| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy D Osko, David W Christianso. Methods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes. Methods in enzymology. vol 626. 2020-06-02. PMID:31606087. |
for example, hdac6 is the cytosolic tubulin deacetylase and its inhibition compromises microtubule dynamics, leading to cancer cell cycle arrest and apoptosis. |
2020-06-02 |
2023-08-13 |
human |
| Panpan Chang, Umar F Bhatti, Aaron M Williams, Isabel S Dennahy, Baoling Liu, Yongqing Li, Hasan B Ala. Inhibition of histone deacetylase 6 attenuates intestinal inflammation and apoptosis in a rodent model of hemorrhagic shock. The journal of trauma and acute care surgery. vol 86. issue 5. 2020-06-01. PMID:30562325. |
in this study, we sought to determine whether hdac6 inhibition by acy1083 can attenuate intestinal inflammation and apoptosis in rats subjected to hs. |
2020-06-01 |
2023-08-13 |
rat |
| Tanveer Sharif, Emma Martell, Cathleen Dai, Mohammad Saleh Ghassemi-Rad, Mark Robert Hanes, Patrick J Murphy, Nandini N Margam, Hirendrasinh B Parmar, Carman A Giacomantonio, Roy Duncan, Patrick W K Lee, Shashi Guja. HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. Autophagy. vol 15. issue 4. 2020-05-11. PMID:30444165. |
in contrast to the results observed in cscs, hdac6 kd in differentiated breast cancer cells downregulates autophagy and increases apoptosis. |
2020-05-11 |
2023-08-13 |
human |
| Dusan Ruzic, Milos Petkovic, Danica Agbaba, A Ganesan, Katarina Nikoli. Combined Ligand and Fragment-based Drug Design of Selective Histone Deacetylase - 6 Inhibitors. Molecular informatics. vol 38. issue 5. 2020-04-15. PMID:30632697. |
comprehensively, hdac6 controls cell motility, apoptosis and protein folding, whereas alterations in its structure and function are related to the pathogenesis of cancer, neurodegeneration and inflammation. |
2020-04-15 |
2023-08-13 |
human |
| Jie Zhang, Jieqiong Tan, Zhiping Hu, Chunli Chen, Liuwang Zen. HDAC6 Inhibition Protects against OGDR-Induced Golgi Fragmentation and Apoptosis. Oxidative medicine and cellular longevity. vol 2019. 2020-02-21. PMID:31354911. |
hdac6 inhibition protects against ogdr-induced golgi fragmentation and apoptosis. |
2020-02-21 |
2023-08-13 |
mouse |
| Jie Zhang, Jieqiong Tan, Zhiping Hu, Chunli Chen, Liuwang Zen. HDAC6 Inhibition Protects against OGDR-Induced Golgi Fragmentation and Apoptosis. Oxidative medicine and cellular longevity. vol 2019. 2020-02-21. PMID:31354911. |
hdac6 inhibition suppresses ogdr-induced tubulin deacetylation, p115 cleavage, and caspase 3 activation and protects against ogdr-induced golgi fragmentation and apoptosis. |
2020-02-21 |
2023-08-13 |
mouse |
| Xiaoyang Sun, Yu Xie, Xiaoshen Sun, Yao Yao, Hujun Li, Zhenyu Li, Ruosi Yao, Kailin X. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Bioscience reports. vol 39. issue 3. 2020-02-20. PMID:30782785. |
the selective hdac6 inhibitor nexturastat a induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. |
2020-02-20 |
2023-08-13 |
Not clear |
| Ping Gong, Kun Li, Ying Li, Dan Liu, Linxiang Zhao, Yongkui Jin. HDAC and Ku70 axis- an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue. Cell death & disease. vol 9. issue 6. 2019-12-10. PMID:29795376. |
silencing of either hdac3 or hdac6 enhanced 10e-induced apoptosis. |
2019-12-10 |
2023-08-13 |
Not clear |
| Sara Ota, Zi-Qiang Zhou, Peter J Hurli. Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities. Oncotarget. vol 9. issue 3. 2019-11-20. PMID:29423038. |
neither hdac6 deficiency nor treatment with tubastatin a altered myc or cyclin d1 levels, and neither induced a dna damage response or apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Kamira Maharaj, John J Powers, Alex Achille, Susan Deng, Renee Fonseca, Mibel Pabon-Saldana, Steven N Quayle, Simon S Jones, Alejandro Villagra, Eduardo M Sotomayor, Eva Sahakian, Javier Pinilla-Ibar. Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia. Blood advances. vol 2. issue 21. 2019-09-19. PMID:30425065. |
administration of isoform-specific hdac6 inhibitor acy738 in the eutcl1 aging and adoptive transfer models deterred proliferation of cll b cells, delayed disease onset via disruption of b-cell receptor signaling, and sensitized cll b cells to apoptosis. |
2019-09-19 |
2023-08-13 |
mouse |
| Alejandro Urdiciain, Elena Erausquin, Bárbara Meléndez, Juan A Rey, Miguel A Idoate, Javier S Castresan. Tubastatin A, an inhibitor of HDAC6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells. International journal of oncology. vol 54. issue 5. 2019-08-13. PMID:30864703. |
tubastatin a, an inhibitor of hdac6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells. |
2019-08-13 |
2023-08-13 |
Not clear |
| Weerayut Wongjampa, Tipaya Ekalaksananan, Peechanika Chopjitt, Jureeporn Chuerduangphui, Pilaiwan Kleebkaow, Natcha Patarapadungkit, Chamsai Pienton. Suppression of miR-22, a tumor suppressor in cervical cancer, by human papillomavirus 16 E6 via a p53/miR-22/HDAC6 pathway. PloS one. vol 13. issue 10. 2019-04-10. PMID:30379969. |
mir-22 acts as tumor suppressor by inhibiting proliferation and migration, and by inducing apoptosis of cervical cancer cell lines by targeting the 3'utr of hdac6. |
2019-04-10 |
2023-08-13 |
human |
| Jinhua Tang, Yingfeng Shi, Na Liu, Liuqing Xu, Xiujuan Zang, Peibin Li, Juanlian Zhang, Xiaoqing Zheng, Andong Qiu, Shougang Zhuan. Blockade of histone deacetylase 6 protects against cisplatin-induced acute kidney injury. Clinical science (London, England : 1979). vol 132. issue 3. 2019-03-21. PMID:29358506. |
cisplatin-induced aki was accompanied by increased expression and activation of hdac6; blocking hdac6 with ta lessened renal dysfunction, attenuated renal pathological changes, reduced expression of neutrophil gelatinase-associated lipocalin and kidney injury molecule 1, and decreased tubular cell apoptosis. |
2019-03-21 |
2023-08-13 |
human |
| Jinhua Tang, Yingfeng Shi, Na Liu, Liuqing Xu, Xiujuan Zang, Peibin Li, Juanlian Zhang, Xiaoqing Zheng, Andong Qiu, Shougang Zhuan. Blockade of histone deacetylase 6 protects against cisplatin-induced acute kidney injury. Clinical science (London, England : 1979). vol 132. issue 3. 2019-03-21. PMID:29358506. |
in cultured human epithelial cells, ta or hdac6 sirna treatment also inhibited cisplatin-induced apoptosis. |
2019-03-21 |
2023-08-13 |
human |
| Ze-Hong Liu, Bing Guo, Guan-Hai Qin, Ying Yuan, Yu-Dong Wang, Yi-Ren Zhou, Shi-Qing Song, Yan-Hua Ho. [Down-regulation of HDAC6 Expression Promotes Apoptosis of Human Leukemia K562 Cells]. Zhongguo shi yan xue ye xue za zhi. vol 26. issue 6. 2019-02-28. PMID:30501695. |
[down-regulation of hdac6 expression promotes apoptosis of human leukemia k562 cells]. |
2019-02-28 |
2023-08-13 |
human |
| Marica Pinazza, Margherita Ghisi, Sonia Minuzzo, Valentina Agnusdei, Gianluca Fossati, Vincenzo Ciminale, Laura Pezzè, Yari Ciribilli, Giorgia Pilotto, Carolina Venturoli, Alberto Amadori, Stefano Indraccol. Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells. Oncogene. vol 37. issue 28. 2019-02-25. PMID:29643474. |
hdac6 silencing by specific shrna was followed by reduced notch3 expression and increased apoptosis of t-all cells. |
2019-02-25 |
2023-08-13 |
mouse |
| Y J Jia, Z B Liu, W G Wang, C B Sun, P Wei, Y L Yang, M J You, B H Yu, X Q Li, X Y Zho. HDAC6 regulates microRNA-27b that suppresses proliferation, promotes apoptosis and target MET in diffuse large B-cell lymphoma. Leukemia. vol 32. issue 3. 2019-02-08. PMID:29135973. |
hdac6 regulates microrna-27b that suppresses proliferation, promotes apoptosis and target met in diffuse large b-cell lymphoma. |
2019-02-08 |
2023-08-13 |
Not clear |
| Nicholas J Porter, Florence F Wagner, David W Christianso. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. vol 57. issue 26. 2019-02-05. PMID:29775292. |
selective inhibition of hdac6 results in microtubule hyperacetylation, leading to cell cycle arrest and apoptosis, which is a validated strategy for cancer chemotherapy and the treatment of other disorders. |
2019-02-05 |
2023-08-13 |
Not clear |
| Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A Goncharova, Steeve Provencher, Sébastien Bonne. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28674407. |
inhibition of hdac6 reduced pah-pasmc proliferation and resistance to apoptosis in vitro sparing control cells. |
2019-01-10 |
2023-08-13 |
mouse |
| Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A Goncharova, Steeve Provencher, Sébastien Bonne. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28674407. |
mechanistically, we demonstrated that hdac6 maintains ku70 in a hypoacetylated state, blocking the translocation of bax to mitochondria and preventing apoptosis. |
2019-01-10 |
2023-08-13 |
mouse |