| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reza Badalzadeh, Ako Azimi, Alireza Alihemmati, Bahman Yousef. Chronic type-I diabetes could not impede the anti-inflammatory and anti-apoptotic effects of combined postconditioning with ischemia and cyclosporine A in myocardial reperfusion injury. Journal of physiology and biochemistry. vol 73. issue 1. 2017-03-09. PMID:27771871. |
administration of either ipostc or csa alone in nondiabetic animals significantly reduced ck, tnf-α, il-1β, and il-6 concentrations, increased the p-gsk3β and bcl-2, and decreased the level of apoptosis (p < 0.05) but had no effect on diabetic hearts. |
2017-03-09 |
2023-08-13 |
rat |
| Weixia Cai, Xuekang Yang, Shichao Han, Haitao Guo, Zhao Zheng, Hongtao Wang, Hao Guan, Yanhui Jia, Jianxin Gao, Tao Yang, Xiongxiang Zhu, Dahai H. Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2/STAT3 Signaling. Oxidative medicine and cellular longevity. vol 2016. 2016-12-26. PMID:27057278. |
this study demonstrated that blockade of notch signaling via knockout of the transcription factor rbp-j or a pharmacological inhibitor aggravated postburn myocardial injury, which manifested as deteriorated serum ck, ck-mb, and ldh levels and increased apoptosis in vitro and in vivo. |
2016-12-26 |
2023-08-13 |
Not clear |
| Mohd Parvez Khan, Atul Kumar Singh, Abhishek Kumar Singh, Pragya Shrivastava, Mahesh Chandra Tiwari, Geet Kumar Nagar, Himangshu Kousik Bora, Venkitanarayanan Parameswaran, Sabyasachi Sanyal, Jayesh R Bellare, Naibedya Chattopadhya. Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 31. issue 3. 2016-12-13. PMID:26391310. |
rabbit bone marrow stromal cells expressed ck and when treated with odn displayed increased formation of mineralized nodules and decreased apoptosis in serum-deficient medium compared with control. |
2016-12-13 |
2023-08-13 |
rabbit |
| Chuanjun Chen, Huan He, Yong Luo, Min Zhou, Dong Yin, Ming H. Involvement of Bcl-2 Signal Pathway in the Protective Effects of Apigenin on Anoxia/Reoxygenation-induced Myocardium Injury. Journal of cardiovascular pharmacology. vol 67. issue 2. 2016-12-13. PMID:26466327. |
the recovery of cardiac contractile function, infarct size, lactate dehydrogenase (ldh) and creatine kinase (ck) in the perfusate, the expression and activity of bcl-2 and caspase-3, and cardiomyocyte apoptosis were measured in the langendorff heart undergoing a/r injury. |
2016-12-13 |
2023-08-13 |
rat |
| Feng Hu, Yali Wang, Kaizheng Gong, Gaoyuan Ge, Mingqiang Cao, Pei Zhao, Xiaoning Sun, Zhengang Zhan. Protective effects of drag-reducing polymers on ischemic reperfusion injury of isolated rat heart. Clinical hemorheology and microcirculation. vol 62. issue 1. 2016-11-14. PMID:25633566. |
lactate dehydrogenase (ldh) and creatine kinase (ck) activity and coronary flow, myocardial infarction size and cardiomyocytes apoptosis were also assayed. |
2016-11-14 |
2023-08-13 |
rat |
| Xu-guang Chen, Yan-xia Lv, Dan Zhao, Lei Zhang, Fei Zheng, Jian-Ye Yang, Xiao-lin Li, Lu Wang, Lin-Yun Guo, Ya-mu Pan, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tang, Yu Wa. Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Molecular and cellular biochemistry. vol 413. issue 1-2. 2016-10-21. PMID:26769665. |
24 h later, the myocardial infarction size, the number of tunel-positive cardiomyocytes, the levels of creatine kinase (ck), ck-mb, cardiac troponin, malondialdehyde (mda) content, and apoptosis protein bax expression were decreased, while bcl2 and pakt expression were increased in vegf-c-treated myocardium as compared to the saline-treated i/r hearts. |
2016-10-21 |
2023-08-13 |
human |
| Zi-Gang Yuan, Jian-Li Wang, Guo-Liang Jin, Xue-Bin Yu, Jin-Quan Li, Tian-Lun Qiu, Rong-Xiao Da. Serum caspase-cleaved cytokeratin-18 levels and outcomes after aneurysmal subarachnoid hemorrhage. Journal of the neurological sciences. vol 359. issue 1-2. 2016-09-28. PMID:26671131. |
the protein cytokeratin-18 (ck-18) is cleaved by the action of caspases during apoptosis, and the resulting fragments are released into the blood as caspase-cleaved ck (ccck)-18. |
2016-09-28 |
2023-08-13 |
Not clear |
| Ma Ruisong, Hu Xiaorong, Hu Gangying, Yi Chunfeng, Zhang Changjiang, Li Xuefei, Li Yuanhong, Jiang Hon. The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling Pathway. PloS one. vol 10. issue 11. 2016-06-17. PMID:26571038. |
compared with the i/r group, the il-33 group had significantly lower cardiac injury (lower serum creatine kinase (ck), lactate dehydrogenase (ldh), and ctni levels and myocardial infarct size), a suppressed inflammatory response in myocardial tissue (lower expression of hmgb1, il-6, tnf-α and inf-γ) and less myocardial apoptosis (much higher bcl-2/bax ratio and lower cleaved caspase-3 expression). |
2016-06-17 |
2023-08-13 |
Not clear |
| Wei Feng, Bo Liu, Di Liu, Tomoka Hasegawa, Wei Wang, Xiuchun Han, Jian Cui, Yimin, Kimimitsu Oda, Norio Amizuka, Minqi L. Long-Term Administration of High-Fat Diet Corrects Abnormal Bone Remodeling in the Tibiae of Interleukin-6-Deficient Mice. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 64. issue 1. 2016-05-02. PMID:26416243. |
meanwhile, tartrate-resistant acid phosphatase staining was inhibited, osteoclast apoptosis rate down-regulated (revealed by tunel assay), and the proportion of cathepsin k (ck)-positive osteoclasts significantly increased in il-6(-/-) mice on a hfd as compared with il-6(-/-) mice on standard chow. |
2016-05-02 |
2023-08-13 |
mouse |
| Leonardo Lorente, María M Martín, Agustín F González-Rivero, Mónica Argueso, Luis Ramos, Jordi Solé-Violán, Juan J Cáceres, Alejandro Jiménez, Juan M Borreguero-Leó. Serum levels of caspase-cleaved cytokeratin-18 in patients with severe traumatic brain injury are associated with mortality: a pilot study. PloS one. vol 10. issue 3. 2016-04-18. PMID:25822281. |
the protein cytokeratin 18 (ck-18), present in epithelial cells, is cleaved by the action of caspases during apoptosis, and the resulting fragments are released into the blood as caspase-cleaved ck (ccck)-18. |
2016-04-18 |
2023-08-13 |
Not clear |
| Chae Won Kwak, Young Min Son, Min Jeong Gu, Girak Kim, In Kyu Lee, Yoon Chul Kye, Han Wool Kim, Ki-Duk Song, Hyuk Chu, Byung-Chul Park, Hak-Kyo Lee, Deok-Chun Yang, Jonathan Sprent, Cheol-Heui Yu. A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β. Journal of microbiology and biotechnology. vol 25. issue 7. 2016-04-18. PMID:26032359. |
among these, compound k (ck), an intestinal bacterial metabolite of the ginsenosides rb1, rb2, and rc from bacteroides jy-6, is reported to inhibit cancer cell growth by inducing cell-cycle arrest or cell death, including apoptosis and necrosis. |
2016-04-18 |
2023-08-13 |
Not clear |
| Chae Won Kwak, Young Min Son, Min Jeong Gu, Girak Kim, In Kyu Lee, Yoon Chul Kye, Han Wool Kim, Ki-Duk Song, Hyuk Chu, Byung-Chul Park, Hak-Kyo Lee, Deok-Chun Yang, Jonathan Sprent, Cheol-Heui Yu. A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β. Journal of microbiology and biotechnology. vol 25. issue 7. 2016-04-18. PMID:26032359. |
interestingly, ck induced programmed necrosis, but not apoptosis, via the gsk3β signaling pathway in mcf-7 cells. |
2016-04-18 |
2023-08-13 |
Not clear |
| Wei Zhang, Baichun Xing, Linlin Yang, Jialun Shi, Xinmin Zho. Icaritin Attenuates Myocardial Ischemia and Reperfusion Injury Via Anti-Inflammatory and Anti-Oxidative Stress Effects in Rats. The American journal of Chinese medicine. vol 43. issue 6. 2016-04-08. PMID:26364662. |
meanwhile, ict reduced plasma creatine kinase (ck), lactate dehydrogenase (ldh) activities and cardiomyocyte apoptosis in i/r heart tissue. |
2016-04-08 |
2023-08-13 |
rat |
| Monica Muratori, Lara Tamburrino, Sara Marchiani, Marta Cambi, Biagio Olivito, Chiara Azzari, Gianni Forti, Elisabetta Bald. Investigation on the Origin of Sperm DNA Fragmentation: Role of Apoptosis, Immaturity and Oxidative Stress. Molecular medicine (Cambridge, Mass.). vol 21. 2016-03-28. PMID:25786204. |
using multicolor flow cytometry and sperm sorting, we challenged the three hypothesized mechanisms by simultaneously evaluating sdf and signs of oxidative damage (8-hydroxy, 2'-deoxyguanosine [8-ohdg] and malondialdehyde [mda]), apoptosis (caspase activity and cleaved poly[adp-ribose] polymerase [cparp]) and sperm immaturity (creatine phosphokinase [ck] and excess of residual histones). |
2016-03-28 |
2023-08-13 |
human |
| Leonardo Lorente, María M Martín, Agustín F González-Rivero, José Ferreres, Jordi Solé-Violán, Lorenzo Labarta, César Díaz, Alejandro Jiménez, Juan M Borreguero-Leó. Serum levels of caspase-cleaved cytokeratin-18 and mortality are associated in severe septic patients: pilot study. PloS one. vol 9. issue 10. 2015-12-17. PMID:25290885. |
cytokeratin 18 (ck-18), a protein of the intermediate filament group present in most epithelial and parenchymal cells, is cleaved by the action of caspases and released into the blood as caspase-cleaved ck (ccck)-18 during apoptosis. |
2015-12-17 |
2023-08-13 |
Not clear |
| Wenqing Wang, Xiangyan Liang, Dong Fu, Ru Tie, Wenjuan Xing, Lele Ji, Fange Liu, Haifeng Zhang, Rong L. Apocynum venetum leaf attenuates myocardial ischemia/reperfusion injury by inhibiting oxidative stress. The American journal of Chinese medicine. vol 43. issue 1. 2015-09-21. PMID:25579758. |
meanwhile, avle reduced infarct size, plasma creatine kinase (ck)/lactate dehydrogenase (ldh) activities and myocardial apoptosis at the end of reperfusion in rat hearts. |
2015-09-21 |
2023-08-13 |
rat |
| Katharina John, Imme Rösner, Ulrich Keilholz, Thomas Gauler, Heike Bantel, Viktor Grünwal. Baseline caspase activity predicts progression free survival of temsirolimus-treated head neck cancer patients. European journal of cancer (Oxford, England : 1990). vol 51. issue 12. 2015-09-21. PMID:26048456. |
during apoptosis of epithelial cells caspases cleave cytokeratin (ck)-18 can be detected in the blood. |
2015-09-21 |
2023-08-13 |
Not clear |
| Jianwu Yu, Jing Wei, Ling Ji, Xutao Hon. Exploration on mechanism of a new type of melatonin receptor agonist Neu-p11 in hypoxia-reoxygenation injury of myocardial cells. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24840226. |
apoptosis rates of myocardial cells in different groups, the contents of creatinine kinase (ck), lactic dehydrogenase (ldh), superoxide dismutase (sod), and malondialdehyde (mda) in cell culture media were compared. |
2015-07-02 |
2023-08-13 |
Not clear |
| Yang Li, Tong Zhou, Chengyuan Ma, Weiwei Song, Jian Zhang, Zhenxiang Y. Ginsenoside metabolite compound K enhances the efficacy of cisplatin in lung cancer cells. Journal of thoracic disease. vol 7. issue 3. 2015-04-29. PMID:25922718. |
to evaluate the potential of ginsenoside metabolite compound k (ck) in enhancing the anti-tumor effects of cisplatin against lung cancer cells, including cell proliferation and apoptosis, and the underlying mechanism. |
2015-04-29 |
2023-08-13 |
Not clear |
| Zhenwei Shi, Feng Fu, Liming Yu, Wenjuan Xing, Feifei Su, Xiangyan Liang, Ru Tie, Lele Ji, Miaozhang Zhu, Jun Yu, Haifeng Zhan. Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. American journal of physiology. Heart and circulatory physiology. vol 308. issue 4. 2015-04-13. PMID:25485902. |
vnp treatment (100 μg/kg iv, 10 min before reperfusion) significantly improved the instantaneous first derivation of left ventricle pressure (±lv dp/dtmax) and lv systolic pressure and reduced lv end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (ck), and lactate dehydrogenase (ldh) activities. |
2015-04-13 |
2023-08-13 |
rat |