| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Vassilev, Z Ozer, C Navara, S Mahajan, F M Ucku. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880544. |
btk-deficient ramos-1 human burkitt's leukemia cells underwent apoptosis after fas ligation, whereas btk-positive nalm-6-um1 human b-cell precursor leukemia cells expressing similar levels of fas did not. |
1999-02-11 |
2023-08-12 |
human |
| A Vassilev, Z Ozer, C Navara, S Mahajan, F M Ucku. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880544. |
treatment of the anti-fas-resistant nalm-6-um1 cells with the leflunomide metabolite analog alpha-cyano-beta-methyl-beta-hydroxy-n-(2, 5-dibromophenyl)propenamide, a potent inhibitor of btk, abrogated the btk-fas association without affecting the expression levels of btk or fas and rendered them sensitive to fas-mediated apoptosis. |
1999-02-11 |
2023-08-12 |
human |
| A Vassilev, Z Ozer, C Navara, S Mahajan, F M Ucku. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880544. |
the ability of btk to inhibit the pro-apoptotic effects of fas ligation prompts the hypothesis that apoptosis of developing b-cell precursors during normal b-cell ontogeny may be reciprocally regulated by fas and btk. |
1999-02-11 |
2023-08-12 |
human |
| H Le-Niculescu, E Bonfoco, Y Kasuya, F X Claret, D R Green, M Kari. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Molecular and cellular biology. vol 19. issue 1. 1999-02-10. PMID:9858598. |
in pc12 cells, deliberate jnk activation is followed by induction of fas ligand (fasl) expression and apoptosis. |
1999-02-10 |
2023-08-12 |
mouse |
| T Zhou, L Song, P Yang, Z Wang, D Lui, R S Jop. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. Nature medicine. vol 5. issue 1. 1999-02-08. PMID:9883838. |
bisindolylmaleimide viii potentiated fas-mediated apoptosis in human astrocytoma 1321n1 cells and in molt-4t cells, both of which were devoid of apoptosis induced by anti-fas antibody in the absence of bisindolylmaleimide viii, and in jurkat and cem-6 t cells, which showed slight and moderate apoptotic responses, respectively, to low levels of fas stimulation. |
1999-02-08 |
2023-08-12 |
mouse |
| G Bossi, G M Griffith. Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells. Nature medicine. vol 5. issue 1. 1999-02-08. PMID:9883845. |
fas ligand (fasl) triggers apoptosis during cytotoxicity mediated by cytotoxic t lymphocytes and during immune downregulation. |
1999-02-08 |
2023-08-12 |
Not clear |
| T Lamy, J H Liu, T H Landowski, W S Dalton, T P Loughra. Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia. Blood. vol 92. issue 12. 1999-02-05. PMID:9845544. |
cd95 (fas)-induced apoptosis plays a critical role in the elimination of activated lymphocytes and induction of peripheral tolerance. |
1999-02-05 |
2023-08-12 |
mouse |
| K Kuwano, H Miyazaki, N Hagimoto, M Kawasaki, M Fujita, R Kunitake, Y Kaneko, N Har. The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. American journal of respiratory cell and molecular biology. vol 20. issue 1. 1999-02-04. PMID:9870917. |
therefore, we hypothesized that fas ligand (fasl), which induces apoptosis in cells expressing fas antigen (fas), is associated with pulmonary fibrosis. |
1999-02-04 |
2023-08-12 |
Not clear |
| K Kuwano, H Miyazaki, N Hagimoto, M Kawasaki, M Fujita, R Kunitake, Y Kaneko, N Har. The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. American journal of respiratory cell and molecular biology. vol 20. issue 1. 1999-02-04. PMID:9870917. |
we conclude that fas and fasl were upregulated in fibrosing lung diseases and may associate with dna damage or apoptosis of bronchiolar and alveolar epithelial cells in this disorder. |
1999-02-04 |
2023-08-12 |
Not clear |
| H J Deeg, V Lesniko. MHC class II and negative regulators of hematopoiesis. Archivum immunologiae et therapiae experimentalis. vol 46. issue 5. 1999-02-03. PMID:9832067. |
signals generated via hla-dr result in upregulation of tumor necrosis factor alpha (tnf-alpha) and nitric oxide as well as an enhanced expression of fas and its natural ligand (fas-l), all molecules associated with programmed cell death (apoptosis). |
1999-02-03 |
2023-08-12 |
Not clear |
| D Vermijlen, D Luo, B Robaye, C Seynaeve, M Baekeland, E Wiss. Pit cells (Hepatic natural killer cells) of the rat induce apoptosis in colon carcinoma cells by the perforin/granzyme pathway. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862849. |
these results show that pit cells use the ca2+-dependent perforin/granzyme pathway to induce apoptosis in the cc531s cells, and not the alternative ca2+-independent fas pathway. |
1999-02-03 |
2023-08-12 |
rat |
| S Jiang, M J Song, E C Shin, M O Lee, S J Kim, J H Par. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862856. |
in the present study, the involvement of fas in chemotherapeutic drug-induced apoptosis in hepatoma cell lines was investigated. |
1999-02-03 |
2023-08-12 |
human |
| S Jiang, M J Song, E C Shin, M O Lee, S J Kim, J H Par. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862856. |
in hep g2 that constitutively expressed fas, 5-fu or cisplatin treatment caused an increase in the expression of fas before the formation of oligonucleosomal dna fragments, a typical feature of apoptosis. |
1999-02-03 |
2023-08-12 |
human |
| S Jiang, M J Song, E C Shin, M O Lee, S J Kim, J H Par. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862856. |
however, in hep 3b, where fas is undetectable, apoptosis could also be induced by 5-fu or cisplatin without induction of fas. |
1999-02-03 |
2023-08-12 |
human |
| A Watso. The role of Fas in apoptosis induced by anticancer drugs. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862879. |
the role of fas in apoptosis induced by anticancer drugs. |
1999-02-03 |
2023-08-12 |
Not clear |
| T Mizuno, Y Endo, Y Momoi, Y Goto, Y Nishimura, K Tsubota, T Mikami, K Ohno, T Watari, H Tsujimoto, A Hasegaw. Molecular cloning of feline Fas antigen and Fas ligand cDNAs. Veterinary immunology and immunopathology. vol 65. issue 2-4. 1999-02-02. PMID:9839871. |
the fas antigen (fasa) and fas ligand (fasl) are key molecules which mediate apoptosis. |
1999-02-02 |
2023-08-12 |
mouse |
| S H Lee, J J Jang, J Y Lee, S Y Kim, W S Park, C S Kim, S H Kim, N J Yo. Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 106. issue 11. 1999-02-02. PMID:9890264. |
fas ligand (fasl) and its receptor, fas, play a key role in the regulation of apoptosis within the immune system. |
1999-02-02 |
2023-08-12 |
human |
| S H Lee, J J Jang, J Y Lee, S Y Kim, W S Park, C S Kim, S H Kim, N J Yo. Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 106. issue 11. 1999-02-02. PMID:9890264. |
several prior experimental studies of fas ligand expression in tumors have suggested a mechanism that enables tumors to evade immune destruction by inducing apoptosis in activated lymphocytes near the tumor cells. |
1999-02-02 |
2023-08-12 |
human |
| P G Conaldi, L Biancone, A Bottelli, A Wade-Evans, L C Racusen, M Boccellino, V Orlandi, C Serra, G Camussi, A Toniol. HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation. The Journal of clinical investigation. vol 102. issue 12. 1999-02-01. PMID:9854039. |
however, after hiv-1 infection, tubular cells became susceptible to apoptosis induced through fas stimulation. |
1999-02-01 |
2023-08-12 |
Not clear |
| M Fleck, E R Kern, T Zhou, B Lang, J D Mount. Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice. Arthritis and rheumatism. vol 41. issue 12. 1999-02-01. PMID:9870874. |
to analyze fas and tumor necrosis factor receptor i (tnfri) apoptosis pathways in salivary gland inflammatory disease induced by murine cytomegalovirus (mcmv) infection. |
1999-02-01 |
2023-08-12 |
mouse |