| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Klein, C Ricordi, A Pugliese, R L Pastor. Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme. Human gene therapy. vol 11. issue 7. 2000-07-27. PMID:10811232. |
inhibition of de novo fas expression in betatc-3 cells expressing the anti-fas ribozyme correlated with resistance to fas-mediated apoptosis as determined by the number of cells exhibiting caspase 3 proteolytic activity. |
2000-07-27 |
2023-08-12 |
mouse |
| D Klein, C Ricordi, A Pugliese, R L Pastor. Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme. Human gene therapy. vol 11. issue 7. 2000-07-27. PMID:10811232. |
hence, we have engineered a ribozyme capable of preventing fas expression in the betatc-3 pancreatic insulinoma cell line and conferring resistance to fas-mediated apoptosis. |
2000-07-27 |
2023-08-12 |
mouse |
| Corina Lorz, Alberto Ortiz, Pilar Justo, Silvia González-Cuadrado, Natalia Duque, Carmen Gómez-Guerrero, Jesús Egid. Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli. Journal of the American Society of Nephrology : JASN. vol 11. issue 7. 2000-07-27. PMID:10864583. |
fas ligand (fasl) is a cell membrane cytokine that can promote apoptosis through activation of fas receptors. |
2000-07-27 |
2023-08-12 |
mouse |
| Corina Lorz, Alberto Ortiz, Pilar Justo, Silvia González-Cuadrado, Natalia Duque, Carmen Gómez-Guerrero, Jesús Egid. Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli. Journal of the American Society of Nephrology : JASN. vol 11. issue 7. 2000-07-27. PMID:10864583. |
fas receptor activation induces glomerular cell apoptosis in vivo and participates in tubular cell death during acute renal failure. |
2000-07-27 |
2023-08-12 |
mouse |
| Corina Lorz, Alberto Ortiz, Pilar Justo, Silvia González-Cuadrado, Natalia Duque, Carmen Gómez-Guerrero, Jesús Egid. Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli. Journal of the American Society of Nephrology : JASN. vol 11. issue 7. 2000-07-27. PMID:10864583. |
however, mct cells stimulated with inflammatory mediators (tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide) increased cell surface fas expression and were sensitized to apoptosis induced by fasl (fasl 55 +/- 5% versus control 8.3 +/- 4.1% apoptotic cells at 24 h, p < 0.05). |
2000-07-27 |
2023-08-12 |
mouse |
| b' S Habibovi\\xc4\\x87, Z Hrgovi\\xc4\\x87, I Bukvi\\xc4\\x87, I Hrgovi\\xc4\\x8. [Molecular mechanisms in apoptosis]. Medicinski arhiv. vol 54. issue 1. 2000-07-27. PMID:10872274.' |
tumor necrosis factor-alpha (tnf-alpha) or fas ligand activated apoptosis by binding of the plasma membrane receptor. |
2000-07-27 |
2023-08-12 |
Not clear |
| A Trautmann, M Akdis, D Kleemann, F Altznauer, H U Simon, T Graeve, M Noll, E B Bröcker, K Blaser, C A Akdi. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. The Journal of clinical investigation. vol 106. issue 1. 2000-07-27. PMID:10880045. |
subsequently, kcs undergo apoptosis induced by anti-fasr mab's, soluble fas ligand, supernatants from activated t cells, or direct contact between t cells and kcs. |
2000-07-27 |
2023-08-12 |
human |
| T Yoshida, T Higuchi, H Hagiyama, A Strasser, K Nishioka, T Tsubat. Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. International immunology. vol 12. issue 4. 2000-07-25. PMID:10744653. |
rapid b cell apoptosis induced by antigen receptor ligation does not require fas (cd95/apo-1), the adaptor protein fadd/mort1 or crma-sensitive caspases but is defective in both mrl-+/+ and mrl-lpr/lpr mice. |
2000-07-25 |
2023-08-12 |
mouse |
| T Yoshida, T Higuchi, H Hagiyama, A Strasser, K Nishioka, T Tsubat. Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. International immunology. vol 12. issue 4. 2000-07-25. PMID:10744653. |
antigen receptor ligation-induced apoptosis of mature t cells and t cell lines requires autocrine or paracrine activation of fas (cd95/apo-1). |
2000-07-25 |
2023-08-12 |
mouse |
| T Yoshida, T Higuchi, H Hagiyama, A Strasser, K Nishioka, T Tsubat. Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. International immunology. vol 12. issue 4. 2000-07-25. PMID:10744653. |
whether b cell antigen receptor (bcr)-mediated apoptosis requires fas or related molecules is unclear. |
2000-07-25 |
2023-08-12 |
mouse |
| T Yoshida, T Higuchi, H Hagiyama, A Strasser, K Nishioka, T Tsubat. Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. International immunology. vol 12. issue 4. 2000-07-25. PMID:10744653. |
these results indicate that bcr ligation activates an apoptotic signaling pathway distinct from fas-mediated apoptosis in wehi-231 cells, and that bcr-mediated apoptosis of wehi-231 cells does not require fas or related molecules such as dr3, dr4 and dr5, as all of these death receptors require fadd/mort1 and/or crma-sensitive caspases for induction of apoptosis. |
2000-07-25 |
2023-08-12 |
mouse |
| T Yoshida, T Higuchi, H Hagiyama, A Strasser, K Nishioka, T Tsubat. Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. International immunology. vol 12. issue 4. 2000-07-25. PMID:10744653. |
moreover, extensive bcr ligation induces death of mature b cells from c57bl/6-lpr/lpr mice as efficiently as those from c57bl/6 mice, indicating that fas is not essential for bcr-mediated apoptosis of mature b cells. |
2000-07-25 |
2023-08-12 |
mouse |
| K Ichikawa, H Yoshida-Kato, M Ohtsuki, J Ohsumi, J Yamaguchi, S Takahashi, Y Tani, M Watanabe, A Shiraishi, K Nishioka, S Yonehara, N Serizaw. A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity. International immunology. vol 12. issue 4. 2000-07-25. PMID:10744657. |
although induction of fas-mediated apoptosis could have therapeutic effects on these diseases, it might cause deleterious effects in liver as fas ligand or an agonistic anti-murine fas antibody jo2 causes severe hepatic injury in mice. |
2000-07-25 |
2023-08-12 |
mouse |
| A E Brannigan, P R O'Connell, H Hurley, A O'Neill, H R Brady, J M Fitzpatrick, R W Watso. Neutrophil apoptosis is delayed in patients with inflammatory bowel disease. Shock (Augusta, Ga.). vol 13. issue 5. 2000-07-25. PMID:10807010. |
pro-caspase 3 expression was also reduced in ibd neutrophils, which may contribute to decreased spontaneous and fas antibody-induced apoptosis. |
2000-07-25 |
2023-08-12 |
Not clear |
| J J Wang, S Rabizadeh, A Tasinato, S Sperandio, X Ye, M Green, N Assa-Munt, D Spencer, D E Bredese. Dimerization-dependent block of the proapoptotic effect of p75(NTR). Journal of neuroscience research. vol 60. issue 5. 2000-07-24. PMID:10820429. |
we report here that, in contrast to other proapoptotic receptors such as fas, apoptosis induction by p75(ntr) requires monomerization, with dimerization inhibiting the effect. |
2000-07-24 |
2023-08-12 |
Not clear |
| L Owen-Schaub, H Chan, J C Cusack, J Roth, L L Hil. Fas and Fas ligand interactions in malignant disease. International journal of oncology. vol 17. issue 1. 2000-07-24. PMID:10853011. |
fas (cd95) and fas ligand (fasl) are an interacting receptor ligand pair that elicits apoptosis in many cell types. |
2000-07-24 |
2023-08-12 |
Not clear |
| L Owen-Schaub, H Chan, J C Cusack, J Roth, L L Hil. Fas and Fas ligand interactions in malignant disease. International journal of oncology. vol 17. issue 1. 2000-07-24. PMID:10853011. |
this review summarizes our current knowledge about the regulation of fas and fasl expression, fas signaling, soluble fas production, the role(s) of fas and fasl in hematopoietic and non-hematopoietic tumorigenesis and progression, and the potential application of fas-induced apoptosis in cancer therapy. |
2000-07-24 |
2023-08-12 |
Not clear |
| R M Siegel, J K Frederiksen, D A Zacharias, F K Chan, M Johnson, D Lynch, R Y Tsien, M J Lenard. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (New York, N.Y.). vol 288. issue 5475. 2000-07-24. PMID:10875918. |
fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. |
2000-07-24 |
2023-08-12 |
human |
| R M Siegel, J K Frederiksen, D A Zacharias, F K Chan, M Johnson, D Lynch, R Y Tsien, M J Lenard. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (New York, N.Y.). vol 288. issue 5475. 2000-07-24. PMID:10875918. |
heterozygous mutations encoding abnormal forms of the death receptor fas dominantly interfere with fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative syndrome. |
2000-07-24 |
2023-08-12 |
human |
| S Kay, N Donin, M Michowitz, D Katzenelson, J Hiss, G Schibi, A Pinchassov, J Leibovic. Release from apoptosis correlates with tumor progression in the AKR lymphoma. Biochimica et biophysica acta. vol 1497. issue 1. 2000-07-20. PMID:10838157. |
comparison of fas receptor, unexpectedly showed an increased expression in mt versus pt cells, possibly indicating resistance to fas-induced apoptosis in the mt cells. |
2000-07-20 |
2023-08-12 |
Not clear |