| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumeet Kaur, Prerna Rajoria, Madhu Chopr. HDAC6: A unique HDAC family member as a cancer target. Cellular oncology (Dordrecht). 2022-08-29. PMID:36036883. |
hdac6, a structurally and functionally distinct member of the hdac family, is an integral part of multiple cellular functions such as cell proliferation, apoptosis, senescence, dna damage and genomic stability, all of which when deregulated contribute to carcinogenesis. |
2022-08-29 |
2023-08-14 |
mouse |
| Xuefeng Pang, Qigang Guan, Xue Lin, Ning Chan. Knockdown of HDAC6 alleviates ventricular remodeling in experimental dilated cardiomyopathy via inhibition of NLRP3 inflammasome activation and promotion of cardiomyocyte autophagy. Cell biology and toxicology. 2022-06-28. PMID:35764897. |
besides, in dox-injured cardiomyocytes, hdac6 silencing also diminished nlrp3 inflammasome activation and cell apoptosis but enhanced cell autophagy, whereas ectopic nlrp3 expression negated the effects of hdac6 silencing. |
2022-06-28 |
2023-08-14 |
rat |
| Xuefeng Pang, Qigang Guan, Xue Lin, Ning Chan. Knockdown of HDAC6 alleviates ventricular remodeling in experimental dilated cardiomyopathy via inhibition of NLRP3 inflammasome activation and promotion of cardiomyocyte autophagy. Cell biology and toxicology. 2022-06-28. PMID:35764897. |
silencing hdac6 promoted autophagy and repressed apoptosis in cardiomyocytes. |
2022-06-28 |
2023-08-14 |
rat |
| Marcela Oliveira Tavares, Thaís Moré Milan, Rayana Longo Bighetti-Trevisan, Andréia Machado Leopoldino, Luciana Oliveira de Almeid. Pharmacological inhibition of HDAC6 overcomes cisplatin chemoresistance by targeting cancer stem cells in OSCC. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2022-06-09. PMID:35678235. |
apoptosis and csc accumulation were investigated by flow cytometry results: we identified the accumulation of hdac6 in cisr cell lines and csc. |
2022-06-09 |
2023-08-14 |
Not clear |
| Marcela Oliveira Tavares, Thaís Moré Milan, Rayana Longo Bighetti-Trevisan, Andréia Machado Leopoldino, Luciana Oliveira de Almeid. Pharmacological inhibition of HDAC6 overcomes cisplatin chemoresistance by targeting cancer stem cells in OSCC. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2022-06-09. PMID:35678235. |
tubastatin a as a monotherapy induced apoptosis in cisr and csc and reduced the stemness phenotype conclusion: high levels of hdac6 sustain csc subpopulation and chemoresistance in oscc, suggesting hdac6 as a pharmacological target to overcome resistance and perhaps prevent recurrence in oscc. |
2022-06-09 |
2023-08-14 |
Not clear |
| Miao Wang, Chao Zhou, Lu Yu, Delian Kong, Weijing Ma, Bingchen Lv, Yan Wang, Weifeng Wu, Mingyue Zhou, Guiyun Cu. Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage. Cellular and molecular life sciences : CMLS. vol 79. issue 7. 2022-06-09. PMID:35678904. |
upregulation of mdh1 acetylation by hdac6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage. |
2022-06-09 |
2023-08-14 |
mouse |
| Jun Sun, Xia Qian, Feifei Zhang, Xiaofeng Tang, Cheng Ju, Renfeng Liu, Ruihao Zhou, Zhiping Zhang, Xiao-Bin Lv, Changhua Zhang, Guofu Huan. HDAC6 inhibitor WT161 induces apoptosis in retinoblastoma cells and synergistically interacts with cisplatin. Translational cancer research. vol 8. issue 8. 2022-02-04. PMID:35117033. |
hdac6 inhibitor wt161 induces apoptosis in retinoblastoma cells and synergistically interacts with cisplatin. |
2022-02-04 |
2023-08-13 |
Not clear |
| Julia K Varga, Kelsey Diffley, Katherine R Welker Leng, Carol A Fierke, Ora Schueler-Furma. Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates. Scientific reports. vol 12. issue 1. 2022-02-03. PMID:35110592. |
in particular, hdac6 is involved in multiple cellular processes such as apoptosis, cytoskeleton reorganization, and protein folding, affecting substrates such as ɑ-tubulin, hsp90 and cortactin proteins. |
2022-02-03 |
2023-08-13 |
Not clear |
| Seong-Jun Park, Sang Hoon Joo, Naeun Lee, Won-Jun Jang, Ji Hae Seo, Chul-Ho Jeon. ACY-241, an HDAC6 inhibitor, overcomes erlotinib resistance in human pancreatic cancer cells by inducing autophagy. Archives of pharmacal research. 2021-11-11. PMID:34761352. |
histone deacetylase 6 (hdac6) is a promising target for cancer treatment because it regulates cell mobility, protein trafficking, cell growth, apoptosis, and metastasis. |
2021-11-11 |
2023-08-13 |
human |
| S V Demyanenko, V A Dzreyan, A B Uzdensk. Overexpression of HDAC6, but not HDAC3 and HDAC4 in the penumbra after photothrombotic stroke in the rat cerebral cortex and the neuroprotective effects of α-phenyl tropolone, HPOB, and sodium valproate. Brain research bulletin. vol 162. 2021-09-29. PMID:32592806. |
hdac6 inhibitor hpob, hdac2/8 inhibitor α-phenyl tropolone, and non-specific histone deacetylase inhibitor sodium valproate, but not hdac3 inhibitor brd3308, or hdac4 inhibitor lmk235, decreased pts-induced infarction volume in the mouse brain, reduced apoptosis, and recovered the motor behavior. |
2021-09-29 |
2023-08-13 |
mouse |
| Ying Shao, Feibin Zhu, Shuping Zhu, Li Ba. HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation. The international journal of biochemistry & cell biology. vol 136. 2021-09-27. PMID:33933678. |
downregulation of hdac6 reduced proliferation, migration, invasion, and resistance to apoptosis of hpv-positive cc cells. |
2021-09-27 |
2023-08-13 |
mouse |
| Ping Liu, Ji Xiao, Yiliang Wang, Xiaowei Song, Lianzhou Huang, Zhe Ren, Kaio Kitazato, Yifei Wan. Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-09-23. PMID:34530730. |
the mutual interaction between hdac6 and hsp90 plays an important role in the regulation of protein stability, cell migration, apoptosis and other functions. |
2021-09-23 |
2023-08-13 |
Not clear |
| Hélène Losson, Sruthi Reddy Gajulapalli, Manon Lernoux, Jin-Young Lee, Aloran Mazumder, Déborah Gérard, Carole Seidel, Hyunggu Hahn, Christo Christov, Mario Dicato, Gilbert Kirsch, Byung Woo Han, Michael Schnekenburger, Marc Diederic. The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia. Pharmacological research. vol 160. 2021-08-16. PMID:32619722. |
the hdac6 inhibitor 7b induces bcr-abl ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yi Ruan, Luoluo Wang, Yeting L. HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin. Drug development research. vol 82. issue 4. 2021-06-07. PMID:33428788. |
hdac6 inhibitor, acy1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin. |
2021-06-07 |
2023-08-13 |
Not clear |
| Yi Ruan, Luoluo Wang, Yeting L. HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin. Drug development research. vol 82. issue 4. 2021-06-07. PMID:33428788. |
whether the expression of hdac6 and its new inhibitor acy1215 can inhibit the proliferation of gallbladder cancer cells and induce their apoptosis remains to be further studied. |
2021-06-07 |
2023-08-13 |
Not clear |
| Yi Ruan, Luoluo Wang, Yeting L. HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin. Drug development research. vol 82. issue 4. 2021-06-07. PMID:33428788. |
the hdac6 inhibitor acy1215 suppressed the proliferation of gbc-sd and sdc-996 cells and promoted the apoptosis of gallbladder cancer cells. |
2021-06-07 |
2023-08-13 |
Not clear |
| Yi Ruan, Luoluo Wang, Yeting L. HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin. Drug development research. vol 82. issue 4. 2021-06-07. PMID:33428788. |
acy1215 could suppress cell proliferation and induce apoptosis of gbc-sd and sgc-996, and increased the chemotherapy effect of gemcitabine and oxaliplatin, which provides a rationale for the combination of hdac6 selective inhibitors with other anticancer agents in treating gallbladder cancer. |
2021-06-07 |
2023-08-13 |
Not clear |
| Tiantian Liang, Chunfang Qi, Yuxiong Lai, Jianteng Xie, Huizhen Wang, Li Zhang, Ting Lin, Menglei Jv, Jing Li, Yanhui Wang, Yifan Zhang, Zujiao Chen, Xueqian Qiu, Ruizhao Li, Zhilian Li, Zhiming Ye, Shuangxin Liu, Xinling Liang, Wei Shi, Wenjian Wan. HDAC6-mediated α-tubulin deacetylation suppresses autophagy and enhances motility of podocytes in diabetic nephropathy. Journal of cellular and molecular medicine. vol 24. issue 19. 2021-05-06. PMID:32885602. |
notably, overexpressing hdac6 inhibited autophagy and promoted motility aside from the apoptosis of podocytes exposed to age. |
2021-05-06 |
2023-08-13 |
mouse |
| Mona Dawood, Mohamed Elbadawi, Madeleine Böckers, Gerhard Bringmann, Thomas Effert. Molecular docking-based virtual drug screening revealing an oxofluorenyl benzamide and a bromonaphthalene sulfonamido hydroxybenzoic acid as HDAC6 inhibitors with cytotoxicity against leukemia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-03-01. PMID:32768947. |
in conclusion, we demonstrate for the first time that these two compounds bind to hdac6, inhibit its function, and exert cytotoxic activity by apoptosis induction. |
2021-03-01 |
2023-08-13 |
Not clear |
| Mona Dawood, Mohamed-Elamir F Hegazy, Mohamed Elbadawi, Edmond Fleischer, Anette Klinger, Gerhard Bringmann, Claudia Kuntner, Letian Shan, Thomas Effert. Vitamin K Biochemical pharmacology. vol 180. 2020-12-31. PMID:32721508. |
particularly, hdac6 has become a promising anti-cancer drug target because of its regulation of cell mobility, protein trafficking, degradation of misfolded proteins, cell growth, apoptosis, and metastasis. |
2020-12-31 |
2023-08-13 |
Not clear |