| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sidong Yang, Feng Zhang, Jiangtao Ma, Wenyuan Din. Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. Ageing research reviews. vol 57. 2020-06-30. PMID:31669486. |
over the past few years, many researchers around the world have widely studied the relevance between oestrogen and ivdd, indicating that oestrogen can effectively alleviate ivdd development by inhibiting the apoptosis of ivd cells. |
2020-06-30 |
2023-08-13 |
Not clear |
| Sidong Yang, Feng Zhang, Jiangtao Ma, Wenyuan Din. Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. Ageing research reviews. vol 57. 2020-06-30. PMID:31669486. |
oestrogen can decrease ivd cell apoptosis in multiple ways, including the inhibition of the inflammatory cytokines il-1β and tnf-α, reducing catabolism because of inhibition of matrix metalloproteinases, upregulating integrin α |
2020-06-30 |
2023-08-13 |
Not clear |
| Rongjin Luo, Yu Song, Zhiwei Liao, Huipeng Yin, Shengfeng Zhan, Kun Wang, Shuai Li, Gaocai Li, Liang Ma, Saideng Lu, Yukun Zhang, Cao Yan. Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats. The FEBS journal. vol 286. issue 21. 2020-06-11. PMID:31230413. |
previous studies identified advanced glycation end products (ages) accumulation in the intervertebral disc (ivd) as an essential risk factor associated with ivd degeneration via accelerated cell apoptosis and impeded extracellular-matrix metabolism; however, the underlying mechanisms have not been fully elucidated. |
2020-06-11 |
2023-08-13 |
human |
| K Ma, S Chen, Z Li, X Deng, D Huang, L Xiong, Z Sha. Mechanisms of endogenous repair failure during intervertebral disc degeneration. Osteoarthritis and cartilage. vol 27. issue 1. 2020-03-16. PMID:30243946. |
although there have been few researches to study the mechanism of cell death and migration of stem/progenitor cells in ivd so far, studies demonstrated that the major inducing factors (compression and hypoxia) of ivd degeneration could decrease the number of np cells by regulating apoptosis, autophagy, and necroptosis, and the particular chemokines and their receptors played a vital role in the migration of mesenchymal stem cells (mscs). |
2020-03-16 |
2023-08-13 |
human |
| Xiangchao Meng, Lingling Zhuang, Jun Wang, Zhuochao Liu, You Wang, Dechang Xiao, Xingkai Zhan. Hypoxia-inducible factor (HIF)-1alpha knockout accelerates intervertebral disc degeneration in mice. International journal of clinical and experimental pathology. vol 11. issue 2. 2020-01-19. PMID:31938140. |
the abnormality of nucleus pulposus (np) plays a critical role in intervertebral disc (ivd) degeneration, in which np cells show apoptosis and fibrosis, leading to the ability of the disc to transfer and distribute loads between the vertebrae is decreased. |
2020-01-19 |
2023-08-13 |
mouse |
| Xiangchao Meng, Lingling Zhuang, Jun Wang, Zhuochao Liu, You Wang, Dechang Xiao, Xingkai Zhan. Hypoxia-inducible factor (HIF)-1alpha knockout accelerates intervertebral disc degeneration in mice. International journal of clinical and experimental pathology. vol 11. issue 2. 2020-01-19. PMID:31938140. |
considering that hypoxia inducible factor-1α (hif-1α) is abundantly expressed in np and that it mediates cell proliferation, migration and apoptosis in various cell types, we hypothesized that np-hif-1α plays an important role in np and evaluate whether np-hif-1α is involved in ivd degeneration. |
2020-01-19 |
2023-08-13 |
mouse |
| Minghui Yang, Chencheng Feng, Yang Zhang, Chang Liu, Bin Li, Qi Zhu, Bo Huang, Yue Zho. Autophagy protects nucleus pulposus cells from cyclic mechanical tension‑induced apoptosis. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173175. |
it has been demonstrated that apoptosis is important in the decrease of functional ivd cells, and that mechanical stress influences disc cell apoptosis. |
2019-12-23 |
2023-08-13 |
Not clear |
| Minghui Yang, Chencheng Feng, Yang Zhang, Chang Liu, Bin Li, Qi Zhu, Bo Huang, Yue Zho. Autophagy protects nucleus pulposus cells from cyclic mechanical tension‑induced apoptosis. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173175. |
recently, cyclic mechanical tension (cmt) has been shown to influence ivd cell apoptosis and autophagy. |
2019-12-23 |
2023-08-13 |
Not clear |
| Xinghuo Wu, Kun Wang, Wenbin Hua, Shuai Li, Xianzhe Liu, Yu Song, Yukun Zhang, Zengwu Shao, Suyun Li, Cao Yan. Fibronectin induced ITGβ1/FAK-dependent apoptotic pathways determines the fate of degenerative NP cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 37. issue 2. 2019-10-31. PMID:30370584. |
intervertebral disc (ivd) degeneration is caused by a decrease in nucleus pulposus (np) cells, due mainly to apoptosis. |
2019-10-31 |
2023-08-13 |
Not clear |
| Xing Yang, Lei Wang, Zhang-Qin Yuan, Ping-Hui Zhou, Geng-Lei Chu, Bin Li, Jun-Ying Su. Interleukin-1β induces apoptosis in annulus fibrosus cells through the extracellular signal-regulated kinase pathway. Connective tissue research. vol 59. issue 6. 2019-10-11. PMID:29457525. |
the loss of intervertebral disc (ivd) cells due to excessive apoptosis induced by inflammatory cytokines is a major cause of ivd degeneration. |
2019-10-11 |
2023-08-13 |
Not clear |
| Rongjin Luo, Zhiwei Liao, Yu Song, Huipeng Yin, Shengfeng Zhan, Gaocai Li, Liang Ma, Saideng Lu, Kun Wang, Shuai Li, Yukun Zhang, Cao Yan. Berberine ameliorates oxidative stress-induced apoptosis by modulating ER stress and autophagy in human nucleus pulposus cells. Life sciences. vol 228. 2019-06-24. PMID:31047897. |
nucleus pulposus (np) cell apoptosis induced by oxidative stress is known to be closely involved in the pathogenesis of intervertebral disc (ivd) degeneration. |
2019-06-24 |
2023-08-13 |
human |
| Liang Zhang, Yang Liu, Zenan Huang, Liping Nan, Feng Wang, Shifeng Zhou, Jingcheng Wang, Xinmin Fen. Toxicity Effects of Methylene Blue on Rat Intervertebral Disc Annulus Fibrosus Cells. Pain physician. vol 22. issue 2. 2019-05-14. PMID:30921981. |
mb could generate dna damage and induce apoptosis in different cell types; however, the effects of mb on intervertebral disc (ivd) annulus fibrosus (af) cells are not clearly understood. |
2019-05-14 |
2023-08-13 |
rat |
| Xiaofei Cheng, Guoying Zhang, Liang Zhang, Ying Hu, Kai Zhang, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zha. Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration. Journal of cellular and molecular medicine. vol 22. issue 1. 2019-02-08. PMID:28805297. |
although mesenchymal stem cells (mscs) transplantation into the ivd (intervertebral disc) may be beneficial in inhibiting apoptosis of nucleus pulposus cells (npcs) and alleviating ivd degeneration, the underlying mechanism of this therapeutic process has not been fully explained. |
2019-02-08 |
2023-08-13 |
rat |
| Xiaofei Cheng, Guoying Zhang, Liang Zhang, Ying Hu, Kai Zhang, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zha. Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration. Journal of cellular and molecular medicine. vol 22. issue 1. 2019-02-08. PMID:28805297. |
the purpose of this study was to explore the protective effect of msc-derived exosomes (msc-exosomes) on npc apoptosis and ivd degeneration and investigate the regulatory effect of mirnas in msc-exosomes and associated mechanisms for npc apoptosis. |
2019-02-08 |
2023-08-13 |
rat |
| Xiaofei Cheng, Guoying Zhang, Liang Zhang, Ying Hu, Kai Zhang, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zha. Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration. Journal of cellular and molecular medicine. vol 22. issue 1. 2019-02-08. PMID:28805297. |
intradiscal injection of msc-exosomes alleviated the npc apoptosis and ivd degeneration in the rat model. |
2019-02-08 |
2023-08-13 |
rat |
| Peng Ao, Wenzhou Huang, Jian Li, Tianlong Wu, Libiao Xu, Zhongbo Deng, Wenjie Chen, Changchang Yin, Xigao Chen. 17β-estradiol protects nucleus pulposus cells from serum deprivation-induced apoptosis and regulates expression of MMP-3 and MMP-13 through promotion of autophagy. Biochemical and biophysical research communications. vol 503. issue 2. 2018-12-17. PMID:29928874. |
serum deprivation is a likely contributor to intervertebral disc (ivd) degeneration (ivdd).17β-estradiol (e2) have been noted to protect nucleus pulposus cells (npcs) against apoptosis. |
2018-12-17 |
2023-08-13 |
Not clear |
| Peng Ao, Wenzhou Huang, Jian Li, Tianlong Wu, Libiao Xu, Zhongbo Deng, Wenjie Chen, Changchang Yin, Xigao Chen. 17β-estradiol protects nucleus pulposus cells from serum deprivation-induced apoptosis and regulates expression of MMP-3 and MMP-13 through promotion of autophagy. Biochemical and biophysical research communications. vol 503. issue 2. 2018-12-17. PMID:29928874. |
autophagy and apoptosis play a paramount role in maintaining the homeostasis of ivd. |
2018-12-17 |
2023-08-13 |
Not clear |
| Yu Song, Shuai Li, Wen Geng, Rongjin Luo, Wei Liu, Ji Tu, Kun Wang, Liang Kang, Huipeng Yin, Xinghuo Wu, Yong Gao, Yukun Zhang, Cao Yan. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox biology. vol 19. 2018-12-11. PMID:30216853. |
apoptosis in nucleus pulposus (np) can aggravate ivd degeneration, and increasing studies have shown that interventions targeting np cell apoptosis can ameliorate ivd degeneration, exhibiting their potential for use as therapeutic strategies. |
2018-12-11 |
2023-08-13 |
human |
| Yu Song, Shuai Li, Wen Geng, Rongjin Luo, Wei Liu, Ji Tu, Kun Wang, Liang Kang, Huipeng Yin, Xinghuo Wu, Yong Gao, Yukun Zhang, Cao Yan. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox biology. vol 19. 2018-12-11. PMID:30216853. |
this study examined whether ages accumulation aggravates np cell apoptosis and ivd degeneration, and explored the mechanisms underlying these effects. |
2018-12-11 |
2023-08-13 |
human |
| Yu Song, Shuai Li, Wen Geng, Rongjin Luo, Wei Liu, Ji Tu, Kun Wang, Liang Kang, Huipeng Yin, Xinghuo Wu, Yong Gao, Yukun Zhang, Cao Yan. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox biology. vol 19. 2018-12-11. PMID:30216853. |
finally, based on findings that nicotinamide mononucleotide (nmn) could restore sirt3 function and rescue human np cell apoptosis through adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor-γ coactivator 1α (ampk-pgc-1α) pathway in vitro, we confirmed its protective effect on ages-induced ivd degeneration in vivo. |
2018-12-11 |
2023-08-13 |
human |