| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Yamamoto, K Yoneda, E Ueta, S Doi, T Osak. Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs. European journal of cancer (Oxford, England : 1990). vol 36. issue 15. 2001-01-04. PMID:11000584. |
these results indicate that anticancer drugs and gamma-rays prime squamous cell carcinoma cells to be susceptible to apoptosis by lak cells, that lak cell-induced apoptosis largely depends on the activation of caspase-3 by the fas/fas-ligand signal and granzyme b, and that lak cells induce roi in the target cells, which is largely mediated by fas and granzyme b. |
2001-01-04 |
2023-08-12 |
Not clear |
| N P Restif. Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity. Current opinion in immunology. vol 12. issue 5. 2001-01-04. PMID:11007365. |
though the apoptosis occurring during normal development is immunologically bland or even tolerizing, the apoptotic death after viral infection or after the ligation of fas can trigger powerful innate and adaptive immune responses. |
2001-01-04 |
2023-08-12 |
Not clear |
| M Nagaki, T Naiki, D A Brenner, Y Osawa, M Imose, H Hayashi, Y Banno, S Nakashima, H Moriwak. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Hepatology (Baltimore, Md.). vol 32. issue 6. 2001-01-04. PMID:11093734. |
these results indicate that tnfr and fas independently regulate murine apoptotic liver failure, and that a rapid defense mechanism induced by the activation of nf-kappab blocks death-signaling at the initiation stage of hepatic apoptosis mediated by tnfr, probably downstream of caspase-8, but not by fas. |
2001-01-04 |
2023-08-12 |
mouse |
| B Bartling, H Tostlebe, D Darmer, J Holtz, R E Silber, H Morawiet. Shear stress-dependent expression of apoptosis-regulating genes in endothelial cells. Biochemical and biophysical research communications. vol 278. issue 3. 2001-01-04. PMID:11095978. |
these diminished signs of apoptosis were accompanied by a decreased mrna expression of apoptosis-inducing fas receptor. |
2001-01-04 |
2023-08-12 |
human |
| B Bartling, H Tostlebe, D Darmer, J Holtz, R E Silber, H Morawiet. Shear stress-dependent expression of apoptosis-regulating genes in endothelial cells. Biochemical and biophysical research communications. vol 278. issue 3. 2001-01-04. PMID:11095978. |
we propose that altered expression of bcl-x(l) and the fas system is involved in the protective effect of laminar shear stress against apoptosis in human endothelial cells. |
2001-01-04 |
2023-08-12 |
human |
| A Ouhtit, A Gorny, H K Muller, L L Hill, L Owen-Schaub, H N Ananthaswam. Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis. The American journal of pathology. vol 157. issue 6. 2001-01-04. PMID:11106570. |
most of the tumors expressed fas but not fas-l. we conclude that chronic uv exposure may induce a loss of fas-l expression and a gain in p53 mutations, leading to dysregulation of apoptosis, expansion of mutated keratinocytes, and initiation of skin cancer. |
2001-01-04 |
2023-08-12 |
mouse |
| L Feuk, J A Prince, G Breen, T Emahazion, A Carothers, D St Clair, A J Brooke. apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. Human genetics. vol 107. issue 4. 2001-01-04. PMID:11129341. |
the tnfrsf6 gene encodes fas, a cell-surface receptor involved in apoptosis initiation. |
2001-01-04 |
2023-08-12 |
Not clear |
| F Okano, K Yamad. Canine interleukin-18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line. Anticancer research. vol 20. issue 5B. 2001-01-04. PMID:11131641. |
canine interleukin-18 induces apoptosis and enhances fas ligand mrna expression in a canine carcinoma cell line. |
2001-01-04 |
2023-08-12 |
mouse |
| E Pace, M Melis, L Siena, F Bucchieri, A M Vignola, M Profita, M Gjomarkaj, G Bonsignor. Effects of gemcitabine on cell proliferation and apoptosis in non-small-cell lung cancer (NSCLC) cell lines. Cancer chemotherapy and pharmacology. vol 46. issue 6. 2001-01-04. PMID:11138460. |
the incubation of nsclc with anti-fas agonistic monoclonal antibody (ch11) induced cell apoptosis in h292 cells, demonstrating that the fas receptor was functionally active. |
2001-01-04 |
2023-08-12 |
Not clear |
| E Pace, M Melis, L Siena, F Bucchieri, A M Vignola, M Profita, M Gjomarkaj, G Bonsignor. Effects of gemcitabine on cell proliferation and apoptosis in non-small-cell lung cancer (NSCLC) cell lines. Cancer chemotherapy and pharmacology. vol 46. issue 6. 2001-01-04. PMID:11138460. |
this study demonstrates that gemcitabine induces apoptosis in nsclc and that this effect might be exerted by modulating functionally active fas expression, and these effects of gemcitabine were stronger in h292 cells than in either corl23 or colo699 cells. |
2001-01-04 |
2023-08-12 |
Not clear |
| S Bang, E J Jeong, I K Kim, Y K Jung, K S Ki. Fas- and tumor necrosis factor-mediated apoptosis uses the same binding surface of FADD to trigger signal transduction. A typical model for convergent signal transduction. The Journal of biological chemistry. vol 275. issue 46. 2000-12-29. PMID:10952991. |
mutations in helices alpha2 and alpha3 of the fadd death domain, the interacting surface with the fas death domain, affected tnf-mediated apoptosis to various extents. |
2000-12-29 |
2023-08-12 |
Not clear |
| S Bang, E J Jeong, I K Kim, Y K Jung, K S Ki. Fas- and tumor necrosis factor-mediated apoptosis uses the same binding surface of FADD to trigger signal transduction. A typical model for convergent signal transduction. The Journal of biological chemistry. vol 275. issue 46. 2000-12-29. PMID:10952991. |
some mutations affected the binding affinity of the fas death domain for the fadd death domain, but did not influence tnf-mediated apoptosis and vice versa. |
2000-12-29 |
2023-08-12 |
Not clear |
| F Fortunato, L K Gate. Alcohol feeding and lipopolysaccharide injection modulate apoptotic effectors in the rat pancreas in vivo. Pancreas. vol 21. issue 2. 2000-12-28. PMID:10975712. |
these data show that (a) long-term alcohol feeding suppresses apoptosis in the pancreas; (b) lps increases the rate of apoptosis in the pancreas; (c) caspase-3 activity and bcl-2 expression change in opposite directions; (d) tunel positivity and fas ligand expression are increased, and bcl-2 is decreased in ethanol-fed + lps-injected rats. |
2000-12-28 |
2023-08-12 |
human |
| Q N Diep, R M Touyz, E L Schiffri. Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension (Dallas, Tex. : 1979). vol 36. issue 5. 2000-12-28. PMID:11082155. |
we previously demonstrated that n-3 fas induce vascular smooth muscle cell (vsmc) apoptosis, which could exert an effect on the structure of blood vessels. |
2000-12-28 |
2023-08-12 |
rat |
| Q N Diep, R M Touyz, E L Schiffri. Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension (Dallas, Tex. : 1979). vol 36. issue 5. 2000-12-28. PMID:11082155. |
in the present study, we investigated signaling pathways through which n-3 fas mediate apoptosis in vsmcs. |
2000-12-28 |
2023-08-12 |
rat |
| A MacLaren, W Clark, D A Gillespi. v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release. Oncogene. vol 19. issue 51. 2000-12-28. PMID:11127822. |
in contrast, inhibition of fas signalling using dominant negative fadd did not inhibit apoptosis, nor was there any evidence for accumulation or activation of p53 in v-jun transformed cells. |
2000-12-28 |
2023-08-12 |
Not clear |
| A MacLaren, W Clark, D A Gillespi. v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release. Oncogene. vol 19. issue 51. 2000-12-28. PMID:11127822. |
taken together, these results suggest that mitochondrial dysfunction is an important component of the mechanism through which v-jun sensitizes cells to apoptosis, but that the apoptotic signals elicited by v-jun upstream of the mitochondria do not depend on increased levels of p53 activity or fas signalling. |
2000-12-28 |
2023-08-12 |
Not clear |
| Z H Zheng, R G Ye, J Bergström, B Lindhol. Effect of dialysate composition on the apoptosis and proliferation of human peritoneal mesothelial cells and protein expression of Fas and c-Myc. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. vol 16. 2000-12-22. PMID:11045257. |
effect of dialysate composition on the apoptosis and proliferation of human peritoneal mesothelial cells and protein expression of fas and c-myc. |
2000-12-22 |
2023-08-12 |
human |
| Z H Zheng, R G Ye, J Bergström, B Lindhol. Effect of dialysate composition on the apoptosis and proliferation of human peritoneal mesothelial cells and protein expression of Fas and c-Myc. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. vol 16. 2000-12-22. PMID:11045257. |
(3) genes associated with apoptosis (fas, c-myc) might play an important role in triggering apoptosis of hpmcs. |
2000-12-22 |
2023-08-12 |
human |
| M K Sharie. Increased cellular expression of the caspase inhibitor FLIP in intrathecal lymphocytes from patients with multiple sclerosis. Journal of neuroimmunology. vol 111. issue 1-2. 2000-12-22. PMID:11063839. |
the intracellular protein flip, a naturally occurring caspase-antagonist, is a potent inhibitor of the fas signalling pathway that may block fas-mediated apoptosis of activated lymphocytes. |
2000-12-22 |
2023-08-12 |
Not clear |