| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze-Hong Liu, Di-Long Chen, Rong Jiang, Yi Chen, Wei Xiong, Fen Wang, Xue-Ping Shi, Hai-Xing Li, Jing L. [Ginsenoside Rh₂-induced inhibition of histone deacetylase 6 promotes K562 cells autophagy and apoptosis in vivo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 4. 2018-07-05. PMID:28871696. |
therefore, ginsenoside rh₂ had good anti-tumor effect in vivo, and the mechanism maybe associated with regulating autophagy and apoptosis through hdac6 and hsp90 pathways and inhibiting the in vivo proliferation of tumor cells. |
2018-07-05 |
2023-08-13 |
human |
| Chien-Yi Lu, Yi-Chih Chang, Chun-Hung Hua, Chieh Chuang, Su-Hua Huang, Szu-Hao Kung, Mann-Jen Hour, Cheng-Wen Li. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. International journal of molecular sciences. vol 18. issue 5. 2018-02-02. PMID:28468311. |
among hdac inhibitors, selective hdac6 inhibitors (tubastatin-a (tbsa) and tubacin) concentration-dependently inhibited jev-induced cytopathic effect and apoptosis, as well as reduced virus yield in human cerebellar medulloblastoma cells. |
2018-02-02 |
2023-08-13 |
human |
| Zong-Yang Li, Qing-Zhong Li, Lei Chen, Bao-Dong Chen, Ce Zhang, Xiang Wang, Wei-Ping L. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27522966. |
hpob, an hdac6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma pc12 cells by inhibiting mitochondrial gr translocation and the intrinsic apoptosis pathway. |
2018-01-03 |
2023-08-13 |
rat |
| Zong-Yang Li, Qing-Zhong Li, Lei Chen, Bao-Dong Chen, Ce Zhang, Xiang Wang, Wei-Ping L. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27522966. |
our previous study showed that hdac6 might be a potential target to regulate gc-induced glucocorticoid receptor (gr) translocation to the mitochondria and subsequent apoptosis. |
2018-01-03 |
2023-08-13 |
rat |
| Zong-Yang Li, Qing-Zhong Li, Lei Chen, Bao-Dong Chen, Ce Zhang, Xiang Wang, Wei-Ping L. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27522966. |
in the present study, we investigated the effect of hpob, a selective hdac6 inhibitor, on corticosterone (cort)-induced apoptosis and explored the possible mechanism of action of hpob in rat adrenal pheochromocytoma (pc12) cells, which possesses typical neuron features and expresses high levels of glucocorticoid receptors. |
2018-01-03 |
2023-08-13 |
rat |
| Zong-Yang Li, Qing-Zhong Li, Lei Chen, Bao-Dong Chen, Ce Zhang, Xiang Wang, Wei-Ping L. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27522966. |
considering all of these findings, the neuroprotective effect of hpob demonstrated the crucial role of hdac6 inhibition in reducing cort-induced apoptosis in pc12 cells. |
2018-01-03 |
2023-08-13 |
rat |
| Song-Yi Park, Sophors Phorl, Suna Jung, Korm Sovannarith, Se-In Lee, Solhee Noh, Miae Han, Rema Naskar, Jae-Young Kim, Yun-Jaie Choi, Joo-Yong Le. HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation. Biochemical and biophysical research communications. vol 494. issue 1-2. 2017-11-13. PMID:29054408. |
hdac6 deficiency induces apoptosis in mesenchymal stem cells through p53 k120 acetylation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Song-Yi Park, Sophors Phorl, Suna Jung, Korm Sovannarith, Se-In Lee, Solhee Noh, Miae Han, Rema Naskar, Jae-Young Kim, Yun-Jaie Choi, Joo-Yong Le. HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation. Biochemical and biophysical research communications. vol 494. issue 1-2. 2017-11-13. PMID:29054408. |
deletion of hdac6 induces caspase-dependent apoptosis by promoting transactivation of bax and suppression of bcl-2. |
2017-11-13 |
2023-08-13 |
Not clear |
| Lucia Altucc. A key HDAC6 dependency of ARID1A-mutated ovarian cancer. Nature cell biology. vol 19. issue 8. 2017-10-26. PMID:28752851. |
hdac6 inhibition selectively promotes apoptosis of arid1a-inactivated cells, supporting the use of hdac6 inhibition in the treatment of clear cell ovarian cancer. |
2017-10-26 |
2023-08-13 |
Not clear |
| Benjamin G Bitler, Shuai Wu, Pyoung Hwa Park, Yang Hai, Katherine M Aird, Yemin Wang, Yali Zhai, Andrew V Kossenkov, Ana Vara-Ailor, Frank J Rauscher, Weiping Zou, David W Speicher, David G Huntsman, Jose R Conejo-Garcia, Kathleen R Cho, David W Christianson, Rugang Zhan. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nature cell biology. vol 19. issue 8. 2017-09-21. PMID:28737768. |
hdac6 inhibition selectively promoted apoptosis of arid1a-mutated cells. |
2017-09-21 |
2023-08-13 |
mouse |
| Zong-Yang Li, Ce Zhang, Yuan Zhang, Lei Chen, Bao-Dong Chen, Qing-Zhong Li, Xie-Jun Zhang, Wei-Ping L. A novel HDAC6 inhibitor Tubastatin A: Controls HDAC6-p97/VCP-mediated ubiquitination-autophagy turnover and reverses Temozolomide-induced ER stress-tolerance in GBM cells. Cancer letters. vol 391. 2017-09-05. PMID:28131906. |
moreover, the combination treatment of tubastatin a (tub, a selective inhibitor of hdac6) and tmz synergistically overcame erst, reduced cell viability and induced apoptosis in tmz-resistant glioma cells. |
2017-09-05 |
2023-08-13 |
Not clear |
| Hyun-Wook Ryu, Dong-Hee Shin, Dong Hoon Lee, Junjeong Choi, Gyoonhee Han, Kang Young Lee, So Hee Kwo. HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis. Cancer letters. vol 391. 2017-09-05. PMID:28153791. |
hdac6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis. |
2017-09-05 |
2023-08-13 |
Not clear |
| Brian J North, Ingrid Almeciga-Pinto, David Tamang, Min Yang, Simon S Jones, Steven N Quayl. Enhancement of pomalidomide anti-tumor response with ACY-241, a selective HDAC6 inhibitor. PloS one. vol 12. issue 3. 2017-08-25. PMID:28264055. |
here, the second generation selective hdac6 inhibitor citarinostat (acy-241), with a more favorable safety profile than non-selective pan-hdac inhibitors, is shown to synergize with pomalidomide in in vitro assays through promoting greater apoptosis and cell cycle arrest. |
2017-08-25 |
2023-08-13 |
Not clear |
| Zhihao Wang, Pengchao Hu, Fang Tang, Haiwei Lian, Xiong Chen, Yingying Zhang, Xiaohua He, Wanhong Liu, Conghua Xi. HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27267806. |
hdac6 overexpression confers resistance to temozolomide (tmz) mediated cell proliferation inhibition and apoptosis induction. |
2017-07-26 |
2023-08-13 |
Not clear |
| Zhihao Wang, Pengchao Hu, Fang Tang, Haiwei Lian, Xiong Chen, Yingying Zhang, Xiaohua He, Wanhong Liu, Conghua Xi. HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27267806. |
the inhibition of hdac6 deacetylase activity by selective inhibitors inhibits the proliferation of glioblastoma cells and induces apoptosis. |
2017-07-26 |
2023-08-13 |
Not clear |
| Insoon Chang, Cun-Yu Wan. Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. The Journal of biological chemistry. vol 291. issue 35. 2017-05-12. PMID:27369083. |
inhibition of hdac6 protein enhances bortezomib-induced apoptosis in head and neck squamous cell carcinoma (hnscc) by reducing autophagy. |
2017-05-12 |
2023-08-13 |
Not clear |
| Insoon Chang, Cun-Yu Wan. Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. The Journal of biological chemistry. vol 291. issue 35. 2017-05-12. PMID:27369083. |
similarly, a combination regimen of bortezomib and the histone deacetylase inhibitor trichostatin a abolished hdac6 activity and decreased autophagy induction while significantly enhancing bortezomib-induced apoptosis in hnscc cells. |
2017-05-12 |
2023-08-13 |
Not clear |
| Insoon Chang, Cun-Yu Wan. Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. The Journal of biological chemistry. vol 291. issue 35. 2017-05-12. PMID:27369083. |
these data uncover a novel molecular mechanism indicating that hdac6 may serve as a critical causal link between autophagy, apoptosis, and the cell survival response in hnscc. |
2017-05-12 |
2023-08-13 |
Not clear |
| Ueihuei Peng, Zhihao Wang, Sa Pei, Yunchao Ou, Pengchao Hu, Wanhong Liu, Jiquan Son. ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:28035401. |
acy-1215, a selective hdac6 inhibitor, inhibits the proliferation and induces the apoptosis of a375 cells. |
2017-03-23 |
2023-08-13 |
Not clear |
| Zhihao Wang, Fang Tang, Pengchao Hu, Ying Wang, Jun Gong, Shaoxing Sun, Conghua Xi. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncology reports. vol 36. issue 1. 2017-03-03. PMID:27221381. |
the inhibition of hdac6 by cay10603, a potent and selective inhibitor of hdac6, inhibited the proliferation of lung adenocarcinoma cells and induced apoptosis. |
2017-03-03 |
2023-08-13 |
Not clear |