| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Coccia, Laura Planells-Ferrer, Raquel Badillos-Rodríguez, Marta Pascual, Miguel F Segura, Rita Fernández-Hernández, Joaquin López-Soriano, Eloi Garí, Eduardo Soriano, Bruna Barneda-Zahonero, Rana S Moubarak, M Jose Pérez-García, Joan X Comell. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Cell death & disease. vol 11. issue 2. 2021-02-16. PMID:32015347. |
the long isoform of fas apoptosis inhibitory molecule (faim-l) is a neuron-specific death receptor antagonist that modulates apoptotic cell death and mechanisms of neuronal plasticity. |
2021-02-16 |
2023-08-13 |
Not clear |
| Atilla Engi. Dark-Side of Exosomes. Advances in experimental medicine and biology. vol 1275. 2021-02-15. PMID:33539013. |
by this mechanism, exosomes participate in the development of diabetes and its associated complications, critically contribute to the spreading of neuronal damage in alzheimer's disease, and non-proteolysed form of fas ligand (mfasl)-bearing exosomes trigger the apoptosis of t lymphocytes. |
2021-02-15 |
2023-08-13 |
human |
| Like Wang, Xiaolei Zeng, Jifeng Ye, Xiaoping Chen, Xixi Li. Diplatin, a novel water-soluble platinum complex, inhibits lung cancer growth via augmentation of Fas-mediated apoptosis. European journal of pharmacology. vol 879. 2021-02-11. PMID:32339512. |
particularly, the exposure of lung cancer cells or xenograft tumors to diplatin resulted in elevated fas level, and knockdown of fas ameliorated diplatin-induced cells apoptosis. |
2021-02-11 |
2023-08-13 |
mouse |
| Eiji Sugihara, Norisato Hashimoto, Satoru Osuka, Takatsune Shimizu, Sayaka Ueno, Shogo Okazaki, Tomonori Yaguchi, Yutaka Kawakami, Kenjiro Kosaki, Taka-Aki Sato, Shinichiro Okamoto, Hideyuki Say. The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma. Cancer research. vol 80. issue 20. 2021-02-10. PMID:32928920. |
cd40 signal activation significantly restored fas expression and thereby induced apoptosis after fas ligand treatment in both mouse and human lymphoma cells. |
2021-02-10 |
2023-08-13 |
mouse |
| Xiaoliang Wang, Damjan Avsec, Aleš Obreza, Shida Yousefi, Irena Mlinarič-Raščan, Hans-Uwe Simo. A Putative Serine Protease is Required to Initiate the RIPK3-MLKL-Mediated Necroptotic Death Pathway in Neutrophils. Frontiers in pharmacology. vol 11. 2021-02-10. PMID:33551816. |
interestingly, neither serine protease inhibitor had any effect on fas receptor-mediated apoptosis. |
2021-02-10 |
2023-08-13 |
human |
| Xiaoliang Wang, Damjan Avsec, Aleš Obreza, Shida Yousefi, Irena Mlinarič-Raščan, Hans-Uwe Simo. A Putative Serine Protease is Required to Initiate the RIPK3-MLKL-Mediated Necroptotic Death Pathway in Neutrophils. Frontiers in pharmacology. vol 11. 2021-02-10. PMID:33551816. |
taken together, these results suggest that a serine protease is involved in non-apoptotic cd44-triggered ripk3-mlkl-dependent neutrophil cell death, but not fas receptor-mediated caspase-dependent apoptosis. |
2021-02-10 |
2023-08-13 |
human |
| Ahmed Ismail, Ahmed S Doghish, Bakheet E M Elsadek, Salama A Salama, Amr D Marie. Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase. Steroids. vol 160. 2021-02-08. PMID:32439410. |
treatment with tam or hca significantly reduced cell viability in a concentration-dependent manner whereas co-treatment synergistically reduced cell viability, promoted apoptosis, and decreased the expression of acly, acc-α, and fas. |
2021-02-08 |
2023-08-13 |
Not clear |
| Lin Zhang, Yaolin Song, Lei Chen, Donghang Li, Haohao Feng, Zilong Lu, Tao Fan, Zubin Chen, Man J Livingston, Qing Gen. MiR-20a-containing exosomes from umbilical cord mesenchymal stem cells alleviates liver ischemia/reperfusion injury. Journal of cellular physiology. vol 235. issue 4. 2021-02-02. PMID:31566731. |
tunel was performed to assess ir-induced apoptosis in ir rats, and luciferase assay was used to confirm the inhibitory effect of mir-20a on beclin-i and fas expression. |
2021-02-02 |
2023-08-13 |
rat |
| Lin Zhang, Yaolin Song, Lei Chen, Donghang Li, Haohao Feng, Zilong Lu, Tao Fan, Zubin Chen, Man J Livingston, Qing Gen. MiR-20a-containing exosomes from umbilical cord mesenchymal stem cells alleviates liver ischemia/reperfusion injury. Journal of cellular physiology. vol 235. issue 4. 2021-02-02. PMID:31566731. |
since beclin-i and fas were aberrantly upregulated in ir, exosomes separated from uc-mscs showed therapeutic efficacy in reversing i/r induced apoptosis. |
2021-02-02 |
2023-08-13 |
rat |
| Straus SE, Jaffe ES, Puck JM, et al. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood. 2001;98(1):194-200. Blood. vol 130. issue 2. 2021-02-02. PMID:31651941. |
the development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline fas mutations and defective lymphocyte apoptosis. |
2021-02-02 |
2023-08-13 |
Not clear |
| Dan Luo, Jia-Bao Zhang, Yan-Xia Peng, Jian-Bo Liu, Dong-Xu Han, Ying Wang, Zhe Zhang, Bao Yuan, Yan Gao, Cheng-Zhen Chen, Hao Jian. Imperatorin improves in vitro porcine embryo development by reducing oxidative stress and autophagy. Theriogenology. vol 146. 2021-01-28. PMID:31831188. |
at the same time, apoptosis of blastocysts was also significantly decreased in the supplemented group compared with the control group, in accordance with the subsequent results of fas and casp3 gene expression analysis. |
2021-01-28 |
2023-08-13 |
Not clear |
| Megan H Noe, Robert G Michelett. Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis. Clinics in dermatology. vol 38. issue 6. 2021-01-26. PMID:33341195. |
drug-specific cd8 t-cells and natural killer cells are thought to be the major inducers of keratinocyte apoptosis via release of soluble cytotoxic mediators, including fas ligand, perforin/granzyme, tumor necrosis factor, and granulysin. |
2021-01-26 |
2023-08-13 |
Not clear |
| Takehiko Doi, Satoshi Okad. [Lymphoproliferative disorders and inborn errors of immunity]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 61. issue 9. 2021-01-18. PMID:33162537. |
autoimmune lymphoproliferative syndrome (alps), a typical lpd disease, is caused by germline mutations in fas, fasl, casp10, casp8 and fadd, which are involved in the apoptosis pathway. |
2021-01-18 |
2023-08-13 |
Not clear |
| Jingjing Gu, Qiqi Liang, Can Liu, Sheng L. Genomic Analyses Reveal Adaptation to Hot Arid and Harsh Environments in Native Chickens of China. Frontiers in genetics. vol 11. 2021-01-12. PMID:33424922. |
we identified several selective regions containing genes that were associated with the circulatory system and blood vessel development (bves, smyd1, il18, pdgfra, nrp1, and corin), related to central nervous system development (sim2 and nalcn), related to apoptosis (clptm1l, app, cradd, and park2) responded to stimuli (ahr, esrrg fas, and ube4b) and involved in fatty acid metabolism (fabp1). |
2021-01-12 |
2023-08-13 |
chicken |
| Efi Makdasi, Shira Amsili, Alexandra Aronin, Tatyana B Prigozhina, Kobi Tzdaka, Yosi Meir Gozlan, Liat Ben Gigi-Tamir, Jitka Yehudith Sagiv, Fanny Shkedy, Noam Shani, Mark L Tykocinski, Michal Dranitzki Elhale. Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL. Molecular cancer therapeutics. vol 19. issue 2. 2021-01-11. PMID:31871267. |
cytotoxic t-lymphocyte antigen 4 (ctla4)-fasl, a homo-hexameric signal converter protein, is capable of inducing robust apoptosis in malignant cells of the b-cell lineage expressing its cognate b7 and fas targets, while sparing nonmalignant ones. |
2021-01-11 |
2023-08-13 |
mouse |
| Tingting Zhao, Wei Li, Jinfei Chen, Weisong Qi. Genomic variants in Fas-mediated apoptosis pathway predict a poor response to Platinum-based Chemotherapy for Chinese Gastric Cancer Patients. Journal of Cancer. vol 12. issue 3. 2021-01-11. PMID:33403042. |
the genomic variants and the gene-gene interactions involved in fas-mediated apoptosis pathway including fas (fas 1377 g > a and 670 a > g), fasl (fasl 844 c > t) and caspase-8 (casp8 -652 6n ins > del or i > d), may paly vital roles in the response to platinum-based treatment. |
2021-01-11 |
2023-08-13 |
Not clear |
| Tingting Zhao, Wei Li, Jinfei Chen, Weisong Qi. Genomic variants in Fas-mediated apoptosis pathway predict a poor response to Platinum-based Chemotherapy for Chinese Gastric Cancer Patients. Journal of Cancer. vol 12. issue 3. 2021-01-11. PMID:33403042. |
our study suggested that fas 1377 g > a and fas 670 a > g variants may serve as potential biomarkers to predict the response to platinum-based adjuvant chemotherapy, and the gene-gene interactions involved in fas-mediated apoptosis pathway may enhance or neutralize the chemosensitivity. |
2021-01-11 |
2023-08-13 |
Not clear |
| Guangmeng Xu, Yajuan Sun, Huaiqiang He, Qiuli Xue, Yajie Liu, Lihua Don. Effect of TrkB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis. Acta biochimica et biophysica Sinica. vol 52. issue 6. 2021-01-06. PMID:32445466. |
mice in the model and k252a groups showed blocked enterocyte cycle progression, elevated apoptosis ratio, and significantly increased mrna and protein expressions of caspase3, bax, fasl, and fas, but significantly reduced mrna and protein expressions of p-trkb, plc-γ1, ip3, and bcl-2 (p<0.05). |
2021-01-06 |
2023-08-13 |
mouse |
| Xiaomin Sun, Cuilian Ye, Qin Deng, Jingyu Chen, Chunbao Gu. Contribution of glutaredoxin-1 to Fas s-glutathionylation and inflammation in ethanol-induced liver injury. Life sciences. vol 264. 2020-12-31. PMID:33127518. |
the reversible protein s-glutathionylation (pssg) modification of fas augments apoptosis, which can be reversed by the cytosolic deglutathionylation enzyme glutaredoxin-1 (grx1), but its roles in alcoholic liver injury remain unknown. |
2020-12-31 |
2023-08-13 |
Not clear |
| Shasha Yu, Haiyu Ji, Xiaodan Dong, Anjun Liu, Juan Y. FAS/FAS-L-mediated apoptosis and autophagy of SPC-A-1 cells induced by water-soluble polysaccharide from Polygala tenuifolia. International journal of biological macromolecules. vol 150. 2020-12-28. PMID:32027895. |
the death receptor pathway demonstrated the up-regulated expression of fas, ligand fas-l, and fadd, which led to a cascade reaction of the caspase family that induced cell apoptosis. |
2020-12-28 |
2023-08-13 |
Not clear |