| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Tortorella, G Piazzolla, F Spaccavento, S Antonac. Effects of granulocyte-macrophage colony-stimulating factor and cyclic AMP interaction on human neutrophil apoptosis. Mediators of inflammation. vol 7. issue 6. 1999-04-13. PMID:9927231. |
the current study was undertaken to evaluate the effects of granulocyte-macrophage colony-stimulating factor (gm-csf) and cyclic amp (camp) signaling interaction on human neutrophil apoptosis, either occurring spontaneously or induced by fas antigen activation. |
1999-04-13 |
2023-08-12 |
human |
| H G Zhang, X Su, D Liu, W Liu, P Yang, Z Wang, C K Edwards, H Bluethmann, J D Mountz, T Zho. Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973398. |
autocrine interaction of fas and fas ligand leads to apoptosis of activated t cells, a process that is critical for the maintenance of peripheral t cell tolerance. |
1999-04-13 |
2023-08-12 |
mouse |
| H G Zhang, X Su, D Liu, W Liu, P Yang, Z Wang, C K Edwards, H Bluethmann, J D Mountz, T Zho. Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973398. |
paracrine interactions of fas ligand with t cells also may play an important role in the maintenance of tolerance, as fas ligand can create immune-privileged sites and prevent graft rejection by inducing apoptosis in t cells. |
1999-04-13 |
2023-08-12 |
mouse |
| H G Zhang, X Su, D Liu, W Liu, P Yang, Z Wang, C K Edwards, H Bluethmann, J D Mountz, T Zho. Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973398. |
we surmised that apcs that express fas ligand might directly induce apoptosis of t cells during presentation of ag to the t cells, thus inducing ag-specific, systemic t cell tolerance. |
1999-04-13 |
2023-08-12 |
mouse |
| H G Zhang, X Su, D Liu, W Liu, P Yang, Z Wang, C K Edwards, H Bluethmann, J D Mountz, T Zho. Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973398. |
these findings demonstrate that ag-specific t cell tolerance can be induced by apcs that express fas ligand and suggest a novel function for apcs in the induction of t cell apoptosis. |
1999-04-13 |
2023-08-12 |
mouse |
| S Jayaraman, M Castro, M O'Sullivan, M J Bragdon, M J Holtzma. Resistance to Fas-mediated T cell apoptosis in asthma. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973434. |
we found that mitogen-stimulated peripheral blood t cells of asthmatic subjects expressed cell surface fas, but failed to undergo the normal degree of apoptosis after fas receptor ligation. |
1999-04-13 |
2023-08-12 |
human |
| S Jayaraman, M Castro, M O'Sullivan, M J Bragdon, M J Holtzma. Resistance to Fas-mediated T cell apoptosis in asthma. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973434. |
taken together, the findings suggest that selective resistance to fas-dependent apoptosis reflects altered ag-driven, accessory cell-dependent signaling and that ineffective activation of fas signal transduction may contribute to t cell-dependent immunoinflammation in asthma. |
1999-04-13 |
2023-08-12 |
human |
| C Choi, J Y Park, J Lee, J H Lim, E C Shin, Y S Ahn, C H Kim, S J Kim, J D Kim, I S Choi, I H Cho. Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 4. 1999-04-13. PMID:9973455. |
fas ligand (fasl) and fas are mediators of apoptosis, which are implicated in the peripheral deletion of autoimmune cells, activation-induced t cell death, and cytotoxicity mediated by cd8+ t cells. |
1999-04-13 |
2023-08-12 |
human |
| C Choi, J Y Park, J Lee, J H Lim, E C Shin, Y S Ahn, C H Kim, S J Kim, J D Kim, I S Choi, I H Cho. Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 4. 1999-04-13. PMID:9973455. |
our data demonstrated that: 1) fasl is expressed constitutively on astrocytes taken from a fetus or an adult and that its expression increases when these cells are treated with il-1, il-6, or tnf-alpha in which the pretreatment of ifn-gamma triggers astrocytes to express more fasl; 2) astrocytes induce apoptosis in molt-4 cells through fasl; 3) fas is also expressed constitutively and is up-regulated by il-1, il-6, or tnf-alpha in which the pretreatment of ifn-gamma triggers astrocytes to express more fas; 4) apoptosis occurs when fetal astrocytes are treated with agonistic anti-fas igm ab after culture with ifn-gamma and tnf-alpha; and 5) tnf-related apoptosis inducing ligand is up-regulated in fetal astrocytes with stimuli of il-1 or tnf-alpha. |
1999-04-13 |
2023-08-12 |
human |
| K Furuke, M Shiraishi, H S Mostowski, E T Bloo. Fas ligand induction in human NK cells is regulated by redox through a calcineurin-nuclear factors of activated T cell-dependent pathway. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 4. 1999-04-13. PMID:9973469. |
fas ligand (fasl) on cytotoxic lymphocytes is important for mediating apoptosis of activated lymphocytes and other target cells. |
1999-04-13 |
2023-08-12 |
human |
| E J Goetzl, Y Kong, B Me. Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 4. 1999-04-13. PMID:9973477. |
at 10-10 m to 10-7 m, both lpa and s1p protected tsup-1 cells from apoptosis induced by abs to fas, cd2, and cd3 plus cd28 in combination. |
1999-04-13 |
2023-08-12 |
human |
| C M Wolf, A Eastma. The temporal relationship between protein phosphatase, mitochondrial cytochrome c release, and caspase activation in apoptosis. Experimental cell research. vol 247. issue 2. 1999-04-13. PMID:10066378. |
apoptosis is mediated by members of the caspase family of proteases which can be activated by release of mitochondrial cytochrome c. additional members of the caspase family are activated at the cell surface in response to direct stimulus from the external environment such as by activation of the fas receptor. |
1999-04-13 |
2023-08-12 |
Not clear |
| C M Wolf, A Eastma. The temporal relationship between protein phosphatase, mitochondrial cytochrome c release, and caspase activation in apoptosis. Experimental cell research. vol 247. issue 2. 1999-04-13. PMID:10066378. |
it has been suggested that these upstream caspases directly activate the downstream caspases which would obviate a role for cytochrome c in apoptosis induced by the fas receptor. |
1999-04-13 |
2023-08-12 |
Not clear |
| D Tang, J M Lahti, J Grenet, V J Kid. Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. The Journal of biological chemistry. vol 274. issue 11. 1999-04-13. PMID:10066786. |
since chx treatment did not result in the induction of fas or fasl, and neutralizing anti-fas and anti-tumor necrosis factor receptor-1 antibodies did not block chx-mediated apoptosis, these results may also indicate that fadd functions in a receptor-independent manner. |
1999-04-13 |
2023-08-12 |
human |
| K F Yoong, S C Afford, S Randhawa, S G Hubscher, D H Adam. Fas/Fas ligand interaction in human colorectal hepatic metastases: A mechanism of hepatocyte destruction to facilitate local tumor invasion. The American journal of pathology. vol 154. issue 3. 1999-04-13. PMID:10079247. |
apoptosis was observed in 45 +/- 13% of the fas(high) hepatocytes at the tumor margin whereas only 7 +/- 3% tumor cells were apoptotic (n = 10). |
1999-04-13 |
2023-08-12 |
human |
| K F Yoong, S C Afford, S Randhawa, S G Hubscher, D H Adam. Fas/Fas ligand interaction in human colorectal hepatic metastases: A mechanism of hepatocyte destruction to facilitate local tumor invasion. The American journal of pathology. vol 154. issue 3. 1999-04-13. PMID:10079247. |
in vitro, primary human hepatocytes expressed fas receptor and crosslinking with anti-fas antibody induced apoptosis in 44 +/- 5% of the cells compared with 4. |
1999-04-13 |
2023-08-12 |
human |
| G L Yount, K S Levine, H Kuriyama, D A Haas-Kogan, M A Israe. Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells. Cancer research. vol 59. issue 6. 1999-04-13. PMID:10096571. |
radiation-induced apoptosis can be mediated through pathways initiated by either dna damage or ceramide-induced fas signaling. |
1999-04-13 |
2023-08-12 |
human |
| G L Yount, K S Levine, H Kuriyama, D A Haas-Kogan, M A Israe. Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells. Cancer research. vol 59. issue 6. 1999-04-13. PMID:10096571. |
these data demonstrate that apoptosis can be induced by ceramide and mediated through the fas pathway in glioma cells, although high-dose ionizing radiation fails to trigger this pathway. |
1999-04-13 |
2023-08-12 |
human |
| J Houghton, R M Korah, M R Condon, K H Ki. Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Digestive diseases and sciences. vol 44. issue 3. 1999-04-07. PMID:10080136. |
apoptosis in helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the fas antigen pathway. |
1999-04-07 |
2023-08-12 |
Not clear |
| J Houghton, R M Korah, M R Condon, K H Ki. Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Digestive diseases and sciences. vol 44. issue 3. 1999-04-07. PMID:10080136. |
one pathway for induction of apoptosis is the fas ag pathway. |
1999-04-07 |
2023-08-12 |
Not clear |