| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Song, Shuai Li, Wen Geng, Rongjin Luo, Wei Liu, Ji Tu, Kun Wang, Liang Kang, Huipeng Yin, Xinghuo Wu, Yong Gao, Yukun Zhang, Cao Yan. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox biology. vol 19. 2018-12-11. PMID:30216853. |
in conclusion, our data demonstrate that sirt3 protects against ages-induced human np cell apoptosis and ivd degeneration. |
2018-12-11 |
2023-08-13 |
human |
| Yazhou Lin, Yucheng Jiao, Ye Yuan, Zezhu Zhou, Yuehuan Zheng, Jiaqi Xiao, Changwei Li, Zhe Chen, Peng Ca. Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway. Emerging microbes & infections. vol 7. issue 1. 2018-11-15. PMID:29323102. |
then, a p. acnes-inoculated ivd animal model was established, and severe ivdd was induced by p. acnes infection by promoting npc apoptosis. |
2018-11-15 |
2023-08-13 |
human |
| Weiheng Wang, Guoying Deng, Yuanyuan Qiu, Xiaodong Huang, Yanhai Xi, Jiangming Yu, Xiangqun Yang, Xiaojian Y. Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436582. |
npcs cultured from rats expressing green fluorescent protein (gfp‑npcs) were transplanted into the degenerated ivd, and the migration of gfp‑npcs, as well as the degeneration and apoptosis of the ivd were detected to evaluate the therapeutic effect in vivo. |
2018-08-27 |
2023-08-13 |
rat |
| Kang Li, Yan Li, Jie Mi, Lu Mao, Xiuguo Han, Jie Zha. Resveratrol protects against sodium nitroprusside induced nucleus pulposus cell apoptosis by scavenging ROS. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436588. |
oxidative stress induced disc cell apoptosis plays an important role in intervertebral disc (ivd) degeneration. |
2018-08-27 |
2023-08-13 |
rat |
| Kang Li, Yan Li, Jie Mi, Lu Mao, Xiuguo Han, Jie Zha. Resveratrol protects against sodium nitroprusside induced nucleus pulposus cell apoptosis by scavenging ROS. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436588. |
in conclusion, rv protects against snp induced np cell apoptosis by scavenging ros but not no, suggesting a promising prospect of rv in ivd degeneration retardation. |
2018-08-27 |
2023-08-13 |
rat |
| Huan Liu, Si-Dong Yang, Ying Xu, Sheng-Hua Ning, Tao Wang, Da-Long Yang, Wen-Yuan Din. Protective role of 17β-estradiol on tumor necrosis factor-α-induced apoptosis in human nucleus pulposus cells. Molecular medicine reports. vol 16. issue 2. 2018-04-09. PMID:28586025. |
tumor necrosis factor-α (tnf-α) has been demonstrated to induce apoptosis of inte rvertebral disc (ivd) cells during ivd degeneration, and 17β‑estradiol (17β‑e2) has a protective effect against ivd cell apoptosis. |
2018-04-09 |
2023-08-13 |
human |
| Qiming Xu, Nan Wu, Lijia Cui, Zhihong Wu, Guixing Qi. Filamin B: The next hotspot in skeletal research? Journal of genetics and genomics = Yi chuan xue bao. vol 44. issue 7. 2018-03-19. PMID:28739045. |
several mechanisms of flnb mutations causing skeletal malformations have been proposed, including delay of ossification in long bone growth plate, reduction of bone mineral density (bmd), dysregulation of muscle differentiation, ossification of intervertebral disc (ivd), disturbance of proliferation, differentiation and apoptosis in chondrocytes, impairment of angiogenesis, and hypomotility of osteoblast, chondrocyte and fibroblast. |
2018-03-19 |
2023-08-13 |
Not clear |
| Fubiao Ye, Hua Wang, Zhaomin Zheng, Peiheng He, Shilabant Sen Sribastav, Huafeng Wang, Jianru Wang, Hui Liu, Victor Y L Leun. Role of SHOX2 in the development of intervertebral disc degeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 35. issue 5. 2017-09-26. PMID:26697824. |
first, we detected the expression of shox2 in different stages of human ivd degeneration; then explored the role of shox2 on nucleus pulposus (np) cells proliferation and apoptosis, finally we evaluated the effect of shox2 on the production of extracellular matrix in np cells. |
2017-09-26 |
2023-08-13 |
human |
| Kun Wang, Wei Liu, Yu Song, Xinghuo Wu, Yukun Zhang, Shuai Li, Yong Gao, Ji Tu, Yingle Liu, Cao Yan. The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration. Laboratory investigation; a journal of technical methods and pathology. vol 97. issue 8. 2017-08-28. PMID:28394321. |
ang-2 release during ivd degeneration causes higher ratio of ang-2 to ang-1, further inhibits np cell viability and adhesion, promoting apoptosis by blocking pi3k/akt signaling. |
2017-08-28 |
2023-08-13 |
human |
| Yu-Ping Liu, Chong-Ming Yuan, Shuai-Gong Zhang, Qing-Hai Hao, Ming-Ming Wang, Zhong Zhang, Qian Meng, Ming Li, Yue-Dong Ha. TWEAK/Fn14 signaling: a promising target in intervertebral disc degeneration. Histology and histopathology. vol 31. issue 9. 2017-04-14. PMID:26907852. |
the interaction of tweak with fn14 is involved in physiological and pathological activities of ivd degeneration patients, which includes apoptosis of endplate chondrocytes, extracellular matrix degradation, reduction in proteoglycan synthesis and so on. |
2017-04-14 |
2023-08-13 |
Not clear |
| Zongchao Liu, Chuan Ma, Jieliang Shen, Dawu Wang, Jie Hao, Zhenming H. SDF‑1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF‑κB pathway. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27220474. |
in conclusion, the sdf‑1/cxcr4 axis promoted cell apoptosis in human degenerative npcs via the nf‑κb pathway, thus suggesting that sdf‑1/cxcr signaling may be a therapeutic target for the treatment of degenerative ivd diseases. |
2017-04-06 |
2023-08-13 |
human |
| Fan Zhang, Xueling Zhao, Hongxing Shen, Caiguo Zhan. Molecular mechanisms of cell death in intervertebral disc degeneration (Review). International journal of molecular medicine. vol 37. issue 6. 2017-02-28. PMID:27121482. |
human clinical trial and animal model studies have documented that cell death, particularly apoptosis and autophagy, significantly contribute to ivd degeneration. |
2017-02-28 |
2023-08-13 |
human |
| Cheng Wang, Xiaohua Yu, Yiguo Yan, Wei Yang, Shujun Zhang, Yongxiao Xiang, Jian Zhang, Wenjun Wan. Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration. Acta biochimica et biophysica Sinica. vol 49. issue 1. 2017-01-30. PMID:27864283. |
tnf-α is highly expressed in degenerative ivd tissues, and it is deeply involved in multiple pathological processes of disc degeneration, including matrix destruction, inflammatory responses, apoptosis, autophagy, and cell proliferation. |
2017-01-30 |
2023-08-13 |
Not clear |
| Hidenobu Ishibashi, Hitoshi Tonomura, Takumi Ikeda, Masateru Nagae, Munehiro Sakata, Hiroyoshi Fujiwara, Takashi Tanida, Ken-Ichi Mastuda, Mitsuhiro Kawata, Toshikazu Kub. Hepatocyte growth factor/c-met promotes proliferation, suppresses apoptosis, and improves matrix metabolism in rabbit nucleus pulposus cells in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 4. 2016-08-15. PMID:26440443. |
the etiology of intervertebral disc (ivd) degeneration is closely related to apoptosis and extracellular matrix degradation in nucleus pulposus (np) cells. |
2016-08-15 |
2023-08-13 |
rabbit |
| Aiqun Wei, Bojiang Shen, Lisa A Williams, Divya Bhargav, Feng Yan, Beng H Chong, Ashish D Diwa. Expression and functional roles of estrogen receptor GPR30 in human intervertebral disc. The Journal of steroid biochemistry and molecular biology. vol 158. 2016-07-18. PMID:26815911. |
this study aimed to evaluate gpr30 expression in ivd, and its role in estrogen-related regulation of proliferation and apoptosis of disc nucleus pulposus (np) cells. |
2016-07-18 |
2023-08-13 |
human |
| Aiqun Wei, Bojiang Shen, Lisa A Williams, Divya Bhargav, Feng Yan, Beng H Chong, Ashish D Diwa. Expression and functional roles of estrogen receptor GPR30 in human intervertebral disc. The Journal of steroid biochemistry and molecular biology. vol 158. 2016-07-18. PMID:26815911. |
this study demonstrates that gpr30 is expressed in human ivd to transmit signals triggering e2-induced np cell proliferation and protecting against il-1β-induced apoptosis. |
2016-07-18 |
2023-08-13 |
human |
| Wei Yang, Xiao-Hua Yu, Cheng Wang, Wen-Si He, Shu-Jun Zhang, Yi-Guo Yan, Jian Zhang, Yong-Xiao Xiang, Wen-Jun Wan. Interleukin-1β in intervertebral disk degeneration. Clinica chimica acta; international journal of clinical chemistry. vol 450. 2016-05-03. PMID:26341894. |
il-1β is highly expressed in degenerative intervertebral disk (ivd) tissues and cells, and it has been shown to be involved in multiple pathological processes during disk degeneration, including inflammatory responses, matrix destruction, angiogenesis and innervation, cellular apoptosis, oxidative stress and cellular senescence. |
2016-05-03 |
2023-08-13 |
Not clear |
| Cheng Wang, Wen-Jun Wang, Yi-Guo Yan, Yong-Xiao Xiang, Jian Zhang, Zhi-Han Tang, Zhi-Sheng Jian. MicroRNAs: New players in intervertebral disc degeneration. Clinica chimica acta; international journal of clinical chemistry. vol 450. 2016-05-03. PMID:26368266. |
chronic low back pain is generally attributed to intervertebral disc (ivd) degeneration (idd), which is closely associated with apoptosis, extracellular matrix (ecm) disruption, cell proliferation and inflammatory response. |
2016-05-03 |
2023-08-13 |
human |
| Katsuhisa Yamada, Hideki Sudo, Koji Iwasaki, Naoki Sasaki, Hideaki Higashi, Yusuke Kameda, Manabu Ito, Masahiko Takahata, Kuniyoshi Abumi, Akio Minami, Norimasa Iwasak. Caspase 3 silencing inhibits biomechanical overload-induced intervertebral disk degeneration. The American journal of pathology. vol 184. issue 3. 2016-04-28. PMID:24389166. |
in addition, we investigated whether the inhibition of apoptosis is a potential clinical therapeutic strategy for the treatment of ivd degeneration induced by biomechanical stress. |
2016-04-28 |
2023-08-12 |
Not clear |
| Katsuhisa Yamada, Hideki Sudo, Koji Iwasaki, Naoki Sasaki, Hideaki Higashi, Yusuke Kameda, Manabu Ito, Masahiko Takahata, Kuniyoshi Abumi, Akio Minami, Norimasa Iwasak. Caspase 3 silencing inhibits biomechanical overload-induced intervertebral disk degeneration. The American journal of pathology. vol 184. issue 3. 2016-04-28. PMID:24389166. |
the present study suggests that caspase 3 sirna attenuates overload-induced ivd degeneration by inhibiting np cell apoptosis and the expression of matrix-degrading enzymes. |
2016-04-28 |
2023-08-12 |
Not clear |