| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Xia Qin, Hong-Kai Cui, Ying Pan, Jun Yang, Yan-Fang Ren, Cai-Hong Hua, Fang-Fang Hua, Yu-Huan Qia. HDAC6 siRNA inhibits proliferation and induces apoptosis of HeLa cells and its related molecular mechanism. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 7. 2013-06-03. PMID:22994762. |
hdac6 sirna inhibits proliferation and induces apoptosis of hela cells and its related molecular mechanism. |
2013-06-03 |
2023-08-12 |
Not clear |
| Hai-Xia Qin, Hong-Kai Cui, Ying Pan, Jun Yang, Yan-Fang Ren, Cai-Hong Hua, Fang-Fang Hua, Yu-Huan Qia. HDAC6 siRNA inhibits proliferation and induces apoptosis of HeLa cells and its related molecular mechanism. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 7. 2013-06-03. PMID:22994762. |
to investigate the effects of histone deacetylase 6 (hdac6) sirna on cell proliferation and cell apoptosis of the hela cervical carcinoma cell line and the molecular mechanisms involved. |
2013-06-03 |
2023-08-12 |
Not clear |
| Lei Wang, Shengyan Xiang, Kendra A Williams, Huiqin Dong, Wenlong Bai, Santo V Nicosia, Saadi Khochbin, Gerold Bepler, Xiaohong Zhan. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PloS one. vol 7. issue 9. 2013-02-14. PMID:22957056. |
depletion of hdac6 enhances cisplatin-induced dna damage and apoptosis in non-small cell lung cancer cells. |
2013-02-14 |
2023-08-12 |
mouse |
| Lei Wang, Shengyan Xiang, Kendra A Williams, Huiqin Dong, Wenlong Bai, Santo V Nicosia, Saadi Khochbin, Gerold Bepler, Xiaohong Zhan. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PloS one. vol 7. issue 9. 2013-02-14. PMID:22957056. |
we suggested that depletion of hdac6 increased cisplatin-induced cytotoxicity was due to the enhancement of apoptosis via activating atr/chk1 pathway. |
2013-02-14 |
2023-08-12 |
mouse |
| Lei Wang, Shengyan Xiang, Kendra A Williams, Huiqin Dong, Wenlong Bai, Santo V Nicosia, Saadi Khochbin, Gerold Bepler, Xiaohong Zhan. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PloS one. vol 7. issue 9. 2013-02-14. PMID:22957056. |
lastly, depletion of hdac6 in h292 xenografts rendered decreased tumor weight and volume and exhibited increased basal apoptosis compared with the controls in a xenograft mouse model. |
2013-02-14 |
2023-08-12 |
mouse |
| Grace I Aldana-Masangkay, Kathleen M Sakamot. The role of HDAC6 in cancer. Journal of biomedicine & biotechnology. vol 2011. 2011-02-14. PMID:21076528. |
previous work demonstrated that in multiple myeloma cells, inhibition of hdac6 results in apoptosis. |
2011-02-14 |
2023-08-12 |
Not clear |
| Jennifer S Carew, Ernest C Medina, Juan A Esquivel, Devalingam Mahalingam, Ronan Swords, Kevin Kelly, Hui Zhang, Peng Huang, Alain C Mita, Monica M Mita, Francis J Giles, Steffan T Nawrock. Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. Journal of cellular and molecular medicine. vol 14. issue 10. 2011-02-10. PMID:19583815. |
knockdown of hdac6 greatly enhanced bz-induced apoptosis, but only marginally sensitized cells to cq. |
2011-02-10 |
2023-08-12 |
Not clear |
| Enkhtsetseg Purev, Lynn Neff, William C Horne, Roland Baro. c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes. Molecular biology of the cell. vol 20. issue 18. 2009-12-09. PMID:19641021. |
c-cbl and cbl-b act redundantly to protect osteoclasts from apoptosis and to displace hdac6 from beta-tubulin, stabilizing microtubules and podosomes. |
2009-12-09 |
2023-08-12 |
mouse |
| Matloob Husain, Kevin S Harro. Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells. FEBS letters. vol 583. issue 15. 2009-08-24. PMID:19596000. |
the cleavage removes most of the c-terminal ubiquitin-binding zinc finger domain from hdac6, which could be significant for hdac6's role in iav-induced apoptosis in infected cells. |
2009-08-24 |
2023-08-12 |
Not clear |
| Douglas C Marchion, Elona Bicaku, Joel G Turner, Morgen L Schmitt, Dawn R Morelli, Pamela N Munste. HDAC2 regulates chromatin plasticity and enhances DNA vulnerability. Molecular cancer therapeutics. vol 8. issue 4. 2009-06-08. PMID:19372552. |
furthermore, depletion of hdac2 but not hdac1 or hdac6 was sufficient to sensitize breast cancer cells to topoisomerase inhibitor-induced apoptosis. |
2009-06-08 |
2023-08-12 |
Not clear |
| Steffan T Nawrocki, Jennifer S Carew, Kirsteen H Maclean, James F Courage, Peng Huang, Janet A Houghton, John L Cleveland, Francis J Giles, David J McConke. Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood. vol 112. issue 7. 2008-10-09. PMID:18641367. |
collectively, our results establish a mechanistic link between myc activity, regulation of protein synthesis, increases in hdac6 expression and aggresome formation, induction of noxa, and sensitivity to bz + saha-induced apoptosis. |
2008-10-09 |
2023-08-12 |
Not clear |
| Elona Biçaku, Douglas C Marchion, Morgen L Schmitt, Pamela N Münste. Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer research. vol 68. issue 5. 2008-04-08. PMID:18316616. |
selective inhibition of hdac2, but not hdac1 or hdac6, was sufficient to potentiate tamoxifen-induced apoptosis in er/pr-positive cells. |
2008-04-08 |
2023-08-12 |
Not clear |
| Ying Wang, Sheng-Yu Wang, Xu-Hui Zhang, Ming Zhao, Chun-Mei Hou, Yuan-Ji Xu, Zhi-Yan Du, Xiao-Dan Y. FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70. Biochemical and biophysical research communications. vol 356. issue 4. 2007-06-28. PMID:17397803. |
some pan-histone-deacetylase (hdac) inhibitors have recently been reported to exert their anti-leukemia effect by inhibiting the activity of class iib hdac6, which is the deacetylase of hsp90 and alpha-tubulin, thereby leading to hyperacetylation of hsp90, disruption of its chaperone function and apoptosis. |
2007-06-28 |
2023-08-12 |
Not clear |
| Ji Won Kim, Oh Yun Kwon, Myoung Hee Ki. Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle. Differentiation; research in biological diversity. vol 75. issue 2. 2007-04-26. PMID:17316384. |
together with these, inrf2, hdac6, podxl, and acyp2 are related more or less to stress-induced apoptosis, indicating the responses to apoptotic changes in mitochondria caused by stretching. |
2007-04-26 |
2023-08-12 |
rat |
| Satoshi Inoue, Antonello Mai, Martin J S Dyer, Gerald M Cohe. Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer research. vol 66. issue 13. 2006-09-07. PMID:16818655. |
using different hdaci together with small interfering rna for hdac1, hdac2, hdac3, and hdac6, we report that inhibition of hdac1 and hdac2 but not hdac3, hdac6, and hdac8 are primarily responsible for sensitization to trail-induced apoptosis. |
2006-09-07 |
2023-08-12 |
Not clear |