| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Cheng, Jin-Peng Zhong, Fu-Xia Wu, Guan-Lan Li, Qing-Xiao Ruan, Gang Luo, Hong Jian. Ebselen protects rat hearts against myocardial ischemia-reperfusion injury. Experimental and therapeutic medicine. vol 17. issue 2. 2020-09-30. PMID:30680022. |
this was indicated by attenuation of histological and ultrastructural changes; reduction of serum ck, ck-mb and ldh activity levels; and decreased cell apoptosis on tunel staining, which was verified by decreased expression of cleaved (c)-caspase-8, c-caspase-3, b-cell lymphoma 2 (bcl-2)-associated x protein and c-parp, and increased expression of bcl-2. |
2020-09-30 |
2023-08-13 |
rat |
| Zhonglin Wu, Yuanyuan Zhang, Tao Song, Qiongtao Song, Ying Zhang, Xuan Zhang, Xue Han, Jianping Zhang, Li Ch. Magnesium isoglycyrrhizinate ameliorates doxorubicin-induced acute cardiac and hepatic toxicity via anti-oxidant and anti-apoptotic mechanisms in mice. Experimental and therapeutic medicine. vol 15. issue 1. 2020-09-29. PMID:29399108. |
the results revealed that mgig (10, 20 and 40 mg/kg/day) could protect the structure and functions of the liver and heart by inhibiting the activities of the myocardial enzymes creatine kinase (ck), ck-mb and lactate dehydrogenase and the hepatic-specific enzymes aspirate aminotransferase and alanine aminotransferase, increasing the activities of the antioxidants superoxide dismutase and glutathione peroxidase, and inhibiting cellular apoptosis induced by dox (30 mg/kg). |
2020-09-29 |
2023-08-13 |
mouse |
| Kang Chen, Jianbao Jiao, Jinwei Xue, Taoping Chen, Yu Hou, Yuantao Jiang, Ligang Qian, Yunfei Wang, Zheng Ma, Zhixing Liang, Bo Sun, Qiao Re. Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway. Oncology reports. vol 43. issue 3. 2020-09-23. PMID:32020217. |
ginsenoside ck induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the pi3k/mtor/p70s6k1 pathway. |
2020-09-23 |
2023-08-13 |
human |
| Kang Chen, Jianbao Jiao, Jinwei Xue, Taoping Chen, Yu Hou, Yuantao Jiang, Ligang Qian, Yunfei Wang, Zheng Ma, Zhixing Liang, Bo Sun, Qiao Re. Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway. Oncology reports. vol 43. issue 3. 2020-09-23. PMID:32020217. |
moreover, it was demonstrated that ck induced apoptosis and inhibited the migration and invasion of osteosarcoma cells via apoptotic staining, annexin v/pi staining, and transwell invasion assays. |
2020-09-23 |
2023-08-13 |
human |
| Kang Chen, Jianbao Jiao, Jinwei Xue, Taoping Chen, Yu Hou, Yuantao Jiang, Ligang Qian, Yunfei Wang, Zheng Ma, Zhixing Liang, Bo Sun, Qiao Re. Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway. Oncology reports. vol 43. issue 3. 2020-09-23. PMID:32020217. |
furthermore, at the molecular level, the present results confirmed that apoptosis and invasion‑related proteins were regulated by ck, which was possibly related to the blockade of the pi3k/mtor/p70s6k1 signaling pathway. |
2020-09-23 |
2023-08-13 |
human |
| Kang Chen, Jianbao Jiao, Jinwei Xue, Taoping Chen, Yu Hou, Yuantao Jiang, Ligang Qian, Yunfei Wang, Zheng Ma, Zhixing Liang, Bo Sun, Qiao Re. Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway. Oncology reports. vol 43. issue 3. 2020-09-23. PMID:32020217. |
in summary, the present findings indicated that ck inhibited viability and proliferation, induced apoptosis, and inhibited the migration and invasion of osteosarcoma cells through the pi3k/mtor/p70s6k1 signaling pathway. |
2020-09-23 |
2023-08-13 |
human |
| Jianlei Cao, Yurong Da, Hang Li, Yuanyuan Peng, Xiaorong H. Upregulation of microRNA-451 attenuates myocardial I/R injury by suppressing HMGB1. PloS one. vol 15. issue 7. 2020-09-14. PMID:32678819. |
after 24 hours of reperfusion injury, the serum content of ck and ldh, the content of mda in tissue and activity of sod were detected; the infarcted areas were defined by ttc staining and evans blue; tunel staining and cleaved-caspase 3 were used to test apoptosis; hmgb1 was detected by real-time fluorescence quantitative pcr and western blotting. |
2020-09-14 |
2023-08-13 |
rat |
| Jianlei Cao, Yurong Da, Hang Li, Yuanyuan Peng, Xiaorong H. Upregulation of microRNA-451 attenuates myocardial I/R injury by suppressing HMGB1. PloS one. vol 15. issue 7. 2020-09-14. PMID:32678819. |
compared with the i/r and i/r+ad-gfp group, upregulation of mir-451 could reduce the infarcted areas, cardiomyocytes apoptosis index, expression of cleaved-caspase 3 and content of ck and ldh significantly(p<0.05); meanwhile, upregulation of mir-451 could also obviously inhibit hmgb1, the increase of mda and the decrease of sod (p<0.05). |
2020-09-14 |
2023-08-13 |
rat |
| Liyuan Zou, Xiaokun Ma, Shuo Lin, Bingyuan Wu, Yang Chen, Chaoquan Pen. Long noncoding RNA-MEG3 contributes to myocardial ischemia-reperfusion injury through suppression of miR-7-5p expression. Bioscience reports. vol 39. issue 8. 2020-09-09. PMID:31366567. |
in contrast, overexpression of meg3 increased the i/r-induced ck and ldh activities and cell apoptosis and decreased cell proliferation. |
2020-09-09 |
2023-08-13 |
rat |
| Liyuan Zou, Xiaokun Ma, Shuo Lin, Bingyuan Wu, Yang Chen, Chaoquan Pen. Long noncoding RNA-MEG3 contributes to myocardial ischemia-reperfusion injury through suppression of miR-7-5p expression. Bioscience reports. vol 39. issue 8. 2020-09-09. PMID:31366567. |
co-transfection of mir-7-5p inhibitor with simeg3 activates ck and ldh, significantly decreased cell proliferation, increased cell apoptosis, and decreased intact poly(adp-ribose) polymerase 1 (parp1) and caspase-3. |
2020-09-09 |
2023-08-13 |
rat |
| Hong-Cheng Fang, Bao-Quan Wu, Yun-Ling Hao, Ying Luo, Hong-Lei Zhao, Wen-Ying Zhang, Zhi-Ling Zhang, Jin-Jie Liang, Wei Liu, Xie-Hui Che. KRT1 gene silencing ameliorates myocardial ischemia-reperfusion injury via the activation of the Notch signaling pathway in mouse models. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30191968. |
myocardial tissues were used for the determination of the positive rate of krt1 protein expression, apoptosis of myocardial cells, creatine kinase (ck) and lactate dehydrogenase (ldh) expression, expression of related biomarkers as well as myocardial infarction area. |
2020-03-16 |
2023-08-13 |
mouse |
| Hong-Cheng Fang, Bao-Quan Wu, Yun-Ling Hao, Ying Luo, Hong-Lei Zhao, Wen-Ying Zhang, Zhi-Ling Zhang, Jin-Jie Liang, Wei Liu, Xie-Hui Che. KRT1 gene silencing ameliorates myocardial ischemia-reperfusion injury via the activation of the Notch signaling pathway in mouse models. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30191968. |
mice with miri had a higher positive rate of krt1 protein expression, apoptosis of myocardial cells, ck and ldh expression, myocardial infarction area, increased expression of mda, no, sdh, il-1, il-6, tnf-α, crp, krt1, bax protein, ck, and ldh, and decreased expression of sod, nicd, hes1, and bcl-2. |
2020-03-16 |
2023-08-13 |
mouse |
| Xijun Chen, Hui Li, Qing Yang, Xingcheng Lan, Jifeng Wang, Zhanhong Cao, Xiaozheng Shi, Jing Li, Mo Kan, Xiaobo Qu, Na L. Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism. Molecular biology reports. vol 46. issue 5. 2020-03-09. PMID:31364016. |
ck treatment improved cell viability, cell growth, and apoptosis induced by aβ, and the cellular localization and expression of aβ. |
2020-03-09 |
2023-08-13 |
Not clear |
| P. Di Napoli, A. A. Taccardi, A. Grilli, M. Felaco, L. Di Gioacchino, R. De Caterina, A. Barsott. Verapamil reduces coronary endothelium damage and cardiomyocyte necrosis but not apoptosis after ischemia and reperfusion: ex-vivo study in rat hearts. International journal of immunopathology and pharmacology. vol 15. issue 3. 2019-11-20. PMID:12575923. |
we evaluated creatinephosphokinase (ck) in coronary effluent, heart weight changes, microvascular permeability (extravasation of fluoresceine-labeled albumin), ultrastructural alterations, and cardiomyocyte apoptosis (by 1.5% agarose gel electrophoresis and terminal deoxynucleotidyl transferase-mediated dutp-biotin nick-end labelling technique). |
2019-11-20 |
2023-08-12 |
rat |
| P. Di Napoli, A. A. Taccardi, A. Grilli, M. Felaco, L. Di Gioacchino, R. De Caterina, A. Barsott. Verapamil reduces coronary endothelium damage and cardiomyocyte necrosis but not apoptosis after ischemia and reperfusion: ex-vivo study in rat hearts. International journal of immunopathology and pharmacology. vol 15. issue 3. 2019-11-20. PMID:12575923. |
in this model, 0.25 &mgr;m verapamil significantly reduced myocardial damage, ck release and vascular hyperpermeability, concomitant with a reduction in endothelial and cardiomyocyte lesions; on the contrary, 0.25 &mgr;m verapamil was unable to reduce cardiomyocyte apoptosis. |
2019-11-20 |
2023-08-12 |
rat |
| Zhu Jie, Wang Xiujian, Li Ji. Pharmacological mechanism and apoptosis effect of baicalein in protecting myocardial ischemia reperfusion injury in rats. Pakistan journal of pharmaceutical sciences. vol 32. issue 1(Special). 2019-09-03. PMID:30852477. |
high concentration of baicalein preconditioning can significantly reduce the release of ck (creatine kinase) and ldh(lactate dehydrogenase) induced by myocardial ischemia/reperfusion injury, reduce the rate of myocardial infarction and reduce the rate of myocardial apoptosis. |
2019-09-03 |
2023-08-13 |
rat |
| Hongying Xu, Rongqiang Li. Effect of baicalein with different concentrations on myocardial ischemia reperfusion injury in rats. Pakistan journal of pharmaceutical sciences. vol 31. issue 4(Special). 2019-08-22. PMID:30203769. |
the results show that baicalein has a significant improvement in i/r damage, mainly in reducing myocardial infarction rate, reducing the release of myocardial isozyme ldh and ck, reducing the level of oxidative stress and reducing the apoptosis of cardiac myocytes. |
2019-08-22 |
2023-08-13 |
rat |
| Lu Sun, Kedi Zhou, Weijun Wang, Xiaojun Zhang, Zhongjian Ju, Baolin Qu, Zhizhong Zhang, Jinyuan Wang, Zhipei Ling, Xinguang Yu, Jinming Zhang, Longsheng Pa. [18F]ML-10 Imaging for Assessment of Apoptosis Response of Intracranial Tumor Early after Radiosurgery by PET/CT. Contrast media & molecular imaging. vol 2018. 2019-07-23. PMID:29983648. |
we assess the apoptosis response of intracranial tumor early after cyberknife (ck) treatment by [18f]ml-10 pet imaging. |
2019-07-23 |
2023-08-13 |
human |
| Xin Jin, Jianping Zhou, Zhenhai Zhang, Huixia L. The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup3. 2019-06-17. PMID:30307334. |
the combined administration of parthenolide and ginsenoside ck in long circulation liposomes with targeted tlyp-1 ligand induce mitochondria-mediated lung cancer apoptosis. |
2019-06-17 |
2023-08-13 |
Not clear |
| A Mahalakshmi, Gino A Kuria. Evaluating the impact of diabetes and diabetic cardiomyopathy rat heart on the outcome of ischemia-reperfusion associated oxidative stress. Free radical biology & medicine. vol 118. 2019-05-14. PMID:29462717. |
cardiac physiological recovery after i/r was assessed by hemodynamic parameters like lvdp, and lvsp, whereas cardiac injury was measured by tissue infarct size, and apoptosis, ldh, and ck release in coronary effluent. |
2019-05-14 |
2023-08-13 |
rat |