| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Bo Zhang, Yi-Cun Hu, Peng Cheng, Hai-Yu Zhou, Xiang-Yi Chen, Ding Wu, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Jin-Tao Shi, Kai Zhang, Shao-Long Li, Peng-Jie Song, Ke-Ping Wan. Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy. International journal of medical sciences. vol 18. issue 13. 2021-07-06. PMID:34220308. |
the pathogenesis is complicated, and the main pathological changes are ivd cell apoptosis and extracellular matrix (ecm) degradation. |
2021-07-06 |
2023-08-13 |
Not clear |
| Xiao-Bo Zhang, Yi-Cun Hu, Peng Cheng, Hai-Yu Zhou, Xiang-Yi Chen, Ding Wu, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Jin-Tao Shi, Kai Zhang, Shao-Long Li, Peng-Jie Song, Ke-Ping Wan. Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy. International journal of medical sciences. vol 18. issue 13. 2021-07-06. PMID:34220308. |
previous studies have shown that ivd cell apoptosis is mainly induced by the death receptor pathway, mitochondrial pathway, and endoplasmic reticulum stress (ers) pathway. |
2021-07-06 |
2023-08-13 |
Not clear |
| Xiao-Bo Zhang, Yi-Cun Hu, Peng Cheng, Hai-Yu Zhou, Xiang-Yi Chen, Ding Wu, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Jin-Tao Shi, Kai Zhang, Shao-Long Li, Peng-Jie Song, Ke-Ping Wan. Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy. International journal of medical sciences. vol 18. issue 13. 2021-07-06. PMID:34220308. |
preliminary animal and cell experiments show that targeting apoptotic pathway genes or drug inhibition can effectively inhibit ivd cell apoptosis and slow idd progression. |
2021-07-06 |
2023-08-13 |
Not clear |
| Sebastian Wangler, Amir Kamali, Christina Wapp, Karin Wuertz-Kozak, Sonja Häckel, Claudia Fortes, Lorin M Benneker, Lisbet Haglund, R Geoff Richards, Mauro Alini, Marianna Peroglio, Sibylle Gra. Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis. Stem cell research & therapy. vol 12. issue 1. 2021-07-05. PMID:33413584. |
in intervertebral disc (ivd) cells, application of msc secretome has been shown to decrease the apoptosis rate, induce proliferation, and promote production of extracellular matrix (ecm). |
2021-07-05 |
2023-08-13 |
Not clear |
| Jin-Woo Kim, Neunghan Jeon, Dong-Eun Shin, So-Young Lee, Myongwhan Kim, Dong Hun Han, Jae Yeon Shin, Soonchul Le. Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc. International journal of molecular sciences. vol 22. issue 10. 2021-07-02. PMID:34067899. |
hif-1α is essential for np development and homeostasis and is involved in various processes of ivd degeneration process, promotes ecm in np, maintains the metabolic activities of np, and regulates dystrophic mineralization of np, as well as angiogenesis, autophagy, and apoptosis during ivd degeneration. |
2021-07-02 |
2023-08-13 |
Not clear |
| Dongdong Xia, Meijun Yan, Xin Yin, Wenhao Hu, Chi Zhang, Baiwen Hu, Ting Ge, Xiaochuan Wu, Jin Xiao, Liang Gao, Junqi Liu, Jun Ta. A Novel Rat Tail Needle Minimally Invasive Puncture Model Using Three-Dimensional Printing for Disk Degeneration and Progressive Osteogenesis Research. Frontiers in cell and developmental biology. vol 9. 2021-06-22. PMID:34150742. |
tunel assay showed cellular apoptosis were stimulated in all puncture group, especially in group d. a progressive idd rat model could be standardly established by the micro-injury ivd puncture using a novel 3d printing device. |
2021-06-22 |
2023-08-13 |
rat |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Z-X Gao, Y-C Lin, Z-P Wu, P Zhang, Q-H Cheng, L-H Ye, F-H Wu, Y-J Chen, M-H Fu, C-G Cheng, Y-C Ga. LncRNA SNHG6 can regulate the proliferation and apoptosis of rat degenerate nucleus pulposus cells via regulating the expression of miR-101-3p. European review for medical and pharmacological sciences. vol 24. issue 16. 2021-05-04. PMID:32894531. |
intervertebral disc (ivd) degeneration (idd) is a well-known consequence of low back pain, as characterized by aberrant cell proliferation and apoptosis of nucleus pulposus (np) cells. |
2021-05-04 |
2023-08-13 |
rat |
| Rigao Chen, Fei Yang, Yong Wang, Xinling Wang, Xiaohong Fa. Pharmacological inhibition of mTORC1 activity protects against inflammation-induced apoptosis of nucleus pulposus cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 5. 2021-03-19. PMID:33729389. |
current studies establish that ivd degeneration is induced by increased apoptosis of nucleus pulposus (np) cells. |
2021-03-19 |
2023-08-13 |
Not clear |
| Hosni Cherif, Daniel G Bisson, Matthew Mannarino, Oded Rabau, Jean A Ouellet, Lisbet Haglun. Senotherapeutic drugs for human intervertebral disc degeneration and low back pain. eLife. vol 9. 2021-02-11. PMID:32821059. |
here, we found that rg-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent ivd cells through apoptosis. |
2021-02-11 |
2023-08-13 |
mouse |
| Estelle C Collin, Oliver Carroll, Michelle Kilcoyne, Marianna Peroglio, Eugene See, Doris Hendig, Mauro Alini, Sibylle Grad, Abhay Pandi. Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc. Signal transduction and targeted therapy. vol 2. 2021-02-02. PMID:29263929. |
the depletion of chondroitin sulfates (css) within the intervertebral disc (ivd) during degenerative disc disease (ddd) results in a decrease in tissue hydration, a loss of fluid movement, cell apoptosis, a loss of nerve growth inhibition and ultimately, the loss of disc function. |
2021-02-02 |
2023-08-13 |
cattle |
| Xinhua Li, Shuting Yang, Lin Han, Keya Mao, Shuying Yan. Ciliary IFT80 is essential for intervertebral disc development and maintenance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 5. 2021-01-22. PMID:32227389. |
mechanistic analyses showed that loss of ift80 caused a significant increase in cell apoptosis in the ivd, and a marked decrease in expression of chondrogenic markers - type ii collagen, sox9, aggrecan, and hedgehog (hh) signaling components, including gli1 and patch1 in the ivd of ift80 |
2021-01-22 |
2023-08-13 |
mouse |
| Takashi Ohnishi, Katsuhisa Yamada, Koji Iwasaki, Takeru Tsujimoto, Hideaki Higashi, Taichi Kimura, Norimasa Iwasaki, Hideki Sud. Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31852919. |
apoptosis may be important in ivd degeneration because suppressing cell apoptosis inside the ivd inhibits degeneration. |
2020-11-09 |
2023-08-13 |
mouse |
| Takashi Ohnishi, Katsuhisa Yamada, Koji Iwasaki, Takeru Tsujimoto, Hideaki Higashi, Taichi Kimura, Norimasa Iwasaki, Hideki Sud. Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31852919. |
apoptosis was suppressed in the ivd cells of casp-3 ko mice, but cellular senescence was enhanced. |
2020-11-09 |
2023-08-13 |
mouse |
| Zhiliang Li, Zengwu Shao, Songfeng Chen, Donghua Huang, Yizhong Peng, Sheng Chen, Kaige M. TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy. Journal of cellular physiology. vol 235. issue 2. 2020-10-16. PMID:31317559. |
to investigate whether tp53-induced glycolysis and apoptosis regulator (tigar) participates in compression-induced intervertebral disc (ivd) degeneration, and to determine the regulatory effect of tigar on nucleus pulposus (np) cell autophagy and apoptosis following compression-induced injuries. |
2020-10-16 |
2023-08-13 |
human |
| Xinghuo Wu, Yu Song, Wei Liu, Kun Wang, Yong Gao, Shuai Li, Zhenfeng Duan, Zengwu Shao, Shuhua Yang, Cao Yan. IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells. Cell death discovery. vol 3. 2020-10-01. PMID:28149534. |
the purpose of this study was to investigate the expression of iapp in degenerated ivd tissue, and iapp modulation of ecm metabolism in human np cells, especially the crosstalk mechanism between apoptosis and autophagy in these cells. |
2020-10-01 |
2023-08-13 |
human |
| Feng Wang, Li-Ping Nan, Shi-Feng Zhou, Yang Liu, Ze-Yu Wang, Jing-Cheng Wang, Xin-Min Feng, Liang Zhan. Injectable Hydrogel Combined with Nucleus Pulposus-Derived Mesenchymal Stem Cells for the Treatment of Degenerative Intervertebral Disc in Rats. Stem cells international. vol 2019. 2020-09-29. PMID:31737077. |
moreover, the hydrogel could support long-term npmsc survival and decrease cell apoptosis rate of the rat ivd. |
2020-09-29 |
2023-08-13 |
rat |
| Nathan Piazza, Mehdi Dehghani, Thomas R Gaborski, Karin Wuertz-Koza. Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32363187. |
msc-derived evs not only promote extracellular matrix synthesis and proliferation in ivd cells, but also reduce apoptosis and inflammation, hence having multifunctional beneficial effects that seem to be mediated by specific mirnas (such as mir-233 and mir-21) within the evs. |
2020-09-28 |
2023-08-13 |
Not clear |
| Feng Cai, Xin Hong, Xiang Tang, Nai-Cheng Liu, Feng Wang, Lei Zhu, Xin-Hui Xie, Zhi-Yang Xie, Xiao-Tao W. ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc. Bioscience reports. vol 39. issue 11. 2020-09-25. PMID:31696219. |
the aim of our study was to confirm whether asic1a activation induces bmsc apoptosis under conditions that mimic the acidic microenvironment of the degenerated ivd. |
2020-09-25 |
2023-08-13 |
Not clear |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
in mice, 3 days after ivd needle puncture injury, phlpp1 knockout (ko) promoted akt phosphorylation and cell proliferation, with less apoptosis. |
2020-08-20 |
2023-08-13 |
mouse |