| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuexiao Ma, Yazhou Lin, Kun Yang, Bin Yue, Hongfei Xiang, Bohua Che. Effect of lentivirus-mediated survivin transfection on the morphology and apoptosis of nucleus pulposus cells derived from degenerative human disc in vitro. International journal of molecular medicine. vol 36. issue 1. 2016-03-24. PMID:26017192. |
however, the excessive apoptosis of disc cells plays an important role in ivd degeneration, particularly in the nucleus pulposus (np). |
2016-03-24 |
2023-08-13 |
human |
| Aiqun Wei, Bojiang Shen, Lisa Williams, Ashish Diwa. Mesenchymal stem cells: potential application in intervertebral disc regeneration. Translational pediatrics. vol 3. issue 2. 2016-02-02. PMID:26835326. |
degeneration of the intervertebral disc (ivd) is a major pathological process implicated in low back pain, which is characterized by cellular apoptosis and senescence with reduced synthesis of extracellular matrix (ecm). |
2016-02-02 |
2023-08-13 |
Not clear |
| Wei Jiang, Xuemei Zhang, Jie Hao, Jieliang Shen, Ji Fang, Wen Dong, Dawu Wang, Xiaojun Zhang, Wei Shui, Yi Luo, Liangbo Lin, Quanhe Qiu, Bin Liu, Zhenming H. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells. Scientific reports. vol 4. 2015-10-09. PMID:25503852. |
we sought to explore the relationship between autophagy and human ivd degeneration and to understand whether autophagy is involved in the protective effect of sirt1 against apoptosis in np cells. |
2015-10-09 |
2023-08-13 |
human |
| Wei Jiang, Xuemei Zhang, Jie Hao, Jieliang Shen, Ji Fang, Wen Dong, Dawu Wang, Xiaojun Zhang, Wei Shui, Yi Luo, Liangbo Lin, Quanhe Qiu, Bin Liu, Zhenming H. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells. Scientific reports. vol 4. 2015-10-09. PMID:25503852. |
these suggested that autophagy may play an important role in ivd degeneration, and sirt1 protected degenerative human np cells against apoptosis via promoting autophagy. |
2015-10-09 |
2023-08-13 |
human |
| Haiying Wang, Wenyuan Ding, Dalong Yang, Tixin Gu, Sidong Yang, Zhilong Ba. Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells. Molecular medicine reports. vol 10. issue 5. 2015-06-09. PMID:25175856. |
il‑1β has been previously reported to induce apoptosis of intervertebral disc (ivd) cells in ivd degeneration. |
2015-06-09 |
2023-08-13 |
rat |
| Haiying Wang, Wenyuan Ding, Dalong Yang, Tixin Gu, Sidong Yang, Zhilong Ba. Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells. Molecular medicine reports. vol 10. issue 5. 2015-06-09. PMID:25175856. |
whether estrogen is able to protect ivd cells from apoptosis remains unclear. |
2015-06-09 |
2023-08-13 |
rat |
| Chang-Chun Zhang, Guo-Peng Cui, Jian-Guo Hu, Yu-Zhou Xiao, Xin-She Zhou, Chen Shao, Qinghua Lin, Jian-Sheng Zho. Effects of adenoviral vector expressing hIGF-1 on apoptosis in nucleus pulposus cells in vitro. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24337543. |
the excessive apoptosis of cells of the nucleus pulposus may plays an important role in intervertebral disc (ivd) degeneration. |
2014-09-18 |
2023-08-12 |
human |
| Steven M Presciutti, David N Paglia, Teja Karukonda, Do Yu Soung, Rosa Guzzo, Hicham Drissi, Isaac L Mos. PDGF-BB inhibits intervertebral disc cell apoptosis in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 32. issue 9. 2014-09-16. PMID:24841673. |
first, pdgf treatment strongly inhibited ivd cell apoptosis in 3d cultures. |
2014-09-16 |
2023-08-13 |
human |
| Arne Mehrkens, M Zia Karim, Sarah Kim, Raychel Hilario, Michael G Fehlings, William Mark Erwi. Canine notochordal cell-secreted factors protect murine and human nucleus pulposus cells from apoptosis by inhibition of activated caspase-9 and caspase-3/7. Evidence-based spine-care journal. vol 4. issue 2. 2014-01-17. PMID:24436715. |
with the presented work, we have investigated if nonchondrodystrophic (ncd) canine intervertebral disc (ivd)-derived notochordal cell conditioned medium (nccm) and chondrodystrophic (cd) canine ivd-derived conditioned medium (cdcm) are able to protect murine and human np cells from apoptosis. |
2014-01-17 |
2023-08-12 |
mouse |
| Arne Mehrkens, M Zia Karim, Sarah Kim, Raychel Hilario, Michael G Fehlings, William Mark Erwi. Canine notochordal cell-secreted factors protect murine and human nucleus pulposus cells from apoptosis by inhibition of activated caspase-9 and caspase-3/7. Evidence-based spine-care journal. vol 4. issue 2. 2014-01-17. PMID:24436715. |
here, we demonstrate that soluble factors secreted by the ncd ivd np strongly protect murine np cells not only from il-1β + fasl but also from etoposide-induced apoptosis via suppression of activated caspase-9 and caspase-3/7. |
2014-01-17 |
2023-08-12 |
mouse |
| Fan Ding, Zeng-wu Shao, Li-ming Xion. Cell death in intervertebral disc degeneration. Apoptosis : an international journal on programmed cell death. vol 18. issue 7. 2013-12-23. PMID:23512131. |
apoptosis, a very important type of ivd cell death, has been considered to play a crucial role in the process of degeneration. |
2013-12-23 |
2023-08-12 |
Not clear |
| Chang-Chun Zhang, Jian-Sheng Zhou, Jian-Guo Hu, Xiang Wang, Xin-She Zhou, Bao-An Sun, Chen Shao, Qinghua Li. Effects of IGF-1 on IL-1β-induced apoptosis in rabbit nucleus pulposus cells in vitro. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23255055. |
excessive apoptosis in intervertebral disc (ivd) cells is important in ivd degeneration. |
2013-11-04 |
2023-08-12 |
rabbit |
| D Greg Anderson, Dessislava Markova, Howard S An, Ana Chee, Motomi Enomoto-Iwamoto, Vladimir Markov, Biagio Saitta, Peng Shi, Chander Gupta, Yejia Zhan. Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair. American journal of physical medicine & rehabilitation. vol 92. issue 5. 2013-06-19. PMID:23598901. |
intervertebral disc (ivd) cell apoptosis and senescence increase with aging and degeneration. |
2013-06-19 |
2023-08-12 |
human |
| Ashraf Uzzaman, Seong H Ch. Chapter 28: Classification of hypersensitivity reactions. Allergy and asthma proceedings. vol 33 Suppl 1. 2012-11-16. PMID:22794701. |
type iv has four major categories: type iva is cd4(+)th1 lymphocyte mediated with activation of macrophages (granuloma formation and type i diabetes mellitus); type ivb is cd4(+)th2 lymphocyte mediated with eosinophilic involvement (persistent asthma and allergic rhinitis); type ivc is cytotoxic cd8(+) t lymphocyte with involvement of perforin-granzme b in apoptosis (stevens-johnson syndrome and toxic epidermal necrolysis); type ivd is t-lymphocyte-driven neutrophilic inflammation (pustular psoriasis and acute generalized exanthematous pustulosis). |
2012-11-16 |
2023-08-12 |
Not clear |
| Fan Ding, Zeng-Wu Shao, Shu-Hua Yang, Qiang Wu, Fei Gao, Li-Ming Xion. Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells. Apoptosis : an international journal on programmed cell death. vol 17. issue 6. 2012-10-22. PMID:22392483. |
various mechanical stresses can induce apoptosis of nucleus pulposus (np) cells and intervertebral disc (ivd) degeneration in vivo, but the underlying molecular mechanism by which the number of np cells is decreased in degenerated ivd is still not elucidated. |
2012-10-22 |
2023-08-12 |
rabbit |
| Yue-Hui Zhang, Chang-Qing Zhao, Lei-Sheng Jiang, Li-Yang Da. Cyclic stretch-induced apoptosis in rat annulus fibrosus cells is mediated in part by endoplasmic reticulum stress through nitric oxide production. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 20. issue 8. 2012-05-31. PMID:21336971. |
various mechanical stresses in vivo induce disc cell apoptosis and intervertebral disc (ivd) degeneration, but the underlying molecular mechanism is not fully known. |
2012-05-31 |
2023-08-12 |
rat |
| Yue-Hui Zhang, Chang-Qing Zhao, Lei-Sheng Jiang, Li-Yang Da. Cyclic stretch-induced apoptosis in rat annulus fibrosus cells is mediated in part by endoplasmic reticulum stress through nitric oxide production. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 20. issue 8. 2012-05-31. PMID:21336971. |
these findings could be helpful to understand the mechanism of disc cell apoptosis, the root cause of ivd degeneration. |
2012-05-31 |
2023-08-12 |
rat |
| Hua Wang, Hui Liu, Zhao-Min Zheng, Kui-Bo Zhang, Tai-Ping Wang, Shilabant-Sen Sribastav, Wen-Sheng Liu, Ting Li. Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21879322. |
intervertebral disc (ivd) cell apoptosis has been suggested to play an important role in promoting the degeneration process. |
2012-01-12 |
2023-08-12 |
human |
| Hua Wang, Hui Liu, Zhao-Min Zheng, Kui-Bo Zhang, Tai-Ping Wang, Shilabant-Sen Sribastav, Wen-Sheng Liu, Ting Li. Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21879322. |
it has been demonstrated that ivd cell apoptosis occurs through either death receptor, mitochondrial or endoplasmic reticulum (er) pathway. |
2012-01-12 |
2023-08-12 |
human |
| Christopher K Kepler, D Greg Anderson, Chadi Tannoury, Ravi K Ponnappa. Intervertebral disk degeneration and emerging biologic treatments. The Journal of the American Academy of Orthopaedic Surgeons. vol 19. issue 9. 2011-11-02. PMID:21885700. |
acceleration of cellular senescence and apoptosis in degenerative ivds and the depletion of matrix proteins have prompted the development of treatments based on replacing ivd cells using various cell sources. |
2011-11-02 |
2023-08-12 |
Not clear |