| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leonardo Lorente, María M Martín, Raquel Ortiz-López, Agustín F González-Rivero, Antonia Pérez-Cejas, Judith Cabrera, Carolina García, Luis Uribe, Alejandro Jiméne. Association between serum sFasL concentrations and sepsis mortality. Infectious diseases (London, England). vol 53. issue 1. 2021-05-31. PMID:32945711. |
there are scarce data on soluble fas ligand (sfasl), one of the main ligands that activate the apoptosis extrinsic pathway, in septic patients. |
2021-05-31 |
2023-08-13 |
Not clear |
| Md Shihabul Islam, Md Sifat Rahi, Chowdhury Arif Jahangir, Israt Jerin, Md Mahmudul Hasan, Kazi Md Faisal Hoque, Md Abu Rez. Deciphering the molecular pathways of apoptosis using purified fractions from leaf extract of Basella alba through studying the regulation of apoptosis related genes. Molecular biology reports. vol 48. issue 1. 2021-05-25. PMID:33454909. |
the polymerase chain reaction amplification of bax, bcl-2 (b-cell lymphoma 2), p53, tumor necrosis factor-α, fas, nf-kβ (nuclear factor-kappa-b), parp-1 (poly (adp-ribose) polymerase), cyt-c cas-8, cas-9 and cas-3 revealed that the experimental sample able to induce apoptosis in both extrinsic and intrinsic pathways through altering the gene expression. |
2021-05-25 |
2023-08-13 |
Not clear |
| b' Jan \\xc5\\xa0r\\xc3\\xa1mek, Vlasta N\\xc4\\x9bmcov\\xc3\\xa1-F\\xc3\\xbcrstov\\xc3\\xa1, Jan Kov\\xc3\\xa1\\xc5\\x9. Molecular Mechanisms of Apoptosis Induction and Its Regulation by Fatty Acids in Pancreatic \\xce\\xb2-Cells. International journal of molecular sciences. vol 22. issue 8. 2021-05-25. PMID:33924206.' |
saturated fas induce apoptosis in pancreatic β-cells, whereas unsaturated fas are well tolerated and are even capable of inhibiting the pro-apoptotic effect of saturated fas. |
2021-05-25 |
2023-08-13 |
Not clear |
| b' Jan \\xc5\\xa0r\\xc3\\xa1mek, Vlasta N\\xc4\\x9bmcov\\xc3\\xa1-F\\xc3\\xbcrstov\\xc3\\xa1, Jan Kov\\xc3\\xa1\\xc5\\x9. Molecular Mechanisms of Apoptosis Induction and Its Regulation by Fatty Acids in Pancreatic \\xce\\xb2-Cells. International journal of molecular sciences. vol 22. issue 8. 2021-05-25. PMID:33924206.' |
molecular mechanisms of apoptosis induction by saturated fas in β-cells are not completely elucidated. |
2021-05-25 |
2023-08-13 |
Not clear |
| Elizabeth F Redente, Sangeeta Chakraborty, Satria Sajuthi, Bart P Black, Ben L Edelman, Max A Seibold, David Wh Riche. Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis. JCI insight. vol 6. issue 1. 2021-05-24. PMID:33290280. |
using genetic loss-of-function approaches to inhibit fas signaling in fibroblasts, potentially novel flow cytometry strategies to quantify lung fibroblast subsets, and transcriptional profiling of lung fibroblasts by bulk and single cell rna sequencing, we show that fas is necessary for lung fibroblast apoptosis during homeostatic resolution of bleomycin-induced pulmonary fibrosis in vivo. |
2021-05-24 |
2023-08-13 |
mouse |
| Leonardo Lorente, María M Martín, Raquel Ortiz-López, Agustín F González-Rivero, Antonia Pérez-Cejas, Eduardo Pastor, Claudia Domínguez-Curell, Lorena Raja, Lisset Lorenzo, Alejandro Jiméne. Association of serum soluble Fas concentrations and mortality of septic patients. Enfermedades infecciosas y microbiologia clinica (English ed.). 2021-05-21. PMID:32972791. |
scarce data on fas, one of the main receptors that activates the apoptosis extrinsic pathway, in septic patients exists. |
2021-05-21 |
2023-08-13 |
Not clear |
| Hao Jin, Hak Sung Kim, Seung Taek Yu, Sae Ron Shin, Sung Hee Lee, Geom Seog Se. Synergistic anticancer effect of docosahexaenoic acid and isoliquiritigenin on human colorectal cancer cells through ROS-mediated regulation of the JNK and cytochrome c release. Molecular biology reports. vol 48. issue 2. 2021-05-19. PMID:33502699. |
moreover, we demonstrated that the synergistic anti-crc activity of cotreatment with these two compounds was achieved by inducing the apoptosis caspase-dependently mediated through augmented ros generation followed by increased fas ligand mrna expression and cytochrome c release. |
2021-05-19 |
2023-08-13 |
human |
| Huaping Xiao, Hamza Alisic, Brandon T Reiman, Zuliang Deng, Ziwen Zhu, Nathan T Givens, Qian Bai, Andrew Tait, Mark R Wakefield, Yujiang Fan. IL-39 Reduces Proliferation and Promotes Apoptosis of Bladder Cancer by Altering the Activity of Cyclin E and Fas. Anticancer research. vol 41. issue 5. 2021-05-17. PMID:33952450. |
il-39 reduces proliferation and promotes apoptosis of bladder cancer by altering the activity of cyclin e and fas. |
2021-05-17 |
2023-08-13 |
Not clear |
| Hannah L Morgan, Isaac Ampong, Nader Eid, Charlène Rouillon, Helen R Griffiths, Adam J Watkin. Low protein diet and methyl-donor supplements modify testicular physiology in mice. Reproduction (Cambridge, England). vol 159. issue 5. 2021-05-14. PMID:32163913. |
furthermore, tunnel staining revealed lpd males possessed a reduced number of tubules positive for apoptosis, while gene expression analysis showed md-lpd testes displayed decreased expression of the pro-apoptotic genes bax, csap1 and fas when compared to npd males. |
2021-05-14 |
2023-08-13 |
mouse |
| Petra Borilova Linhartova, Daniela Gachova, Bretislav Lipov. Responsiveness to i.v. immunoglobulin therapy in patients with toxic epidermal necrolysis: A novel pharmaco-immunogenetic concept. The Journal of dermatology. vol 47. issue 11. 2021-05-14. PMID:32935409. |
although the etiopathophysiology has not yet been fully elucidated, the binding of fas ligand (fasl, cd95l) to the fas receptor (cd95) was shown to play a key role in the induction of apoptosis in this syndrome. |
2021-05-14 |
2023-08-13 |
Not clear |
| Seunggyu Kim, Joonha Park, Jeongsik Kim, Jessie S Jeo. Microfluidic Tumor Vasculature Model to Recapitulate an Endothelial Immune Barrier Expressing FasL. ACS biomaterials science & engineering. vol 7. issue 3. 2021-05-14. PMID:33586426. |
fas ligand (fasl, cd178) is known to bind to its receptor (fas, cd95) and mediate cellular apoptosis to maintain immune homeostasis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Evangel Kummari, Erin Rushing, Ashleigh Nicaise, Amye McDonald, Barbara L F Kapla. TCDD attenuates EAE through induction of FasL on B cells and inhibition of IgG production. Toxicology. vol 448. 2021-05-12. PMID:33253778. |
we specifically hypothesized that a fas ligand (fasl)+ breg population would be induced by tcdd in eae thereby triggering apoptosis in fas-expressing effector t cells as one mechanism to account for inhibition of t cell function by tcdd. |
2021-05-12 |
2023-08-13 |
mouse |
| Yonghan He, Wen Li, Dongwen Lv, Xin Zhang, Xuan Zhang, Yuma T Ortiz, Vivekananda Budamagunta, Judith Campisi, Guangrong Zheng, Daohong Zho. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging cell. vol 19. issue 3. 2021-05-10. PMID:32064756. |
this degradation increases the levels of p53, which in turn induces the pro-apoptotic proteins puma, noxa, and fas and inhibits the interaction of bcl-xl and bak to selectively induce apoptosis in sncs. |
2021-05-10 |
2023-08-13 |
mouse |
| P Huang, C H Wang, L Y Zhuo, X S Xia, S Yang, J W Zhang, H Z Fan, J J Wu, R Yu, M Yue, Y Zhan. Polymorphisms rs763110 in British journal of biomedical science. vol 77. issue 3. 2021-05-10. PMID:32209020. |
polymorphisms rs763110 in the fas cell surface death receptor (fas) and fas ligand (fasl) can participate in the apoptosis of immune cells and target cells infected with a virus through the fas-fasl signalling pathway. |
2021-05-10 |
2023-08-13 |
Not clear |
| Betül Kuzu, Gökhan Cüce, İlknur Çınar Ayan, Burcu Gültekin, Halime Tuba Canbaz, Hatice Gül Dursun, Zafer Şahin, İlknur Keskin, Sabiha Serpil Kalka. Evaluation of Apoptosis Pathway of Geraniol on Ishikawa Cells. Nutrition and cancer. 2021-05-06. PMID:33086902. |
a significant increase in the bax, caspase3, caspase-8, cytochrome c and fas genes and a significant decrease in the bcl-2 gene was observed when the ic50 dose group was compared to the cells in the control group based on their mrna expression levels.analysis of expression of genes whose products are involved in apoptosis suggests the involvement of the mitochondrial pathway. |
2021-05-06 |
2023-08-13 |
Not clear |
| Yang Tan, Wei Zhang, Hai-Ying Wu, Jing Xia, Huang-Bo Zhang, Ming-Wei Liu, Chuan-Yun Qia. Effects of emodin on intestinal mucosal barrier by the upregulation of miR-218a-5p expression in rats with acute necrotizing pancreatitis. International journal of immunopathology and pharmacology. vol 34. 2021-04-22. PMID:32664763. |
after 24 h of acute severe pancreatitis induced by taurocholate, emodin reduced the expression of mir-218a-5p in the intestinal tract; increased the expression of notch1 and bcl-2; decreased the expression levels of rhoa, rock1, akt, bax, fas, fasl, caspase-3, and caspase-9; inhibited the intestinal cell apoptosis caused by acute severe pancreatitis; increased the protein expression levels of occludin, zonula occludens-1 (zo-1), and e-cadherin in the intestinal tract; and alleviated intestinal dysfunction caused by acute severe pancreatitis. |
2021-04-22 |
2023-08-13 |
rat |
| Madalina Dumitrescu, Violeta Georgeta Trusca, Lorand Savu, Ioana Georgeta Stancu, Attila Cristian Ratiu, Maya Simionescu, Anca Violeta Gafenc. Adenovirus-Mediated International journal of molecular sciences. vol 21. issue 17. 2021-04-13. PMID:32825521. |
adenovirus-mediated fas ligand (first apoptosis signal ligand, fasl, also known as cd95l) is the common executioner of apoptosis within the tumor necrosis factor (tnf) superfamily. |
2021-04-13 |
2023-08-13 |
Not clear |
| Xin-Yue Zhao, Zhi-Bin Li, Hong-Jie Yuan, Xiao Han, Jia-Shun Wu, Xiu-Yun Feng, Min Zhang, Jing-He Ta. Restraint stress and elevation of corticotrophin-releasing hormone in female mice impair oocyte competence through activation of the tumour necrosis factor α (TNF-α) system. Reproduction, fertility, and development. vol 32. issue 9. 2021-04-09. PMID:32527376. |
although one study demonstrated that rs and crh elevation triggered apoptosis in ovarian cells and oocytes via activating fas/fasl signalling, other studies suggested that rs might damage cells by activating other pathways as well as fas signalling. |
2021-04-09 |
2023-08-13 |
mouse |
| Xiaoxiong Xiao, Lei Jiang, Huoli Hu, Yunhe Huang, Lun Yang, Yang Jiao, Guangxia We. Silencing of UAP1L1 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma. Molecular carcinogenesis. vol 60. issue 3. 2021-04-09. PMID:33434300. |
moreover, the apoptosis of escc cells was induced by knockdown of uap1l1 via regulating a variety of apoptosis-related proteins, such as upregulation of bax, cd40, cd40l, fas, fasl, igfbp-6, p21, p27, p53, and smac. |
2021-04-09 |
2023-08-13 |
Not clear |
| Mohamed Hamyeh, Florence Bernex, Romain M Larive, Aurélien Naldi, Serge Urbach, Joelle Simony-Lafontaine, Carole Puech, William Bakhache, Jérome Solassol, Peter J Coopman, Wiljan J A J Hendriks, Gilles Freis. PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness. Theranostics. vol 10. issue 3. 2021-04-08. PMID:31938048. |
its exact role in tumorigenesis remains, however, unclear due to its negative impact on fas receptor-induced apoptosis. |
2021-04-08 |
2023-08-13 |
Not clear |