| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Boekelheide, J Lee, E B Shipp, J H Richburg, G L. Expression of Fas system-related genes in the testis during development and after toxicant exposure. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022303. |
both fas ligand (fasl) and fas receptor (fas) were expressed postnatally in rat testis with peak expression associated with the high levels of germ cell apoptosis found during the first wave of spermatogenesis. |
1999-02-25 |
2023-08-12 |
rat |
| K Boekelheide, J Lee, E B Shipp, J H Richburg, G L. Expression of Fas system-related genes in the testis during development and after toxicant exposure. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022303. |
these results provide additional support for the following concepts: (1) sertoli-germ cell interactions are important in the control of germ cell apoptosis; and (2) the fas system and similar paracrine systems are important modulators of testicular homeostasis. |
1999-02-25 |
2023-08-12 |
rat |
| M D Srivastava, B I Srivastav. Soluble Fas and soluble Fas ligand proteins in human milk: possible significance in the development of immunological tolerance. Scandinavian journal of immunology. vol 49. issue 1. 1999-02-25. PMID:10023857. |
this study reports the results of an elisa-based quantitation of soluble fas and soluble fas ligand in human milk which may modulate the fas/fasl system that is critical for the expression of immune tolerance and apoptosis. |
1999-02-25 |
2023-08-12 |
human |
| M D Srivastava, B I Srivastav. Soluble Fas and soluble Fas ligand proteins in human milk: possible significance in the development of immunological tolerance. Scandinavian journal of immunology. vol 49. issue 1. 1999-02-25. PMID:10023857. |
an excess of soluble fas in human milk may bind to fasl preventing apoptosis and preserving epithelial barriers, and may represent an additional new mechanism whereby human milk favours immune tolerance and normal gastrointestinal development. |
1999-02-25 |
2023-08-12 |
human |
| P Gupta, G A Niehans, S C LeRoy, K Gupta, V A Morrison, C Schultz, D J Knapp, R A Kratzk. Fas ligand expression in the bone marrow in myelodysplastic syndromes correlates with FAB subtype and anemia, and predicts survival. Leukemia. vol 13. issue 1. 1999-02-25. PMID:10049059. |
the fas receptor, fas ligand (fasl) pathway is a major mechanism of apoptosis. |
1999-02-25 |
2023-08-12 |
Not clear |
| P Gupta, G A Niehans, S C LeRoy, K Gupta, V A Morrison, C Schultz, D J Knapp, R A Kratzk. Fas ligand expression in the bone marrow in myelodysplastic syndromes correlates with FAB subtype and anemia, and predicts survival. Leukemia. vol 13. issue 1. 1999-02-25. PMID:10049059. |
since hematopoietic progenitors can express the fas receptor, they may be susceptible to apoptosis induced by fasl-expressing cells. |
1999-02-25 |
2023-08-12 |
Not clear |
| S C Afford, S Randhawa, A G Eliopoulos, S G Hubscher, L S Young, D H Adam. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. The Journal of experimental medicine. vol 189. issue 2. 1999-02-23. PMID:9892626. |
cd40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. |
1999-02-23 |
2023-08-12 |
human |
| S C Afford, S Randhawa, A G Eliopoulos, S G Hubscher, L S Young, D H Adam. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. The Journal of experimental medicine. vol 189. issue 2. 1999-02-23. PMID:9892626. |
we propose that a novel mechanism of hepatocyte apoptosis, involving a cooperative interaction between cd40 and fas, is involved in the hepatocyte loss of chronic liver allograft rejection. |
1999-02-23 |
2023-08-12 |
human |
| S C Afford, S Randhawa, A G Eliopoulos, S G Hubscher, L S Young, D H Adam. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. The Journal of experimental medicine. vol 189. issue 2. 1999-02-23. PMID:9892626. |
a functional role for cd40 and fas in hepatocyte apoptosis was demonstrated in vitro using primary human hepatocytes and the hepg2 cell line in both of which apoptosis was induced, not only by cross-linking fas directly but also via cd40 activation. |
1999-02-23 |
2023-08-12 |
human |
| S C Afford, S Randhawa, A G Eliopoulos, S G Hubscher, L S Young, D H Adam. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. The Journal of experimental medicine. vol 189. issue 2. 1999-02-23. PMID:9892626. |
our data suggest that cd40 activation induces apoptosis via fas because (a) ligation of cd40 upregulated hepatocyte fasl expression, and (b) apoptosis induced via activation of cd40 was prevented by a neutralizing monoclonal antibody to fasl. |
1999-02-23 |
2023-08-12 |
human |
| J Lee, J H Richburg, E B Shipp, M L Meistrich, K Boekelheid. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology. vol 140. issue 2. 1999-02-23. PMID:9927315. |
the fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in sertoli cell versus germ cell injury of the testis. |
1999-02-23 |
2023-08-12 |
rat |
| J Lee, J H Richburg, E B Shipp, M L Meistrich, K Boekelheid. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology. vol 140. issue 2. 1999-02-23. PMID:9927315. |
the fas system has been proposed as a key regulator of the activation of germ cell apoptosis. |
1999-02-23 |
2023-08-12 |
rat |
| G Feldmann, C Lamboley, A Moreau, A Bringuie. Fas-mediated apoptosis of hepatic cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 52. issue 9. 1999-02-19. PMID:9856284. |
however it is the localization of fas on the plasma membrane of hepatocytes which explains why these cells are mainly destroyed by apoptosis--in a picture resembling human fulminant hepatitis--when mice are administered with anti-fas antibodies or fas ligand. |
1999-02-19 |
2023-08-12 |
mouse |
| G Feldmann, C Lamboley, A Moreau, A Bringuie. Fas-mediated apoptosis of hepatic cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 52. issue 9. 1999-02-19. PMID:9856284. |
it is also established that fas is surexpressed in some human chronic liver diseases, such as those induced by hepatitis b or c virus, a situation which could explain the pathogenesis of some liver lesions occurring during these diseases, such as the apoptosis of hepatocytes in piecemeal necrosis. |
1999-02-19 |
2023-08-12 |
mouse |
| R De Maria, U Testa, L Luchetti, A Zeuner, G Stassi, E Pelosi, R Riccioni, N Felli, P Samoggia, C Peschl. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood. vol 93. issue 3. 1999-02-18. PMID:9920828. |
however, fas crosslinking was effective only in less mature erythroblasts, particularly at basophilic level, where it induced apoptosis antagonized by high levels of erythropoietin (epo). |
1999-02-18 |
2023-08-12 |
Not clear |
| W A Faubion, M E Guicciardi, H Miyoshi, S F Bronk, P J Roberts, P A Svingen, S H Kaufmann, G J Gore. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. The Journal of clinical investigation. vol 103. issue 1. 1999-02-16. PMID:9884343. |
toxic bile salts induce rodent hepatocyte apoptosis via direct activation of fas. |
1999-02-16 |
2023-08-12 |
mouse |
| W A Faubion, M E Guicciardi, H Miyoshi, S F Bronk, P J Roberts, P A Svingen, S H Kaufmann, G J Gore. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. The Journal of clinical investigation. vol 103. issue 1. 1999-02-16. PMID:9884343. |
collectively, these data suggest that gcdc-induced hepatocyte apoptosis involves ligand-independent oligomerization of fas, recruitment of fadd, activation of caspase 8, and subsequent activation of effector proteases, including downstream caspases and cathepsin b. |
1999-02-16 |
2023-08-12 |
mouse |
| L Kong, C P Robinson, A B Peck, N Vela-Roch, K M Sakata, H Dang, N Talal, M G Humphreys-Behe. Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice. Clinical and experimental rheumatology. vol 16. issue 6. 1999-02-12. PMID:9844759. |
to examine the role of the glandular epithelial cells in the pathogenesis of autoimmune exocrinopathy, we studied fas and fas ligand (fasl) expression and quantitated the levels of apoptosis in salivary and lacrimal glands from nod and nod-scid mice, an animal model that develops a sjögren's syndrome-like pathology. |
1999-02-12 |
2023-08-12 |
mouse |
| C S Ng, S T Lo, J K Cha. Peripheral T and putative natural killer cell lymphomas commonly coexpress CD95 and CD95 ligand. Human pathology. vol 30. issue 1. 1999-02-12. PMID:9923926. |
the cd95 (fas)/cd95 ligand (cd95l) system is an important mechanism triggering apoptosis, and cd95l expression has recently been implicated for immune evasion and aggressive behavior in malignancies. |
1999-02-12 |
2023-08-12 |
Not clear |
| A Vassilev, Z Ozer, C Navara, S Mahajan, F M Ucku. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880544. |
fas-resistant dt-40 lymphoma b-cells rendered btk-deficient through targeted disruption of the btk gene by homologous recombination knockout underwent apoptosis after fas ligation, but wild-type dt-40 cells or btk-deficient dt-40 cells reconstituted with wild-type human btk gene did not. |
1999-02-11 |
2023-08-12 |
human |