| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irina N Gaisina, Werner Tueckmantel, Andrey Ugolkov, Sida Shen, Jessica Hoffen, Oleksii Dubrovskyi, Andrew Mazar, Renee A Schoon, Daniel Billadeau, Alan P Kozikowsk. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. ChemMedChem. vol 11. issue 1. 2016-10-05. PMID:26592932. |
a series of hdacis previously reported by us were found to display some selectivity for hdac6 and to induce cell-cycle arrest and apoptosis in pancreatic cancer cells. |
2016-10-05 |
2023-08-13 |
Not clear |
| Irina N Gaisina, Werner Tueckmantel, Andrey Ugolkov, Sida Shen, Jessica Hoffen, Oleksii Dubrovskyi, Andrew Mazar, Renee A Schoon, Daniel Billadeau, Alan P Kozikowsk. Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity. ChemMedChem. vol 11. issue 1. 2016-10-05. PMID:26592932. |
three inhibitors with lower hdac6 selectivity inhibit the growth of cell lines bxpc3 and l3.6pl, and they only induce apoptosis in l3.6pl cells. |
2016-10-05 |
2023-08-13 |
Not clear |
| Ting Zhu, Deming Zhao, Zhiqi Song, Zhen Yuan, Chaosi Li, Yunsheng Wang, Xiangmei Zhou, Xiaomin Yin, Muhammad Farooque Hassan, Lifeng Yan. HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway. Neurobiology of aging. vol 37. 2016-09-26. PMID:26507311. |
histone deacetylase 6 (hdac6) controls several major cellular responses to stress that play a role in neurodegenerative diseases, including aggresome formation, autophagy, and apoptosis. |
2016-09-26 |
2023-08-13 |
Not clear |
| Zhen Lv, Xiaoyu Weng, Chengli Du, Cheng Zhang, Heng Xiao, Xianlei Cai, Sunyi Ye, Jun Cheng, Chaofeng Ding, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zhen. Downregulation of HDAC6 promotes angiogenesis in hepatocellular carcinoma cells and predicts poor prognosis in liver transplantation patients. Molecular carcinogenesis. vol 55. issue 5. 2016-09-21. PMID:26086159. |
moreover, knockdown of hdac6 could promote huvec migration, proliferation, and tube formation in vitro, and suppress hcc cell apoptosis, and promote hcc cell proliferation in hypoxia. |
2016-09-21 |
2023-08-13 |
Not clear |
| Min Su, Huaqing Guan, Fan Zhang, Yarong Gao, Xiaomei Teng, Weixin Yan. HDAC6 Regulates the Chaperone-Mediated Autophagy to Prevent Oxidative Damage in Injured Neurons after Experimental Spinal Cord Injury. Oxidative medicine and cellular longevity. vol 2016. 2016-09-08. PMID:26649145. |
this paper found that inhibition of hdac6 accelerated reactive oxygen species (ros) generation and cell apoptosis in response to the hi. |
2016-09-08 |
2023-08-13 |
Not clear |
| K V Woan, M Lienlaf, P Perez-Villaroel, C Lee, F Cheng, T Knox, D M Woods, K Barrios, J Powers, E Sahakian, H W Wang, J Canales, D Marante, K S M Smalley, J Bergman, E Seto, A Kozikowski, J Pinilla-Ibarz, A Sarnaik, E Celis, J Weber, E M Sotomayor, A Villagr. Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Molecular oncology. vol 9. issue 7. 2016-06-03. PMID:25957812. |
we found that both genetic abrogation and pharmacologic inhibition of hdac6 decreases in vitro proliferation and induces g1 arrest of melanoma cell lines without inducing apoptosis. |
2016-06-03 |
2023-08-13 |
Not clear |
| Yi-Min Liu, Hsueh-Yun Lee, Mei-Jung Lai, Shiow-Lin Pan, Hsiang-Ling Huang, Fei-Chiao Kuo, Mei-Chuan Chen, Jing-Ping Lio. Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. Organic & biomolecular chemistry. vol 13. issue 40. 2016-04-12. PMID:26309122. |
the results indicate that compound 6, 4-[5-fluoro-2,6-dioxo-3-(tetrahydro-furan-2-yl)-3,6-dihydro-2h-pyrimidin-1-ylmethyl]-n-hydroxy-benzamide, exhibits potent antiproliferative activity, apoptosis induction with cleavage of caspase and parp, and enhanced tendency to inhibit hdac6 (ic50 = 12.4 nm) activity over hdac1 (ic50 = 1710 nm) and hdac2 (ic50 = 5500 nm). |
2016-04-12 |
2023-08-13 |
Not clear |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
knockdown of hdac6 significantly inhibited the proliferation and colony formation ability of a375.s2 cells, promoted cell arrest at g0/g1 phase and apoptosis. |
2015-10-16 |
2023-08-13 |
human |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
additionally, western blotting assay showed that hdac6 silencing suppressed bcl-2 level and enhanced bax level, then activated caspase-9 and caspase-3, and further activated the release of cytochrome c from mitochondria to cytoplasm, finally induced cell apoptosis involving the mitochondrial pathway. |
2015-10-16 |
2023-08-13 |
human |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
furthermore, ros inhibitor, nac reduced hdac6 sirna-induced ros production, and blocked hdac6 sirna-induced loss of mmp and apoptosis. |
2015-10-16 |
2023-08-13 |
human |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
in conclusion, the results showed that knockdown of hdac6 induced apoptosis in human melanoma a375.s2 cells through a ros-dependent mitochondrial pathway. |
2015-10-16 |
2023-08-13 |
human |
| Shota Moriya, Seiichiro Komatsu, Kaho Yamasaki, Yusuke Kawai, Hiroko Kokuba, Ayako Hirota, Xiao-Fang Che, Masato Inazu, Akihiko Gotoh, Masaki Hiramoto, Keisuke Miyazaw. Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells. International journal of oncology. vol 46. issue 2. 2015-08-21. PMID:25422130. |
pronounced apoptosis was induced by the combination of vorinostat [suberoylanilide hydroxamic acid (saha); potently inhibits hdac6] with cam and bz compared with each reagent or a 2‑reagent combination. |
2015-08-21 |
2023-08-13 |
Not clear |
| Smita Salian-Mehta, Mei Xu, Timothy A McKinsey, Stuart Tobet, Margaret E Wierma. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. The Journal of biological chemistry. vol 290. issue 22. 2015-08-18. PMID:25873389. |
silencing of hdac6, hdac9, or both, in gt1-7 cells augmented apoptosis compared with controls. |
2015-08-18 |
2023-08-13 |
Not clear |
| N Chaudhary, K K Nakka, P L Chavali, J Bhat, S Chatterjee, S Chattopadhya. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation. Cell death & disease. vol 5. 2015-07-07. PMID:25299772. |
thus, we provide mechanistic insights of smar1-mediated regulation of repair and apoptosis via a complex crosstalk involving ku70, hdac6 and bax. |
2015-07-07 |
2023-08-13 |
Not clear |
| Kwai Fung Hui, Alan K S Chian. Combination of proteasome and class I HDAC inhibitors induces apoptosis of NPC cells through an HDAC6-independent ER stress-induced mechanism. International journal of cancer. vol 135. issue 12. 2014-12-09. PMID:24771510. |
our study aims to investigate the effect of combining different class i hdac inhibitors (without hdac6 action) with a proteasome inhibitor on apoptosis of nasopharyngeal carcinoma (npc). |
2014-12-09 |
2023-08-13 |
Not clear |
| Kwai Fung Hui, Alan K S Chian. Combination of proteasome and class I HDAC inhibitors induces apoptosis of NPC cells through an HDAC6-independent ER stress-induced mechanism. International journal of cancer. vol 135. issue 12. 2014-12-09. PMID:24771510. |
the apoptosis of npc cells was reactive oxygen species (ros)- and caspase-dependent but was independent of hdac6 inhibition. |
2014-12-09 |
2023-08-13 |
Not clear |
| Kwai Fung Hui, Alan K S Chian. Combination of proteasome and class I HDAC inhibitors induces apoptosis of NPC cells through an HDAC6-independent ER stress-induced mechanism. International journal of cancer. vol 135. issue 12. 2014-12-09. PMID:24771510. |
collectively, our data demonstrate a model of synergism between proteasome and class i hdac inhibitors in the induction of ros-dependent er stress-induced apoptosis of npc cells, independent of hdac6 inhibition, and provide the rationale to combine the more specific and potent class i hdac inhibitors with proteasome inhibitors for the treatment of cancers. |
2014-12-09 |
2023-08-13 |
Not clear |
| M New, H Olzscha, G Liu, O Khan, L Stimson, J McGouran, D Kerr, A Coutts, B Kessler, M Middleton, N B La Thangu. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell death and differentiation. vol 20. issue 10. 2014-06-12. PMID:23703321. |
the mechanism responsible involves the interaction of hdac6 with hr23b, which downregulates hr23b and thereby reduces the level of ubiquitinated substrates targeted to the proteasome, ultimately desensitising cells to apoptosis. |
2014-06-12 |
2023-08-12 |
Not clear |
| T Ozaki, D Wu, H Sugimoto, H Nagase, A Nakagawar. Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage. Cell death & disease. vol 4. 2013-10-23. PMID:23618908. |
runt-related transcription factor 2 (runx2) inhibits p53-dependent apoptosis through the collaboration with hdac6 in response to dna damage. |
2013-10-23 |
2023-08-12 |
human |
| Seiichiro Komatsu, Shota Moriya, Xiao-Fang Che, Tomohisa Yokoyama, Norio Kohno, Keisuke Miyazaw. Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells. Biochemical and biophysical research communications. vol 437. issue 1. 2013-10-01. PMID:23792097. |
these data suggest that simultaneous targeting of intracellular proteolytic pathways and hdac6 enhances er-stress-mediated apoptosis in breast cancer cells. |
2013-10-01 |
2023-08-12 |
Not clear |