| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Ran, Min Liu, Jie Feng, Haixia Li, Huixian Ma, Ting Song, Yu Cao, Peng Zhou, Yuhan Wu, Yunfan Yang, Yang Yang, Fan Yu, Heng Guo, Liang Zhang, Songbo Xie, Dengwen Li, Jinmin Gao, Xiaomin Zhang, Xueliang Zhu, Jun Zho. ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia. Developmental cell. vol 53. issue 3. 2020-12-14. PMID:32275885. |
we also show that in response to oxygen changes, apoptosis signal-regulating kinase 1 (ask1) is activated and phosphorylates hdac6, blocking its ubiquitination by von hippel-lindau and subsequent degradation by the proteasome. |
2020-12-14 |
2023-08-13 |
mouse |
| Yan Hao, Fan Guo, Zhuo Huang, Yuying Feng, Zijing Xia, Jing Liu, Lingzhi Li, Rongshuang Huang, Lin Lin, Liang Ma, Ping F. 2-Methylquinazoline derivative 23BB as a highly selective histone deacetylase 6 inhibitor alleviated cisplatin-induced acute kidney injury. Bioscience reports. vol 40. issue 1. 2020-11-30. PMID:31894849. |
overall, these data highlighted that hdac6 inhibitor 23bb modulated apoptosis via the inhibition of er stress in the tubular epithelial cells of cisplatin-induced aki. |
2020-11-30 |
2023-08-13 |
mouse |
| Fang-I Huang, Yi-Wen Wu, Ting-Yi Sung, Jing-Ping Liou, Mei-Hsiang Lin, Shiow-Lin Pan, Chia-Ron Yan. MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells. Frontiers in oncology. vol 9. 2020-10-01. PMID:31024851. |
accordingly, a combination of an hdac6 inhibitor and bortezomib (btz) could increase ubiquitinated protein accumulation, leading to further apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yuying Feng, Rongshuang Huang, Fan Guo, Yan Liang, Jin Xiang, Song Lei, Min Shi, Lingzhi Li, Jing Liu, Yanhuan Feng, Liang Ma, Ping F. Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis. Frontiers in pharmacology. vol 9. 2020-09-29. PMID:29632491. |
hdac6 inhibition also resulted in reduced tdt-mediated dutp nick-end labeling (tunel)-positive tubular cells, suppressed bax, bak, cleaved caspase-3 levels, and preserved bcl-2 expression, indicating that 23bb exerted potent renoprotective effects by the regulation of tubular cell apoptosis. |
2020-09-29 |
2023-08-13 |
mouse |
| Yuying Feng, Rongshuang Huang, Fan Guo, Yan Liang, Jin Xiang, Song Lei, Min Shi, Lingzhi Li, Jing Liu, Yanhuan Feng, Liang Ma, Ping F. Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis. Frontiers in pharmacology. vol 9. 2020-09-29. PMID:29632491. |
overall, these data highlighted that renal protection of novel hdac6 inhibitor 23bb is substantiated by the reduction of er stress-mediated apoptosis in tubular epithelial cells of rhabdomyolysis-induced aki. |
2020-09-29 |
2023-08-13 |
mouse |
| Zhusheng Yin, Wei Xu, Hao Xu, Junnian Zheng, Yuming G. Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/β-catenin signaling pathway in hepatocellular carcinoma. Oncology letters. vol 16. issue 6. 2020-09-29. PMID:30546442. |
histone deacetylase 6 (hdac6), a specific histone deacetylase family member, serves an essential role in the regulation of gene expression, cell cycle progression, autophagy and apoptosis. |
2020-09-29 |
2023-08-13 |
human |
| Zhusheng Yin, Wei Xu, Hao Xu, Junnian Zheng, Yuming G. Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/β-catenin signaling pathway in hepatocellular carcinoma. Oncology letters. vol 16. issue 6. 2020-09-29. PMID:30546442. |
furthermore, hdac6 also exerted an effect on the cell cycle arrest and the induction of apoptosis. |
2020-09-29 |
2023-08-13 |
human |
| Yifan Yang, Yang Sun, Huaitao Wang, Hansi Li, Mingjie Zhang, Lei Zhou, Xiangli Meng, Yunhao Wu, Peng Liu, Xin Liu, Jun Zhang, Xiaodong Ta. MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer. Oncology letters. vol 16. issue 6. 2020-09-29. PMID:30546469. |
microrna-221 induces autophagy through suppressing hdac6 expression and promoting apoptosis in pancreatic cancer. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yifan Yang, Yang Sun, Huaitao Wang, Hansi Li, Mingjie Zhang, Lei Zhou, Xiangli Meng, Yunhao Wu, Peng Liu, Xin Liu, Jun Zhang, Xiaodong Ta. MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer. Oncology letters. vol 16. issue 6. 2020-09-29. PMID:30546469. |
additionally, the results of the present study suggest that the downregulation of mir-221 expression may serve an oncogenic function in the apoptosis and autophagy of pancreatic cancer cells by inducing the expression of hdac6. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mei-Chuan Chen, Yu-Chen Lin, Yu-Hsuan Liao, Jing-Ping Liou, Chun-Han Che. MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells. Cancers. vol 11. issue 10. 2020-09-28. PMID:31652644. |
mpt0g612, a novel hdac6 inhibitor, induces apoptosis and suppresses ifn-γ-induced programmed death-ligand 1 in human colorectal carcinoma cells. |
2020-09-28 |
2023-08-13 |
human |
| Brian Deskin, Qinyan Yin, Yan Zhuang, Shigeki Saito, Bin Shan, Joseph A Lask. Inhibition of HDAC6 Attenuates Tumor Growth of Non-Small Cell Lung Cancer. Translational oncology. vol 13. issue 2. 2020-09-28. PMID:31865176. |
hdac6 inhibition with acy1215 led to g2 arrest, increased apoptosis, and increased levels of cleaved parp1 in a549, ll2, and h1299 cell lines. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jia Yang, Dengwen Li, Jun Zho. Histone Deacetylase 6 as a Therapeutic Target in B cell-associated Hematological Malignancies. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32676030. |
mechanistically, hdac6 inhibitors promote malignant tumor cell apoptosis by inhibiting protein degradation, reinvigorating anti-tumor immunity, and inhibiting cell survival signaling pathways. |
2020-09-28 |
2023-08-13 |
Not clear |
| Cristina Corno, Noemi Arrighetti, Emilio Ciusani, Elisabetta Corna, Nives Carenini, Nadia Zaffaroni, Laura Gatti, Paola Pereg. Synergistic Interaction of Histone Deacetylase 6- and MEK-Inhibitors in Castration-Resistant Prostate Cancer Cells. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32754596. |
rnai-mediated knockdown of hdac6 in selumetinib-treated 22rv1 cells resulted in increased apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Svetlana Demyanenko, Elena Berezhnaya, Maria Neginskaya, Stanislav Rodkin, Valentina Dzreyan, Maria Pitinov. Сlass II histone deacetylases in the post-stroke recovery period-expression, cellular, and subcellular localization-promising targets for neuroprotection. Journal of cellular biochemistry. vol 120. issue 12. 2020-09-18. PMID:31264264. |
tubostatin a (tub a)-induced decrease in the activity of hdac6 restored acetylation of α-tubulin during the early poststroke recovery period and reduced apoptosis of nerve cells thus protecting the brain tissue. |
2020-09-18 |
2023-08-13 |
mouse |
| Qingsong Yang, Sizhen Li, Zixiu Zhou, Min Fu, Xiaodong Yang, Kuanxiao Hao, Yating Li. HDAC6 inhibitor Cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells via regulating NF-κB and NLRP3 inflammasome pathway. General physiology and biophysics. vol 39. issue 2. 2020-09-03. PMID:32329444. |
hdac6 inhibitor cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells via regulating nf-κb and nlrp3 inflammasome pathway. |
2020-09-03 |
2023-08-13 |
human |
| Jeremy D Osko, David W Christianso. Methods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes. Methods in enzymology. vol 626. 2020-06-02. PMID:31606087. |
for example, hdac6 is the cytosolic tubulin deacetylase and its inhibition compromises microtubule dynamics, leading to cancer cell cycle arrest and apoptosis. |
2020-06-02 |
2023-08-13 |
human |
| Panpan Chang, Umar F Bhatti, Aaron M Williams, Isabel S Dennahy, Baoling Liu, Yongqing Li, Hasan B Ala. Inhibition of histone deacetylase 6 attenuates intestinal inflammation and apoptosis in a rodent model of hemorrhagic shock. The journal of trauma and acute care surgery. vol 86. issue 5. 2020-06-01. PMID:30562325. |
in this study, we sought to determine whether hdac6 inhibition by acy1083 can attenuate intestinal inflammation and apoptosis in rats subjected to hs. |
2020-06-01 |
2023-08-13 |
rat |
| Tanveer Sharif, Emma Martell, Cathleen Dai, Mohammad Saleh Ghassemi-Rad, Mark Robert Hanes, Patrick J Murphy, Nandini N Margam, Hirendrasinh B Parmar, Carman A Giacomantonio, Roy Duncan, Patrick W K Lee, Shashi Guja. HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. Autophagy. vol 15. issue 4. 2020-05-11. PMID:30444165. |
in contrast to the results observed in cscs, hdac6 kd in differentiated breast cancer cells downregulates autophagy and increases apoptosis. |
2020-05-11 |
2023-08-13 |
human |
| Dusan Ruzic, Milos Petkovic, Danica Agbaba, A Ganesan, Katarina Nikoli. Combined Ligand and Fragment-based Drug Design of Selective Histone Deacetylase - 6 Inhibitors. Molecular informatics. vol 38. issue 5. 2020-04-15. PMID:30632697. |
comprehensively, hdac6 controls cell motility, apoptosis and protein folding, whereas alterations in its structure and function are related to the pathogenesis of cancer, neurodegeneration and inflammation. |
2020-04-15 |
2023-08-13 |
human |
| Jie Zhang, Jieqiong Tan, Zhiping Hu, Chunli Chen, Liuwang Zen. HDAC6 Inhibition Protects against OGDR-Induced Golgi Fragmentation and Apoptosis. Oxidative medicine and cellular longevity. vol 2019. 2020-02-21. PMID:31354911. |
hdac6 inhibition protects against ogdr-induced golgi fragmentation and apoptosis. |
2020-02-21 |
2023-08-13 |
mouse |