reduced apoptosis induction and attenuated inhibition of cellular proliferation when compared to depletion of kit alone. |
2018-02-22 |
2023-08-13 |
human |
| Katarina Lyberg, Hani Abdulkadir Ali, Jennine Grootens, Matilda Kjellander, Malin Tirfing, Michel Arock, Hans Hägglund, Gunnar Nilsson, Johanna Ungersted. Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis. Oncotarget. vol 8. issue 6. 2018-02-22. PMID:28038453. |
saha downregulated kit, followed by major mc apoptosis. |
2018-02-22 |
2023-08-13 |
human |
| Changjiang Ying, Lei Chen, Shanshan Wang, Yizhen Mao, Hongwei Ling, Wei Li, Xiaoyan Zho. Zeaxanthin ameliorates high glucose-induced mesangial cell apoptosis through inhibiting oxidative stress via activating AKT signalling-pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-16. PMID:28431381. |
to that end, superoxide dismutase (sod) activity and methane dicarboxylic aldehyde (mda) levels were measured by an assay kit, and mesangial cell apoptosis and ros levels were assessed using flow cytometry analysis. |
2018-02-16 |
2023-08-13 |
Not clear |
| Aycan Asik, Cagla Kayabasi, Besra Ozmen Yelken, Sunde Yılmaz Susluer, Zeynep Ozlem Dogan Sigva, Tugce Balcı Okcanoglu, Guray Saydam, Cıgır Biray Avci, Cumhur Gundu. Antileukemic effect of paclitaxel in combination with metformin in HL-60 cell line. Gene. vol 647. 2018-02-09. PMID:29309887. |
the effect of combinational dose on apoptosis was assessed in fluorescence microscope after using annexinv-egfp apoptosis and jc-1 assay kit. |
2018-02-09 |
2023-08-13 |
Not clear |
| Tian Qing, Zhang Yamin, Wang Guijie, Jin Yan, Shen Zhongyan. STAT6 silencing induces hepatocellular carcinoma-derived cell apoptosis and growth inhibition by decreasing the RANKL expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-02-05. PMID:28525794. |
we observed that depletion of stat6 increased hepg2 and hep3b cell apoptosis by using a histone dna elisa detection kit. |
2018-02-05 |
2023-08-13 |
human |
| Johanna Falkenhorst, Susanne Grunewald, Thomas Mühlenberg, Adrian Marino-Enriquez, Anna-Carina Reis, Christopher Corless, Michael Heinrich, Jürgen Treckmann, Lars Erik Podleska, Martin Schuler, Jonathan Alfred Fletcher, Sebastian Baue. Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib. Oncotarget. vol 7. issue 27. 2018-01-12. PMID:27167336. |
nonetheless, kit inhibition alone does not cure gist as a subset of gist cells evade apoptosis and eventually develop resistance. |
2018-01-12 |
2023-08-13 |
Not clear |
| Yantian Chen, Fengli Zhang, Qiang Fu, Yong Liu, Zejian Wang, Nianmin Q. In vitro proliferation and osteogenic differentiation of human dental pulp stem cells in injectable thermo-sensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel. Journal of biomaterials applications. vol 31. issue 3. 2018-01-03. PMID:27496540. |
the proliferation of dental pulp stem cells was detected by using an alamar blue kit, while cell apoptosis was determined by using a live/dead viability/cytotoxicity kit. |
2018-01-03 |
2023-08-13 |
human |
| Weipeng Zhao, Xichuan Li, Jun Wang, Chen Wang, Yongsheng Jia, Shunzong Yuan, Yong Huang, Yehui Shi, Zhongsheng Ton. Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-12-15. PMID:28854163. |
we utilized the stress and apoptosis signaling antibody array kit, while p-erk1/2, p-akt, p-smad2, p-p38 mapk, cleaved caspase-3, and cleaved caspase-7 were explored between eif3c-sirna and controls. |
2017-12-15 |
2023-08-13 |
human |
| Jun Li, Siyang Ren, Yongjian Liu, Zhigang Lian, Bin Dong, Yiqun Yao, Yinghui X. Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. Journal of neuro-oncology. vol 132. issue 1. 2017-12-13. PMID:28000106. |
facs analysis and a signaling antibody array kit were used to detect the mechanism by which nupr1 modulates cell cycle and apoptosis activities in glioblastoma cells. |
2017-12-13 |
2023-08-13 |
human |
| Yu An, Dan-Di Zhang, Huan-Ling Yu, Wei-Wei Ma, Yan-Hui Lu, Quan-Ri Liu, Rong Xia. 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. Neurotoxicology. vol 59. 2017-11-22. PMID:28167099. |
c6 cells were treated with 5, 10 and 20μm 27-ohc for 24h and the cell viability and apoptosis, the cholesterol levels and metabolism-related mediators, genes and proteins were subsequently assessed using cell-counting kit (cck)-8, amplex red, elisa, real-time pcr and western blot, respectively. |
2017-11-22 |
2023-08-13 |
Not clear |
| Oluwatosin Adaramoye, Bettina Erguen, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabie. Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells. Chemico-biological interactions. vol 274. 2017-09-05. PMID:28709945. |
antiangiogenic effects were measured using cam assay, while apoptosis was assessed by dna fragmentation, enrichment factor by cell death detection elisa kit and expressions of caspases-3 and -8. |
2017-09-05 |
2023-08-13 |
human |
| Tsuyoshi Takahashi, Asmaa Elzawahry, Sachiyo Mimaki, Eisaku Furukawa, Rie Nakatsuka, Hiromi Nakamura, Takahiko Nishigaki, Satoshi Serada, Tetsuji Naka, Seiichi Hirota, Tatsuhiro Shibata, Katsuya Tsuchihara, Toshirou Nishida, Mamoru Kat. Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors. Genes, chromosomes & cancer. vol 56. issue 4. 2017-07-21. PMID:27997714. |
pre-existing cancer cells with genetic alterations promoting apoptosis resistance may serve as a basis whereby cancer cells with critical mutations, such as secondary kit mutations, can establish full imatinib resistance. |
2017-07-21 |
2023-08-13 |
Not clear |
| Jie Wen, Yan-Kun Zhao, Yan Liu, Jin-Feng Zha. MicroRNA-34a inhibits tumor invasion and metastasis in osteosarcoma partly by effecting C-IAP2 and Bcl-2. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28635396. |
the effect of overexpression of mir-34a on osteosarcoma was detected by colony-forming assay, annexin v-fluorescein isothiocyanate apoptosis detection kit i, transwell assay, and animal experiment in vivo. |
2017-07-18 |
2023-08-13 |
Not clear |
| Hong-Zhou Meng, Xiao-Feng Ni, Hai-Ning Yu, Shan-Shan Wang, Sheng-Rong She. Effects of astaxanthin on oxidative stress induced by Cu Journal of Zhejiang University. Science. B. vol 18. issue 2. 2017-07-11. PMID:28124844. |
in the current paper, the effects of ast on viability of prostate cells were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) assay; cell apoptosis and intracellular reactive oxygen species (ros) levels were determined by flow cytometry; the mitochondrial membrane potential (mmp) was measured by fluorospectrophotometer; and activities of malondialdehyde (mda), superoxide dismutase (sod), catalase (cat), and glutathione peroxidase (gsh-px) were evaluated by a detection kit. |
2017-07-11 |
2023-08-13 |
cat |
| Gamze Altıntaş Kazar, Ece Şe. [Investigation of antitumorigenic effects of food-borne non-pathogenic and pathogenic Salmonella enterica strains on MEF, DU145 and HeLa cell lines]. Mikrobiyoloji bulteni. vol 50. issue 3. 2017-06-30. PMID:27525394. |
the cell viability was measured by colorimetric mtt cytotoxicity assay, the percentage of apoptosis was assessed by tali® apoptosis assay-annexin v alexa fluor® 488 kit (invitrogen, molecular probes, life technologies, usa), and the caspase-3 activity was determined by colorimetric protease apotarget™ kit (invitrogen, biosource international, usa). |
2017-06-30 |
2023-08-13 |
mouse |