| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akshara Pande, Mahesh Manchanda, Hans Raj Bhat, Partha Sarathi Bairy, Navin Kumar, Prashant Gahtor. Molecular insights into a mechanism of resveratrol action using hybrid computational docking/CoMFA and machine learning approach. Journal of biomolecular structure & dynamics. 2021-04-08. PMID:33829956. |
although earlier wet-lab experiments rendering its multiple biological targets, for example, epidermal growth factors, pro-apoptotic protein p53, sirtuins, and first apoptosis signal (fas) receptor, mouse double minute 2 (mdm2) ubiquitin-protein ligase, estrogen receptor, quinone reductase, etc. |
2021-04-08 |
2023-08-13 |
mouse |
| Tingting Pang, Liping Du, Fuzhen Li, Yizong Liu, Xin Ma, Qingfeng Cao, Liying Shi, Na Li, Aize Kijlstra, Peizeng Yan. Association of apoptosis genes in PDCD1 but not PDCD1LG2, FAS, and FASLG with pediatric idiopathic uveitis in Han Chinese. Pediatric research. vol 87. issue 4. 2021-04-06. PMID:31618754. |
association of apoptosis genes in pdcd1 but not pdcd1lg2, fas, and faslg with pediatric idiopathic uveitis in han chinese. |
2021-04-06 |
2023-08-13 |
human |
| Tingting Pang, Liping Du, Fuzhen Li, Yizong Liu, Xin Ma, Qingfeng Cao, Liying Shi, Na Li, Aize Kijlstra, Peizeng Yan. Association of apoptosis genes in PDCD1 but not PDCD1LG2, FAS, and FASLG with pediatric idiopathic uveitis in Han Chinese. Pediatric research. vol 87. issue 4. 2021-04-06. PMID:31618754. |
genetic variants of apoptotic pathway-related factors (including pdcd1, pdcd1lg2, fas, and faslg) may affect apoptosis and in turn predict susceptibility to autoimmune disease. |
2021-04-06 |
2023-08-13 |
human |
| Gui-Ming Li, Li-Ping Liu, Bin Yin, Yue-Yue Liu, Wen-Wen Dong, Shuai Gong, Jie Zhang, Jing-He Ta. Heat stress decreases egg production of laying hens by inducing apoptosis of follicular cells via activating the FasL/Fas and TNF-α systems. Poultry science. vol 99. issue 11. 2021-04-02. PMID:33142528. |
the results demonstrated that hs on hens significantly 1) decreased laying rates from day s3 to r6; 2) reduced numbers of large yellow and hierarchical follicles; 3) triggered apoptosis while increasing the expression of fasl, fas, tnf-α, and tnf-receptor 1 in small and large yellow follicles; and 4) increased levels of oxidative stress, corticotrophin-releasing hormone, and corticosterone while decreasing the estradiol/progesterone ratio in follicular fluid in small and large yellow follicles. |
2021-04-02 |
2023-08-13 |
Not clear |
| Xiaoliang Wang, Francois Gessier, Remo Perozzo, Darko Stojkov, Aref Hosseini, Keyvan Amirshahrokhi, Stefan Kuchen, Shida Yousefi, Pius Lötscher, Hans-Uwe Simo. RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. Journal of immunology (Baltimore, Md. : 1950). vol 205. issue 6. 2021-04-01. PMID:32796025. |
specifically, we observed that several inhibitors known to block the enzymatic function of fibroblast activation protein-α (fap-α) were able to block cd44-mediated reactive oxygen species production and cell death, but not fas receptor-mediated apoptosis. |
2021-04-01 |
2023-08-13 |
human |
| Yawen Zeng, Zhiqin Zhang, Wenping Wang, Longtai You, Xiaoxv Dong, Xingbin Yin, Changhai Qu, Jian N. Underlying mechanisms of apoptosis in HepG2 cells induced by polyphyllin I through Fas death and mitochondrial pathways. Toxicology mechanisms and methods. vol 30. issue 6. 2021-03-31. PMID:32208876. |
underlying mechanisms of apoptosis in hepg2 cells induced by polyphyllin i through fas death and mitochondrial pathways. |
2021-03-31 |
2023-08-13 |
Not clear |
| Tinghua Huang, Caiyun Jiang, Min Yang, Hong Xiao, Xiali Huang, Lingbo Wu, Min Ya. Salmonella enterica serovar Typhimurium inhibits the innate immune response and promotes apoptosis in a ribosomal/TRP53-dependent manner in swine neutrophils. Veterinary research. vol 51. issue 1. 2021-03-25. PMID:32854785. |
silencing of rpl39 and rpl9 also resulted in the up-regulation of fas, rb1, casp6, and gadd45a, which play roles in cell cycle arrest and apoptosis. |
2021-03-25 |
2023-08-13 |
Not clear |
| Ana-Maria Vacaru, Madalina Dumitrescu, Andrei Mircea Vacaru, Ioana Madalina Fenyo, Radu Ionita, Anca Violeta Gafencu, Maya Simionesc. Enhanced Suppression of Immune Cells In Vitro by MSC Overexpressing FasL. International journal of molecular sciences. vol 22. issue 1. 2021-03-25. PMID:33396269. |
we aimed to enhance it by transforming msc to overexpress a first apoptosis signal (fas) ligand (fasl). |
2021-03-25 |
2023-08-13 |
Not clear |
| Emese Molnár, Nesrine Radwan, Gábor Kovács, Hajnalka Andrikovics, Frances Henriquez, Anton Zarafov, Matthew Hayman, Daniela Linzner, Adrian J Thrasher, Matthew Buckland, Siobhan O Burns, Kimberly C Gilmou. Key diagnostic markers for autoimmune lymphoproliferative syndrome with molecular genetic diagnosis. Blood. vol 136. issue 17. 2021-03-24. PMID:32599613. |
double-negative t-cell (dnt) percentage and in vitro apoptosis functional tests were evaluated by fluorescence-activated cell sorting; interleukin 10 (il-10) and il-18 and soluble fas ligand (sfasl) were measured by enzyme-linked immunosorbent assay. |
2021-03-24 |
2023-08-13 |
Not clear |
| Emese Molnár, Nesrine Radwan, Gábor Kovács, Hajnalka Andrikovics, Frances Henriquez, Anton Zarafov, Matthew Hayman, Daniela Linzner, Adrian J Thrasher, Matthew Buckland, Siobhan O Burns, Kimberly C Gilmou. Key diagnostic markers for autoimmune lymphoproliferative syndrome with molecular genetic diagnosis. Blood. vol 136. issue 17. 2021-03-24. PMID:32599613. |
the combination of elevated sfasls and abnormal apoptosis function was the most valuable prognosticator for patients with fas mutations. |
2021-03-24 |
2023-08-13 |
Not clear |
| Nune Darbinian, Armine Darbinyan, Nana Merabova, Ahsun Bajwa, Gabriel Tatevosian, Diana Martirosyan, Huaqing Zhao, Michael E Selzer, Laura Goetz. Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain. Neurobiology of disease. vol 148. 2021-03-23. PMID:33189883. |
experimental rodent models of fas have shown dysregulation of cytokine expression leading to apoptosis of oligodendrocyte precursor cells (opcs) and altered oligodendrocyte (ol) differentiation, but whether this is representative of human fas pathogenesis has not been determined. |
2021-03-23 |
2023-08-13 |
human |
| Ga-Hee Ryoo, Young Jae Moon, Sunghee Choi, Eun Ju Bae, Jae-Ha Ryu, Byung-Hyun Par. Tussilagone promotes osteoclast apoptosis and prevents estrogen deficiency-induced osteoporosis in mice. Biochemical and biophysical research communications. vol 531. issue 4. 2021-03-19. PMID:32807498. |
as demonstrated by apopercentage dye staining and western blotting, tussilagone enhanced apoptosis in differentiated osteoclasts by increasing estrogen receptor α and fas ligand expression. |
2021-03-19 |
2023-08-13 |
mouse |
| Robyn L Schenk, Lahiru Gangoda, Kate E Lawlor, Lorraine A O'Reilly, Andreas Strasser, Marco J Herol. The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils. Cell death & disease. vol 11. issue 6. 2021-03-18. PMID:32555150. |
the pro-survival bcl-2 family member a1 delays spontaneous and fas ligand-induced apoptosis of activated neutrophils. |
2021-03-18 |
2023-08-13 |
Not clear |
| Qianni Ma, Mincheng Yu, Binghai Zhou, Haijun Zho. QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis. Biochemical and biophysical research communications. vol 532. issue 2. 2021-03-18. PMID:32863002. |
qsox1 inhibited de novo synthesis of fatty acids (fas) and cholesterol (che) and reduced their content in the detached hcc cells, and thus mediated mitochondrial apoptosis of hcc cells. |
2021-03-18 |
2023-08-13 |
Not clear |
| Hongwei Yan, Yuxiao Hong, Yunfei Ca. Association between FAS gene -670 A/G and -1377 G/A polymorphisms and the risk of autoimmune diseases: a meta-analysis. Bioscience reports. vol 40. issue 1. 2021-03-16. PMID:31840751. |
fas plays a critical role in the extrinsic apoptosis pathway in autoimmune diseases. |
2021-03-16 |
2023-08-13 |
Not clear |
| Mengya Zhong, Xingfeng Qiu, Yu Liu, Yan Yang, Lei Gu, Chenxi Wang, Huiyu Chen, Zhongchen Liu, Jiayin Miao, Guohong Zhuan. TIPE Regulates DcR3 Expression and Function by Activating the PI3K/AKT Signaling Pathway in CRC. Frontiers in oncology. vol 10. 2021-03-16. PMID:33718119. |
decoy receptor 3 (dcr3) is a soluble secreted protein that can antagonize fas ligand (fasl)-induced apoptosis and promote tumorigenesis. |
2021-03-16 |
2023-08-13 |
Not clear |
| Shannon K Oda, Kristin G Anderson, Pranali Ravikumar, Patrick Bonson, Nicolas M Garcia, Cody M Jenkins, Summer Zhuang, Andrew W Daman, Edison Y Chiu, Breanna M Bates, Philip D Greenber. A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy. The Journal of experimental medicine. vol 217. issue 12. 2021-03-11. PMID:32860705. |
for example, fas ligand is commonly overexpressed in tmes and induces apoptosis in tumor-infiltrating, fas receptor-positive lymphocytes. |
2021-03-11 |
2023-08-13 |
human |
| Hsin-Ying Lu, Chun-Ming Shih, Chun-Yang Huang, Alexander T H Wu, Tsai-Mu Cheng, Fwu-Long Mi, Chun-Che Shi. Galectin-3 Modulates Macrophage Activation and Contributes Smooth Muscle Cells Apoptosis in Abdominal Aortic Aneurysm Pathogenesis. International journal of molecular sciences. vol 21. issue 21. 2021-03-09. PMID:33158139. |
moreover, gal-3-deficient cm weakened smc apoptosis through fas activation. |
2021-03-09 |
2023-08-13 |
mouse |
| Zhen-Zhen Wang, Tian-Yu Huang, Yong-Fang Gong, Xiao-Ming Zhang, Feng-Wang, Xue-Ying Huan. Effects of sorafenib on fibroblast-like synoviocyte apoptosis in rats with adjuvant arthritis. International immunopharmacology. vol 83. 2021-02-26. PMID:32199349. |
in summary, these results demonstrate that sorafenib promotes aa fls apoptosis, which may be related to the upregulation of fas and caspase-3 and downregulation of nf-κb and c-jun. |
2021-02-26 |
2023-08-13 |
rat |
| Tao Zhang, Yu-Chao Yin, Xiang Ji, Bo Zhang, Sheng Wu, Xiao-Zhe Wu, Hong Li, Ya-Dan Li, Ya-Ling Ma, Yu Wang, Hai-Tao Li, Bin Zhang, Di W. AT1R knockdown confers cardioprotection against sepsis-induced myocardial injury by inhibiting the MAPK signaling pathway in rats. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-22. PMID:31433522. |
terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling staining was applied to measure cell apoptosis, and messenger rna and protein levels of apoptosis-related proteins (fas ligand [fasl], b-cell cll/lymphoma [bcl-2], p53) were also detected. |
2021-02-22 |
2023-08-13 |
rat |