| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo-Yi Zhang, Gen-Lin He, Ze-Ze Wang, Huan Zhou, Xue-Yan Huang, Ting-Ting Shen, Xiao-Qian Liu, Yi-Shan Liu, Zhen Luo, Ping Li, Yu-Long Tan, Xue Luo, Xue-Sen Yan. L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats. Heliyon. vol 10. issue 22. 2024-12-06. PMID:39641050. |
here, we found that lc exerted a greater protective effect on ehs-induced cardiac dysfunction and mortality, which also significantly attenuated certain negative effects, including increased myocardial apoptosis, pathological changes, and ultrastructural impairment, enhanced activity levels of such serum enzymes as ast, ldh, ck, and ck-mb, reduced bcl-2 expression, increased the expression of cleaved caspase-3 and the critical endoplasmic reticulum stress (ers) indices like chop and grp78 in ehs rats. |
2024-12-06 |
2024-12-08 |
rat |
| Zeping Luo, Liwei Pa. Synthesis of Formononetin Derivatives and Cardioprotective Effects. Chemical & pharmaceutical bulletin. vol 72. issue 11. 2024-11-17. PMID:39551522. |
further mechanistic investigations revealed that c4 could mitigate apoptosis rates, reduce the activity of myocardial enzyme (such as aspartate aminotransferase (ast), lactate dehydrogenase (ldh), and ck), diminish the number of autophagic vesicles, and restore excessive autophagy. |
2024-11-17 |
2024-11-22 |
Not clear |
| Qian Yang, Qi-Ming Zhong, Mei-Qing Song, Li-Guo Tong, Chong-Zhi Ba. Exosomes derived from Danshen decoction-pretreated bone marrow mesenchymal stem cells alleviate myocardial infarction via anti-apoptosis and up-regulation of autophagy. Heliyon. vol 10. issue 18. 2024-09-30. PMID:39347388. |
on the 7th, 14th and 28th days, serum ck, ldh, α-hbdh, alt, and ast were measured and electrocardiogram changes were monitored to identify cardiac function; triphenyltetrazolium chloride staining, hematein&eosin staining, masson trichrome staining and transmission electron microscope were adopted to analyze infarct area, cardiac morphology, histopathology, and fibrosis and cardiomyocyte ultrastructure; tunel assay, real-time pcr and western blot were performed to detect cardiomyocyte apoptosis and autophagy. |
2024-09-30 |
2024-10-02 |
rat |
| Zhiyue Chang, Yanhui Zhang, Lu Wang, Huizhen Wang, Ling Tian, Juan Qia. Analysis of the improvement effect of Astragalus extract on oxidative stress injury in viral myocarditis through STAT3/IL-6. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279453. |
cell multiplication and apoptosis, as well as levels of myocardial injury markers (ctnt, bnp and ck), inflammatory cytokines (ics; tnf-α, il-1β and il-6) and os indices (sod, gsh-px and mda), were measured. |
2024-01-27 |
2024-01-29 |
Not clear |
| Ruiye Qiu, Yajuan Zhang, Jun Li, Jun Wu, Ruifeng H. Influences of microRNA-451 on the expression of HMGB1 in myocardial cells and its mechanism in ischemia-reperfusion injury. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279466. |
myocardial cell apoptosis, the contents of serum lactic acid dehydrogenase (ldh), creatine kinase (ck), and malondialdehyde (mda), the activity of superoxide dismutase (sod), and the expressions of mir-451 and hmgb1mrna were detected. |
2024-01-27 |
2024-01-29 |
rat |
| Jingjing Zhang, Yao Liu, Chao An, Chen Liu, Saijian Ma, Qiwen Zhang, Hao Ding, Jingjing Shao, Wenjiao Xu. Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A. Foods (Basel, Switzerland). vol 12. issue 24. 2023-12-23. PMID:38137182. |
meanwhile, ginsenoside ck suppressed hepatocyte apoptosis, which was observed in pathological data, and immunoblotting results showed that the expression of bax, bcl-2, and other proteins was regulated by ck. |
2023-12-23 |
2023-12-25 |
mouse |
| Rongzhen Liang, Taicheng Wang, Dewen Lin, Xuejiao Yin, Li Li. [Apelin-13 promotes mitochondrial autophagy and improves rat myocardial ischemia-reperfusion injury by blocking PINK1/parkin signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980549. |
results compared with sham operation group or ap13-treated sham group, serum ck, ldh, ctni, myocardial infarction area and apoptosis rate of miri group or ap13-treated miri rats were significantly increased, and there was no significant difference between the first two groups. |
2023-11-19 |
2023-11-20 |
rat |
| Wonjun Cho, Heeseung Oh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jun. Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. Tissue & cell. vol 86. 2023-11-18. PMID:37979397. |
in this study, we investigated the potential of ginsenoside compound k (ck), known for its antidiabetic properties, to mitigate tenocyte apoptosis, inflammation, oxidative stress, and the metalloproteinase (mmp) system under hyperglycemic conditions. |
2023-11-18 |
2023-11-20 |
Not clear |
| Wonjun Cho, Heeseung Oh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jun. Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. Tissue & cell. vol 86. 2023-11-18. PMID:37979397. |
our findings indicate that ck treatment effectively countered high glucose-induced apoptosis, inflammation, and oxidative stress in cultured tenocytes. |
2023-11-18 |
2023-11-20 |
Not clear |
| Jun-Ho Yang, Hyun Ho Shin, Donghyeon Kim, Ji Hyun Ryu, Eun-Jung Ji. Adhesive ginsenoside compound K patches for cartilage tissue regeneration. Regenerative biomaterials. vol 10. 2023-09-26. PMID:37750082. |
ck-loaded hydrocaffeic acid-conjugated chitosan patches significantly inhibited the stimulation of cartilage-degrading enzymes and apoptosis in osteoarthritic cartilage by releasing ck in cartilage defects. |
2023-09-26 |
2023-10-07 |
Not clear |
| Zhaoli Chu, Yao Tan, Chenxing Xu, Dongting Zhangsun, Xiaopeng Zh. Potential Mechanisms of Metformin-Induced Apoptosis in HeLa Cells. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371530. |
the rna-seq results indicated a total of 239 differentially expressed genes between the metformin and control check (ck) groups, with 136 genes upregulated and 103 genes downregulated, and 14 of them were found to be associated with apoptosis signaling pathways. |
2023-06-28 |
2023-08-14 |
Not clear |
| Jiawei Li, Fangfang Li, Dan Ji. Ginsenosides are Promising Medicine for Tumor and Inflammation: A Review. The American journal of Chinese medicine. 2023-04-15. PMID:37060192. |
the antitumor effects of ginsenosides, such as rg3, rh2, rg5, and ck, are well known, and their potential mechanisms are thought to be related to inducing apoptosis, enhancing the immune response, reversing drug resistance to chemotherapy, and regulating signaling pathways, such as mapk, pi3k/akt/mtor, wnt/[formula: see text]-catenin, nf-[formula: see text]b, ask-1/jnk, ampk, and egfr/akt/sox2. |
2023-04-15 |
2023-08-14 |
Not clear |
| Gareth J Miles, Ian Powley, Seid Mohammed, Lynne Howells, J Howard Pringle, Tim Hammonds, Marion MacFarlane, Catrin Pritchar. Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 3. 2023-02-12. PMID:36775502. |
we compare three image analysis software platforms (qupath, immunoratio and visiopharm) for evaluating ki67 as a marker for proliferation, cleaved parp (cparp) as a marker for apoptosis and pan-cytokeratin (ck) as a marker for tumour areas and find that all three generate comparable data to the views of a histomorphometrist. |
2023-02-12 |
2023-08-14 |
Not clear |
| Qian-Nan Li, Jin-Feng Shang, Ting-Yue Jiang, Lei Bi, Jia-Kang Jiao, Ying-Hui Lu, Qi Song, Shabuer-Jiang Lizha, Xin Li. [Exploration of mechanism of "simultaneous treatment of brain and heart" of Naoxintong Capsules based on Toll-like receptor signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 15. 2022-09-01. PMID:36046901. |
at the same time, the reduction in apoptosis rate of cardiocytes and the content of serum aspartate aminotransferase(ast), alanine aminotransferase(alt), creatine kinase(ck), and lactate dehydrogenase(ldh) were decreased in the nxt group.systems pharmacological results and previous research showed that tlr signaling pathway played an important role in immune inflammatory response.the study of tlr signaling pathway and related proteins is helpful to elucidate the mechanism of "simultaneous treatment of the brain and the heart". |
2022-09-01 |
2023-08-14 |
rat |
| Miyesaier Abudureyimu, Lifang Zhao, Xuanming Luo, Xiang Wang, Haibo Li. Influences of ALDH2 on Cardiomyocyte Apoptosis in Heart Failure Rats Through Regulating PINK1-Parkin Signaling Pathway-Mediated Mitophagy. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 2. 2022-07-23. PMID:35869735. |
the myocardial function index creatine kinase (ck) was measured, the status of myocardial tissue injury was determined using hematoxylin and eosin staining, and the apoptosis was observed via terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) staining. |
2022-07-23 |
2023-08-14 |
rat |
| Jinlong Liu, Yuchen Wang, Zhun Yu, Guangfu Lv, Xiaowei Huang, He Lin, Chao Ma, Zhe Lin, Peng Q. Functional Mechanism of Ginsenoside Compound K on Tumor Growth and Metastasis. Integrative cancer therapies. vol 21. 2022-05-26. PMID:35615883. |
ck inhibits tumor growth by inducing tumor apoptosis and tumor cell differentiation, regulates the tumor microenvironment by suppressing tumor angiogenesis-related proteins, and downregulates the roles of immunosuppressive cells, such as myeloid-derived suppressor cells (mdscs). |
2022-05-26 |
2023-08-13 |
Not clear |
| Bo Zhang, Rongzhan Fu, Zhiguang Duan, Shihong Shen, Chenhui Zhu, Daidi Fa. Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism. Biochemical pharmacology. 2022-05-26. PMID:35618001. |
ginsenoside ck induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism. |
2022-05-26 |
2023-08-13 |
mouse |
| Bo Zhang, Rongzhan Fu, Zhiguang Duan, Shihong Shen, Chenhui Zhu, Daidi Fa. Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism. Biochemical pharmacology. 2022-05-26. PMID:35618001. |
ck treatment further decreased cellular atp production, reduced the utilisation of amino acids associated with glutamine metabolism, and induced glutathione (gsh) depletion and reactive oxygen species (ros) accumulation, consequently triggering apoptosis in tnbc. |
2022-05-26 |
2023-08-13 |
mouse |
| H C Yang, Z K Xing, H Shao, X W Tan, E Q Wang, Y Liao, H J Chen, X W Wu, X L Chen, S J Zhan. The expression of cytokeratin and apoptosis-related molecules in echinococcosis related liver injury. Molecular and biochemical parasitology. 2022-01-12. PMID:35016896. |
echinococcus granulosus and echinococcus multilocularis in the co-culture model in vitro could promote the expression of ck, caspase3, caspase9, and bax protein, decrease the expression of bcl-2, promote hepatocyte apoptosis, and inhibit cell proliferation; in clinical samples, we found that compared with that in the normal tissues, the expression of cytokeratin, caspase3, caspase9, and bax in echinococcus tissues was high, but that in bcl-2 was low. |
2022-01-12 |
2023-08-13 |
mouse |
| Li Zhou, Zhong-Kun Li, Cong-Yuan Li, Yue-Qin Liang, Fan Yan. Anticancer properties and pharmaceutical applications of ginsenoside compound K: A review. Chemical biology & drug design. 2021-11-26. PMID:34793617. |
briefly, ck exerts anticancer effects via multiple molecular mechanisms, including the inhibition of proliferation, invasion, and migration, the induction of apoptosis and autophagy, and anti-angiogenesis. |
2021-11-26 |
2023-08-13 |
Not clear |