| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Houghton, F G Harwood, A A Gibson, D M Tillma. The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 12 Pt 1. 1999-03-03. PMID:9815616. |
fas is expressed in colonic epithelial cells and is also expressed in colon carcinomas, although its functional significance in the regulation of apoptosis in cells outside of the immune system remains unknown. |
1999-03-03 |
2023-08-12 |
Not clear |
| J A Houghton, F G Harwood, A A Gibson, D M Tillma. The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 12 Pt 1. 1999-03-03. PMID:9815616. |
in this study, we determined the role of fas signaling on cellular growth of cultured colon carcinoma cells and demonstrated apoptosis induced by a cytotoxic anti-fas monoclonal antibody (ch-11) in cells of the gc3/c1 lineage (gc3/c1, ts-, thy4) but not in hct116 or caco2 cells. |
1999-03-03 |
2023-08-12 |
Not clear |
| J A Houghton, F G Harwood, A A Gibson, D M Tillma. The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 12 Pt 1. 1999-03-03. PMID:9815616. |
in addition, the survival factor bcl-2, which has demonstrated inconsistent protective effects against fas signaling in other systems, was inhibitory to fas-induced apoptosis in colon carcinoma cells after adenoviral transduction. |
1999-03-03 |
2023-08-12 |
Not clear |
| J A Houghton, F G Harwood, A A Gibson, D M Tillma. The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 12 Pt 1. 1999-03-03. PMID:9815616. |
fas was expressed at the highest levels in ts- and thy4 cells, which were the most sensitive cell lines to fas-induced apoptosis. |
1999-03-03 |
2023-08-12 |
Not clear |
| J A Houghton, F G Harwood, A A Gibson, D M Tillma. The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 12 Pt 1. 1999-03-03. PMID:9815616. |
fap-1, a protein tyrosine phosphatase that interacts with the cytosolic negative regulatory domain of fas, was expressed in each cell line but did not correlate with sensitivity to fas-mediated apoptosis. |
1999-03-03 |
2023-08-12 |
Not clear |
| J A Houghton, F G Harwood, A A Gibson, D M Tillma. The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 12 Pt 1. 1999-03-03. PMID:9815616. |
hence, the role of fas signaling in the regulation of apoptosis in colon carcinoma cells and its role in influencing the response to treatment with chemotherapeutic agents should be further explored. |
1999-03-03 |
2023-08-12 |
Not clear |
| Y Ogawa, A Nishioka, N Hamada, M Terashima, T Inomata, S Yoshida, H Seguchi, S Kishimot. Expression of fas (CD95/APO-1) antigen induced by radiation therapy for diffuse B-cell lymphoma: immunohistochemical study. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 3. issue 12 Pt 1. 1999-03-03. PMID:9815617. |
recently, the fas (cd95/apo-1)/fas ligand system has been identified as a key regulator of apoptosis in some types of lymphoma cell lines. |
1999-03-03 |
2023-08-12 |
Not clear |
| T Sugiura, Y Murakawa, A Nagai, M Kondo, S Kobayash. Fas and Fas ligand interaction induces apoptosis in inflammatory myopathies: CD4+ T cells cause muscle cell injury directly in polymyositis. Arthritis and rheumatism. vol 42. issue 2. 1999-03-03. PMID:10025923. |
fas and fas ligand interaction induces apoptosis in inflammatory myopathies: cd4+ t cells cause muscle cell injury directly in polymyositis. |
1999-03-03 |
2023-08-12 |
Not clear |
| T Tanaka, N Umesaki, K Mizuno, L Chang, S Ohtaki, S Ogit. Enhancement of apoptotic susceptibility by interleukin-1 beta in human endometrial epithelial cells. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 12. issue 5. 1999-03-01. PMID:9859023. |
the enhancement of endometrial apoptosis by il-1 beta was not accompanied by any increase in cell-surface expression of fas, which suggested that il-1 beta enhanced the postreceptor apoptotic signals in the activated cells. |
1999-03-01 |
2023-08-12 |
mouse |
| C Mangurian, R O Johnson, R McMahan, R H Clothier, L N Rube. Expression of a Fas-like proapoptotic molecule on the lymphocytes of Xenopus laevis. Immunology letters. vol 64. issue 1. 1999-03-01. PMID:9865599. |
ligation of the externally expressed fas (apo1/cd95) molecule will initiate programmed cell death (apoptosis), in many mammalian developing and adult cells. |
1999-03-01 |
2023-08-12 |
mouse |
| C Mangurian, R O Johnson, R McMahan, R H Clothier, L N Rube. Expression of a Fas-like proapoptotic molecule on the lymphocytes of Xenopus laevis. Immunology letters. vol 64. issue 1. 1999-03-01. PMID:9865599. |
a monoclonal mouse anti-human fas antibody, previously used to stimulate apoptosis in mammalian cells, induced significant levels of apoptosis in adult xenopus splenocytes and additionally, bound specifically to a splenocyte extract, as assayed by elisa. |
1999-03-01 |
2023-08-12 |
mouse |
| C Mangurian, R O Johnson, R McMahan, R H Clothier, L N Rube. Expression of a Fas-like proapoptotic molecule on the lymphocytes of Xenopus laevis. Immunology letters. vol 64. issue 1. 1999-03-01. PMID:9865599. |
thus, a molecule on xenopus splenocytes shares both structural and functional homologies with human fas, indicating the evolutionary conservation within vertebrates of this means of initiating apoptosis. |
1999-03-01 |
2023-08-12 |
mouse |
| C Giardina, H Boulares, M S Ina. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. Biochimica et biophysica acta. vol 1448. issue 3. 1999-03-01. PMID:9990295. |
here we demonstrate that these agents sensitize the normally resistant human ht-29 colon cancer cell line to apoptosis induced by tnf-alpha or a fas ligating antibody. |
1999-03-01 |
2023-08-12 |
human |
| C Giardina, H Boulares, M S Ina. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. Biochimica et biophysica acta. vol 1448. issue 3. 1999-03-01. PMID:9990295. |
the antioxidant n-acetylcysteine (nac) blocks cell death and nf-kappa b activation induced by fas ligation, suggesting a potential role for nf-kappa b in fas-induced apoptosis in these cells. |
1999-03-01 |
2023-08-12 |
human |
| F Brignole, M De Saint-Jean, M Goldschild, F Becquet, A Goguel, C Baudoui. Expression of Fas-Fas ligand antigens and apoptotic marker APO2.7 by the human conjunctival epithelium. Positive correlation with class II HLA DR expression in inflammatory ocular surface disorders. Experimental eye research. vol 67. issue 6. 1999-03-01. PMID:9990333. |
fas antigen (cd95) is a membrane receptor that plays a major role in induction of apoptosis. |
1999-03-01 |
2023-08-12 |
human |
| P S Koh, G C Hughes, G R Faulkner, W W Keeble, G C Bagb. The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor-alpha and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor superfamily. Experimental hematology. vol 27. issue 1. 1999-02-25. PMID:9923438. |
because the ifn-gamma hypersensitivity of cells lacking the fac protein is mediated, in part, through priming of the fas pathway, and because several other members of this family are capable of inducing apoptosis either alone or in concert with each other, we tested the hypothesis that ifn-gamma induces increased expression of members of the tnf receptor (tnfr) superfamily in cells nullizygous for the fac gene. |
1999-02-25 |
2023-08-12 |
mouse |
| M M Keane, S A Ettenberg, M M Nau, E K Russell, S Lipkowit. Chemotherapy augments TRAIL-induced apoptosis in breast cell lines. Cancer research. vol 59. issue 3. 1999-02-25. PMID:9973225. |
only gst-trail constructs containing regions homologous to the fas self-association and ligand binding domains could induce apoptosis. |
1999-02-25 |
2023-08-12 |
Not clear |
| N H James, J H Gill, R Brindle, N J Woodyatt, N Macdonald, M Rolfe, S C Hasmall, J D Tugwood, P R Holden, R A Robert. Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022238. |
more recently, we have demonstrated that pps can suppress apoptosis induced by more diverse stimuli such as dna damage or ligation of fas, a receptor related to the tumour necrosis factor alpha (tnf alpha) family of cell surface receptors. |
1999-02-25 |
2023-08-12 |
human |
| J Zhuang, G M Cohe. Release of mitochondrial cytochrome c is upstream of caspase activation in chemical-induced apoptosis in human monocytic tumour cells. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022243. |
this contrasts to receptor-mediated apoptosis, such as fas, which results in an initial activation of caspase-8. |
1999-02-25 |
2023-08-12 |
human |
| K Boekelheide, J Lee, E B Shipp, J H Richburg, G L. Expression of Fas system-related genes in the testis during development and after toxicant exposure. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022303. |
the fas system has been identified as a key regulator of testicular germ cell apoptosis. |
1999-02-25 |
2023-08-12 |
rat |