| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hoon Huh, Yong-Jik Lee, Jung-Hee Kim, Min-Ho Kong, Kwan-Young Song, Gun Cho. The Effects of TWEAK, Fn14, and TGF-beta1 on Degeneration of Human Intervertebral Disc. Journal of Korean Neurosurgical Society. vol 47. issue 1. 2011-07-14. PMID:20157375. |
the purpose of this study is to explain the effect and reciprocal action among tumor necrosis factor (tnf) like weak inducer of apoptosis (tweak), fibroblast growth factor-inducible 14 (fn14), and transforming growth factor-beta1 (tgf-beta1) on degeneration of human intervertebral disc (ivd). |
2011-07-14 |
2023-08-12 |
human |
| Dunfu Han, Yue Ding, Shang-Li Liu, Gang Wang, In-Cheong Si, Xinguang Wang, Liyang Cui, Dongshang Huan. Double role of Fas ligand in the apoptosis of intervertebral disc cells in vitro. Acta biochimica et biophysica Sinica. vol 41. issue 11. 2010-01-13. PMID:19902128. |
interestingly, rna interference results indicated that the increase of fas expression and the np cell apoptosis described previously were inhibited by fas sirna, suggesting that rna interference might be one of novel strategies to prevent ivd cells from apoptosis. |
2010-01-13 |
2023-08-12 |
rat |
| Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Yohan Robinson, Wolfgang Ertel, Andreas Oberholzer, Christoph-E Heyd. Apoptosis of human intervertebral discs after trauma compares to degenerated discs involving both receptor-mediated and mitochondrial-dependent pathways. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 26. issue 7. 2008-07-08. PMID:18302283. |
intervertebral disc (ivd) cell apoptosis has been suggested to play a vital role in promoting the degeneration process. |
2008-07-08 |
2023-08-12 |
human |
| Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Yohan Robinson, Wolfgang Ertel, Andreas Oberholzer, Christoph-E Heyd. Apoptosis of human intervertebral discs after trauma compares to degenerated discs involving both receptor-mediated and mitochondrial-dependent pathways. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 26. issue 7. 2008-07-08. PMID:18302283. |
both traumatic and degenerative ivd demonstrated a significant increase of caspase-3/7 activity with evident apoptosis. |
2008-07-08 |
2023-08-12 |
human |
| Chang-Qing Zhao, Da Liu, Hai Li, Lei-Sheng Jiang, Li-Yang Da. Interleukin-1beta enhances the effect of serum deprivation on rat annular cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 12. 2008-01-30. PMID:17912642. |
excessive apoptosis of disc cells is believed to play an important role in intervertebral disc (ivd) degeneration. |
2008-01-30 |
2023-08-12 |
rat |
| Christoph-E Heyde, Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Wolfgang Ertel, Andreas Oberholze. Trauma induces apoptosis in human thoracolumbar intervertebral discs. BMC clinical pathology. vol 6. 2007-07-02. PMID:16719914. |
in this regard, apoptosis of ivd cells has been suggested to be involved in the critical changes of the extracellular matrix. |
2007-07-02 |
2023-08-12 |
human |
| François Rannou, Tzong-Shyuan Lee, Rui-Hai Zhou, Jennie Chin, Jeffrey C Lotz, Marie-Anne Mayoux-Benhamou, Jacques Patrick Barbet, Alain Chevrot, John Y-J Shy. Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. The American journal of pathology. vol 164. issue 3. 2004-03-31. PMID:14982845. |
the association of human ivd degeneration, assessed by magnetic resonance imaging, with annulus fibrosus cell apoptosis and anti-cytochrome c staining revealed that the activation of the mitochondria-dependent apoptosome was a major event in the degeneration process. |
2004-03-31 |
2023-08-12 |
mouse |
| François Rannou, Tzong-Shyuan Lee, Rui-Hai Zhou, Jennie Chin, Jeffrey C Lotz, Marie-Anne Mayoux-Benhamou, Jacques Patrick Barbet, Alain Chevrot, John Y-J Shy. Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. The American journal of pathology. vol 164. issue 3. 2004-03-31. PMID:14982845. |
the role of the caspase-9-dependent mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload was investigated further with the use of cultured rabbit ivd cells in a stretch device. |
2004-03-31 |
2023-08-12 |
mouse |
| Hea-Nam Hong, Seung-Yong Yoon, Juyoun Suh, Jong-Hwan Lee, DongHou Ki. Differential activation of caspase-3 at two maturational stages during okadaic acid-induced rat neuronal death. Neuroscience letters. vol 334. issue 1. 2003-01-17. PMID:12431776. |
we reported previously that oa induces neuronal apoptosis of immature neurons (in vitro days (ivd) 3-5), which is inhibited by cycloheximide (chx). |
2003-01-17 |
2023-08-12 |
rat |