| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Zhang, Jieqiong Tan, Zhiping Hu, Chunli Chen, Liuwang Zen. HDAC6 Inhibition Protects against OGDR-Induced Golgi Fragmentation and Apoptosis. Oxidative medicine and cellular longevity. vol 2019. 2020-02-21. PMID:31354911. |
hdac6 inhibition suppresses ogdr-induced tubulin deacetylation, p115 cleavage, and caspase 3 activation and protects against ogdr-induced golgi fragmentation and apoptosis. |
2020-02-21 |
2023-08-13 |
mouse |
| Xiaoyang Sun, Yu Xie, Xiaoshen Sun, Yao Yao, Hujun Li, Zhenyu Li, Ruosi Yao, Kailin X. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Bioscience reports. vol 39. issue 3. 2020-02-20. PMID:30782785. |
the selective hdac6 inhibitor nexturastat a induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. |
2020-02-20 |
2023-08-13 |
Not clear |
| Ping Gong, Kun Li, Ying Li, Dan Liu, Linxiang Zhao, Yongkui Jin. HDAC and Ku70 axis- an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue. Cell death & disease. vol 9. issue 6. 2019-12-10. PMID:29795376. |
silencing of either hdac3 or hdac6 enhanced 10e-induced apoptosis. |
2019-12-10 |
2023-08-13 |
Not clear |
| Sara Ota, Zi-Qiang Zhou, Peter J Hurli. Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities. Oncotarget. vol 9. issue 3. 2019-11-20. PMID:29423038. |
neither hdac6 deficiency nor treatment with tubastatin a altered myc or cyclin d1 levels, and neither induced a dna damage response or apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Kamira Maharaj, John J Powers, Alex Achille, Susan Deng, Renee Fonseca, Mibel Pabon-Saldana, Steven N Quayle, Simon S Jones, Alejandro Villagra, Eduardo M Sotomayor, Eva Sahakian, Javier Pinilla-Ibar. Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia. Blood advances. vol 2. issue 21. 2019-09-19. PMID:30425065. |
administration of isoform-specific hdac6 inhibitor acy738 in the eutcl1 aging and adoptive transfer models deterred proliferation of cll b cells, delayed disease onset via disruption of b-cell receptor signaling, and sensitized cll b cells to apoptosis. |
2019-09-19 |
2023-08-13 |
mouse |
| Alejandro Urdiciain, Elena Erausquin, Bárbara Meléndez, Juan A Rey, Miguel A Idoate, Javier S Castresan. Tubastatin A, an inhibitor of HDAC6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells. International journal of oncology. vol 54. issue 5. 2019-08-13. PMID:30864703. |
tubastatin a, an inhibitor of hdac6, enhances temozolomide‑induced apoptosis and reverses the malignant phenotype of glioblastoma cells. |
2019-08-13 |
2023-08-13 |
Not clear |
| Weerayut Wongjampa, Tipaya Ekalaksananan, Peechanika Chopjitt, Jureeporn Chuerduangphui, Pilaiwan Kleebkaow, Natcha Patarapadungkit, Chamsai Pienton. Suppression of miR-22, a tumor suppressor in cervical cancer, by human papillomavirus 16 E6 via a p53/miR-22/HDAC6 pathway. PloS one. vol 13. issue 10. 2019-04-10. PMID:30379969. |
mir-22 acts as tumor suppressor by inhibiting proliferation and migration, and by inducing apoptosis of cervical cancer cell lines by targeting the 3'utr of hdac6. |
2019-04-10 |
2023-08-13 |
human |
| Jinhua Tang, Yingfeng Shi, Na Liu, Liuqing Xu, Xiujuan Zang, Peibin Li, Juanlian Zhang, Xiaoqing Zheng, Andong Qiu, Shougang Zhuan. Blockade of histone deacetylase 6 protects against cisplatin-induced acute kidney injury. Clinical science (London, England : 1979). vol 132. issue 3. 2019-03-21. PMID:29358506. |
cisplatin-induced aki was accompanied by increased expression and activation of hdac6; blocking hdac6 with ta lessened renal dysfunction, attenuated renal pathological changes, reduced expression of neutrophil gelatinase-associated lipocalin and kidney injury molecule 1, and decreased tubular cell apoptosis. |
2019-03-21 |
2023-08-13 |
human |
| Jinhua Tang, Yingfeng Shi, Na Liu, Liuqing Xu, Xiujuan Zang, Peibin Li, Juanlian Zhang, Xiaoqing Zheng, Andong Qiu, Shougang Zhuan. Blockade of histone deacetylase 6 protects against cisplatin-induced acute kidney injury. Clinical science (London, England : 1979). vol 132. issue 3. 2019-03-21. PMID:29358506. |
in cultured human epithelial cells, ta or hdac6 sirna treatment also inhibited cisplatin-induced apoptosis. |
2019-03-21 |
2023-08-13 |
human |
| Ze-Hong Liu, Bing Guo, Guan-Hai Qin, Ying Yuan, Yu-Dong Wang, Yi-Ren Zhou, Shi-Qing Song, Yan-Hua Ho. [Down-regulation of HDAC6 Expression Promotes Apoptosis of Human Leukemia K562 Cells]. Zhongguo shi yan xue ye xue za zhi. vol 26. issue 6. 2019-02-28. PMID:30501695. |
[down-regulation of hdac6 expression promotes apoptosis of human leukemia k562 cells]. |
2019-02-28 |
2023-08-13 |
human |
| Marica Pinazza, Margherita Ghisi, Sonia Minuzzo, Valentina Agnusdei, Gianluca Fossati, Vincenzo Ciminale, Laura Pezzè, Yari Ciribilli, Giorgia Pilotto, Carolina Venturoli, Alberto Amadori, Stefano Indraccol. Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells. Oncogene. vol 37. issue 28. 2019-02-25. PMID:29643474. |
hdac6 silencing by specific shrna was followed by reduced notch3 expression and increased apoptosis of t-all cells. |
2019-02-25 |
2023-08-13 |
mouse |
| Y J Jia, Z B Liu, W G Wang, C B Sun, P Wei, Y L Yang, M J You, B H Yu, X Q Li, X Y Zho. HDAC6 regulates microRNA-27b that suppresses proliferation, promotes apoptosis and target MET in diffuse large B-cell lymphoma. Leukemia. vol 32. issue 3. 2019-02-08. PMID:29135973. |
hdac6 regulates microrna-27b that suppresses proliferation, promotes apoptosis and target met in diffuse large b-cell lymphoma. |
2019-02-08 |
2023-08-13 |
Not clear |
| Nicholas J Porter, Florence F Wagner, David W Christianso. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. vol 57. issue 26. 2019-02-05. PMID:29775292. |
selective inhibition of hdac6 results in microtubule hyperacetylation, leading to cell cycle arrest and apoptosis, which is a validated strategy for cancer chemotherapy and the treatment of other disorders. |
2019-02-05 |
2023-08-13 |
Not clear |
| Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A Goncharova, Steeve Provencher, Sébastien Bonne. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28674407. |
inhibition of hdac6 reduced pah-pasmc proliferation and resistance to apoptosis in vitro sparing control cells. |
2019-01-10 |
2023-08-13 |
mouse |
| Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A Goncharova, Steeve Provencher, Sébastien Bonne. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28674407. |
mechanistically, we demonstrated that hdac6 maintains ku70 in a hypoacetylated state, blocking the translocation of bax to mitochondria and preventing apoptosis. |
2019-01-10 |
2023-08-13 |
mouse |
| Chen-Chen Zhang, Fang Lu, Jia-Qiang Liang, Yan-Fang Zho. [Research progress of histone deacetylase 6 inhibitors in the therapy of ischemic stroke]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 3. 2019-01-04. PMID:29926072. |
this article summarized the latest research results in recent years and expounded that hdac6 inhibitors could produce a positive and effective neuroprotective effect on ischemic stroke by reducing the neuronal damage induced by excitotoxicity and oxidative stress, depressing the release of inflammatory mediators, inhibiting the apoptosis of neurons and promoting the growth of nerve and blood vessel. |
2019-01-04 |
2023-08-13 |
Not clear |
| Wei Yang, Yingying Liu, Ruoling Gao, Hongquan Yu, Ting Su. HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway. Cancer letters. vol 415. 2018-10-22. PMID:29222038. |
restraining hdac6 decreased cell proliferation, induces differentiation and increased apoptosis of gscs via inactivation of shh/gli1 signaling pathway. |
2018-10-22 |
2023-08-13 |
human |
| Wei Yang, Yingying Liu, Ruoling Gao, Hongquan Yu, Ting Su. HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway. Cancer letters. vol 415. 2018-10-22. PMID:29222038. |
moreover, hdac6 inhibition decreased dna damage repair capacity of gscs through degradation of checkpoint kinase (chk) 1 caused by x-linked inhibitor of apoptosis (xiap) downregulation, leading to elevated radiosensitivity. |
2018-10-22 |
2023-08-13 |
human |
| Jing Dong, Nan Zheng, Xue Wang, Chu Tang, Ping Yan, Hai-Bing Zhou, Jian Huan. A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer. European journal of pharmacology. vol 828. 2018-09-19. PMID:29563065. |
a novel hdac6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer. |
2018-09-19 |
2023-08-13 |
Not clear |
| Jing Dong, Nan Zheng, Xue Wang, Chu Tang, Ping Yan, Hai-Bing Zhou, Jian Huan. A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer. European journal of pharmacology. vol 828. 2018-09-19. PMID:29563065. |
all the above data supported that tc24 was a selective inhibitor of hdac6 and strongly suppressed the proliferation of gastric cancer cells via inducing cell cycle arrest and cell apoptosis and tumor angiogenesis inhibition, suggesting tc24 is potentially a novel therapeutic agent for gastric cancer and the research on chemical structure of tc24 would promote the understanding of the drug design of related compounds. |
2018-09-19 |
2023-08-13 |
Not clear |