| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Gómez-Angelats, C D Bortner, J A Cidlowsk. Protein kinase C (PKC) inhibits fas receptor-induced apoptosis through modulation of the loss of K+ and cell shrinkage. A role for PKC upstream of caspases. The Journal of biological chemistry. vol 275. issue 26. 2000-08-10. PMID:10867019. |
protein kinase c (pkc) inhibits fas receptor-induced apoptosis through modulation of the loss of k+ and cell shrinkage. |
2000-08-10 |
2023-08-12 |
Not clear |
| M Gómez-Angelats, C D Bortner, J A Cidlowsk. Protein kinase C (PKC) inhibits fas receptor-induced apoptosis through modulation of the loss of K+ and cell shrinkage. A role for PKC upstream of caspases. The Journal of biological chemistry. vol 275. issue 26. 2000-08-10. PMID:10867019. |
cell shrinkage and loss of intracellular k(+) are early requisite features for the activation of effector caspases and apoptotic nucleases in fas receptor-mediated apoptosis of jurkat cells, although the mechanisms responsible for both process remain unclear (bortner, c. d., hughes, f. m., jr., and cidlowski, j. |
2000-08-10 |
2023-08-12 |
Not clear |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
cd4 t lymphocytes are primed to express fas ligand by cd4 cross-linking and to contribute to cd8 t-cell apoptosis via fas/fasl death signaling pathway. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
in the present study, we demonstrate that cd4xl in purified t cells not only led to fas up-regulation but also primed cd4 t cells to express fasl upon cd3 stimulation and rendered the t cells susceptible to fas-mediated apoptosis. |
2000-08-10 |
2023-08-12 |
human |
| A G Eliopoulos, C Davies, P G Knox, N J Gallagher, S C Afford, D H Adams, L S Youn. CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Molecular and cellular biology. vol 20. issue 15. 2000-08-10. PMID:10891490. |
the ability of cd40 to mediate apoptosis in carcinoma cells is intriguing given the fact that the cd40 cytoplasmic c terminus lacks a death domain homology with the cytotoxic members of the tnfr superfamily, such as fas, tnfr1, and tnf-related apoptosis-inducing ligand (trail) receptors. |
2000-08-10 |
2023-08-12 |
Not clear |
| M A Belaud-Rotureau, F Durrieu, G Labroille, F Lacombe, O Fitoussi, P Agape, G Marit, J Reiffers, F Bello. Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment. Leukemia. vol 14. issue 7. 2000-08-10. PMID:10914552. |
finally, fas induction and anthracycline-induced apoptosis on blast cells were significantly higher when a complete remission was achieved, thus shedding light on potential new prognostic factors in acute leukemia. |
2000-08-10 |
2023-08-12 |
Not clear |
| P Schneider, J Tschop. Apoptosis induced by death receptors. Pharmaceutica acta Helvetiae. vol 74. issue 2-3. 2000-08-09. PMID:10812970. |
this suggests that more than three fas molecules need to be aggregated to efficiently signal apoptosis. |
2000-08-09 |
2023-08-12 |
Not clear |
| M Rivero, J Crespo, M Mayorga, E Fábrega, B de las Heras, C Almohalla, F Pons-Romer. [Soluble Fas in acute rejection in patients with liver transplantation. Response to treatment]. Gastroenterologia y hepatologia. vol 23. issue 5. 2000-08-09. PMID:10902272. |
it has been suggested that in the cellular rejection of hepatic graft, the lesion provoked by cytotoxic t-lymphocytes might be mediated by the fas antigen/fas ligand system, producing cell death by apoptosis. |
2000-08-09 |
2023-08-12 |
Not clear |
| D Liu, D Pavlovic, M C Chen, M Flodström, S Sandler, D L Eiziri. Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). Diabetes. vol 49. issue 7. 2000-08-09. PMID:10909967. |
from these data, we concluded that 1) no is required for cytokine-induced hsp 70 mrna expression but not for fas and mnsod expression, 2) cytokines induce both apoptosis and necrosis in mouse beta-cells, and 3) cytokine-induced apoptosis is mostly no-independent, whereas necrosis requires no formation. |
2000-08-09 |
2023-08-12 |
mouse |
| D Heuss, S Probst-Cousin, C Kayser, B Neundörfe. Cell death in vasculitic neuropathy. Muscle & nerve. vol 23. issue 7. 2000-08-07. PMID:10882993. |
a nonsecretory ligand-mediated mechanism has been proposed for apoptosis and requires the interaction of fas and fas-ligand. |
2000-08-07 |
2023-08-12 |
Not clear |
| S Rubinchik, R Ding, A J Qiu, F Zhang, J Don. Adenoviral vector which delivers FasL-GFP fusion protein regulated by the tet-inducible expression system. Gene therapy. vol 7. issue 10. 2000-08-04. PMID:10845726. |
fas ligand (fasl) is a member of the tumor necrosis family and when bound to its receptor, fas, induces apoptosis. |
2000-08-04 |
2023-08-12 |
Not clear |
| C Selleri, J P Maciejewsk. The role of FAS-mediated apoptosis in chronic myelogenous leukemia. Leukemia & lymphoma. vol 37. issue 3-4. 2000-08-03. PMID:10752980. |
in comparison to the chronic phase, cml cells derived from patients in blast crisis are refractory to fas-mediated apoptosis, regardless of the expression levels of fas, suggesting that an immune-mediated selection pressure could result in acquisition of fas-resistance. |
2000-08-03 |
2023-08-12 |
Not clear |
| H J Deeg, C Beckham, M R Loken, E Bryant, M Lesnikova, H M Shulman, T Goole. Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome. Leukemia & lymphoma. vol 37. issue 3-4. 2000-08-03. PMID:10752992. |
there is evidence, however, that regulatory molecules such as tumor necrosis factor (tnf)-alpha, fas (cd95), and fas-ligand, which negatively affect hemopoiesis by way of apoptosis are upregulated. |
2000-08-03 |
2023-08-12 |
Not clear |
| J Ciccolini, L Peillard, A Evrard, P Cuq, C Aubert, A Pelegrin, P Formento, G Milano, J Catali. Enhanced antitumor activity of 5-fluorouracil in combination with 2'-deoxyinosine in human colorectal cell lines and human colon tumor xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 4. 2000-08-03. PMID:10778986. |
this fas component could explain the discrepancy between the lines because caco2 has been described as insensitive to fas-mediated apoptosis. |
2000-08-03 |
2023-08-12 |
mouse |
| A Riccioli, D Starace, A D'Alessio, G Starace, F Padula, P De Cesaris, A Filippini, E Zipar. TNF-alpha and IFN-gamma regulate expression and function of the Fas system in the seminiferous epithelium. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 2. 2000-08-03. PMID:10878347. |
more recently, the fas system has been implicated in the maintenance of the immune privilege in the testis as well as in the regulation of germ cell apoptosis. |
2000-08-03 |
2023-08-12 |
mouse |
| A Riccioli, D Starace, A D'Alessio, G Starace, F Padula, P De Cesaris, A Filippini, E Zipar. TNF-alpha and IFN-gamma regulate expression and function of the Fas system in the seminiferous epithelium. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 2. 2000-08-03. PMID:10878347. |
taken together, our data suggest a possible regulatory role of tnf-alpha and ifn-gamma on fas-mediated apoptosis in the testis through disruption of the balance between different forms of fas. |
2000-08-03 |
2023-08-12 |
mouse |
| M D Pascoe, S E Marshall, K I Welsh, L M Fulton, D A Hughe. Increased accuracy of renal allograft rejection diagnosis using combined perforin, granzyme B, and Fas ligand fine-needle aspiration immunocytology. Transplantation. vol 69. issue 12. 2000-08-03. PMID:10910275. |
two major routes by which cytotoxic t lymphocytes induce apoptosis in target cells are the perforin-granzyme and the fas ligand/fas pathways. |
2000-08-03 |
2023-08-12 |
human |
| T Kataoka, R C Budd, N Holler, M Thome, F Martinon, M Irmler, K Burns, M Hahne, N Kennedy, M Kovacsovics, J Tschop. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Current biology : CB. vol 10. issue 11. 2000-08-02. PMID:10837247. |
however, fas signals do not always result in apoptosis but can also trigger a pathway that leads to proliferation. |
2000-08-02 |
2023-08-12 |
Not clear |
| M Delgado, D Gane. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit T cell-mediated cytotoxicity by inhibiting Fas ligand expression. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 1. 2000-07-31. PMID:10861043. |
we reported recently that the neuropeptides vasoactive intestinal peptide (vip) and pituitary adenylate cyclase-activating polypeptide (pacap) protect cd4+ t cells against ag-induced apoptosis by down-regulating the expression of fas ligand (fasl). |
2000-07-31 |
2023-08-12 |
Not clear |
| F C Kischkel, D A Lawrence, A Chuntharapai, P Schow, K J Kim, A Ashkenaz. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity. vol 12. issue 6. 2000-07-31. PMID:10894161. |
fas (apo-1/cd95) and tumor necrosis factor receptor 1 (tnfr1) trigger apoptosis by recruiting the apoptosis initiator caspase-8 through the adaptor fadd. |
2000-07-31 |
2023-08-12 |
Not clear |