| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Marti, H Graber, H Lazar, P M Ritter, A Baltzer, A Srinivasan, R Jagg. Caspases: decoders of apoptotic signals during mammary involution. Caspase activation during involution. Advances in experimental medicine and biology. vol 480. 2000-12-01. PMID:10959427. |
using fas-deficient mice we present evidence that the fas signaling pathway is not essential for caspase activation and apoptosis during mammary gland involution. |
2000-12-01 |
2023-08-12 |
mouse |
| S Kawauchi, T Fukuda, Y Oda, T Saito, A Oga, M Takeshita, K Yokoyama, H Chuman, Y Iwamoto, K Sasaki, M Tsuneyosh. Prognostic significance of apoptosis in synovial sarcoma: correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 13. issue 7. 2000-11-30. PMID:10912935. |
the degree of apoptosis was analyzed in relation to several clinicopathologic parameters, cell proliferative activity, and immunohistochemical expression of apoptosis-related proteins, including bcl-2, bax, bcl-x, bak, p53, p21 (waf1/cip1), fas, and fas ligand. |
2000-11-30 |
2023-08-12 |
Not clear |
| T Yokozawa, K Miyamura, R Fujino, S Yonehara, R Ueda, M Tanimoto, H Sait. Gelatin beads as platforms for targeting molecule and anti-Fas antibody: two major properties of cytotoxic T lymphocytes. Experimental hematology. vol 28. issue 10. 2000-11-30. PMID:11027831. |
cytotoxic t lymphocytes (ctl) initially recognize target cells using the t-cell receptor (tcr), then strongly adhere to these cells by accessory molecules, and finally induce apoptosis by fas ligand (fasl)/fas or lyse by the granzyme/perforin system. |
2000-11-30 |
2023-08-12 |
Not clear |
| H Muta, L H Boise, L Fang, E R Podac. CD30 signals integrate expression of cytotoxic effector molecules, lymphocyte trafficking signals, and signals for proliferation and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 9. 2000-11-30. PMID:11046041. |
the up-regulation of fas, death receptor 3, and tnf-related apoptosis-inducing ligand by cd30 indicates an increase in susceptibility to apoptotic signals whereas up-regulation of tnfr-associated factor 1 and cellular inhibitor of apoptosis 2 protect cells from certain types of apoptosis. |
2000-11-30 |
2023-08-12 |
Not clear |
| M L Bajt, J A Lawson, S L Vonderfecht, J S Gujral, H Jaeschk. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicological sciences : an official journal of the Society of Toxicology. vol 58. issue 1. 2000-11-30. PMID:11053547. |
protection against fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. |
2000-11-30 |
2023-08-12 |
mouse |
| M L Bajt, J A Lawson, S L Vonderfecht, J S Gujral, H Jaeschk. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicological sciences : an official journal of the Society of Toxicology. vol 58. issue 1. 2000-11-30. PMID:11053547. |
lymphocytes can kill target cells including hepatocytes during various inflammatory diseases by fas receptor-mediated apoptosis. |
2000-11-30 |
2023-08-12 |
mouse |
| K Reynaud, M A Driancour. Oocyte attrition. Molecular and cellular endocrinology. vol 163. issue 1-2. 2000-11-28. PMID:10963881. |
the control of oocyte apoptosis is not fully understood, although survival factors (lif, kit ligand and fgf), as well as death inducing factors (fas ligand, tgfbeta), have been identified. |
2000-11-28 |
2023-08-12 |
Not clear |
| P Saas, J Boucraut, P R Walker, A L Quiquerez, M Billot, S Desplat-Jego, Y Chicheportiche, P Y Dietric. TWEAK stimulation of astrocytes and the proinflammatory consequences. Glia. vol 32. issue 1. 2000-11-21. PMID:10975915. |
it was previously shown that reactive astrocytes express high levels of fas (cd95) and respond to fas ligand (cd95l) by apoptosis or il-8 production. |
2000-11-21 |
2023-08-12 |
human |
| B M Segal, A H Cros. Fas(t) track to apoptosis in MS: TNF receptors may suppress or potentiate CNS demyelination. Neurology. vol 55. issue 7. 2000-11-21. PMID:11061241. |
fas(t) track to apoptosis in ms: tnf receptors may suppress or potentiate cns demyelination. |
2000-11-21 |
2023-08-12 |
Not clear |
| A C Knapp, J Huang, G Starling, P A Kiene. Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death. Atherosclerosis. vol 152. issue 1. 2000-11-15. PMID:10996358. |
we have found that smc are normally resistant to fas or cytokine-induced apoptosis, but can be sensitized to these agents with pharmacological concentrations of some statins. |
2000-11-15 |
2023-08-12 |
human |
| M L Hyer, C Voelkel-Johnson, S Rubinchik, J Dong, J S Norri. Intracellular Fas ligand expression causes Fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 2. issue 4. 2000-11-15. PMID:11020350. |
intracellular fas ligand expression causes fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis. |
2000-11-15 |
2023-08-12 |
human |
| M L Hyer, C Voelkel-Johnson, S Rubinchik, J Dong, J S Norri. Intracellular Fas ligand expression causes Fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 2. issue 4. 2000-11-15. PMID:11020350. |
several laboratories have attempted with little success to induce fas-mediated apoptosis in prostate cancer (pca) cells, using different external fas agonists, i.e., anti-fas antibodies and membrane-bound fasl. |
2000-11-15 |
2023-08-12 |
human |
| J Cinatl, R Blaheta, M Bittoova, M Scholz, S Margraf, J U Vogel, J Cinatl, H W Doer. Decreased neutrophil adhesion to human cytomegalovirus-infected retinal pigment epithelial cells is mediated by virus-induced up-regulation of Fas ligand independent of neutrophil apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 8. 2000-11-14. PMID:11035078. |
decreased neutrophil adhesion to human cytomegalovirus-infected retinal pigment epithelial cells is mediated by virus-induced up-regulation of fas ligand independent of neutrophil apoptosis. |
2000-11-14 |
2023-08-12 |
human |
| D Bernhard, I Tinhofer, M Tonko, H Hübl, M J Ausserlechner, R Greil, R Kofler, A Csorda. Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042678. |
antagonist antibodies to fas or fasl, or constitutive expression of crma did not diminish the extent of resveratrol-induced apoptosis. |
2000-11-14 |
2023-08-12 |
Not clear |
| C G Tepper, M F Seldin, M Mudry. Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts. Experimental cell research. vol 260. issue 1. 2000-11-13. PMID:11010806. |
ligation of the fas receptor in the presence of cycloheximide or actinomycin d resulted in apoptosis of proliferating cells, cells transiently growth arrested by gamma-irradiation or serum starvation (i.e., g(0) arrest), and permanently growth-arrested senescent fibroblasts. |
2000-11-13 |
2023-08-12 |
human |
| C G Tepper, M F Seldin, M Mudry. Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts. Experimental cell research. vol 260. issue 1. 2000-11-13. PMID:11010806. |
fas-mediated apoptosis of senescent fibroblasts was evidenced by chromosome condensation and by activation of caspase-8 and -3, proteases crucial for the execution of the fas apoptosis pathway. |
2000-11-13 |
2023-08-12 |
human |
| H Ritchie, A Fragoyanni. Thrombin inhibits apoptosis of monocytes and plasminogen activator inhibitor 2 (PAI-2) is not responsible for this inhibition. Experimental cell research. vol 260. issue 1. 2000-11-13. PMID:11010807. |
apoptosis of monocytes was rapidly induced by removal of serum, addition of hydrogen peroxide, or binding of a monoclonal antibody to fas. |
2000-11-13 |
2023-08-12 |
human |
| Y J Choi, E Baranowska-Daca, V Nguyen, T Koji, C M Ballantyne, D Sheikh-Hamad, W N Suki, L D Truon. Mechanism of chronic obstructive uropathy: increased expression of apoptosis-promoting molecules. Kidney international. vol 58. issue 4. 2000-11-13. PMID:11012883. |
these families may include receptor/ligand molecules such as fas, fas ligand, tumor necrosis factor receptor-1 (tnfr-1), and tnf-related apoptosis inducing ligand (trail); signal transduction adapter molecules such as fas-associated death domain (fadd), tnfr-1 associated death domain (tradd), receptor-interacting protein (rip), fas-associated factor (faf), and fas-associated phosphatase (fap); or effector molecules such as caspases. |
2000-11-13 |
2023-08-12 |
Not clear |
| C S Hahn, Y G Cho, B S Kang, I M Lester, Y S Hah. The HCV core protein acts as a positive regulator of fas-mediated apoptosis in a human lymphoblastoid T cell line. Virology. vol 276. issue 1. 2000-11-13. PMID:11022001. |
in addition, we demonstrated that the core protein binds to the cytoplasmic domain of fas which may enhance the downstream signaling event of fas-mediated apoptosis. |
2000-11-13 |
2023-08-12 |
human |
| C S Hahn, Y G Cho, B S Kang, I M Lester, Y S Hah. The HCV core protein acts as a positive regulator of fas-mediated apoptosis in a human lymphoblastoid T cell line. Virology. vol 276. issue 1. 2000-11-13. PMID:11022001. |
these results suggest that the core protein may promote the apoptosis of immune cells during hcv infection via the fas signaling pathway, thus facilitating hcv persistence. |
2000-11-13 |
2023-08-12 |
human |