| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhihao Wang, Pengchao Hu, Fang Tang, Haiwei Lian, Xiong Chen, Yingying Zhang, Xiaohua He, Wanhong Liu, Conghua Xi. HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27267806. |
the inhibition of hdac6 deacetylase activity by selective inhibitors inhibits the proliferation of glioblastoma cells and induces apoptosis. |
2017-07-26 |
2023-08-13 |
Not clear |
| Insoon Chang, Cun-Yu Wan. Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. The Journal of biological chemistry. vol 291. issue 35. 2017-05-12. PMID:27369083. |
inhibition of hdac6 protein enhances bortezomib-induced apoptosis in head and neck squamous cell carcinoma (hnscc) by reducing autophagy. |
2017-05-12 |
2023-08-13 |
Not clear |
| Insoon Chang, Cun-Yu Wan. Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. The Journal of biological chemistry. vol 291. issue 35. 2017-05-12. PMID:27369083. |
similarly, a combination regimen of bortezomib and the histone deacetylase inhibitor trichostatin a abolished hdac6 activity and decreased autophagy induction while significantly enhancing bortezomib-induced apoptosis in hnscc cells. |
2017-05-12 |
2023-08-13 |
Not clear |
| Insoon Chang, Cun-Yu Wan. Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. The Journal of biological chemistry. vol 291. issue 35. 2017-05-12. PMID:27369083. |
these data uncover a novel molecular mechanism indicating that hdac6 may serve as a critical causal link between autophagy, apoptosis, and the cell survival response in hnscc. |
2017-05-12 |
2023-08-13 |
Not clear |
| Ueihuei Peng, Zhihao Wang, Sa Pei, Yunchao Ou, Pengchao Hu, Wanhong Liu, Jiquan Son. ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:28035401. |
acy-1215, a selective hdac6 inhibitor, inhibits the proliferation and induces the apoptosis of a375 cells. |
2017-03-23 |
2023-08-13 |
Not clear |
| Zhihao Wang, Fang Tang, Pengchao Hu, Ying Wang, Jun Gong, Shaoxing Sun, Conghua Xi. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncology reports. vol 36. issue 1. 2017-03-03. PMID:27221381. |
the inhibition of hdac6 by cay10603, a potent and selective inhibitor of hdac6, inhibited the proliferation of lung adenocarcinoma cells and induced apoptosis. |
2017-03-03 |
2023-08-13 |
Not clear |
| Irina N Gaisina, Werner Tueckmantel, Andrey Ugolkov, Sida Shen, Jessica Hoffen, Oleksii Dubrovskyi, Andrew Mazar, Renee A Schoon, Daniel Billadeau, Alan P Kozikowsk. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. ChemMedChem. vol 11. issue 1. 2016-10-05. PMID:26592932. |
a series of hdacis previously reported by us were found to display some selectivity for hdac6 and to induce cell-cycle arrest and apoptosis in pancreatic cancer cells. |
2016-10-05 |
2023-08-13 |
Not clear |
| Irina N Gaisina, Werner Tueckmantel, Andrey Ugolkov, Sida Shen, Jessica Hoffen, Oleksii Dubrovskyi, Andrew Mazar, Renee A Schoon, Daniel Billadeau, Alan P Kozikowsk. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. ChemMedChem. vol 11. issue 1. 2016-10-05. PMID:26592932. |
three inhibitors with lower hdac6 selectivity inhibit the growth of cell lines bxpc3 and l3.6pl, and they only induce apoptosis in l3.6pl cells. |
2016-10-05 |
2023-08-13 |
Not clear |
| Ting Zhu, Deming Zhao, Zhiqi Song, Zhen Yuan, Chaosi Li, Yunsheng Wang, Xiangmei Zhou, Xiaomin Yin, Muhammad Farooque Hassan, Lifeng Yan. HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway. Neurobiology of aging. vol 37. 2016-09-26. PMID:26507311. |
histone deacetylase 6 (hdac6) controls several major cellular responses to stress that play a role in neurodegenerative diseases, including aggresome formation, autophagy, and apoptosis. |
2016-09-26 |
2023-08-13 |
Not clear |
| Zhen Lv, Xiaoyu Weng, Chengli Du, Cheng Zhang, Heng Xiao, Xianlei Cai, Sunyi Ye, Jun Cheng, Chaofeng Ding, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zhen. Downregulation of HDAC6 promotes angiogenesis in hepatocellular carcinoma cells and predicts poor prognosis in liver transplantation patients. Molecular carcinogenesis. vol 55. issue 5. 2016-09-21. PMID:26086159. |
moreover, knockdown of hdac6 could promote huvec migration, proliferation, and tube formation in vitro, and suppress hcc cell apoptosis, and promote hcc cell proliferation in hypoxia. |
2016-09-21 |
2023-08-13 |
Not clear |
| Min Su, Huaqing Guan, Fan Zhang, Yarong Gao, Xiaomei Teng, Weixin Yan. HDAC6 Regulates the Chaperone-Mediated Autophagy to Prevent Oxidative Damage in Injured Neurons after Experimental Spinal Cord Injury. Oxidative medicine and cellular longevity. vol 2016. 2016-09-08. PMID:26649145. |
this paper found that inhibition of hdac6 accelerated reactive oxygen species (ros) generation and cell apoptosis in response to the hi. |
2016-09-08 |
2023-08-13 |
Not clear |
| K V Woan, M Lienlaf, P Perez-Villaroel, C Lee, F Cheng, T Knox, D M Woods, K Barrios, J Powers, E Sahakian, H W Wang, J Canales, D Marante, K S M Smalley, J Bergman, E Seto, A Kozikowski, J Pinilla-Ibarz, A Sarnaik, E Celis, J Weber, E M Sotomayor, A Villagr. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Molecular oncology. vol 9. issue 7. 2016-06-03. PMID:25957812. |
we found that both genetic abrogation and pharmacologic inhibition of hdac6 decreases in vitro proliferation and induces g1 arrest of melanoma cell lines without inducing apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| Yi-Min Liu, Hsueh-Yun Lee, Mei-Jung Lai, Shiow-Lin Pan, Hsiang-Ling Huang, Fei-Chiao Kuo, Mei-Chuan Chen, Jing-Ping Lio. Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. Organic & biomolecular chemistry. vol 13. issue 40. 2016-04-12. PMID:26309122. |
the results indicate that compound 6, 4-[5-fluoro-2,6-dioxo-3-(tetrahydro-furan-2-yl)-3,6-dihydro-2h-pyrimidin-1-ylmethyl]-n-hydroxy-benzamide, exhibits potent antiproliferative activity, apoptosis induction with cleavage of caspase and parp, and enhanced tendency to inhibit hdac6 (ic50 = 12.4 nm) activity over hdac1 (ic50 = 1710 nm) and hdac2 (ic50 = 5500 nm). |
2016-04-12 |
2023-08-13 |
Not clear |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
knockdown of hdac6 significantly inhibited the proliferation and colony formation ability of a375.s2 cells, promoted cell arrest at g0/g1 phase and apoptosis. |
2015-10-16 |
2023-08-13 |
human |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
additionally, western blotting assay showed that hdac6 silencing suppressed bcl-2 level and enhanced bax level, then activated caspase-9 and caspase-3, and further activated the release of cytochrome c from mitochondria to cytoplasm, finally induced cell apoptosis involving the mitochondrial pathway. |
2015-10-16 |
2023-08-13 |
human |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
furthermore, ros inhibitor, nac reduced hdac6 sirna-induced ros production, and blocked hdac6 sirna-induced loss of mmp and apoptosis. |
2015-10-16 |
2023-08-13 |
human |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
in conclusion, the results showed that knockdown of hdac6 induced apoptosis in human melanoma a375.s2 cells through a ros-dependent mitochondrial pathway. |
2015-10-16 |
2023-08-13 |
human |
| Shota Moriya, Seiichiro Komatsu, Kaho Yamasaki, Yusuke Kawai, Hiroko Kokuba, Ayako Hirota, Xiao-Fang Che, Masato Inazu, Akihiko Gotoh, Masaki Hiramoto, Keisuke Miyazaw. Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells. International journal of oncology. vol 46. issue 2. 2015-08-21. PMID:25422130. |
pronounced apoptosis was induced by the combination of vorinostat [suberoylanilide hydroxamic acid (saha); potently inhibits hdac6] with cam and bz compared with each reagent or a 2‑reagent combination. |
2015-08-21 |
2023-08-13 |
Not clear |
| Smita Salian-Mehta, Mei Xu, Timothy A McKinsey, Stuart Tobet, Margaret E Wierma. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. The Journal of biological chemistry. vol 290. issue 22. 2015-08-18. PMID:25873389. |
silencing of hdac6, hdac9, or both, in gt1-7 cells augmented apoptosis compared with controls. |
2015-08-18 |
2023-08-13 |
Not clear |
| N Chaudhary, K K Nakka, P L Chavali, J Bhat, S Chatterjee, S Chattopadhya. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation. Cell death & disease. vol 5. 2015-07-07. PMID:25299772. |
thus, we provide mechanistic insights of smar1-mediated regulation of repair and apoptosis via a complex crosstalk involving ku70, hdac6 and bax. |
2015-07-07 |
2023-08-13 |
Not clear |