| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Yang, Jianan Lin, Huiyuan Zhang, Yingna Liu, Mo Kan, Zhiru Xiu, Xijun Chen, Xingcheng Lan, Xiaohua Li, Xiaozheng Shi, Na Li, Xiaobo Q. Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments. Journal of molecular neuroscience : MN. vol 67. issue 1. 2019-01-31. PMID:30535776. |
ginsenoside ck was found to enhance memory function, normalize neuronal morphology, decrease neuronal apoptosis, increase superoxide dismutase and glutathione peroxidase levels, reduce malondialdehyde levels, inhibit aβ expression, and activate the nrf2/keap1 signaling pathway in scopolamine-exposed animals. |
2019-01-31 |
2023-08-13 |
mouse |
| Qing Yang, Jianan Lin, Huiyuan Zhang, Yingna Liu, Mo Kan, Zhiru Xiu, Xijun Chen, Xingcheng Lan, Xiaohua Li, Xiaozheng Shi, Na Li, Xiaobo Q. Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments. Journal of molecular neuroscience : MN. vol 67. issue 1. 2019-01-31. PMID:30535776. |
based on these results, we conclude that ck may improve memory function in scopolamine-injured mice by regulating aβ aggregation and promoting the transduction of the nrf2/keap1 signaling pathway, thereby reducing oxidative damage to neurons and inhibiting neuronal apoptosis. |
2019-01-31 |
2023-08-13 |
mouse |
| Huan He, Yong Luo, Yang Qiao, Zeyu Zhang, Dong Yin, Jianguo Yao, Jiegen You, Ming H. Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ. Food & function. vol 9. issue 8. 2018-12-18. PMID:30063064. |
the effects of cur were assessed by determining the heart rate and ecg's st segments, as well as lactate dehydrogenase (ldh) and creatine kinase (ck) activities in the serum, caspase-3 activity, apoptosis rate, and histopathological changes of the myocardium (in vivo). |
2018-12-18 |
2023-08-13 |
mouse |
| Huan He, Yong Luo, Yang Qiao, Zeyu Zhang, Dong Yin, Jianguo Yao, Jiegen You, Ming H. Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ. Food & function. vol 9. issue 8. 2018-12-18. PMID:30063064. |
our results showed that dox-induced injury to the myocardium was decreased by cur treatment via upregulating the protein expression of 14-3-3γ in total protein and bcl-2 expression on mitochondria, activating bad (s112) phosphorylation, reducing the heart rate and st segment, and reducing ldh and ck activities in the serum, thereby causing a reduction in caspase-3 activity, the apoptosis rate, and histopathological changes of the myocardium (in vivo). |
2018-12-18 |
2023-08-13 |
mouse |
| Xu-Jia Chen, Wen-Jing Liu, Meng-Liang Wen, Hong Liang, Shao-Mei Wu, Yun-Zhen Zhu, Jiang-Yuan Zhao, Xiang-Qian Dong, Ming-Gang Li, Li Bian, Cheng-Gang Zou, Lan-Qing M. Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats. Scientific reports. vol 7. 2018-10-25. PMID:28106137. |
in vitro experiments demonstrated that treatment with ck or rh1 alone or in combination markedly induced cell apoptosis, and inhibited cell proliferation and activation in hsc-t6 cells. |
2018-10-25 |
2023-08-13 |
rat |
| Jianxiang Gan, Weichun Qian, Song Li. Umbelliferone Alleviates Myocardial Ischemia: the Role of Inflammation and Apoptosis. Inflammation. vol 41. issue 2. 2018-10-01. PMID:29188498. |
st-segment elevation, lactate dehydrogenase (ldh), creatine kinase (ck), catalase (sod), malondialdehyde (mda), inflammatory cytokines, toll-like receptors (tlrs)/nuclear factor (nf)-κbp65 pathway, and apoptosis were evaluated in rats treated with or without umb. |
2018-10-01 |
2023-08-13 |
rat |
| Chengtai Ma, Yanxia Jiang, Xiaohui Zhang, Xiaoxue Chen, Zhenfang Liu, Xintao Tia. Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29532872. |
isoquercetin ameliorated myocardial infarct size, creatine kinase (ck), ck‑mb and lactic dehydrogenase activity and inhibited inflammation, oxidative stress and heart cell apoptosis in a rat with ami. |
2018-09-13 |
2023-08-13 |
rat |
| Xin Jin, Qing Yang, Ning Ca. Preparation of ginsenoside compound-K mixed micelles with improved retention and antitumor efficacy. International journal of nanomedicine. vol 13. 2018-08-03. PMID:30013338. |
ginsenoside compound k (ck) has effects on cell-cycle regulation, tumor growth inhibition, and apoptosis induction. |
2018-08-03 |
2023-08-13 |
Not clear |
| Sanghun Lee, Min Cheol Kwon, Jun-Pil Jang, Jae Kyung Sohng, Hye Jin Jun. The ginsenoside metabolite compound K inhibits growth, migration and stemness of glioblastoma cells. International journal of oncology. vol 51. issue 2. 2018-05-25. PMID:28656196. |
ck also induced apoptosis in gbm cells through nuclear condensation, an increase in ros generation, mitochondrial membrane potential depolarization, and activation of caspase-3, caspase-9 and poly(adp-ribose) polymerase (parp). |
2018-05-25 |
2023-08-13 |
Not clear |
| Roberta Ceci, Maria Reyes Beltran Valls, Guglielmo Duranti, Ivan Dimauro, Federico Quaranta, Monica Pittaluga, Stefania Sabatini, Paolo Caserotti, Paolo Parisi, Attilio Parisi, Daniela Capoross. Oxidative stress responses to a graded maximal exercise test in older adults following explosive-type resistance training. Redox biology. vol 2. 2018-01-11. PMID:25460722. |
blood glutathione (gsh, gssg, gsh/gssg), plasma malonaldehyde (mda), protein carbonyls and creatine kinase (ck) levels, as well as pbmcs cellular damage (comet assay, apoptosis) and stress-protein response (hsp70 and hsp27 expression) were evaluated. |
2018-01-11 |
2023-08-13 |
human |
| Zun-Ping Ke, Peng Xu, Yan Shi, Ai-Mei Ga. MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN. Oncotarget. vol 7. issue 20. 2018-01-08. PMID:27119510. |
in addtion, ad-mir-93 also attenuated myocardial i/r injury in vivo, manifested by reduced ldh and ck levels, infarct area and cell apoptosis. |
2018-01-08 |
2023-08-13 |
Not clear |
| Jian Sun, Tao Wei, Shuzhi Bai, Hongtao Zhao, Xiaoqin Liu, Jinfeng Yu, Li Li, Gaochen Song, Hairong Luan, Changqing X. Calcium-sensing receptor-mediated mitogen-activated protein kinase pathway improves the status of transplanted mouse embryonic stem cells in rats with acute myocardial infarction. Molecular and cellular biochemistry. vol 431. issue 1-2. 2017-12-04. PMID:28281186. |
using acute myocardial infarction rat models, we found that a combination therapy of casr inhibition and embryonic stem cell (esc) transplantation after acute myocardial infarction (ami) leads to a dramatic reduction in the infarct size; a significant increase in the maximum rising and falling rate (+dp/dtmax and -dp/dtmax, respectively) of left ventricular pressure; a significant decrease in left ventricular end-diastolic pressure; a significant decrease in the mrna expression level of casr, bax, bcl-2, cleaved caspase-3, cleaved caspase-9, p-erk, p-jnk and p-p38 protein together with apoptosis indexes in the c and e groups; and a significant decrease in ctnt levels as well as ldh and ck activity. |
2017-12-04 |
2023-08-13 |
mouse |
| Zhu Meng, Mei-Yan Song, Chuan-Fang Li, Jia-Qi Zha. shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation. Biochemical and biophysical research communications. vol 494. issue 3-4. 2017-11-21. PMID:29069583. |
nlrp3 silence had nearly no impact on myocardial enzymes (ast, ldh and ck) expressions, inflammatory factors (tnf-α and il-1β) expressions and cell apoptosis in rats without i/r injury. |
2017-11-21 |
2023-08-13 |
rat |
| Lei Chen, Yue Meng, Qi Sun, Zhongyu Zhang, Xiaoqing Guo, Xiaotong Sheng, Guihua Tai, Hairong Cheng, Yifa Zho. Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. Cell death & disease. vol 7. issue 8. 2017-10-10. PMID:27512955. |
this article reports that ginsenoside compound k (ck) potentiates trail-induced apoptosis in hct116 colon cancer cells and sensitizes trail-resistant colon cancer ht-29 cells to trail. |
2017-10-10 |
2023-08-13 |
human |
| Lei Chen, Yue Meng, Qi Sun, Zhongyu Zhang, Xiaoqing Guo, Xiaotong Sheng, Guihua Tai, Hairong Cheng, Yifa Zho. Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. Cell death & disease. vol 7. issue 8. 2017-10-10. PMID:27512955. |
on a cellular mechanistic level, ck downregulated cell survival proteins including mcl-1, bcl-2, surviving, x-linked inhibitor of apoptosis protein and fas-associated death domain-like il-1-converting enzyme-inhibitory protein, upregulated cell pro-apoptotic proteins including bax, tbid and cytochrome c, and induced the cell surface expression of trail death receptor dr5. |
2017-10-10 |
2023-08-13 |
human |
| Zhaoqi Wang, Duomao Lin, Liang Zhang, Wenjun Liu, Hongbao Tan, Jun M. Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway. European journal of pharmacology. vol 797. 2017-04-07. PMID:28089921. |
to investigate apoptosis, we used the cell viability assay, annexin-v/pi assay, and lactate dehydrogenase (ldh) and creatine kinase (ck) activity measurements. |
2017-04-07 |
2023-08-13 |
Not clear |
| Leonardo Lorente, Sergio T Rodriguez, Pablo Sanz, Antonia Pérez-Cejas, Javier Padilla, Dácil Díaz, Antonio González, María M Martín, Alejandro Jiménez, Manuel A Barrer. Prognostic Value of Serum Caspase-Cleaved Cytokeratin-18 Levels before Liver Transplantation for One-Year Survival of Patients with Hepatocellular Carcinoma. International journal of molecular sciences. vol 17. issue 9. 2017-03-29. PMID:27618033. |
cytokeratin (ck)-18 is the major intermediate filament protein in the liver and during hepatocyte apoptosis is cleaved by the action of caspases; the resulting fragments are released into the blood as caspase-cleaved cytokeratin (ccck)-18. |
2017-03-29 |
2023-08-13 |
Not clear |
| Xiaojin Yu, Zhenyu Wang, Zunpeng Shu, Zhengqing Li, Yuan Ning, Keli Yun, Haina Bai, Ruihai Liu, Wenli Li. Effect and mechanism of Sorbus pohuashanensis (Hante) Hedl. flavonoids protect against arsenic trioxide-induced cardiotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-27. PMID:28092839. |
at the same time, spf significantly reduced levels of creatine kinase (ck), creatine kinase-mb (ck-mb) lactate dehydrogenase (ldh), and glutamic oxaloacetic transaminase (got) against ato-induced injury and inhibited ato-induced apoptosis both in vivo and in vitro. |
2017-03-27 |
2023-08-13 |
mouse |
| Youwen Zhang, Deyin Tong, Daobiao Che, Bing Pei, Xiaodong Xia, Gaofeng Yuan, Xin Ji. Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo. International journal of nanomedicine. vol 12. 2017-03-13. PMID:28144142. |
furthermore, in an in vitro a549 cell model, ck ap/tpgs mixed micelles significantly inhibited cell growth, induced g0/g1 phase cell cycle arrest, induced cell apoptosis, and inhibited cell migration compared to free ck, all indicating that the developed micellar delivery system could increase the antitumor effect of ck in vitro. |
2017-03-13 |
2023-08-13 |
mouse |
| Reza Badalzadeh, Ako Azimi, Alireza Alihemmati, Bahman Yousef. Chronic type-I diabetes could not impede the anti-inflammatory and anti-apoptotic effects of combined postconditioning with ischemia and cyclosporine A in myocardial reperfusion injury. Journal of physiology and biochemistry. vol 73. issue 1. 2017-03-09. PMID:27771871. |
the concentration of creatine kinase (ck), tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 were determined; the levels of total and phosphorylated glycogen synthase kinase 3 beta (p-gsk3β) and b-cell lymphoma 2 (bcl-2) were quantified by western blotting, and the rate of apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling (tunel) staining. |
2017-03-09 |
2023-08-13 |
rat |