| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Li, Jiale He, Guangzhi Zhang, Haiwei Chen, Zhangbin Luo, Bo Deng, Yuan Zhou, Xuewen Kan. Role of Caspase Family in Intervertebral Disc Degeneration and Its Therapeutic Prospects. Biomolecules. vol 12. issue 8. 2022-08-26. PMID:36008968. |
with continuous research on the pathogenesis and pathological process of ivdd, an increasing number of studies have shown that caspases are closely related to the ivdd process, especially in the intervertebral disc (ivd) cell apoptosis and inflammatory response. |
2022-08-26 |
2023-08-14 |
Not clear |
| Yi-Cun Hu, Xiao-Bo Zhang, Mao-Qiang Lin, Hai-Yu Zhou, Meng-Xue Cong, Xiang-Yi Chen, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Tao-Wen Gu. Nanoscale treatment of intervertebral disc deneration: mesenchymal stem cell exosome transplantation. Current stem cell research & therapy. 2022-04-25. PMID:35466881. |
reducing inflammation and apoptosis can significantly promote ivd regeneration to facilitate repair of the ivd. |
2022-04-25 |
2023-08-13 |
Not clear |
| Maite Esquijarosa Hechavarria, Seidu A Richar. Edifying the Focal Factors Influencing Mesenchymal Stem Cells by the Microenvironment of Intervertebral Disc Degeneration in Low Back Pain. Pain research & management. vol 2022. 2022-04-07. PMID:35386857. |
ivd microenvironment clues such as nucleopulpocytes, potential of hydrogen (ph), osmotic changes, glucose, hypoxia, apoptosis, pyroptosis, and hydrogels are capable of influencing the mscs aimed for the treatment of ivdd. |
2022-04-07 |
2023-08-13 |
Not clear |
| Xiaofei Feng, Yongchao Li, Qihang Su, Jun Ta. Degenerative Nucleus Pulposus Cells Derived Exosomes Promoted Cartilage Endplate Cells Apoptosis and Aggravated Intervertebral Disc Degeneration. Frontiers in molecular biosciences. vol 9. 2022-04-01. PMID:35359595. |
the purpose of this study was to explore whether degenerative np cells-derived exosomes promoted cep cells apoptosis and aggravated ivd degeneration. |
2022-04-01 |
2023-08-13 |
rat |
| Xiaofei Feng, Yongchao Li, Qihang Su, Jun Ta. Degenerative Nucleus Pulposus Cells Derived Exosomes Promoted Cartilage Endplate Cells Apoptosis and Aggravated Intervertebral Disc Degeneration. Frontiers in molecular biosciences. vol 9. 2022-04-01. PMID:35359595. |
tnfα-npc-exo aggravates ivd degeneration in a rat model and promoted cepc apoptosis. |
2022-04-01 |
2023-08-13 |
rat |
| Jun-Wu Wang, Lei Zhu, Peng-Zhi Shi, Ping-Chuan Wang, Yan Dai, Yong-Xiang Wang, Xu-Hua Lu, Xiao-Fei Cheng, Xin-Min Feng, Liang Zhan. 1,25(OH) Oxidative medicine and cellular longevity. vol 2022. 2022-03-28. PMID:35340208. |
the local environment of the degenerated intervertebral disc (ivd) increases oxidative stress and apoptosis of endogenous nucleus pulposus-derived mesenchymal stem cells (npmscs) and weakens its ability of endogenous repair ability in degenerated ivds. |
2022-03-28 |
2023-08-13 |
Not clear |
| Karim Hemati, Mohammad Hossein Pourhanifeh, Iman Fatemi, Azam Hosseinzadeh, Saeed Mehrzad. Anti-degenerative effect of melatonin on intervertebral disc: protective contribution against inflammation, oxidative stress, apoptosis, and autophagy. Current drug targets. 2022-01-17. PMID:35034592. |
although the etiology of ivd degeneration (ivdd) is unclear, excessive oxidative stress, inflammation and apoptosis and disruption of autophagy play important role in the pathogenesis of ivdd. |
2022-01-17 |
2023-08-13 |
Not clear |
| Karim Hemati, Mohammad Hossein Pourhanifeh, Iman Fatemi, Azam Hosseinzadeh, Saeed Mehrzad. Anti-degenerative effect of melatonin on intervertebral disc: protective contribution against inflammation, oxidative stress, apoptosis, and autophagy. Current drug targets. 2022-01-17. PMID:35034592. |
these protective effects may be mediated by the inhibition of oxidative stress, inflammation and apoptosis, and regulation of autophagy in ivd cells. |
2022-01-17 |
2023-08-13 |
Not clear |
| Zhenyu Wang, Shaokun Zhang, Yuguang Zhao, Zhigang Qu, Xinming Zhuang, Qingxu Song, Jiali Leng, Yi Li. MicroRNA-140-3p alleviates intervertebral disc degeneration RNA biology. vol 18. issue 12. 2021-12-03. PMID:33904383. |
mesenchymal stem cells (mscs) were extracted from degenerated ivd nucleus pulposus (np), and the expression of mir-140-3p/klf5/n-cadherin/mdm2/slug was manipulated to explore their effects on cell proliferation, migration, apoptosis and differentiation. |
2021-12-03 |
2023-08-13 |
Not clear |
| Zhenyu Wang, Shaokun Zhang, Yuguang Zhao, Zhigang Qu, Xinming Zhuang, Qingxu Song, Jiali Leng, Yi Li. MicroRNA-140-3p alleviates intervertebral disc degeneration RNA biology. vol 18. issue 12. 2021-12-03. PMID:33904383. |
the experimental data indicated that mir-140-3p enhanced the proliferation, migration and differentiation of degenerated ivd np-derived mscs and repressed their apoptosis. |
2021-12-03 |
2023-08-13 |
Not clear |
| Wen-Cheng Lo, Chi-Sheng Chiou, Feng-Chou Tsai, Chun-Hao Chan, Samantha Mao, Yue-Hua Deng, Chia-Yu Wu, Bou-Yue Peng, Win-Ping Den. Platelet-Derived Biomaterials Inhibit Nicotine-Induced Intervertebral Disc Degeneration Through Regulating IGF-1/AKT/IRS-1 Signaling Axis. Cell transplantation. vol 30. 2021-11-17. PMID:34586895. |
since nicotine has been demonstrated to adversely impact various physiological processes, such as sympathetic nervous system, leading to impaired vasculature and cellular apoptosis, we aimed to investigate whether nicotine could induce ivd degeneration. |
2021-11-17 |
2023-08-13 |
mouse |
| Ruihong Wang, Dawei Luo, Zhiwei Li, Huimin Ha. Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2/HO-1 Pathway in Intervertebral Disc Degeneration. Computational and mathematical methods in medicine. vol 2021. 2021-11-12. PMID:34754326. |
oxidative stress, inflammation, and nucleus pulposus cells (npcs) apoptosis are involved in pathogenesis of intervertebral disc (ivd) degeneration (ivdd). |
2021-11-12 |
2023-08-13 |
Not clear |
| Zuo-Long Wu, Qi-Qi Xie, Tai-Cong Liu, Xing Yang, Guang-Zhi Zhang, Hai-Hong Zhan. Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs. Pathology, research and practice. vol 220. 2021-11-09. PMID:33647863. |
however, the activation of the wnt pathway after birth promotes ivd cell senescence, apoptosis, and degradation of the extracellular matrix and induces the production of inflammatory factors, thereby accelerating the ivdd process. |
2021-11-09 |
2023-08-13 |
Not clear |
| Yiqiang Hu, Ranyang Tao, Linfang Wang, Lang Chen, Ze Lin, Adriana C Panayi, Hang Xue, Hui Li, Liming Xiong, Guohui Li. Exosomes Derived from Bone Mesenchymal Stem Cells Alleviate Compression-Induced Nucleus Pulposus Cell Apoptosis by Inhibiting Oxidative Stress. Oxidative medicine and cellular longevity. vol 2021. 2021-11-05. PMID:34733401. |
oxidative stress is relevant in compression-induced nucleus pulposus (np) cell apoptosis and intervertebral disc (ivd) degeneration. |
2021-11-05 |
2023-08-13 |
Not clear |
| Yiqiang Hu, Ranyang Tao, Linfang Wang, Lang Chen, Ze Lin, Adriana C Panayi, Hang Xue, Hui Li, Liming Xiong, Guohui Li. Exosomes Derived from Bone Mesenchymal Stem Cells Alleviate Compression-Induced Nucleus Pulposus Cell Apoptosis by Inhibiting Oxidative Stress. Oxidative medicine and cellular longevity. vol 2021. 2021-11-05. PMID:34733401. |
these results indicate that bmscs-exos alleviate compression-mediated np apoptosis by suppressing oxidative stress, which may provide a promising cell-free therapy for treating ivd degeneration. |
2021-11-05 |
2023-08-13 |
Not clear |
| Hai-Jun Zhang, Hai-Yang Liao, Deng-Yan Bai, Zhi-Qiang Wang, Xing-Wen Xi. MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 143. 2021-10-13. PMID:34536759. |
furthermore, the mitogen-activated protein kinase (mapk)/extracellular signal-regulated kinase (erk) signaling pathway is closely related to various pathological processes in idd, and the activation of the mapk/erk pathway promotes the degradation of the ivd extracellular matrix, cell aging, apoptosis, and inflammatory responses. |
2021-10-13 |
2023-08-13 |
Not clear |
| Fangda Fu, Ronghua Bao, Sai Yao, Chengcong Zhou, Huan Luo, Zhiguo Zhang, Huihao Zhang, Yan Li, Shuxin Yan, Huan Yu, Weibin Du, Yanping Yang, Hongting Jin, Peijian Tong, Zhi-Tao Sun, Ming Yue, Di Chen, Chengliang Wu, Hongfeng Rua. Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth. Scientific reports. vol 11. issue 1. 2021-08-25. PMID:33437038. |
the apoptosis of ivd cells was tested by tunel assay. |
2021-08-25 |
2023-08-13 |
mouse |
| Fangda Fu, Ronghua Bao, Sai Yao, Chengcong Zhou, Huan Luo, Zhiguo Zhang, Huihao Zhang, Yan Li, Shuxin Yan, Huan Yu, Weibin Du, Yanping Yang, Hongting Jin, Peijian Tong, Zhi-Tao Sun, Ming Yue, Di Chen, Chengliang Wu, Hongfeng Rua. Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth. Scientific reports. vol 11. issue 1. 2021-08-25. PMID:33437038. |
lsi administration led to the histologic change of disc degeneration, disruption of the matrix metabolism, promotion of apoptosis of ivd cells and invasion of sensory nerves into annulus fibrosus, as well as induction of pyroptosis. |
2021-08-25 |
2023-08-13 |
mouse |
| Tyler J DiStefano, Keti Vaso, George Danias, Henry N Chionuma, Jennifer R Weiser, James C Iatridi. Extracellular Vesicles as an Emerging Treatment Option for Intervertebral Disc Degeneration: Therapeutic Potential, Translational Pathways, and Regulatory Considerations. Advanced healthcare materials. 2021-07-23. PMID:34297485. |
emergent approaches in regenerative medicine look toward the use of extracellular vesicles (evs) as a next-generation treatment strategy for intervertebral disc (ivd) degeneration (ivdd) because of their ability to attenuate chronic inflammation, reduce apoptosis, and stimulate proliferation in a number of tissue systems. |
2021-07-23 |
2023-08-13 |
Not clear |
| Daliang Kong, Rui Gu, Chengtao Zhang, Ruofeng Yi. Knockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting Drug design, development and therapy. vol 14. 2021-07-15. PMID:33061300. |
knockdown of hsa_circ_0059955 induces apoptosis and cell cycle arrest in nucleus pulposus cells via inhibiting circular rnas (circrnas) play an important role in the progression of intervertebral disc (ivd) degeneration (ivdd). |
2021-07-15 |
2023-08-13 |
Not clear |